Article
Chemistry, Multidisciplinary
Qammer Zaib, Matthew J. Eckelman, Yi Yang, Daeseung Kyung
Summary: This study evaluates the potential environmental impacts of a representative choline chloride (ChCl)/urea deep eutectic solvent (DES) called reline, using life-cycle assessment (LCA). The results show that reline has lower environmental impacts compared to certain organic solvents, but higher impacts compared to methanol and ethanol. The chemical constituent materials used in the synthesis of reline DES contribute significantly to its life-cycle environmental impacts. Additionally, LCA is performed on four other ChCl-based DESs, with ChCl/citric acid DES showing the highest environmental impacts.
Article
Chemistry, Multidisciplinary
Xinjie Liang, Bingqing Lv, Shitao Sun, Zhixuan Wu, Bin Lin, Xuefei Bao, Guoliang Chen
Summary: A novel method was developed to prepare hydroxamic acids from ester precursors in environmentally benign deep eutectic solvents. The method features a base-free reaction and the involvement of zinc oxide for product separation. Through an integrated solution of product purification and reagent recovery, the resource efficiency was improved and environmental impact was reduced. Various hydroxamic acids, including enantiomerically pure ones, were prepared in high yields. The recyclability of both zinc oxide and deep eutectic solvents was demonstrated through gram-scale preparation for multiple runs.
Article
Chemistry, Physical
Eduardo Picciolini, Genny Pastore, Tiziana Del Giacco, Gianluca Ciancaleoni, Matteo Tiecco, Raimondo Germani
Summary: Deep Eutectic Solvents (DESs) are a class of solvents that are becoming more and more important in research due to their environmentally friendly features, structural characteristics, and catalytic properties. They are formed by mixing a hydrogen bond donor and a hydrogen bond acceptor, and are finding applications as alternatives to common organic compounds.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Bricker D. Like, Christina E. Uhlenbrock, Matthew J. Panzer
Summary: Deep eutectic solvents (DESs) are a rapidly expanding class of liquid phase mixtures that have many useful features. However, there is currently no widely accepted criterion for identifying whether a particular mixture is a DES or not. This study introduces a quantitative metric based on the molar excess Gibbs energy of a eutectic mixture and proposes a threshold value to classify a eutectic system as a DES.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Laura Lomba, M. Pilar Ribate, Estela Sanguesa, Julia Concha, M. Pilar Garralaga, Diego Errazquin, Cristina B. Garcia, Beatriz Giner
Summary: Deep eutectic solvents (DESs) have gained attention for their environmentally friendly properties and versatility in various applications. Characterizing DESs, including their toxicity and biodegradation, is challenging due to the diverse factors involved.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Ningning Zhang, Fabian Steininger, Lars-Erik Meyer, Klaus Koren, Selin Kara
Summary: This study reported the oxygen transfer rates (OTR) of various deep eutectic solvents (DESs) and evaluated their effects on viscosity, water activity, and volumetric mass transfer coefficient. Results showed that the k(L)a values of different DESs were lower compared to water. Additionally, the addition of external water and adjustment of DES composition can impact the k(L)a values.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Chemistry, Physical
Shaina Joarder, Divyam Bansal, Harshvardhan Meena, Neha Kaushik, Jaya Tomar, Kamlesh Kumari, Indra Bahadur, Eun Ha Choi, Nagendra Kumar Kaushik, Prashant Singh
Summary: In the past decade, deep eutectic solvents (DESs) have been widely used as green solvents due to their advantages over traditional organic solvents and ionic liquids. DESs have been applied in various fields such as biotechnology, nanotechnology, synthesis, and catalysis. However, there is still uncertainty about their toxicity and conflicting reports on their biocompatibility. This review focuses on the catalytic potential of DESs and discusses their biocompatibility on different organisms.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Zonghua Wang, Congyi Wu, Ze Wang, Shaoze Zhang, Dezhong Yang
Summary: In this study, DESs were used for CO2 capture, and the results showed that the strength of hydrogen bonds plays a significant role in the absorption and desorption of CO2.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Dingyi Shi, Fengyi Zhou, Wenbo Mu, Cheng Ling, Tiancheng Mu, Gangqiang Yu, Ruiqi Li
Summary: This study developed a machine learning model that can accurately predict the viscosity of diverse deep eutectic solvents (DESs) at different temperatures, providing convenience for the design and application of DESs.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Andrey Shishov, Patrycja Makos-Chelstowska, Andrey Bulatov, Vasil Andruch
