Article
Nutrition & Dietetics
Josip Delmis, Slavko Oreskovic, Vesna Elvedji Gasparovic, Mirta Starcevic, Mislav Herman, Nada Dessardo, Vito Starcevic, Marina Ivanisevic
Summary: This study aimed to explore the relationship between glucose, C-peptide, brain-derived neurotrophic factor (BDNF), and leptin in maternal-fetal circulation as well as neonatal weight. The results showed a strong correlation between maternal and umbilical vein glucose levels, as well as maternal glucose and C-peptide levels in umbilical vein blood. Additionally, a negative correlation was found between BDNF levels in umbilical vein blood and maternal blood glucose levels, while a strong correlation was observed between BMI and maternal blood leptin levels, neonatal fat body mass, and umbilical vein blood leptin levels.
Review
Biochemistry & Molecular Biology
Angelos Dimas, Anastasia Politi, George Papaioannou, Thomas M. Barber, Martin O. Weickert, Dimitris K. Grammatopoulos, Sudhesh Kumar, Sophia Kalantaridou, Georgios Valsamakis
Summary: Increased maternal food intake affects fetal development and metabolism, with gut-hormone molecules playing a crucial role. However, the correlation between maternal appetite axis hormones and birth weight is not consistent, suggesting their role in regulating fetal energy deposition mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chelsey McConnell, Melissa Thoene, Matthew Van Ormer, Jeremy D. Furtado, Zeljka Korade, Thiago C. Genaro-Mattos, Corrine Hanson, Ann Anderson-Berry
Summary: The study analyzed the differences in maternal and umbilical cord plasma carotenoid concentrations and maternal-umbilical cord plasma ratios among different birth gestational age groups. Maternal plasma concentrations increased with birth gestational age, while there was less variability in umbilical cord plasma concentrations, leading to an increase in the maternal-umbilical cord plasma ratio. Further research is needed to determine the physiological relevance of carotenoid concentrations to varying gestational ages or if they are influenced by factors associated with preterm birth.
Article
Obstetrics & Gynecology
Jing Wei, Qiaoyun Li, Hongbo Zhai
Summary: Umbilical artery thrombosis is a challenging and rare condition that may occur at different gestational ages, especially when diagnosed in the third trimester with fetal growth restriction. Close monitoring of umbilical blood flow and fetal growth, as well as timely intervention, are essential for achieving optimal outcomes in these patients.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Clinical Neurology
Min Meng, Yanrui Jiang, Lixia Zhu, Guanghai Wang, Qingmin Lin, Wanqi Sun, Yuanjin Song, Shumei Dong, Yujiao Deng, Tingyu Rong, Qi Zhu, Hao Mei, Fan Jiang
Summary: The study found that maternal sleep duration and sleep efficiency in late pregnancy were significantly associated with newborn triglyceride levels in umbilical cord blood, and sleep duration was also positively correlated with newborn leptin levels. However, no significant association was found between other maternal sleep parameters in late pregnancy and birth weight, leptin, and lipid levels.
Review
Biochemistry & Molecular Biology
Andrea Olmos-Ortiz, Pilar Flores-Espinosa, Lorenza Diaz, Pilar Velazquez, Carlos Ramirez-Isarraraz, Veronica Zaga-Clavellina
Summary: Gestational Diabetes Mellitus (GDM) is a transient metabolic condition caused by dysregulation due to intolerance to carbohydrates during pregnancy, resulting in harmful effects to the mother and fetus, with the placenta playing a key role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Maria del Mar Roca-Rodriguez, Pablo Ramos-Garcia, Cristina Lopez-Tinoco, Manuel Aguilar-Diosdado
Summary: Cord blood leptin levels were significantly higher in gestational diabetes mellitus (GDM) compared to controls. Subgroup analyses based on continents, analysis technique, and sample source also showed consistent results. Further research is needed to determine the predictive role of cord blood leptin levels in metabolic diseases in GDM mothers and their offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Rieko Sagara, Satoshi Hirayama, Tsuyoshi Ueno, Atsushi Hori, Yutaro Kobori, Takahito Kai, Emiko Nishioka, Takehisa Matsukawa, Shintaro Makino, Takashi Miida
Summary: Insulin resistance worsens during pregnancy due to increases in insulin counterregulatory hormones. Maternal lipids greatly influence neonatal growth, but triglyceride-rich lipoproteins cannot be transferred directly to the fetus. This study investigated the association between maternal metabolic parameters and fetal development with maternal and umbilical cord blood LPL concentrations.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Janneke G. F. Hogervorst, Nelly D. Saenen, Tim S. Nawrot
Summary: The study found a negative association between prenatal acrylamide exposure and fetal growth, possibly mediated through modulation of thyroid hormones, neurotrophins, and insulin-related factors. Further research is needed to explore the potential health consequences of these associations.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Fatemeh Behrasi, Mansour Karajibani, Samira Khayat, Hamed Fanaei, Farzaneh Montazerifar
Summary: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring obesity and health, while excessive gestational weight gain was associated with higher levels of neonatal asprosin and lower Apgar scores. Maternal asprosin concentrations did not show significant differences between normal weight gain and EGWG groups.
