Review
Engineering, Biomedical
Huige Zhou, Fenglan Qin, Chunying Chen
Summary: Hypoxia in solid tumors hinders drug delivery and poses challenges for tumor treatment. Recent research on hypoxia-responsive nanomaterials shows promise in overcoming these obstacles and improving therapeutic efficiency.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Yang Xie, Yudi Wang, Wenjie Pei, Yue Chen
Summary: Theranostic in nuclear medicine combines diagnostic imaging and internal irradiation therapy using different therapeutic nuclear probes for visual diagnosis and precise treatment. GLP-1R molecular imaging has made breakthroughs in the application of endocrine diseases, steatohepatitis, tumors, and other areas. However, it is currently limited to imaging diagnosis research. This article discusses the current research status, challenges, and emerging opportunities for GLP-1R molecular imaging in order to promote the development of molecular medicine.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Alexandra Foster, Shubhanchi Nigam, David S. Tatum, Itay Raphael, Jide Xu, Rajeev Kumar, Elizabeth Plakseychuk, Joseph D. Latoche, Sarah Vincze, Bo Li, Rajan Giri, Lauren H. McCarl, Robert Edinger, Murat Ak, Vishal Peddagangireddy, Lesley M. Foley, T. Kevin Hitchens, Rivka R. Colen, Ian F. Pollack, Ashok Panigrahy, Darren Magda, Carolyn J. Anderson, W. Barry Edwards, Gary Kohanbash
Summary: Researchers successfully labeled CD11b antibody using a bifunctional chelator Lumi804 to image and treat TAMCs in murine gliomas. The Lu-177-Lumi804-alpha CD11b treatment not only reduced TAMC population but also improved the efficacy of immunotherapy.
Article
Polymer Science
Dedai Lu, Mingshu Chen, Lili Yu, Jiachen Wang, Hongyun Guo, Xing Zhou, Zhiming Han, Zubang Zhou, Haijun Wang, Shiqi Liao, Ziqiang Lei
Summary: A new noncatheter target embolization therapy was developed using triblock poly[(l-glutamic acid-ran-l-tyrosine)-b-l-threonine-b-l-cysteine]s-coating perfluoropentane-loaded mesoporous-SiO2 nanoparticles. The pH-responsive system showed excellent ultrasound contrast imaging capability and effectively inhibited and eradicated solid tumors.
Review
Medicine, Research & Experimental
Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Summary: Photodynamic Therapy (PDT) has emerged as a promising alternative in cancer diagnosis and treatment, utilizing light-induced activation of photosensitizers to kill cancer cells. PDT offers advantages such as minimal invasiveness and spatio-temporal control, with proper planning of parameters being crucial for efficacy. The design of PS formulations for imaging-guided PDT has shown promising potential, with recent advances in activatable phototheranostic agents enhancing the specificity of treatment.
Review
Pharmacology & Pharmacy
Haozhe He, Xindan Zhang, Lihua Du, Minwen Ye, Yonglai Lu, Jiajia Xue, Jun Wu, Xintao Shuai
Summary: This article summarizes the recent progress of nanosized molecular imaging probes, including ultrasound, magnetic resonance, and computed tomography imaging nanoprobes, and discusses their applications in detail. The article highlights the importance of molecular imaging and the challenges in synthesizing efficient imaging probes.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Analytical
Cailing He, Jiayuan Zhu, Huayue Zhang, Ruirui Qiao, Run Zhang
Summary: Photoacoustic imaging (PAI) utilizes endogenous chromophores and exogenous contrast agents to provide detailed information on diseased tissues, offering advantages in spatial resolution, tissue penetrability, and imaging contrast over traditional technologies. Recent developments in nanomaterials and organic dyes as PAI probes show promise for disease diagnosis and treatment, but challenges remain in designing and fabricating future PAI probes.
Article
Biotechnology & Applied Microbiology
Zhengzou Fang, Ziyu Zhu, Zijian Zhuang, Zhangzuo Li, Cheng Yan, Mengting Yang, Qian Chen, Xinyuan Li, Aihua Gong
Summary: In this study, a glutathione-responsive FA-EM@MnO2-GO/ICG&DOX nanoplatform was successfully developed, which can achieve drug-targeting delivery and precise drug release.
