Article
Spectroscopy
Cristian Suarez-Oubina, Paloma Herbello-Hermelo, Pilar Bermejo-Barrera, Antonio Moreda-Pineiro
Summary: Analytical methods based on DRC technology and using ammonia as a reaction gas have been developed for the determination of ultra-trace Ti, Zn, Cu, and Ag by ICP-MS. DRC effectively overcomes spectral interferences from complex matrices, and different DRC approaches using ammonium as a reaction gas are compared to improve the measurement accuracy and precision.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Article
Biochemical Research Methods
Prasad Phapale, Andrew Palmer, Rose Muthoni Gathungu, Dipali Kale, Britta Brugger, Theodore Alexandrov
Summary: EMBL-MCF is an open LC-MS/MS spectral library with over 1600 fragmentation spectra from 435 authentic standards of endogenous metabolites and lipids. It features chromatographic profiles acquired with different LC-MS methods and coverage of different adduct ions. The library contains many biologically important metabolites and unique metabolites and lipids compared to other public libraries.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kevin P. Gillespie, Ross Pirnie, Clementina Mesaros, Ian A. Blair
Summary: It has been found that cisplatin treatment can induce secretion of HMGB1 from human non-small cell lung cancer cells, while carboplatin cannot. This secretion is dose-dependent and regulated by nuclear exportin 1. Additionally, the secreted HMGB1 after cisplatin treatment is mainly in the fully reduced form.
Article
Biochemical Research Methods
Claudia Patriarca, Jeffrey A. Hawkes
Summary: This paper investigates interferences in molecular mass spectra from aquatic samples, specifically identifying double charged ions from high molecular weight material as the main source. A strategy for filtering interference peaks based on isotopologue peaks at similar mass defects is proposed.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Chemistry, Analytical
Yoshiki Makino, Hiroki Matsuo, Koichiro Masuda, Shun-ya Onozawa, Tetsuya Nakazato
Summary: The evaluation of metal leaching in metal-catalyzed reactions is crucial, but current analytical methods for trace metal determination in organic reaction solutions are time-consuming and require high purity reagents. In this study, a rapid and sensitive method using LA-ICP-MS was developed for the determination of platinum group elements (PGEs) in organic reaction solutions. The proposed method allows for quick detection without the need for pre-treatment and can be completed in a short amount of time. The accuracy and adaptability of this method were confirmed through comparison with conventional methods.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Sacco, Matteo Tarchi, Giarita Ferraro, Antonello Merlino, Giorgio Facchetti, Isabella Rimoldi, Luigi Messori, Lara Massai
Summary: The study investigated the reactions of three novel platinum(II) complexes with model proteins through ESI MS analysis, revealing diverse reactivity patterns depending on the nature of the Pt complex and interacting proteins. The formation of protein-bound Pt fragments was identified, and crystal structures were used to determine the exact location of Pt binding sites, contributing to understanding the potential mechanisms of action of these innovative anticancer Pt complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Yuanjia Chen, Zhuofeng Ke, Zhenlin Xu, Weilong Huang, Yuanming Sun, Hongtao Lei, Xiaoqun Wei
Summary: A rapid, low-cost, and selective liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous determination of maneb group residues in fruit. The validated method showed sensitive quantification limits, steady recovery, and excellent precision. This method was successfully applied to analyze fruit samples and achieved satisfactory results.
Article
Chemistry, Physical
Jie Li, Yuhua Xu, Cheng Wang, Zhengying Wu, Yukihide Shiraishi, Yukou Du
Summary: This review summarizes recent research progress in PGMs-based interfacial catalysts for advanced electrocatalysis. The classification and fabrication strategies of different types of interfacial catalysts are introduced, and the promotion effect of interfacial catalysts on electrocatalytic performance is elaborated.
SURFACES AND INTERFACES
(2023)
Review
Biochemical Research Methods
Sven Heiles
Summary: Metabolomics and lipidomics are driving forces in the omics era, with tandem mass spectrometry methods playing a crucial role in characterizing the structural details of metabolites and lipids. Recent advancements in alternative tandem MS methodologies aim to provide full structural characterization of these compounds. The review critically examines the principles, capabilities, drawbacks, and initial applications of these advanced tandem mass spectrometry strategies in the fields of metabolomics and lipidomics.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Stamatios Giannoukos, Mohamed Tarik, Christian Ludwig, Serge Biollaz, Jay Slowik, Urs Baltensperger, Andre Stephan Henry Prevot
Summary: Real-time detection and characterization of metals and trace elements in a Swiss biogas production plant were successfully performed using a novel technology, with fast responses and low detection limits. The results of offline and online methods showed good agreement.
Article
Biochemical Research Methods
Tao Huan, Shipei Xing
Summary: We introduce the BUDDY software for accurately determining the molecular formulae of unknown chemicals in mass spectrometry data. BUDDY is a bottom-up approach that exhibits superior annotation performance on reference spectra and experimental datasets. Integration of global peak annotation could enhance BUDDY's formula annotations and uncover feature interrelationships.
