Article
Food Science & Technology
Mengting Wang, Haiguang Mao, Jianchu Chen, Qiang Li, Wei Ma, Nan Zhu, Lili Qi, Jinbo Wang
Summary: Chinese bayberry leaves proanthocyanidins (BLPs) have significant effects on hepatic glucose metabolism, promoting glycogen synthesis and reducing gluconeogenesis. These effects may be achieved through the activation of the PI3K/AKT signaling pathway. Additionally, BLPs can also regulate the expression of specific miRNAs, further influencing hepatic glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Yanting Ding, Sijing Xia, Haowen Fang, Bing Niu, Qin Chen
Summary: Loureirin B was found to have positive effects on glucose metabolism in insulin-resistant cells by promoting AKT phosphorylation, inhibiting ROS production, and regulating the expression of key genes, potentially ameliorating type 2 diabetes symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dai Ying, Shan Mengya, Li Peilin, Zhao Lingong, Ma Huan, Xu Jing, Zhang Le, Zhang Kebin, Chen Bin, Yan Jun, Guo Shaodong, Xu Zihui
Summary: Mibefradil has been shown to decrease cytoplasmic calcium levels, increase phosphorylation of Akt and FoxO1, and contribute to the cytoplasmic localization of FoxO1, ultimately alleviating insulin resistance and glucose output. Additionally, it decreases the expression of key gluconeogenesis enzymes, thus helping to control blood sugar levels and reduce insulin resistance through the Ca2+-CaMKII dependent Akt/FoxO1 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park
Summary: This study reveals a novel function of p-PDHA1 and PKM2 in regulating transcription of specific genes and promoting cell migration in hepatocarcinoma cells upon insulin stimulation.
Article
Biochemistry & Molecular Biology
Signe Schultz Pedersen, Lars Roed Ingerslev, Mathias Olsen, Michala Prause, Nils Billestrup
Summary: Butyrate can prevent pancreatic islet dysfunction by modifying histone acetylation levels, which may have potential therapeutic effects on type 2 diabetes.
Article
Biochemistry & Molecular Biology
Tipthida Pasachan, Acharaporn Duangjai, Atcharaporn Ontawong, Doungporn Amornlerdpison, Metee Jinakote, Manussabhorn Phatsara, Sunhapas Soodvilai, Chutima Srimaroeng
Summary: The study showed that Tiliacora triandra aqueous extract could reduce hepatic glucose production and enhance antioxidant capacity in HepG2 cells and T2DM rats. It also improved insulin resistance and regulated key gene expressions related to glucose metabolism. These findings suggest the potential use of TTE as a nutraceutical product for diabetes management.
Article
Medicine, Research & Experimental
Vitor F. Martins, Samuel A. LaBarge, Alexandra Stanley, Kristoffer Svensson, Chao-Wei Hung, Omer Keinan, Theodore P. Ciaraldi, Dion Banoian, Ji E. Park, Christina Ha, Byron Hetrick, Gretchen A. Meyer, Andrew Philp, Larry L. David, Robert R. Henry, Joseph E. Aslan, Alan R. Saltiel, Carrie. E. McCurdy, Simon Schenk
Summary: This study highlights the fundamental role of acetylation and p300/CBP in the direct regulation of insulin-stimulated glucose transport in skeletal muscle and adipocytes.
Article
Biochemistry & Molecular Biology
Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P. Boka, Yiman Liu, Guochao Chen, Zhenyang Liu, Kaeli M. Mathias, Lingbo Xia, Qinglan Li, Mustafa Mir, Yuanyuan Li, Haitao Li, Liling Wan
Summary: Growing evidence suggests the presence of transcriptional condensates on chromatin, but their formation mechanisms and functional significance are still unclear. This study reveals that mutations in the histone acetylation reader ENL can lead to aberrant condensate formation, which drives oncogenic gene activation in human cancer.
