5-Fluorouracil-induced mitochondrial oxidative cytotoxicity and apoptosis are increased in MCF-7 human breast cancer cells by TRPV1 channel activation but not Hypericum perforatum treatment

Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats

(2017) Fuat Uslusoy et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Chemoresistance is associated with overexpression of HAX-1, inhibition of which resensitizes drug-resistant breast cancer cells to chemotherapy

(2017) Ji Yang et al.   TUMOR BIOLOGY

Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons

(2016) László Pecze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impact of very low physical activity, BMI, and comorbidities on mortality among breast cancer survivors

(2016) Sandahl H. Nelson et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of Orai1-mediated Ca2+entry enhances chemosensitivity of HepG2 hepatocarcinoma cells to 5-fluorouracil

(2016) Bao-Dong Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selenium potentiates the anticancer effect of cisplatin against oxidative stress and calcium ion signaling-induced intracellular toxicity in MCF-7 breast cancer cells: involvement of the TRPV1 channel

(2016) Esin Sakallı Çetin et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells

(2016) Ahmed Malki et al.   MOLECULES

Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil

(2016) Kiichiro Yamaguchi et al.   PAIN

Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells

(2015) Bilal Çiğ et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line

(2015) Seyed Abbas Mirmalek et al.   Cancer Cell International

TRPV1 Channel: A Potential Drug Target for Treating Epilepsy

(2015) Mustafa Nazıroglu   Current Neuropharmacology

Synergic Effects of Doxorubicin and Melatonin on Apoptosis and Mitochondrial Oxidative Stress in MCF-7 Breast Cancer Cells: Involvement of TRPV1 Channels

(2015) Pınar Aslan Koşar et al.   JOURNAL OF MEMBRANE BIOLOGY

Hypericum perforatum Attenuates Spinal Cord Injury-Induced Oxidative Stress and Apoptosis in the Dorsal Root Ganglion of Rats: Involvement of TRPM2 and TRPV1 Channels

(2015) Ümit Sinan Özdemir et al.   MOLECULAR NEUROBIOLOGY

Involvement of apoptosis and calcium accumulation through TRPV1 channels in neurobiology of epilepsy

(2015) M. Nazıroğlu et al.   NEUROSCIENCE

Transient Receptor Potential Vanilloid 1 Expression and Functionality in MCF-7 Cells: A Preliminary Investigation

(2014) Cristina Vercelli et al.   Journal of Breast Cancer

Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease

(2014) Mustafa Nazıroğlu et al.   JOURNAL OF MEMBRANE BIOLOGY

Modulation of oxidative stress and Ca2+ mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum

(2014) M. Nazıroğlu et al.   NEUROSCIENCE

Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis byHypericum perforatum

(2014) Mustafa Naziroglu et al.   NUTRITIONAL NEUROSCIENCE

Knockdown of EpCAM Enhances the Chemosensitivity of Breast Cancer Cells to 5-fluorouracil by Downregulating the Antiapoptotic Factor Bcl-2

(2014) Jiujiao Gao et al.   PLoS One

Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

(2013) Emilio Russo et al.   PHYTOTHERAPY RESEARCH

Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+-permeable TRPC6 channels

(2012) Kristina Leuner et al.   HIPPOCAMPUS

The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells

(2012) Martina Šemeláková et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

(2012) Abdulhadi C. Uguz et al.   JOURNAL OF PINEAL RESEARCH

Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+signaling molecular pathways in breast cancer

(2012) Mustafa Nazıroğlu et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin – a theoretical study

(2012) Emma S. E. Eriksson et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents

(2011) Y. Sun et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin Counteracts Alterations in Oxidative Metabolism and Cell Viability Induced by Intracellular Calcium Overload in Human Leucocytes: Changes with Age

(2010) Javier Espino et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Selenium Modulates Oxidative Stress-Induced Cell Apoptosis in Human Myeloid HL-60 Cells Through Regulation of Calcium Release and Caspase-3 and -9 Activities

(2009) Abdülhadi Cihangir Uğuz et al.   JOURNAL OF MEMBRANE BIOLOGY

Participation of DNA repair in the response to 5-fluorouracil

(2008) M. D. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES