Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 17, Issue 7, Pages 603-632Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160914194134
Keywords
Acromonium fungi; alkaloids; bioactivities; beta-lactam antibiotic; marine organisms; secondary metabolites
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Funding
- Chinese Universities Scientific Fund [2014BH026, 2014RC020, 2016QC047]
- Hi-Tech R&D Program of China [2011AA10A202]
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Background: Acremonium fungi have been isolated from various sources, such as soil, plants, and marine organisms. Method: The species in Acremonium have been proved to be rich sources of novel and bioactive secondary metabolites. Up to now, 356 metabolites belonging to steroids (6 compounds), terpenoids (86), meroterpenoids (66), polyketides (89), alkaloids (28), peptides (75), and miscellaneous types (6) have been isolated from Acremonium fungi. These metabolites displayed a wide range of biological activities including antimicrobial, cytotoxic, antitumor, immunosuppressive, antioxidant, anti-inflammatory, antimalarial, phytotoxic, tremorgenic, antiviral, neuritogenic, insecticidal and enzymes-inhibiting activities. Conclusion: This review highlights the structures and bioactivities of the secondary metabolites from Acremonium fungi reported until July 2016.
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