Article
Medicine, General & Internal
Elzbieta Malujlo-Balcerska, Tadeusz Pietras
Summary: This study evaluated the expression levels of certain molecules in patients with depressive disorders and controls. The results showed decreased expression of DIO2 and increased expression of IL1B, IL6, and TNFA in patients. Protein concentrations also showed corresponding changes. The AUC of IL-1 beta, IL-6, DIO1, and DIO3 proteins was >0.7, suggesting their potential as biomarkers for distinguishing patients with depressive disorders. Further studies are recommended to understand the exact role of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Dotan Moskovich, Yael Finkelshtein, Adi Alfandari, Amit Rosemarin, Tzuri Lifschytz, Avivit Weisz, Santanu Mondal, Harinarayana Ungati, Aviva Katzav, Debora Kidron, Govindasamy Mugesh, Martin Ellis, Bernard Lerer, Osnat Ashur-Fabian
Summary: The enzyme iodothyronine deiodinase type 3 (DIO3) plays a role in promoting cancer proliferation by inactivating the tumor-suppressive actions of thyroid hormone (T3). Inhibitors targeting DIO3 have shown promise in treating high-grade serous ovarian cancer and potentially other DIO3-dependent malignancies, with strong antitumor effects demonstrated in experimental models.
Article
Biochemistry & Molecular Biology
Wallace Klein Schwengber, Vitor Bock Silveira, Guilherme Moreira Hetzel, Amanda Robaina, Lucieli Ceolin, Marli Teresinha Camelier, Iuri Goemann, Roberta Rigo Dalla Corte, Rafael Selbach Scheffel, Renato Gorga Bandeira de Mello, Ana Luiza Maia, Jose Miguel Dora
Summary: This study found no association between Thr92Ala DIO2 polymorphism and cognitive impairment in older adults.
Article
Biochemistry & Molecular Biology
Anna Borgstroem, Barbara Hauert, Sven Kappel, Eugenio Zoni, Mirjam Kiener, Paulina Stoklosa, Roland Baur, Martin Spahn, Marianna Kruithof-de Julio, Christine Peinelt
Summary: TRPM4 is a widely expressed ion channel that plays a role in cancer hallmark functions, such as viability, migration, cell cycle shift, and adhesion, in prostate cancer cells. However, blocking TRPM4 ion conductivity is not sufficient to prevent its role in these functions.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Annarita Nappi, Maria Angela De Stefano, Monica Dentice, Domenico Salvatore
Summary: Hormones play a key role in cancer development, and the alteration of intratumoral thyroid hormone concentration is a common feature in many human tumors. Deiodinases are crucial for cell-autonomous control of TH action, and their expression is often altered in tumors. Studies have shown a dynamic expression of deiodinases in cancer cells, influenced by a network of factors, which exposes cancer cells to varying concentrations of TH with functional implications on cellular functions.
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Chuanjie Zhang, Yan Shen, Lili Gao, Xiaojing Wang, Da Huang, Xin Xie, Danfeng Xu, Hongchao He
Summary: This study investigated the biological functions and mechanisms of DNA polymerase epsilon subunit 2 (POLE2) in renal cell carcinoma (RCC). Results showed that high POLE2 expression in RCC tissues was correlated with poor prognosis. Knockdown of POLE2 inhibited cell proliferation, migration and promoted apoptosis, and its regulation of STC1 suggested potential as a target for RCC therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Xue Shi, Yu-Qing Wang, Yue-Ming Yang, Yi-Feng Li
Summary: This study investigated the expression of two deiodinase genes, McDx and McDy, in the larval stages of Mytilus coruscus. The results showed that these two genes are essential for larval development and knockdown of their expression significantly reduced larval metamorphosis. The study suggests a synergistic action of adrenergic and thyroid hormones in larval development and metamorphic transition in M. coruscus.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jorge Hidalgo-Alvarez, Federico Salas-Lucia, Diana Vera Cruz, Tatiana Fonseca, Antonio Bianco
Summary: The timed surge in DIO2-T3 signaling is critical in determining the fate of developing human hepatoblasts and the transcriptome of maturing hepatocytes, with physiological and clinical implications for how the liver handles energy substrates.
Article
Environmental Sciences
Xiao Liang, Yin Wang, Lu Liu, Xi Zhang, Li Li, Rong Tang, Dapeng Li
Summary: This study investigated the effects of nitrite exposure on thyroid hormone levels and intestinal iodothyronine deiodinases activity in grass carp. The results showed that nitrite exposure altered thyroid hormone levels, morphology of thyroid follicles, and gene expressions related to thyroid hormone metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Jiehui Di, Guang Zhao, Hui Wang, Yaoyao Wu, Zhongjun Zhao, Bao Zhu, Yanping Zhang, Junnian Zheng, Yong Liu, Ying Hu
Summary: A novel regulatory feedback loop between p53 and CPEB2 was identified in this study, where CPEB2 promotes renal cancer cell proliferation and migration by reducing p53 levels. This suggests that CPEB2 may serve as a potential therapeutic target in human renal cancer.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Multidisciplinary Sciences
Hirotake Takahashi, Yusuke Kashiwagi, Tomohisa Nagoshi, Yoshiro Tanaka, Yuhei Oi, Haruka Kimura, Kousuke Minai, Michihiro Yoshimura
Summary: The study found that low T3 levels are associated with high BNP levels in patients with cardiovascular disorders, and this relationship remains significant even in patients with normal BNP levels. The results suggest that low T3 levels are associated with high plasma BNP levels rather than worsening of hemodynamics.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Mikiko Okazaki-Hada, Azusa Maruoka, Masatoshi Yamamoto, Mitsuru Ito, Mitsuyoshi Hirokawa, Mitsushige Nishikawa, Takashi Akamizu, Akira Miyauchi, Nagaoki Toyoda
Summary: This case report describes a rare case of poorly differentiated thyroid carcinoma with triiodothyronine (T3) thyrotoxicosis, characterized by elevated type 1 and type 2 iodothyronine deiodinases (D1 and D2) activities in the tumor.
Review
Endocrinology & Metabolism
Yan Deng, Yi Han, Sheng Gao, Wei Dong, Yang Yu
Summary: DIO2 is an important enzyme that converts the prohormone thyroxine to the active form triiodothyronine, which is necessary for intracellular functions. It plays a crucial role in various physiological processes including tissue development, thermogenesis, and brain function. The Thr92Ala polymorphism in DIO2 is associated with clinical syndromes such as diabetes, obesity, hypertension, and bone and neurodegenerative diseases and tumors.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Environmental Sciences
Min Joo Kim, Sunmi Kim, Sohyeon Choi, Inae Lee, Min Kyong Moon, Kyungho Choi, Young Joo Park, Yoon Hee Cho, Young Min Kwon, Jiyoung Yoo, Gi Jeong Cheon, Jeongim Park
Summary: Exposure to mercury and cadmium may disrupt thyroid hormones, possibly through alteration of deiodinase activity. The association of exposure to PAHs with thyroid hormones appears to be insignificant.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Melitza S. M. Elizabeth, Annemieke J. M. H. Verkerk, Anita C. S. Hokken-Koelega, Joost A. M. Verlouw, Jesus Argente, Roland Pfaeffle, Theo J. Visser, Robin P. Peeters, Laura C. G. De Graaff
GROWTH HORMONE & IGF RESEARCH
(2020)
Correction
Biochemistry & Molecular Biology
Hanna Kedzierska, Piotr Poplawski, Grazyna Hoser, Beata Rybicka, Katarzyna Rodzik, Elzbieta Sokol, Joanna Boguslawska, Zbigniew Tanski, Anna Fogtman, Marta Koblowska, Agnieszka Piekielko-Witkowska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Anna Adamiok-Ostrowska, Agnieszka Piekielko-Witkowska
Article
Endocrinology & Metabolism
Celia Di Munno, Rosa Anna Busiello, Julie Calonne, Anna Maria Salzano, Jennifer Miles-Chan, Andrea Scaloni, Michele Ceccarelli, Pieter de Lange, Assunta Lombardi, Rosalba Senese, Federica Cioffi, Theo J. Visser, Robin P. Peeters, Abdul G. Dulloo, Elena Silvestri