Article
Chemistry, Analytical
Daniel Torregrosa, Carlos Gomez-Pertusa, Guillermo Grindlay, Luis Gras, Juan Mora
Summary: The number of studies on nanomaterial characterization in organic matrices using spICP-MS is increasing, but limited knowledge exists about the non-spectral interferences caused by this matrix. This study aims to investigate non-spectral interferences on nanoparticle characterization (number concentration and size distribution) by organic materials with spICP-MS. The results show that 10% w/w ethanol causes positive matrix effects on the number concentration, while the size distribution can be affected positively or negatively depending on the plasma conditions, instrument characteristics, and nanoparticle composition. Internal standardization can help mitigate these organic non-spectral interferences.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Review
Chemistry, Multidisciplinary
Minsu Han, Kenya Kani, Jongbeom Na, Jeonghun Kim, Yoshio Bando, Tansir Ahamad, Saad M. Alshehri, Yusuke Yamauchi
Summary: Nanoarchitectonics involves the control of physical and chemical properties, surface charge or energy, and atomic arrangements in materials at the nanoscale, allowing for precise modification of materials for specific applications. In metal materials, nanoarchitecture has a significant impact on activity, selectivity, and stability, particularly in platinum-group metals (PGMs) which are highly efficient in energy and environmental applications. This article provides a comprehensive review of synthetic methods for morphological control of metal nanomaterials, classifying them into different atomic arrangements and nanoporous structures. It also highlights future challenges in achieving novel metal nanoarchitecture and offers valuable insights for designing and synthesizing innovative metal nanostructures.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Joseph V. Goodwin, Benjamin T. Manard, Brian W. Ticknor, Paula Cable-Dunlap, R. Kenneth Marcus
Summary: The determination of actinide content and isotopics is important in nuclear forensics. This study demonstrates the use of high-resolution mass spectrometry to measure uranium isotope ratios in the presence of impurities without prior sample treatment.
MICROCHEMICAL JOURNAL
(2024)
Article
Acoustics
Eugeniu Vasile, Adrian Ciocanea, Viorel Ionescu, Ioan Lepadatu, Cornelia Diac, Serban N. Stamatin
Summary: The two-step method successfully separated the nanoparticles of Pd and Pt, significantly increasing the concentrations of Pd and Pt. In the absence of hydrodynamic cavitation and using conventional electrochemistry, the recovery rates of Pt and Pd were very low. Cost analysis showed that the method could recover Pd and Pt at a lower price.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Food Science & Technology
Ana Beatriz S. Silva, Ivero P. Sa, Julymar M. Higuera, Ana Rita A. Nogueira
Summary: The sensitivity of molybdenum determination in lamb meat was improved using the DLLME-MIP OES method, with optimized operational parameters. The proposed method showed satisfactory accuracy and suitable sensitivity for analytical purposes.
FOOD ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Luana S. Moreira, Ana P. R. Santana, Floriatan S. Costa, Josiane B. Vera, Mario H. Gonzalez, Erik G. P. da Silva, Clarice D. B. Amaral
Summary: A natural deep eutectic solvent (NADES) was used as a solvent in ultrasound-assisted extraction (UAE) for the determination of As and Cd in fish and shellfish samples. The study found that the use of KED mode resulted in higher sensitivity, and the extraction procedure was accurate and reliable.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ivero Pita de Sa, Gilberto Batista de Souza, Ana Rita de Araujo Nogueira
Summary: A new method for determining Cr(VI) in organic fertilizers was developed, utilizing adjustments in extraction and cloud point extraction methods to accurately quantify Cr(VI) content and meet regulatory requirements.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Julymar M. Higuera, Ana Beatriz S. Silva, Wignez Henrique, Sergio N. Esteves, Waldomiro Barioni, George L. Donati, Ana Rita A. Nogueira
Summary: The study evaluated the effects of genetic crossing and nutritional management on mineral and trace element concentrations in various body components of sheep. The diets had minimal impact on the elemental composition in different body parts, and OTX and OTS breeds exhibited the highest weight gain.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Leticia Kreutz Rosa, Floriatan Santos Costa, Cecilia Moraes Hauagge, Rafael Zancan Mobile, Antonio Adilson Soares de Lima, Clarice D. B. Amaral, Raquel C. Machado, Ana Rita A. Nogueira, Joao Armando Brancher, Melissa Rodrigues de Araujo
Summary: The study found significant increases in salivary concentrations of certain macro- and microelements in schizophrenia patients, along with higher prevalence of caries and periodontal disease. Exploratory analysis revealed different patterns in salivary composition of schizophrenia patients influenced by oral health conditions and medication usage.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Analytical
Matheus L. de Mello, Fernanda C. Pinheiro, Diego Carnaroglio, Joaquim A. Nobrega
Summary: This study explores the use of microwave-assisted sample preparation combined with inductively coupled plasma-optical emission spectrometry to determine the content of various inorganic elements. It was found that using diluted nitric acid solutions instead of HF for quantitative analysis of zinc oxide, kaolin, zinc residue, and zinc sulfide is feasible, but tailored procedures need to be considered.