Summary: Deep eutectic solvents have the potential to replace hazardous organic solvents in some areas, and this study investigated the mixtures of tetrabutylammonium bromide and nonanoic acid to better understand their properties. The results showed the formation of a deep eutectic solvent and other eutectic mixtures.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Engineering, Chemical
Francesca Russo, Matteo Tiecco, Francesco Galiano, Raffaella Mancuso, Bartolo Gabriele, Alberto Figoli
Summary: In this study, porous polymeric membranes were prepared using DESs and NADESs for the first time, and the performance of the membranes was optimized by adding co-solvents and adjusting the composition of the coagulation bath. The results demonstrated the potential of DESs and NADESs as solvents for the preparation of sustainable polymeric membranes for water treatment applications.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Na Wang, Baoming Xu, Xinhui Wang, Jinyan Lang, Heng Zhang
Summary: This study analyzed the solubility parameters of lignin and compared them with those of Deep Eutectic Solvents (DESs) and commonly used solvents. The results showed that DESs had a better dissolution effect on lignin compared to common solvents. The mechanism of DESs for dissolving lignin was analyzed using Hansen solubility theory, and it was found that dispersion, polarity, and hydrogen bonding forces played important roles in the dissolution process. Among the three forces, hydrogen bonding force was the most dominant. The high strength of hydrogen bonding force and the similarity of solubility parameters between the forces and lignin were key factors in determining the solubility properties of solvents for lignin, which were met by DESs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Environmental
M. Candia-Lomeli, I Covarrubias-Garcia, A. Aizpuru, S. Arriaga
Summary: Styrene emissions can be treated using physicochemical, biological, or physicochemical/biological methods. This study focused on preparing and evaluating the characteristics of novel non-aqueous phases (NAPs) such as ionic liquids (ILs), deep eutectic solvents (DESs), and natural deep eutectic solvents (NADEs) for treating styrene vapors. The experiments showed that ILs and DESs were the best NAPs for styrene absorption.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Physical
Sweety Verma, Kanhaiya Saini, Sanjeev Maken
Summary: Deep eutectic solvents (DESs) are a class of mixtures with lower melting points, offering potential as low-cost, customizable solvents with adjustable physicochemical features. However, there is currently a lack of predictive understanding of their microscopic mechanisms and structure-property connections, making it important to conduct research using simulations and experiments to gain a better understanding of DESs and establish a foundational framework.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Akshay Malik, Hemant K. Kashyap
Summary: Due to the increasing emission of anthropogenic ammonia (NH3) in the atmosphere, researchers are developing new techniques to capture NH3. Deep eutectic solvents (DESs) have been identified as potential solvents for NH3 mitigation. This study uses ab initio molecular dynamics (AIMD) simulations to investigate the solvation shell structures of NH3 in reline (a mixture of choline chloride and urea) and ethaline (a mixture of choline chloride and ethylene glycol) DESs. The findings reveal the preferred interactions between NH3 and the different species in the DESs, such as hydrogen bonding and solute-solvent charge transfer.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Biochemical Research Methods
Rossella Svigelj, Nicolo Dossi, Cristian Grazioli, Rosanna Toniolo
Summary: Paper has been widely used as a cheap material for developing sensors, with a paper-based electrochemical platform now capable of detecting gluten in a deep eutectic solvent. This innovative method combines paper biosensors with DES ethaline, providing a sensitive detection tool for individuals with gluten sensitivities who may be affected by very low concentrations of gluten.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rossella Svigelj, Ivan Zuliani, Cristian Grazioli, Nicolo Dossi, Rosanna Toniolo
Summary: Nanomaterials, particularly gold-based nanostructures, can enhance the conductivity and performance of electrochemical sensors. By utilizing gold nanoparticles and truncated aptamers, an impedimetric biosensor was developed for quantifying gluten in hydrolyzed matrices, achieving a low limit of detection and successfully detecting gluten in real food samples.
