Article
Gastroenterology & Hepatology
Ying Shang, Linnea Widman, Fahim Ebrahimi, Jonas F. Ludvigsson, Hannes Hagstrom, Axel Wester
Summary: This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and infections. The results showed that NAFLD patients had a higher risk of severe infections and infection-related mortality compared to the general population. This suggests that increased clinical vigilance for severe infections in NAFLD patients may reduce the risk of premature death.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Shuo-Yan Gau, Ching-Hua Huang, Yih Yang, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee
Summary: This study aims to evaluate the association between non-alcoholic fatty liver disease (NAFLD) and atopic dermatitis. The results showed that compared to individuals without NAFLD, NAFLD patients had a decreased risk of atopic dermatitis (aHR = 0.93, 95% CI 0.87-0.98). The decreased risk was especially observed in young NAFLD patients, with a 20% reduction in the risk of atopic dermatitis (aHR = 0.80, 95% CI 0.70-0.92).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Axel Wester, Hannes Hagstrom
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have a slightly higher risk of fractures, but their long-term risk of fractures is comparable to the general population. This suggests that broad surveillance of risk factors for fractures in patients with NAFLD is not necessary.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Abdel Aziz Shaheen, Gilaad G. Kaplan, Keith A. Sharkey, Brendan Cord Lethebe, Mark G. Swain
Summary: The study found that MDD was more common in patients with alcoholic liver disease, while antidepressant usage was common in both ALD and NAFLD patients. MDD was not associated with decompensated cirrhosis-free survival, but mirtazapine may increase the risk of decompensated cirrhosis or death.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Tora Grauers Willadsen, Volkert Siersma, Dagny Ros Nicolaisdottir, Dorte Jarbol, Ann Dorrit Guassora, Susanne Reventlow, Rasmus Koster-Rasmussen
Summary: This study examined symptom burden in patients with multimorbidity compared to those with a single morbidity, finding that having multiple morbidities results in a higher number of symptoms. In most cases of multimorbidity, the symptom burden was found to be additive.
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Maja Thiele, Rajani Sharma, Tracey G. Simon, Bjorn Roelstraete, Jonas Soderling, Jonas F. Ludvigsson
Summary: Patients with ALD have an increased risk of cancer, particularly HCC, after surviving the initial time post-diagnosis, but routine surveillance for HCC in ALD cirrhosis is not cost-effective.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Ola Olen, Michael C. Sachs, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Johan Askling, Anders Ekbom, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Crohn's disease patients are at increased risk of developing small bowel cancer and dying from it, with higher risks for recently diagnosed patients and those with childhood-onset, ileal, and stricturing CD. However, the absolute risks are low overall.
Article
Oncology
Thomas N. N. Nissen, Catherine Rechnitzer, Birgitte K. K. Albertsen, Lotte Borgwardt, Vibeke B. B. Christensen, Eva Fallentin, Henrik Hasle, Lars S. S. Johansen, Lisa L. L. Maroun, Karin B. B. Nissen, Allan Rasmussen, Mathias Rathe, Steen Rosthoj, Nicolai A. A. Schultz, Peder S. S. Wehner, Marianne H. H. Jorgensen, Jesper Brok
Summary: This study reports the incidence, outcomes, and long-term adverse events of malignant liver tumors in Danish children over the past 35 years. The overall incidence of liver tumors in Danish children was approximately 2.29 per 1 million children per year, with hepatoblastoma being the most common tumor. The overall 5-year survival rate was 84% and 78% for hepatoblastomas and hepatocellular carcinomas, respectively, with age≥8 years being the most significant factor associated with a poorer prognosis. Adverse events included reduced renal and cardiac function, as well as impaired hearing function, affecting a significant number of patients.
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Hannes Hagstrom, Johan Sundstroem, Jonas F. Ludvigsson
Summary: This study demonstrated that patients with biopsy-proven NAFLD have a significantly higher risk of major adverse cardiovascular events, including ischemic heart disease, stroke, congestive heart failure, and cardiovascular mortality, compared to matched population controls. The risk of such events increases progressively with worsening NAFLD severity.
Article
Oncology
Natacha Wurtz Yazdanfard, Lauge Hjorth Mikkelsen, Nille Behrendt, Katrine Fuglsang, Jan Blaakaer, Lisbet Rosenkrantz Holmich, Ligita Paskeviciute Froding, Helga Fibiger Munch-Petersen, Steffen Heegaard
Summary: This study investigated the clinical, pathological, and genetic characteristics of patients with vaginal melanoma in Denmark. The results showed that vaginal melanoma is a rare disease with a poor prognosis, possibly due to vague symptoms and the anatomical location of the disease. Co-mutations in ATRX and TP53 and mutations in TP53 alone were associated with a poor prognosis, suggesting that these genes could be potential targets for future therapy.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Habibollah Azarbakhsh, Leila Moftakhar, Sanaz Amiri, Alireza Mirahmadizadeh
Summary: The trend of suicide attempt by medication overdose has been increasing in recent years. This study investigated the epidemiology of suicide attempts and completed suicide by medication overdoses in Fars's province from 2011 to 2019. The highest suicide attempt rate by medication overdose was found in the age range of 15-24 years. Men, individuals with a family history of suicide, and those with a previous history of suicide had higher odds of completing suicide.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Environmental Sciences
Zhengyu Hu, Yan Li, Yuexin Yang, Weidi Yu, Wangcheng Xie, Guodong Song, Yaqin Qian, Zhenshun Song
Summary: This study investigated the levels of PAHs in the US population and their association with the risk of NAFLD. The results showed a positive correlation between multiple PAHs and NAFLD, with HDL and TG mediating the association between PAHs and NAFLD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Dentistry, Oral Surgery & Medicine
Diego Gomez-Costa, Jesus San-Roman-Montero, Rosa Rojo, Angel Gil, Rafael Gomez de Diego, Antonio F. Lopez-Sanchez
Summary: This study found that immigrants in Spain have a lower probability of developing signs associated with periodontal disease compared to the Spanish population. Among immigrants, females and adults had lower prevalence rates of periodontal disease.
Article
Medicine, General & Internal
Hui Wang, Priscilla Ming Yi Lee, Jun Zhang, Katrine Svendsen, Fei Li, Jiong Li
Summary: Individuals with intellectual disability are at increased risk of early-onset cardiovascular diseases, particularly cerebrovascular disease, stroke, heart failure, and deep vein thrombosis. The severity of intellectual disability is positively associated with the risk of cardiovascular diseases. This study highlights the importance of recognizing the cardiovascular disease risks in individuals with intellectual disability.
Article
Medicine, General & Internal
Qian Chen, Ji Chen, Yingchun Zhou, Lisu Huang, Yincai Tang, Jiong Li, Jun Zhang
Summary: Female children have a lower risk of asthma and a better chance of remission, while maternal asthma history has an opposite effect. Early life factors may influence the natural course of childhood asthma.
Article
Gastroenterology & Hepatology
Alfred Adiamah, Colin J. Crooks, John S. Hammond, Peter Jepsen, Joe West, David J. Humes
Summary: This cohort study aimed to examine the outcomes of cholecystectomy in patients with cirrhosis. Data from the UK were analyzed to determine length of stay, re-admission, case fatality, and odds of 90-day mortality in patients with and without cirrhosis. The study found that patients with cirrhosis had longer hospital stays, higher readmission rates, and increased mortality following cholecystectomy, particularly in emergency cases.
Article
Infectious Diseases
Signe Bollerup, Maria Wessman, Janne Fuglsang Hansen, Stine Nielsen, Gordon Hay, Susan Cowan, Henrik Krarup, Lars Omland, Peter Jepsen, Nina Weis, Peer Brehm Christensen
Summary: This study aimed to update the prevalence of chronic hepatitis B virus infection in Denmark and assess the completeness of reporting to the national register of communicable diseases. The results showed an increase in the prevalence of chronic hepatitis B virus infection from 2007 to 2017. However, a large number of diagnosed individuals were not receiving recommended care and were not reported to the communicable diseases register. Future efforts should focus on improving care for diagnosed individuals and enhancing reporting to the surveillance system.
INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Frederik Kraglund, Gerda Elisabeth Villadsen, Peter Jepsen
Summary: The study aimed to investigate the chances of statistical cure from hepatocellular carcinoma (HCC) in patients with alcohol-related liver disease (ALD) cirrhosis. The cure fraction analyses showed that resection for HCC statistically cured 31.8% of patients, while ablation statistically cured 22.9% of patients. Surviving patients after 7 years of curative-intent treatments were 90% likely to be statistically cured of HCC.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Substance Abuse
Ulrik Becker, Amalie Timmermann, Ola Ekholm, Morten Gronbaek, Asbjorn Mohr Drewes, Srdan Novovic, Camilla Nojgaard, Soren Schou Olesen, Janne Schurmann Tolstrup
Summary: This study analyzed the effects of drinking pattern and type of alcohol on the risk of acute and chronic pancreatitis. The results showed that increased alcohol intake was associated with increased development of pancreatitis. Frequent binge drinking and long-term drinking (daily drinking) were associated with the development of pancreatitis. The intake of large amounts of spirits and beer was associated with the development of acute and chronic pancreatitis, while the consumption of wine was not associated with the development of pancreatitis.