Review
Pharmacology & Pharmacy
Longhai Jin, Chenyi Yang, Jianqiu Wang, Jiannan Li, Nannan Xu
Summary: Nanomaterials have gained increasing attention in the biomedical field and are considered a new generation of MRI contrast agents. Stimuli-responsive nanomaterials have been synthesized as TME-responsive MRI CAs, improving diagnostic sensitivity and accuracy. This review focuses on recent advances and future challenges in the application of nanomaterials as TME-responsive MRI CAs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea K. Miyahira, Howard R. Soule
Summary: This article reviews the history of PSMA in the field of prostate cancer theranostics and discusses the role of Prostate Cancer Foundation funding in this area.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jiankun Guan, Yuxin Wu, Huimin Wang, Haowen Zeng, Zifu Li, Xiangliang Yang
Summary: The study developed a multifunctional therapeutic nanoparticle platform with selective drug release for targeted tumor treatment, which improved the diagnosis and treatment of cancer through tumor targeting and minimally invasive therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kondapa Naidu Bobba, Anil P. Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin, Robert R. Flavell
Summary: This study presents efficient radiolabeling methods using 225Ac-chelators DOTA and MACROPA, and their application in prostate cancer imaging agents. The results demonstrate the potential of 134Ce/134La-labeled agents as PET imaging surrogate for 225Ac-based radioligand therapies, with similar chemical and pharmacokinetic characteristics.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Chemistry, Physical
Anh Nguyen, Sahana Kumar, Ashish A. Kulkarni
Summary: Despite advancements in cancer immunotherapy, the heterogeneity in tumor response poses obstacles to successful treatments and accurate prognosis. Existing imaging techniques have limitations in early assessment of immune response. Engineered nanomaterials play a significant role in overcoming these challenges by improving drug delivery and dynamic imaging techniques.
Article
Engineering, Biomedical
Ying Wang, Xiaowen Xu, Xuan Zhao, Zongning Yin
Summary: A functionalized polymeric hybrid micelle system was developed for specific imaging and dissolution of thrombi, showing potential for developing nanotheranostic agents in preclinical thrombotic vascular disease models.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Rong Hu, Xinzhe Yang, Anjun Qin, Ben Zhong Tang
Summary: Aggregation-induced emission (AIE) has become a hot research topic in chemistry and materials science, with AIE polymers combining the advantages of polymeric materials and AIE luminogens for applications in sensing, imaging and theranostics. There is great potential for future development in this promising field.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Conen, Francesca Pennetta, Katharina Dendl, Fabian Hertel, Andreas Vogg, Uwe Haberkorn, Frederik L. Giesel, Felix M. Mottaghy
Summary: In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed. The results showed a significant negative correlation between renal parenchymal [(68) Ga]Ga-FAPI uptake and glomerular filtration rate (GFR), highlighting the potential value of [(68) Ga]Ga-FAPI for the noninvasive evaluation of kidney fibrosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Vanessa Nadig, Ken Herrmann, Felix M. Mottaghy, Volkmar Schulz
Summary: This study summarizes the current status and future developments of total-body PET/CT scanners, with three human TB PET/CT systems developed and increasing system sensitivity paving the way for new imaging methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Karl-Josefi Langen, Felix M. Mottaghy
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Bell, Martin Lemos, Felix M. Mottaghy, Oliver Lindner, Alexander Heinzel
Summary: The aim of this study was to evaluate the transfer of an interactive nuclear cardiology teaching module to an online, distance learning setting. The results showed that the teaching module was successfully transferred during the pandemic, but it was perceived to be less efficient in its course didactics, demands and applicability compared to classroom teaching.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ellen Boswijk, Marlies de Ligt, Marie-Fleur J. Habets, Alma M. A. Mingels, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Patrick Schrauwen, Joachim E. Wildberger, Jan Bucerius
Summary: Resveratrol treatment did not significantly attenuate arterial or systemic inflammation as measured by (18) F-FDG PET in subjects at risk of developing type 2 diabetes, although there was a slight increase in (18) F-FDG uptake in visceral adipose tissue. CRP levels were also not significantly affected by resveratrol treatment. Further validation in larger human studies is required.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Isabel Alkhasli, Felix M. Mottaghy, Ferdinand Binkofski, Katrin Sakreida
