Article
Chemistry, Applied
Juntao Yan, Chenghao Zhang, Chunlei Wang, Dengbo Lu, Shizhong Chen
Summary: A direct immersion dual-drop microextraction (DIDDME) method was developed for the separation and preconcentration of Cr(III) and Cr(VI). Using two organic drops on needle tips of microsyringes, each containing a specific chelating reagent, Cr(III) and Cr(VI) were selectively extracted into different drops. The method showed low detection limits, wide linear range, high enrichment factors, and good precision, and was successfully applied to quantify Cr(III) and Cr(VI) in food samples.
Article
Spectroscopy
Ondrej Zverina, Monika Vychytilov, Jaqueline Rieger, Walter Goessler
Summary: This article presents a rapid and accurate method for determining the zinc and iron content in food using high-resolution continuum source graphite-furnace atomic absorption spectrometry. By monitoring a narrow spectral interval, both elements can be measured simultaneously in a single firing, making the analysis fast and sensitive. Analysis of a large set of vegetable samples indicates higher zinc and iron contents in homegrown vegetables compared to store-bought ones.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2023)
Article
Biochemical Research Methods
Alexander Winckelmann, Dalia Morcillo, Silke Richter, Sebastian Recknagel, Jens Riedel, Jochen Vogl, Ulrich Panne, Carlos Abad
Summary: A fast, simple, and cost-effective analytical procedure for traceable determination of lithium concentration in human serum has been proposed. The method is based on monitoring lithium isotope dilution through the partially resolved isotope shift in its electronic transition. The results are comparable to more complex and expensive techniques such as isotope dilution mass spectrometry.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Spectroscopy
Denis S. Irisov, Rustam Kh Musin, Yuri A. Zakharov
Summary: A new two-stage probe atomization method was proposed for determining total arsenic in urine, using a high-resolution continuum source graphite furnace atomic absorption spectrometer. This method effectively separates arsenic from matrix components, with a low detection limit and a wide quantification range.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Arlene Santos Silva, Geovani Cardoso Brandao, Sergio Luis Costa Ferreira, Ana Maria Pinto dos Santos
Summary: An analytical method for the multielemental determination of Cd, Fe and Ni in toothpaste using slurry sampling high-resolution continuum source electrothermal atomic absorption spectrometry (HR-CS ET AAS) was reported. The method was successfully applied to analyze five toothpaste samples of different brands, demonstrating accurate and reliable results.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Analytical
Mikhail Yu Burylin, Elena S. Kopeyko, Viktoriya A. Bauer
Summary: The study compared the determination characteristics of copper and manganese in seawater by high-resolution continuum-source and low-resolution line-source graphite furnace atomic absorption spectrometry. HR-CS GFAAS can determine elements in undiluted samples, while LR-LS GFAAS only allows determination at double dilution. The detection and quantification limits for manganese were significantly lower in HR-CS GFAAS.
ANALYTICAL LETTERS
(2022)
Review
Instruments & Instrumentation
David J. Butcher
Summary: Graphite furnace atomic absorption spectrometry (GFAAS) is a highly sensitive method for determining elements in samples with low sample volume requirements. While line-source GFAAS is widely used, high-resolution continuum source (HR-CS) GFAAS allows for more accurate correction of matrix-induced spectral backgrounds. This article reviews recent innovations and developments in GFAAS, including instrumentation, characterization of fundamental properties, progress in HR-CS GFAAS, sample preparation procedures, elemental speciation, preconcentration/separation protocols, and direct analysis.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Review
Instruments & Instrumentation
David J. Butcher
Summary: Graphite furnace atomic absorption spectrometry (GFAAS), also known as electrothermal atomization (ETAAS), is a widely used method for sensitive elemental analysis. This article provides a summary of its principles, recent developments, and applications. The advancements in atomization mechanisms and instrumentation, as well as new approaches for direct solid sampling (SS) and preconcentration, are discussed. The article also reviews direct analyses for various sample types and discusses future developments in green protocols and speciation analyses in GFAAS.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Amir Ghaderi, Amir Hossein Khoshakhlagh, Masoome Irani, Azam Ghaseminezhad, Prem Gautam, Nezam Mirzaei, Hamid Reza Banafshe, Bahador Nemati, Heshmatollah Moradpour Ghalerashidi
Summary: This study investigated the levels of heavy metals and elements in urine and blood of hookah users and non-users, as well as their clinical symptoms. Results showed significantly higher levels of lead, arsenic, and thallium in hookah users compared to non-users, along with common clinical symptoms of constipation and fatigue. These findings can guide policy development to regulate hookah smoking and prevent associated health risks.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Analytical
Maiara Maziero, Franciele Rovasi Adolfo, Gabriela Camera Leal, Leandro Machado de Carvalho, Paulo Cicero do Nascimento, Carine Viana