NUTRITION BULLETIN
(2022)
Article
Medicine, General & Internal
Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu
Summary: This study evaluated the effect of weight gain in different trimesters on the risk of gestational diabetes mellitus (GDM). The results showed that insufficient weight gain in early pregnancy and excessive weight gain in middle pregnancy were associated with an increased risk of GDM. Strict control of weight gain in early pregnancy and sufficient nutrition in middle pregnancy are necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Ksawery Golawski, Wojciech Giermaziak, Michal Ciebiera, Cezary Wojtyla
Summary: Adequate weight gain during pregnancy is important for a healthy pregnancy, but excessive weight gain is associated with adverse pregnancy outcomes. Based on a Polish national survey of 10,319 women and 6930 children, excessive gestational weight gain is associated with higher birthweight, increased risk of birthweight over 4500 g, cesarean section/assisted delivery, pregnancy induced hypertension, hospitalization during pregnancy, and lower Apgar score in the first minute of neonate's life. However, there was no significant difference in premature rupture of membranes and labor inductions. Our study highlights the increased risk of adverse pregnancy outcomes with excessive gestational weight gain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ning Wang, Yanqi Peng, Lu Wang, Lin Song, Bo Sun, Junxiang Wei, Ting Wang, Yang Mi, Wei Cui
Summary: The study aimed to analyze the risk factors for gestational diabetes mellitus (GDM) heterogeneity and its correlation with obesity. Results showed that GDM patients exhibit different glycemic physiology types, with specific obesity-related risk factors for the GDM-resistance subtype mediated by pre-pregnancy overweight/obesity and increased gestational weight gain in the first trimester.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Karen L. Lindsay, Lauren E. Gyllenhammer, Sonja Entringer, Pathik D. Wadhwa
Summary: Objective: The study aimed to determine the association between rate of gestational weight gain (rGWG) and glucose-insulin metabolism in Hispanic pregnant women with overweight and obesity. The findings revealed that rGWG was inversely associated with beta-cell function in a high-risk population of Hispanic pregnant women with overweight and obesity, potentially contributing to the development of type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Fei Fei, Shaoyang Sun, Qiang Li, Zhou Pei, Lei Wang, Ranran Zhang, Feihong Luo, Min Yu, Xu Wang
Summary: This study found that combinatorial counterbalances of the leptin and Igf1 signaling pathways in HCC models significantly relieve cachexia. Genetic replenishment of Igf1 in a lepr-mutant background effectively relieved the cachexia-like phenotype without affecting tumor growth, providing a practical strategy for treating certain HCC-associated cachexia. The results describe the synergistic impact of leptin and Igf1 normalization in rescuing anorexia, muscle wasting, and adipose wasting in HCC models.