Summary: This study found that preconditioning frontal networks using tDCS and subsequently stimulating the lDLPFC using TMS resulted in more robust functional connectivity compared to excitatory iTBS to a tDCS-enhanced DLPFC. The whole brain stimulation effects demonstrated the feasibility of using tDCS to modulate subsequent TMS effects. This proof-of-principle study may encourage further research into using the principle of preconditioning for DLPFC as a stimulation site for the treatment of depression.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Oncology
Marguerite Mueller, Oliver Winz, Robin Gutsche, Ralph T. H. Leijenaar, Martin Kocher, Christoph Lerche, Christian P. Filss, Gabriele Stoffels, Eike Steidl, Elke Hattingen, Joachim P. Steinbach, Gabriele D. Maurer, Alexander Heinzel, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen, Philipp Lohmann
Summary: This study investigated the potential of radiomics applied to static clinical PET data in differentiating treatment-related changes (TRC) from tumor progression (TP) in patients with gliomas. The results showed that static FET PET scans can be used with high accuracy to differentiate TRC and TP in gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Editorial Material
Cell Biology
Natascha Ingrid Drude
Summary: By simultaneously engaging in fundamental research and clinical research, individuals can achieve permanent positions in academia. In this article, Natascha Drude's success in bridging her academic work in drug development with clinical research is highlighted.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Oncology
Ahmed Allam Mohamed, Kathrin Risse, Jennifer Stock, Alexander Heinzel, Felix M. Mottaghy, Philipp Bruners, Michael J. Eble
Summary: Obesity and high visceral-to-subcutaneous fat ratio are significantly associated with worsened survival outcomes in patients with anal cancer, highlighting the importance of addressing obesity as a potential factor influencing treatment effectiveness.
Review
Medicine, General & Internal
Prodromos Gavriilidis, Michel Koole, Salvatore Annunziata, Felix M. Mottaghy, Roel Wierts
Summary: This literature review discusses the impact of positron range correction and denoising techniques on the image quality of Ga-68 PET. The results show that these techniques can improve image quality and achieve comparable results to F-18 PET in some cases. However, further validation in clinical studies is needed.
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Article
Cell Biology
Amelie Heesch, Lars Ortmanns, Jochen Maurer, Elmar Stickeler, Sabri E. M. Sahnoun, Felix M. Mottaghy, Agnieszka Morgenroth
Summary: Recent studies have shown that PSMA expression on TNBC cells and adjacent endothelial cells may serve as a new target for therapy. This study analyzed the expression of PSMA and its isoforms in TNBC cells, BCSCs, and tumor-associated endothelial cells. The results demonstrated that PSMA was highly expressed in TNBC cell lines and its isoforms were predominantly found in BCSCs. In addition, tumor-conditioned media had a significant pro-angiogenic effect and all TNBC cell lines induced PSMA expression in HUVEC. These findings suggest the potential of PSMA-targeted therapy in TNBC.
Review
Pharmacology & Pharmacy
Clarissa F. D. Carneiro, Natascha Drude, Maren Huelsemann, Anja Collazo, Ulf Toelch
Summary: This review summarizes different strategies to improve external validity in in vivo, in vitro, or ex vivo experiments, including systematic heterogenization, generalizability tests, and multi-batch and multicenter experiments. Special considerations in sample size planning, analysis options, and practical feasibility are also discussed.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Robert T. Thibault, Olavo B. Amaral, Felipe Argolo, Anita E. Bandrowski, Alexandra R. Davidson, Natascha I. Drude
Summary: Conversations about open science have become mainstream, but practices like data sharing are still uncommon. This Essay provides an overview of past open science initiatives and explores the potential future of open science. It also offers recommendations for creating an environment conducive to open science.
Review
Oncology
Karl-Josef Langen, Norbert Galldiks, Joerg Mauler, Martin Kocher, Christian Peter Filss, Gabriele Stoffels, Claudia Regio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann
Summary: Advanced MRI methods and PET using radiolabelled amino acids provide valuable additional information for brain tumour diagnostics. While the hybrid PET/MRI has allowed for the convergence of these methods, simultaneous imaging has limited relevance in clinical neuro-oncology. A multimodal approach that combines PET and MRI shows promising improvement in the diagnosis of cerebral gliomas.
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.
