Journal
MICROBIAL PATHOGENESIS
Volume 105, Issue -, Pages 226-230Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2017.02.018
Keywords
Helicobacter pylori; Genotype; Clinical outcome
Categories
Funding
- Research Center for Gastroenterology
- Liver Disease Research Center, Shahid Beheshti University of Medical Science Fund [RCGLD-407]
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There is diversity in clinical outcome of Helicobacter pylori infection in different regions. Microbial, host and environmental factors seem to be reason of such variation. Considering microbial factors, we studied H. pylori genotypes and their association with clinical feature of the infection. Overall 160 H. pylori positive patients were enrolled in this study. Clinical information and biopsy were collected from each patient. The presence of the major virulence genes were determined by PCR. Regardless to clinical outcomes, vacA, cagA, cagE, oipA, iceAl, babA2 and babB genes was positive in 100%, 69%, 51%, 55%, 26%,78% and 28% of 160 strains respectively. The s1m2 was more common vacA allels and sla and m1a were predominant s and m regions. In patient with gastric cancer (GC), the oipA was less frequent while the iceAl was the most common. The babA2 was common in all patient groups. The babB was significantly observed in strains isolated from patients with GC. There were significant association among cagA status with presence of vacAsl, vacAm2, cagE, oipA, iceAl and babA2. Presence of the babB and oipA was connected with higher and lower risk for GC respectively. There was no association between the cagA, vacA, cagE or iceA status and clinical outcome in patients in Iran. We showed that presence of the babB and iceAl were significantly connected with higher risk for gastric cancer development in Iranian dyspeptic patients while H. pylori isolates with positive oipA had little threat for leading patients to cancer. (C) 2017 Elsevier Ltd. All rights reserved.
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