Summary: In a rat model of semistarvation-refeeding, catch-up fat is associated with metabolic and contractile adjustments in skeletal muscle, as well as potential implications for thyroid hormone metabolism as a part of adaptive thermogenesis sustaining body fat recovery.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Karolina Hanusek, Beata Rybicka, Piotr Poplawski, Anna Adamiok-Ostrowska, Katarzyna Gluchowska, Agnieszka Piekielko-Witkowska, Joanna Boguslawska
Summary: TGF-beta 1 has been found to regulate the expression of multiple microRNAs involved in renal cell carcinoma (RCC), forming a complex network. It controls RCC cell proliferation and modifies the expression of oncogenic regulators, including ETS1. Additionally, TGF-beta 1 regulates the expression of several miRNAs and reciprocally modifies the expression of genes encoding TGF-beta 1 receptors and SMADs, suggesting a novel feedback mechanism mediated through miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Piotr Poplawski, Joanna Boguslawska, Karolina Hanusek, Agnieszka Piekielko-Witkowska
Summary: Renal cell cancer, especially clear cell renal cell carcinoma (ccRCC), is known for its high aggressiveness and poor prognosis for patients. The nucleoli, as crucial substructures of nuclei, play a significant role in controlling cellular functioning and homeostasis through multiple non-coding RNAs, such as snoRNAs. Dysregulation of snoRNAs, including SNHG1, SNHG4, and SNHG12, in ccRCC tumors contributes to the aberrant expression of oncogenes and tumor suppressors, directly impacting ccRCC development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Karolina Hanusek, Slawomir Poletajew, Piotr Kryst, Agnieszka Piekielko-Witkowska, Joanna Boguslawska
Summary: piRNAs are a class of small non-coding RNAs that regulate transposon and gene expression through mechanisms such as DNA methylation, histone modifications, and mRNA degradation. Recent studies suggest that piRNAs could serve as potential biomarkers for early cancer detection and therapeutic interventions, playing a role in the progression of prostate cancer.
Article
Oncology
Piotr Poplawski, Saleh Alseekh, Urszula Jankowska, Bozena Skupien-Rabian, Roksana Iwanicka-Nowicka, Helena Kossowska, Anna Fogtman, Beata Rybicka, Joanna Boguslawska, Anna Adamiok-Ostrowska, Karolina Hanusek, Jan Hanusek, Marta Koblowska, Alisdair R. Fernie, Agnieszka Piekielko-Witkowska
Summary: This study analyzed the transcriptome, proteome, and metabolome of ccRCC cells and identified molecules associated with the renal tumor microenvironment, which can serve as valuable non-invasive biomarkers detectable in plasma.
CANCER CELL INTERNATIONAL
(2023)
Review
Pediatrics
Artur Niedzielski, Lechoslaw Pawel Chmielik, Grazyna Mielnik-Niedzielska, Anna Kasprzyk, Joanna Boguslawska
Summary: Adenoids, part of Waldeyer's ring, are lymphoid tissues located at the junction of the roof and posterior wall of the nasopharynx. They play a crucial role in immune system development and serve as the first line of defense against respiratory and digestive antigens. The causes of adenoid hypertrophy are not fully understood, but they are likely associated with immune reactions, infections, environmental exposures, and hormonal or genetic factors. This review aims to summarize current knowledge about adenoid hypertrophy in children and its associated diseases. Adenoid hypertrophy has various clinical manifestations in pediatric patients and is often accompanied by comorbidities.
BMJ PAEDIATRICS OPEN
(2023)
Article
Cell & Tissue Engineering
Piotr Poplawski, Weronika Zarychta-Wisniewska, Anna Burdzinska, Joanna Boguslawska, Anna Adamiok-Ostrowska, Karolina Hanusek, Beata Rybicka, Alex Bialas, Helena Kossowska, Roksana Iwanicka-Rokicka, Marta Koblowska, Leszek Paczek, Agnieszka Piekielko-Witkowska
Summary: In this study, it was found that advanced RCC cells secrete AREG, FN1, and HA to induce MSCs migration, and MSCs' gene expression is reprogrammed to facilitate their migration. The identified components of RCC secretome may serve as potential therapeutic targets.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
