Article
Plant Sciences
Samina Rubnawaz, Mohammad K. Okla, Nosheen Akhtar, Imdad Ullah Khan, Muhammad Zeeshan Bhatti, Hong-Quan Duong, Mohamed A. El-Tayeb, Yahaya B. Elbadawi, Khalid S. Almaary, Ihab M. Moussa, Zahid Khurshid Abbas, Bushra Mirza
Summary: The study confirmed that transgenic Ajuga bracteosa plants have higher metabolic content and stronger biological activities. Among them, ABRL3 showed the highest antibacterial, anticancer, and antiparasitic activities, as well as high toxicity against human cancer cell lines.
Article
Biochemistry & Molecular Biology
Muhammad Shakeeb Sharif, Hajra Hameed, Abdul Waheed, Muhammad Tariq, Afshan Afreen, Asif Kamal, Eman A. Mahmoud, Hosam O. Elansary, Saddam Saqib, Wajid Zaman
Summary: This study synthesized iron oxide nanoparticles from algae and plant extracts using a simple, environmentally friendly, and cost-effective method, and characterized their properties. Plant-based Fe3O4 NPs exhibited stronger antioxidant and antibacterial activities compared to algal-based NPs, possibly due to the higher content of phytochemicals in plants, which can encapsulate the nanoparticles during the fabrication process.
Article
Chemistry, Inorganic & Nuclear
Ab Majeed Ahanger, Suresh Kumar, Dolly Kain, Atul Arya, Vandana
Summary: Researchers encapsulated Ajuga bracteosa extract into the ZIF-8 framework to form a nanoconjugate, which showed superior antibacterial efficiency through a specific mechanism of inhibiting bacterial growth.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Samina Rubnawaz, Waqas Khan Kayani, Nosheen Akhtar, Rashid Mahmood, Asif Khan, Mohammad K. Okla, Saud A. Alamri, Ibrahim A. Alaraidh, Yasmeen A. Alwasel, Bushra Mirza
Summary: In transgenic regenerants of Ajuga bracteosa, kaempferol was the most abundant polyphenol among 18 standards, and transgenic line ABRL3 exhibited the highest phenolics and flavonoids content. Furthermore, transformed plant extracts showed significant analgesic, anti-inflammatory, anticoagulant, and antidepressant activities in BALB/c mice models.
Article
Multidisciplinary Sciences
Sadaf Azad Raja, Saiqa Andleeb, Aneela Javed, Sana Sabahat, Fahed Parvaiz, Hafsah Mureed, Sohaib Ahmad, Falak Naz
Summary: This study synthesized gold nanoparticles using extract from Ajuga bracteosa, a medicinal herb found in the northern Himalayas. The synthesized nanoparticles were characterized and their antibacterial efficacy was tested against pathogenic bacteria. The study also assessed the anticancer activity of the nanoparticles and the toxicity of the supernatant. In addition, in-silico analysis was conducted to evaluate the binding efficacy of small molecular weight ligands from Ajuga bracteosa. The findings revealed that the Aj-AuNps have good antibacterial and anticancer properties, while the Nps-free supernatant is highly effective against resistant pathogens and cancer cell lines.
Article
Chemistry, Applied
Ab Majeed Ahanger, Suresh Kumar
Summary: This article introduces a novel drug delivery system based on ZIF-8 nanoparticles, which shows biocompatibility, precise drug release ability, and high stability. The system encapsulates drugs extracted from Ajuga bracteosa and demonstrates effective inhibition of cancer growth.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biology
Muhammad Imran, Hasnain Jan, Shah Faisal, Sajjad Ali Shah, Sumaira Shah, Muhammad Naeem Khan, Muhammad Taj Akbar, Muhammad Rizwan, Faheem Jan, Suliman Syed
Summary: This study evaluated the anti-parasitic, insecticidal, cytotoxic, and anti-Alzheimer potential of various leaf extracts of Ajuga bracteosa. The n-hexane extract showed significant activity against Leishmania Tropica and promising anti-Alzheimer activity. The insecticidal potential of the extracts varied, with n-hexane showing the highest mortality rate.urther research is warranted to explore the potential of Ajuga bracteosa as a botanical insecticide and source of anti-tumor compounds.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sadia Nazer, Saiqa Andleeb, Shaukat Ali, Nazia Gulzar, Abida Raza, Habib Khan, Kalsoom Akhtar, Muhammad Naeem Ahmed
Summary: The study investigated the anti-diabetic and hepato-protective effects of green synthesized silver nanoparticles using Ajuga bracteosa. Results showed valuable potential in reducing blood glucose levels, improving liver function, and protecting the liver in diabetic and CCl4-induced mice. These findings suggest that ABaqu and ABAgNPs possess strong anti-diabetic and hepatoprotective properties.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Malik Hassan Mehmood, Bushra Shaukat, Babar Murtaza, Farah Javaid, Muhammad Tariq Khan, Maryam Farrukh, Reemal Rana, Muhammad Shahzad
Summary: This study investigated the beneficial effects and mechanisms of A. bracteosa in L-NAME-induced hypertensive rats. The results showed that A. bracteosa has antihypertensive, antioxidant, and anti-inflammatory activities, possibly mediated through the regulation of eNOS, ACE, NF-kB, and COX-2 gene expressions.