ALCOHOL AND ALCOHOLISM
(2023)
Letter
Gastroenterology & Hepatology
Joe West, Peter Jepsen, Timothy R. Card, Colin J. Crooks, Mark Bishton
Article
Public, Environmental & Occupational Health
Morten Daniel Jensen, Hugh Watson, Hendrik Vilstrup, Peter Jepsen
Summary: This study aimed to determine whether non-selective beta-blockers (NSBB) reduce the risk of infection in patients with cirrhosis. The research found that the risk of infection was lower in patients who used NSBB compared to those who did not use NSBB.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marine Solling Ramsing, Frederik Kraglund, Peter Jepsen
Summary: The use of statins has increased among Danish patients with ALD cirrhosis, and it is related to socioeconomic factors. Patients with lower education, cohabitation, and employment are more likely to start taking statins, while unemployment predicts statin discontinuation.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lars Bossen, Tobias Stemann Lau, Mette Bak Nielsen, Marlene Christina Nielsen, Astrid Hjmark Andersen, Peter Ott, Sabine Becker, Henning Glerup, Lise Svenningsen, Martin Eivindson, Linda Kornerup, Niels Bjrndal Kjeldsen, Anders Neumann, Holger Jon Moller, Peter Jepsen, Henning Gronbaek
Summary: This study investigated the effect of ursodeoxycholic acid (UDCA) on macrophage activation in patients with primary biliary cholangitis (PBC). The results showed that UDCA treatment can reduce the levels of the macrophage activation marker soluble CD163, which is associated with disease severity and treatment response in PBC.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Weiqi Liao, Carol A. C. Coupland, Hamish Innes, Peter Jepsen, Philippa C. Matthews, Cori Campbell, The DeLIVER consortium DeLIVER consortium, Eleanor Barnes, Julia Hippisley-Cox
Summary: This study aims to understand the disparities in epidemiology and clinical pathways of primary liver cancer in England. The findings show that age, sex, socioeconomic deprivation, ethnicity, and geographical regions are all significantly associated with liver cancer incidence. Patients aged 80 years and above have a higher risk of being diagnosed at late stages and have poorer survival rates. Men are at a higher risk of liver cancer than women, and survival rates are generally poor.
Article
Health Care Sciences & Services
Caroline Holt Udesen, Signe Skovgaard Hviid, Ulrik Becker, Janne S. Tolstrup
Summary: Adolescents and young adults aged 15-24 years are disproportionately affected by alcohol-related deaths. This study aimed to explore the extent and circumstances surrounding these deaths, as well as the potential differences in socioeconomic background and ethnicity compared to the general population.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Psychology, Developmental
Louise Hjarnaa, Sanne Pagh Moller, Alberte Brix Curtis, Ulrik Becker, Ove Andersen, Fartein Ask Torvik, Janne Schurmann Tolstrup
Summary: This study investigated the relationship between alcohol consumption and academic performance in teenagers. The findings showed that binge drinking and high weekly alcohol intake were associated with lower academic performance and increased risk of dropping out. These effects were consistent across different socioeconomic backgrounds and levels of academic ambition.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Medicine, General & Internal
Janne S. Tolstrup, Sofie Kruckow, Ulrik Becker, Ove Andersen, Susan M. Sawyer, Srinivasa Vittal Katikireddi, Sanne Pagh Moller
Summary: This study investigated the association between socioeconomic position (SEP) and alcohol-related hospital contacts in adolescents, and whether differences in risk can be explained by levels of alcohol consumption, drinking pattern, and substance use. The findings showed that despite similar levels of alcohol consumption, socioeconomically disadvantaged adolescents are more likely to experience alcohol-related harm, regardless of differences in drinking pattern or substance use. Therefore, future preventive strategies should prioritize young adolescents, especially those who are most disadvantaged.
Article
Medicine, General & Internal
Sofie Kruckow, Ziggi Ivan Santini, Louise Hjarnaa, Ulrik Becker, Ove Andersen, Janne S. Tolstrup
Summary: This study investigated the dose-response relationship between alcohol intake and the risk of hospital contacts due to alcohol and unintentional injuries in adolescents. The results showed that adolescents who drink alcohol have an increased risk of hospital admissions due to alcohol and unintentional injuries, suggesting the need for awareness and prevention measures for youth drinking.
Article
Gastroenterology & Hepatology
Frederik Kraglund, Diana H. Christensen, Andreas H. Eiset, Gerda E. Villadsen, Joe West, Peter Jepsen
Summary: Observational studies have shown an association between the use of statins or aspirin and a decreased risk of HCC. However, the effects of a well-defined treatment strategy are still unknown. This study emulated trials to investigate the effects of continuous statin or aspirin use on HCC risk in patients with alcohol-related liver disease cirrhosis. The findings suggest that continuous statin use for 5 years may significantly reduce the risk of HCC in these patients, while aspirin use does not have a significant effect on HCC risk.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Gro Askgaard, Lone Galmstrup Madsen, Natasja von Wowern, Matilde Winther-Jensen, Cathrine Juel Lau, Anne Illemann Christensen, Colin Crooks, Joe West, Peter Jepsen
Summary: This study examined the prevalence of weak social relationships in individuals with cirrhosis and their impact on health-related quality of life and mortality risk. The findings showed that individuals with cirrhosis were more likely to report low social support, loneliness, and living alone compared to the control group. Low social support and loneliness were associated with lower mental health-related quality of life and increased mortality risk in cirrhosis.