Summary: The development of a method for determining Al, Cd, Cu, Mo, and Pb in pharmaceuticals for patients with chronic kidney disease using high-resolution continuum source graphite furnace atomic absorption spectrometry (HR-CS GFAAS) after microwave-assisted acid digestion is reported. The method involved utilizing different chemical modifiers and temperature conditions for the analysis of the elements, with successful application in 50 pharmaceutical formulations.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Analytical
Juntao Yan, Chenghao Zhang, Chunlei Wang, Dengbo Lu, Shizhong Chen
Summary: This study proposes a new method based on direct immersion dual-drop microextraction for simultaneous speciation and enrichment of V(IV) and V(V). The method avoids tedious and complicated pre-oxidation/pre-reduction and centrifugation/filtration operations, and has been successfully applied to determine V(IV) and V(V) in water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
Jens Friedland, Anja Brandt, Kerstin Leopold, Robert Guettel
Summary: This study combines experimental and computational modeling to achieve simultaneous sizing and quantification of gold nanoparticles. The simulation-assisted calibration method shows competitiveness and can reduce calibration time by up to 80%.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Geochemistry & Geophysics
Norbert Schreiter, Oliver Wiche, Ines Aubel, Quirina Roode-Gutzmer, Martin Bertau
Summary: A modified AAS method using HR CS GFAAS was developed for the determination of Ge in solid samples, without the need for time-consuming sample preparation steps. The results obtained showed a good agreement with those obtained using ICP-MS. The detection limit for Ge was down to 500 μg kg(-1), making the method suitable for routine analysis in geochemical laboratories.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2021)
Article
Chemistry, Multidisciplinary
Andrzej Gawor, Andrii Tupys, Anna Ruszczynska, Ewa Bulska
Summary: The determination of trace amounts of fluorine in biological samples poses challenges due to the chemically-rich matrix of biological tissues. High-resolution continuum source graphite furnace molecular absorption spectrometry (HR-CS GF MAS) is an effective method for precise fluorine determination, especially when optimized experimental conditions are employed. This method was validated through the use of certified reference materials, demonstrating its applicability to samples with similar matrices.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Pilaipan Chaikhan, Yuthapong Udnan, Richmond J. Ampiah-Bonney, Wipharat Chuachuad Chaiyasith
Summary: A novel hybrid air-assisted solvent terminated dispersive liquid-liquid microextraction (AA-ST-DLLME) method using a domestic fish-tank pump as a bubble generator was developed for the determination of Pb in water and beverage samples by GFAAS. The method achieved a high enrichment factor, preconcentration factor, and extraction efficiency under optimized conditions, with low LOD and LOQ. The method was successfully applied for the determination of trace level of Pb in various samples, with satisfactory spiked recovery results and good agreement with standard reference materials.
MICROCHEMICAL JOURNAL
(2021)
Article
Energy & Fuels
Robson M. de Jesus, Jeancarlo P. dos Anjos, Ednildo A. Torres, Gisele O. da Rocha, Jailson B. de Andrade
Article
Multidisciplinary Sciences
Luis Alberto Breda Mascarenhas, Bruna Aparecida Souza Machado, Leticia de Alencar Pereira Rodrigues, Katharine Valeria Saraiva Hodel, Alex Alisson Bandeira Santos, Paulo Roberto Freitas Neves, Leone Peter Correia da Silva Andrade, Milena Botelho Soares, Jailson Bittencourt de Andrade, Roberto Badaro
Summary: The research evaluated a spray disinfection technology for instant decontamination of PPE, showing that the technology can effectively reduce the number of different microorganisms.
Article
Environmental Sciences
Maria Claudia R. Sola, Aldenor G. Santos, Madson M. Nascimento, Gisele Olimpio da Rocha, Jailson Bittencourt de Andrade
Summary: This study investigated the concentrations of polycyclic aromatic compounds in sediment samples from beaches in Salvador, Brazil. The results showed high levels of parent PAHs and nitro-PAHs, with a potent mutagenic compound found in most samples. Calculations of carcinogenic PAHs and risk assessments for benthic species indicated moderate risks in the sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Analytical
Maria Elisabete Machado, Madson Moreira Nascimento, Pedro Victor Bomfim Bahia, Sabrina Teixeira Martinez, Jailson Bittencourt de Andrade
Summary: This study reviews the methods for assessing NSO-HET in sediments, examines the advantages and challenges, and discusses future trends and challenges to be overcome.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Pedro Victor Bomfim Bahia, Madson Moreira Nascimento, Jailson Bittencourt de Andrade, Maria Elisabete Machado
Summary: A green microscale solid-liquid extraction method was developed for the determination of n- alkanes in marine sediments. The method performance was validated and successfully applied to marine sediment samples.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Environmental Sciences
Natalia Menezes, Igor Cruz, Gisele O. da Rocha, Jailson B. de Andrade, Zelinda M. A. N. Leao
Summary: This study investigates the impact of petroleum exploitation and oil spills on coral reefs in marine ecosystems through a systematic review and bibliometric analysis. The main matrices studied are sediments, corals, and water, while air and other invertebrates have been less studied. Recommendations for future research include improving the detection capability of non-conventional PAHs, conducting more studies in underexplored regions in developing countries, and establishing databases to facilitate management planning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Fabio N. dos Santos, Madson M. Nascimento, Gisele O. da Rocha, Jailson B. de Andrade