Article
Chemistry, Multidisciplinary
Ab Majeed Ahanger, Suresh Kumar, Atul Arya, Amrita Suryavanshi, Dolly Kain, Vandana
Summary: Infectious diseases caused by bacteria have become a public health issue. Antibiotic therapy and overuse have led to antibiotic-resistant strains. The researchers have developed a nanocomposite called APE@ZIF-8 with outstanding antibacterial activity against MRSA and CCREC. The nanocomposite damages bacterial cell organelles by producing reactive oxygen species upon contact with the bacterial surface. It shows potential in treating drug-resistant infections caused by gram-positive and gram-negative bacteria.
Review
Agriculture, Multidisciplinary
Fazlurrahman Khan, Nazia Tabassum, Nilushi Indika Bamunuarachchi, Young-Mog Kim
Summary: Phloroglucinol and its derivatives have been widely used to treat microbial infections and exhibit diverse biological activities. With the increasing resistance of microorganisms to antimicrobial drugs, the synthesis of more phloroglucinol derivatives is crucial to meet the growing demand. This review provides an overview of the application of phloroglucinol and its derivatives in antibacterial action and explores their potential future perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Anatomy & Morphology
Shumaila Mumtaz, Shaukat Ali, Syed Akif Raza Kazmi, Tafail Akbar Mughal, Samaira Mumtaz, Hafiz Muhammad Tahir, Muhammad Summer, Chaman Ara, Muhammad Imran Rashid
Summary: Researchers fabricated sericin-coated silver nanoparticles using sericin as a stabilizer and reductant, and evaluated their antibacterial potential using the agar well diffusion method. The nanoparticles exhibited strong inhibitory effects on various pathogenic bacteria and fungi at different concentrations and temperatures, and showed stability under different environmental conditions.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Food Science & Technology
Yi Hao, Mengmeng Zhang, Li Wang, Ningping Tao, Li Li, Weizhong Zhu, Changhua Xu, Shanggui Deng, Yifen Wang
Summary: This study demonstrates that chitosan-graft-polylactic acid and lysozyme-graft-polylactic acid films have antibacterial effects against Staphylococcus aureus and Escherichia coli by disrupting the integrity of bacterial cell membranes and changing permeability. Additionally, immobilized chitosan can enter bacterial cells and bind to DNA, further inhibiting bacterial growth and reproduction.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Syed Mahmood, Tan Siew Mei, Wong Xi Yee, Ayah Rebhi Hilles, Walla Alelwani, Azzah M. Bannunah
Summary: The study developed a novel combination of capsaicin loaded silver nanoparticles (AgCNPs) using nanotechnology, which exhibited potent antimicrobial activity against bacteria, especially gram-negative bacteria (E. coli). The green synthesised AgCNPs showed highly significant anti-bacterial activity, suggesting promising potential for treating psoriasis.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Environmental Sciences
Muzamil Ahmad Rather, Pranab Jyoti Deori, Kuldeep Gupta, Niran Daimary, Dhanapati Deka, Asifa Qureshi, Tapan Kumar Dutta, Siddhartha Narayan Joardar, Manabendra Mandal
Summary: This study described a green synthesis method of silver nanoparticles using Cuphea carthagenensis leaf extract and investigated their properties and antibacterial activity. The results showed that the synthesized nanoparticles have potential medical applications.