Article
Public, Environmental & Occupational Health
Brian T. Joyce, Tao Gao, Kalsea Koss, Yinan Zheng, Andres Cardenas, Jonathan Heiss, Allan Just, Kai Zhang, Linda van Horn, Norrina Bai Allen, Philip Greenland, Sheldon Cohen, Penny Gordon-Larsen, Colter Mitchell, Sara McLanahan, Lisa Schneper, Daniel Notterman, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Robert Wright, Andrea Baccarelli, Donald Lloyd-Jones, Lifang Hou
Summary: This study examines the relationship between individual, parental, and neighborhood socioeconomic status and epigenetic age acceleration (EAA), and finds that paternal education is associated with EAA.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Hassan S. Dashti, Douglas E. Levy, Marie-France Hivert, Kaitlyn Alimenti, Jessica L. McCurley, Richa Saxena, Anne N. Thorndike
Summary: This study found associations between higher BMI genetic risk and increased body weight and lower quality purchases. However, a 12-month behavioral intervention improved employees' food choices and may have attenuated weight gain associated with genetic risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Elmar W. Tobi, Diana L. Juvinao-Quintero, Justiina Ronkainen, Raffael Ott, Rossella Alfano, Mickael Canouil, Madelon L. Geurtsen, Amna Khamis, Leanne K. Kupers, Ives Y. Lim, Patrice Perron, Giancarlo Pesce, Johanna Tuhkanen, Anne P. Starling, Toby Andrew, Elisabeth Binder, Robert Caiazzo, Jerry K. Y. Chan, Romy Gaillard, Peter D. Gluckman, Elina Keikkala, Neerja Karnani, Sanna Mustaniemi, Tim S. Nawrot, Francois Pattou, Michelle Plusquin, Violeta Raverdy, Kok Hian Tan, Evangelia Tzala, Katri Raikkonen, Christiane Winkler, Anette-G Ziegler, Isabella Annesi-Maesano, Luigi Bouchard, Yap Seng Chong, Dana Dabelea, Janine F. Felix, Barbara Heude, Vincent W. V. Jaddoe, Jari Lahti, Brigitte Reimann, Marja Vaarasmaki, Amelie Bonnefond, Philippe Froguel, Sandra Hummel, Eero Kajantie, Marjo-Riita Jarvelin, Regine P. M. Steegers-Theunissen, Caitlin G. Howe, Marie-France Hivert, Sylvain Sebert
Summary: Maternal hyperglycemia is associated with lower cord blood DNAm at TXNIP, and these CpGs may be candidate loci for future causal and mediation analyses.
Article
Biochemistry & Molecular Biology
Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P. Cook, Catherine Allard, Robin N. Beaumont, Mickael Canouil, Gad Hatem, Anni Heiskala, Anni Joensuu, Ville Karhunen, Soo Heon Kwak, Frederick T. J. Lin, Jun Liu, Sheryl Rifas-Shiman, Claudia H. Tam, Wing Hung Tam, Gudmar Thorleifsson, Toby Andrew, Juha Auvinen, Bishwajit Bhowmik, Amelie Bonnefond, Fabien Delahaye, Ayse Demirkan, Philippe Froguel, Kadri Haller-Kikkatalo, Hildur Hardardottir, Sandra Hummel, Akhtar Hussain, Eero Kajantie, Elina Keikkala, Amna Khamis, Jari Lahti, Tove Lekva, Sanna Mustaniemi, Christine Sommer, Aili Tagoma, Evangelia Tzala, Raivo Uibo, Marja Vaarasmaki, Pia M. Villa, Kare Birkeland, Luigi Bouchard, Cornelia M. Duijn, Sarah Finer, Leif Groop, Esa Hamalainen, Geoffrey M. Hayes, Graham A. Hitman, Hak C. Jang, Marjo-Riitta Jarvelin, Anne Karen Jenum, Hannele Laivuori, Ronald C. Ma, Olle Melander, Emily Oken, Kyong Soo Park, Patrice Perron, Rashmi B. Prasad, Elisabeth Qvigstad, Sylvain Sebert, Kari Stefansson, Valgerdur Steinthorsdottir, Tiinamaija Tuomi, Marie-France Hivert, Paul W. Franks, Mark McCarthy, Cecilia M. Lindgren, Rachel M. Freathy, Deborah A. Lawlor, Andrew P. Morris, Reedik Magi
Summary: The study found that gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) share the same underlying pathology, but there are also genetic determinants specific to glucose regulation in pregnancy.
HUMAN MOLECULAR GENETICS
(2022)
Article
Gastroenterology & Hepatology
Allison J. Wu, Izzuddin M. Aris, Marie-France Hivert, Lauren Fiechtner, Kirsten K. Davison, Susan Redline, Elsie M. Taveras
Summary: The study found that exclusive breastfeeding and avoiding bottle use in bed were associated with lower BMI z-score. Adherence to 4-5 healthy infant feeding practices was also associated with lower BMI z-score. Following healthy infant feeding practices may reduce the risk of excessive adiposity in early childhood.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Nathan Cohen, Sabrina Faleschini, Sheryl L. Rifas-Shiman, Luigi Bouchard, Myriam Doyon, Olivier Simard, Melina Arguin, Guy Fink, Amy C. Alman, Russell Kirby, Henian Chen, Ronee Wilson, Kimberly Fryer, Patrice Perron, Emily Oken, Marie-France Hivert
Summary: The relationship between maternal hyperglycemia and offspring cortisol levels is still unclear.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Pediatrics
Nidhi Ghildayal, Catherine Allard, Kasandra Blais, Myriam Doyon, Melina Arguin, Luigi Bouchard, Patrice Perron, Marie-France Hivert
Summary: The study found an association between maternal insulin sensitivity during pregnancy and adiposity measures in children. Lower maternal insulin sensitivity was correlated with higher child adiposity, particularly in central adiposity measures.