Summary: We used MALDI-MS to investigate if pristine and functionalized fullerenes could be constituents of atmospheric aerosols. We identified several fullerene species, including C-60 and C-70, using matrix laser desorption ionization. The presence of these fullerenes as original constituents of atmospheric particles suggests their potential role in atmospheric chemistry and toxicity studies.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Pedro Victor Bomfim Bahia, Valdiria Almeida de Oliveira, Madson Moreira Nascimento, Leila Oliveira Santos, Gisele Olimpio da Rocha, Jailson Bittencourt de Andrade, Maria Elisabete Machado
Summary: This study presents the optimization and validation of a microscale extraction procedure for the determination of PANHs in PM2.5 samples, and it demonstrates low limits of detection and quantification as well as accurate and precise results. Additionally, the method is evaluated to be environmentally friendly and scored high in terms of greenness.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Madson Moreira Nascimento, Melise Lemos Nascimento, Jeancarlo Pereira dos Anjos, Ricardo Leal Cunha, Gisele Olimpio da Rocha, Ivanice Ferreira dos Santos, Pedro Afonso de Paula Pereira, Jailson Bittencourt de Andrade
Summary: Liquid-phase microextraction (LPME) is a simple, low-cost, and eco-friendly technique used to detect trace concentrations of organic contaminants in water samples. In this study, a novel customized micro-extraction device was developed for the extraction and preconcentration of illicit drugs in surface water and wastewater samples. The method was applied to real samples collected in Brazil, and the main drug detected and quantified was cocaine. The proposed method was considered environmentally friendly according to the AGREE metrics.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Environmental Sciences
Pedro Victor Bomfim Bahia, Madson Moreira Nascimento, Gisele Olimpio da Rocha, Jailson Bittencourt de Andrade, Maria Elisabete Machado
Summary: A green microscale solid-liquid extraction method was developed and applied for the analysis of 23 polycyclic aromatic sulfur heterocycles (PASHs) in PM2.5 samples. The optimal extraction conditions were determined through experimental design and successfully applied to samples collected from different time intervals and sulfur contents in diesel. The reduction of sulfur content in diesel showed a significant impact on the concentration of PASHs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Madson Moreira Nascimento, Sabrina Teixeira Martinez, Maria Elisabete Machado, Gisele Olimpio da Rocha, Jailson Bittencourt de Andrade
Summary: Baia de Todos os Santos (BTS) is the second-largest Brazilian bay and an important oil producing region in Brazil. This study presents recent research on contamination by polycyclic aromatic compounds (PACs) and Hg in the BTS region, focusing on sediments, water, and biota. The study also discusses the presence of different types of PACs, such as PAHs, nitro-PAHs, oxy-PAHs, and PASHs, as well as the distribution of Hg in seawater, sediments, and biota. The findings on biomonitoring organisms, including polychaetes, ascidians, and corals, are also discussed. The study concludes with suggestions for future research.
Article
Chemistry, Multidisciplinary
Marinice S. S. Acacio, Eliete C. Alves, Jailson B. de Andrade, Jeancarlo P. dos Anjos
Summary: Carbonyl compounds can be formed during craft beer production process, affecting sensory properties and posing a risk to health due to their toxicity. This study quantified 15 carbonyl compounds in craft beers, both in free and bound forms, using hydrolysis and derivatization reactions. The presence of acrolein, benzaldehyde, heptanal, and formaldehyde in craft beers suggests potential undesirable flavors. Frequent consumption of craft beers containing these carbonyl compounds could be harmful to health.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Lilian L. N. Guarieiro, Michelle J. C. Rezende, Willams T. Barbosa, Gisele O. da Rocha, Pedro Afonso P. Pereira, Daniella R. Fernandes, Wilson A. Lopes, Claudio J. A. Mota, Jailson B. de Andrade
Summary: Circular chemistry is an approach that aims to establish sustainable and circular chemical processes. It combines the principles of circular economy, life cycle approaches, and systems thinking to address sustainability issues. By promoting reuse, circular chemistry brings benefits in social, environmental, and economic spheres. It can contribute to constructing a mutually beneficial relationship between science, society, and the environment by maximizing benefits and reducing adverse impacts.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Sabrina T. Martinez, Caio S. A. Felix, Rayane Sorrentino, Igor C. S. Cruz, Jailson B. de Andrade
Summary: This study suggests that Phallusia nigra can be used as a potential biomonitor for mercury contamination. The study measured mercury levels in seawater and different parts of the ascidians from various sites in the Todos os Santos Bay. The results showed that the branchial basket had the highest concentration of mercury, followed by the hepatopancreas and tunic. Additionally, the branchial basket was the only tissue capable of identifying spatial differences in pollution between the sites.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Maritza F. Diaz, Marcia C. C. Veloso, Pedro A. P. Pereira, Yaima Sanchez, Iran Fernandez, Jailson B. de Andrade
Summary: The study evaluated the quality indicators of ozonized vegetable oils, with dende oil showing higher peroxide index and antibacterial activity, making it suitable for pharmaceutical or cosmetic formulations.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)