Article
Chemistry, Analytical
Ivan Zuliani, Andrea Fattori, Rossella Svigelj, Nicolo Dossi, Cristian Grazioli, Gino Bontempelli, Rosanna Toniolo
Summary: This study tested a convenient assembly for measuring the ethanol content in gaseous samples. The assembly consists of filter paper and an ionic liquid, providing a portable electrochemical platform. Experiments with real alcoholic drink samples confirmed the feasibility of this assembly.
Article
Chemistry, Analytical
Cristian Grazioli, Nicolo Dossi, Francesco Cesaro, Rossella Svigelj, Rosanna Toniolo, Gino Bontempelli
Summary: A low-cost portable analytical device for reflectance measurements on paper supports is proposed. It utilizes paper-based analytical devices and shows good performance and repeatability. The device's measurements are in good agreement with those obtained from a benchtop spectrophotometer, indicating its reliability for various applications.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Conca, Mery Malandrino, Aleandro Diana, Ornella Abollino, Agnese Giacomino, Rafael Bartroli, Teresa Moreno, Xavier Querol, Fulvio Amato
Summary: An efficient analytical procedure was developed for the determination of metals in PM samples collected on aluminium foils by a cascade impactor, allowing for accurate size distribution and elemental composition analysis. The procedure proved effective in determining extremely low concentrations of analytes in different size fractions of PM emitted by a brake system.
Article
Chemistry, Multidisciplinary
Silvia Berto, Enrico Cagno, Enrico Prenesti, Giulia Aragona, Stefano Bertinetti, Agnese Giacomino, Paolo Inaudi, Mery Malandrino, Emanuele Terranova, Ornella Abollino
Summary: The knowledge gained from this study on the electrochemical behavior of diclofenac is crucial for the development of a voltammetric sensor for detecting the drug in water samples. Different carbon-based electrodes were examined, and the optimal voltammetric procedure for determining diclofenac concentration was established. The results showed that the glassy carbon electrode and the smaller surface of the screen-printed carbon electrode immersed in solution had the lowest detection limits.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Agnese Giacomino, Paolo Inaudi, Gessica Silletta, Aleandro Diana, Stefano Bertinetti, Elisa Gaggero, Mery Malandrino, Federico Stilo, Ornella Abollino
Summary: The determination of the authenticity of extra virgin olive oils (EVOOs) has gained increasing interest, especially in Italy, which has the highest number of Protected Designation of Origin (PDO) oils in Europe. This study focused on using the inorganic content and electrochemical properties as markers to identify the region of origin and plant species of EVOOs. The results showed that the inorganic composition can be a useful marker for the geographical origin of EVOOs, while the voltammetric analysis can effectively distinguish the plant species of origin. This method could also be used to monitor the conservation status of the oils.
Article
Environmental Sciences
Aleandro Diana, Stefano Bertinetti, Ornella Abollino, Agnese Giacomino, Sandro Buoso, Laura Favilli, Paolo Inaudi, Mery Malandrino
Summary: This work evaluates the air quality of two industrial cities in Italy, Turin and Biella, and identifies the main sources of pollution and its evolution over 15 years. The analysis reveals that urban activities and soil/road dust resuspension are the main contributors to metal pollution. Although Biella has lower pollution levels than Turin, the daily average concentration of PM10 frequently exceeds the European limit value.