ANALYTICAL LETTERS
(2022)
Article
Environmental Sciences
Daniel Fernandes Andrade, Jeyne Pricylla Castro, Jose Augusto Garcia, Raquel Cardoso Machado, Edenir Rodrigues Pereira-Filho, Dulasiri Amarasiriwardena
Summary: Recycling of precious materials from waste electrical and electronic equipment (WEEE) requires effective methods. Both traditional and emerging technologies play important roles in metal recovery, with green recycling technologies like biometallurgical, plasma arc fusion, and mechanochemical methods also being widely applied.
Article
Chemistry, Physical
Taciana G. S. Guimaraes, Daniel F. Andrade, Ana P. R. Santana, Poliana Moser, Sabrina S. Ferreira, Iohanna M. N. R. Menezes, Clarice D. B. Amaral, Andrea Oliveira, Mario H. Gonzalez
Summary: Amino acid-based deep eutectic solvents (AADES) were prepared in this study by mixing beta-alanine with various hydrogen bond donors and water. The optimal proportions of components were determined to achieve low density and viscosity, which are crucial for efficient sample preparation. AADES showed promising potential as solvents for extracting polar compounds, metals, and semimetals, with solvatochromic and thermal analyses providing additional insights into their properties.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Food Science & Technology
Luana S. Moreira, Floriatan S. Costa, Rita de Cassia Lidorio, Luan W. S. Toledo, Andrea Oliveira, Mario H. Gonzalez, Erik G. P. da Silva, Clarice D. B. Amaral
Summary: In this study, formic acid was used for the extraction of Cd and Pb in biological tissues, followed by graphite furnace atomic absorption spectrometry (GF AAS) for their determination. The accuracy and precision of the method were evaluated using certified reference materials, and the limits of quantification were found to be below the regulatory limits. The method was successfully applied to mollusks and fish tissue samples from coastal areas in Brazil, showing concentrations below the allowed limits, except for one mollusk sample. This study presents a promising and cost-effective analytical procedure for the extraction of toxic elements in biological tissues.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Applied
Floriatan Santos Costa, Luana Santos Moreira, Alisson Moreira Silva, Rafael J. Silva, Mayara Padovan dos Santos, Erik Galvao Paranhos da Silva, Marco Tadeu Grassi, Mario Henrique Gonzalez, Clarice D. B. Amaral
Summary: A MAE method using NADES was developed for the determination of Cd, Cu, Fe, Mn, and Zn in medicinal herb samples, showing high recovery rates and low standard deviation, making it suitable for mineral element analysis in herbal samples.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Beatriz M. M. Fontoura, Ariane I. I. Barros, Joaquim A. A. Nobrega
Summary: This study focused on using microwave-induced plasma optical emission spectrometry (MIP-OES) for urine analysis in a complex matrix with high concentrations of easily ionizable elements (EIEs). The urine matrix caused interferences for different elements, and strategies such as internal standardization and dilution were employed to correct these effects. Several potential internal standards were investigated, and the accuracy and precision of the method were evaluated. The results showed successful urine analysis by MIP-OES using these strategies.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Legna Colina-Vegas, Mariana da Cruz B. Silva, Caroline de Souza Pereira, Ariane Isis Barros, Joaquim Araujo Nobrega, Maribel Navarro, Matthias Rottmann, Sarah D'Alessandro, Nicoletta Basilico, Alzir Azevedo Batista, Diogo R. M. Moreira
Summary: Coordination of metal complexes with antimalarial quinolines shows potential in improving their bioactivity and inhibiting multiple stages of the Plasmodium life cycle.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Letter
Clinical Neurology
Patricia Aurea Andreucci Martins Bonilha, Victoria Cavalcanti de Souza, Isadora Branda, Floriatan Santos Costa, Clarice D. B. Amaral, Beatriz Gioppo Betini, Egberto Reis Barbosa, Helio Afonso Ghizoni Teive
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Chemistry, Analytical
Beatriz M. Fontoura, Florencia Cora Jofre, Trey Williams, Marianela Savio, George L. Donati, Joaquim A. Nobrega
Summary: Microwave-induced plasma optical emission spectrometry (MIP-OES) has made significant advancements in recent years, positioning itself as a competitive alternative to traditional inductively coupled plasma optical emission spectrometry (ICP-OES). This review compares the performance and matrix effect handling of MIP-OES with ICP-OES, and discusses strategies to overcome limitations of MIP-OES. Improvements in instrument accessories, plasma diagnostics, calibration methods, and sample preparation have enhanced the sensitivity and accuracy of MIP-OES.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Multidisciplinary
Julymar M. de Higuera, Herick M. Santos, Aline F. de Oliveira, Ana Rita A. Nogueira
Summary: A bioaccessibility test was conducted on raw and cooked lamb meat samples, showing that different cooking devices and methods can affect the physicochemical parameters and bioaccessibility of nutrients in lamb meat samples. Based on the results, lamb meat is considered a good source of Fe, P, and Zn.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)