Article
Environmental Sciences
Pi-I D. Lin, Andres Cardenas, Sheryl L. Rifas-Shiman, Ami R. Zota, Marie-France Hivert, Izzuddin M. Aris, Alison P. Sanders
Summary: This study aimed to explore the association between trace elements and maternal kidney function during the first trimester of pregnancy. The findings suggest that high lead levels and low magnesium, selenium, and zinc levels are associated with decreased kidney function. Furthermore, the analysis of trace element mixtures shows that a higher concentration of non-essential trace elements is associated with reduced kidney function, while a higher concentration of essential trace elements is associated with improved kidney function.
ENVIRONMENTAL RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Emily Oken, Theresa M. Bastain, Nicole Bornkamp, Carrie Breton, Rebecca C. Fry, Diane R. Gold, Marie-France Hivert, Steve Howland, Daniel J. Jackson, Christine C. Johnson, Kyra Jones, MollyAn Killingbeck, T. Michael O'Shea, Marleny Ortega, Dennis Ownby, Frederica Perera, Julie Rollins, Julie B. Herbstman
Summary: High-quality evidence from prospective longitudinal studies in humans is essential for understanding the developmental origins of health and disease. This paper discusses the challenges faced by birth cohort studies and provides recommendations for long-term funding, maintaining contact with participants, maximizing engagement, and addressing sensitive topics. Successful longitudinal follow-up requires flexibility, adaptability, and appropriate incentives.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Ella Parsons, Sheryl L. Rifas-Shiman, Anne K. Bozack, Andrea A. Baccarelli, Dawn L. DeMeo, Marie-France Hivert, Lode Godderis, Radu-Corneliu Duca, Emily Oken, Andres Cardenas
Summary: The prenatal environment may program health and disease susceptibility via epigenetic mechanisms. This study found associations between maternal trimester-specific intake of micronutrients and global DNA methylation and 5-hydroxymethylation in cord blood, with some associations persisting into early childhood.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Tiange Liu, Fan Jia, Moira K. Differding, Ni Zhao, Myriam Doyon, Luigi Bouchard, Patrice Perron, Renee Guerin, Eric Masse, Marie-France Hivert, Noel T. Mueller
Summary: Maternal pre-pregnancy body mass index (BMI) is associated with the diversity and composition of gut microbiota in mothers and children 5 years after birth. However, the nature and direction of these associations differ between mothers and children, suggesting the need for further research.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Jordi Merino, Hassan S. Dashti, Douglas E. Levy, Magdalena Del Rocio Sevilla-Gonzalez, Marie-France Hivert, Bianca C. Porneala, Richa Saxena, Anne N. Thorndike
Summary: This study investigates the impact of genetic variants on macronutrient preference and long-term food choices. The results show that an increase in the polygenic score for carbohydrate preference is associated with more monthly food purchases and a higher number of purchases with green-labeled food. However, there is no evidence of associations between fat and protein polygenic scores and food purchases.
MOLECULAR PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Sheryl L. Rifas-Shiman, Izzuddin M. Aris, Karen M. Switkowski, Jessica Young, Abby F. Fleisch, Tamarra James-Todd, Ami R. Zota, Wei Perng, Marie-France Hivert, Janet W. Rich-Edwards, Melissa Perez Capotosto, Jorge E. Chavarro, Emily Oken
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Mingyu Zhang, Izzuddin M. Aris, Pi-I Debby Lin, Sheryl L. Rifas-Shiman, Tammy M. Brady, Tamarra James-Todd, Emily Oken, Marie-France Hivert
Summary: This study found associations between prenatal and childhood PFAS exposures and blood pressure at specific time points, but no consistent associations across all time points or PFAS types.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)