Article
Chemistry, Analytical
Cristian Grazioli, Rossella Svigelj, Nicolo Dossi
Summary: In recent years, there has been increasing attention on 3D printing of carbon-based conductive filaments for assembling electrodes in electroanalytical devices. However, the potential of using this method for assembling 2D electrodes in a planar configuration has not been fully explored. This study presents a rapid and solvent-free method for assembling fully 3D printed flexible planar electroanalytical platforms (3DEPs) and a novel protocol for surface pre-treatment of 3D printed electrodes. The results demonstrate the efficiency and reusability of the electrodes produced.
Article
Materials Science, Multidisciplinary
Francesca Parenti, Raffaella Capelli, Adele Mucci, Cecilia Mortalo, Guido Paolicelli, Laura Pigani, Davide Vanossi, Monica Caselli
Summary: This paper reports the synthesis and characterization of a new alkoxy benzodithiophene-based small molecule, BDTCOR, which has two stereocenters and two end-capping acetyl groups. The spectroscopic properties and computational data suggest that BDTCOR is a candidate for optoelectronic applications due to its broad UV-Vis absorption spectrum and suitable fluorescence properties. Thin films of BDTCOR were deposited on SiO2 and PMMA substrates, and it was found that enantiopure BDTCOR shows different film morphology compared to the stereoisomeric mixture, indicating a tendency to generate supramolecular well-ordered structures. Additionally, the electronic circular dichroism spectra showed intense Cotton effect in vapor-deposited films, suggesting a synergic role of chirality and deposition technique on molecular order.
Article
Chemistry, Analytical
Rossella Svigelj, Fabiola Zanette, Rosanna Toniolo
Summary: The use of inexpensive and biodegradable deep eutectic solvents as nonaqueous solvents and electrolytes can potentially enhance the performance of enzyme biosensors and broaden their application in gas-phase. However, understanding the enzyme activity in these solvents is still lacking. This study employed an electrochemical approach to monitor the activity of tyrosinase enzyme in a deep eutectic solvent consisting of choline chloride (ChCl) as a hydrogen bond acceptor (HBA) and glycerol as a hydrogen bond donor (HBD). The immobilized tyrosinase enzyme on a gold-nanoparticle-modified screen-printed carbon electrode was used, and its activity was monitored by measuring the reduction current of orthoquinone generated by the enzyme's biocatalysis of phenol. This work represents a foundational step towards developing green electrochemical biosensors capable of operating in both nonaqueous and gaseous media for phenol analysis.
Article
Biochemistry & Molecular Biology
Claudia D'Ercole, Matteo De March, Gianluca Veggiani, Sandra Oloketuyi, Rossella Svigelj, Ario de Marco
Summary: A new adhiron phage display library was created and successfully used to select binders against antigens with different characteristics, resulting in isolated binders specifically targeting membrane epitopes of plant cells. These adhirons exhibited strong binding affinity and were suitable for various experimental applications.
Proceedings Paper
Engineering, Electrical & Electronic
Alessandro Monari, Chiara Zanardi, Loris Bruzzi, Barbara Zanfrognini, Stefano Cattini, Luigi Rovati, Laura Pigani
Summary: Given the beneficial properties of CBD, many countries have legalized fiber-type Cannabis products. However, it is common to find illegal levels of THC in freely commercialized products. Chromatographic techniques are typically used to analyze THC/CBD ratio but are costly and time-consuming. This study presents a preliminary investigation into the use of screen-printed electrodes modified with carbon black for in-situ analysis of cannabinoids in cannabis-derived products, which shows promising results.
2023 IEEE INTERNATIONAL INSTRUMENTATION AND MEASUREMENT TECHNOLOGY CONFERENCE, I2MTC
(2023)
Article
Biochemical Research Methods
Rossella Svigelj, Noemi Dassi, Andrea Gorassini, Rosanna Toniolo
Summary: This study developed an electrochemical smartphone-based aptasensor for the rapid and convenient detection of fipronil. By using a competitive replacement assay, the sensor showed excellent analytical performance in standard solutions. The use and performance of the sensor on honey samples were also evaluated, demonstrating its wide applicability.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)