Journal
MOLECULAR BIOLOGY
Volume 51, Issue 4, Pages 596-601Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893317040112
Keywords
beta NAC; spermatogenesis; spermatocytes; tissue-specific ribosomes
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Funding
- Program for Leading Scientific Schools [NSh-7231.2016.4]
- Russian Foundation for Basic Research [15-04-00824]
- Program of Russian Academy of Sciences Molecular and Cellular Biology
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During the process of spermatogenesis, the proliferation of spermatogonia (stem cell descendants) is replaced by their differentiation in growing spermatocytes responsible for the preparation to meiosis, which is accompanied by a cardinal change in transcriptional programs. We have demonstrated that, in drosophila, this process is accompanied by a splash of the expression of beta-subunit of nascent polypeptide-associated complex (NAC) associated by ribosomes. Nascent polypeptide-associated complex is known as a chaperone involved in co-translational protein folding. This is the first case of the detection of tissue-specific co-translational NAC cofactor in multicellular eukaryotes. It is proposed that spermatocyte specific NAC is involved in the modulation of the expression of the proteins that provide the functioning of subsequent stages of spermatogenesis.
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