4.5 Article

Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

Journal

MITOCHONDRION
Volume 44, Issue -, Pages 1-6

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.12.004

Keywords

Cardiovascular disease; Myocardial infarction; Stroke; Hypertension; mtDNA haplogroups; Spain

Funding

  1. MINECO [CGL2014-53781-r]
  2. Generalitat de Catalunya [2009 SGR 566]

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There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVOs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440-3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144-0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.

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