Editorial Material
Endocrinology & Metabolism
Natalie Niemi
Summary: Previous studies suggested that acetylation of mitochondrial proteins occurs non-enzymatically, but a new research challenges this notion by demonstrating the involvement of a histone acetyltransferase in enhancing mitochondrial metabolism through acetylating a complex IV assembly factor.
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Yusuke Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai
Summary: The study developed a chemical catalyst that can achieve histone acetylation in living cells without genetic manipulation, offering a new tool for studying epigenetic regulation. This chemical method competes with and suppresses normal chromatin function markers, providing insights into epigenetic mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biophysics
Yan Chen, Yunlei Zhou, Huanshun Yin
Summary: Histone acetylation, a crucial histone modification, is closely related to various diseases. Detection of HAT activity plays a significant role in disease discovery, prevention, and treatment, with recent research focusing on new methods combining different technologies.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Medicinal
Kairui Yue, Simin Sun, Geng Jia, Mengting Qin, Xiaohan Hou, C. James Chou, Chao Huang, Xiaoyang Li
Summary: This study reports the development of a highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which exhibits superior pharmacokinetic properties compared to current hydroxamic acid inhibitors. Structure-activity relationship analysis reveals that the presence of an ethyl group substituent in the hydrazide-based ZBG and a cap group with increased rigidity and volume enhance the HDAC6 selectivity of the designed compounds. The representative inhibitor 35m demonstrates potent HDAC6 inhibitory activity and improved pharmacokinetic properties compared to hydroxamic acid-based HDAC6 inhibitors Tubastatin A and ACY1215. Furthermore, low-dose 35m effectively decreases LPS-induced IL-1 beta release by blocking the activation of NLRP3, indicating its potential as an orally active therapeutic agent for NLRP3-related diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
K. Gomathi, N. Akshaya, N. Srinaath, M. Rohini, N. Selvamurugan
Summary: Bone remodeling is a complex event crucial for maintaining bone homeostasis, with histone acetylation playing a key role in the process. Studies have shown that histone acetyltransferases are major promoters of acetylation, and noncoding RNAs are also involved in regulating acetylation. Understanding these regulatory mechanisms may offer new insights for epigenetic therapies of bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Genetics & Heredity
Naoki Goda, Haruna Murase, Nobuhiko Kasezawa, Toshinao Goda, Kimiko Yamakawa-Kobayashi
BMC MEDICAL GENETICS
(2015)
Article
Nutrition & Dietetics
Kentaro Murakami, M. Barbara E. Livingstone, Satoshi Sasaki, Kazuhiro Uenishi
BRITISH JOURNAL OF NUTRITION
(2015)
Article
Nutrition & Dietetics
Misa Ikeda, Kazue Honma, Kazuki Mochizuki, Toshinao Goda
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Nutrition & Dietetics
Chihiro Imai, Tomomi Harazaki, Seiya Inoue, Kazuki Mochizuki, Toshinao Goda
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Nutrition & Dietetics
Masami Yamada, Kazuki Mochizuki, Kazue Honma, Rie Miyauchi, Nobuhiko Kasezawa, Kazushige Tohyama, Toshinao Goda
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Nutrition & Dietetics
Natsuyo Hariya, Kunio Miyake, Takeo Kubota, Toshinao Goda, Kazuki Mochizuki
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Nutrition & Dietetics
Yukiko Oe, Kazuki Mochizuki, Rie Miyauchi, Yasumi Misaki, Nobuhiko Kasezawa, Kazushige Tohyama, Toshinao Goda
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Endocrinology & Metabolism
Aki Yamada, Kazue Honma, Kazuki Mochizuki, Toshinao Goda
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Endocrinology & Metabolism
Kazue Honma, Maki Hikosaka, Kazuki Mochizuki, Toshinao Goda
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Nutrition & Dietetics
Kazue Honma, Riko Mawatari, Misa Likeda, Kazuki Mochizuki, Toshinao Goda
Article
Biochemistry & Molecular Biology
Keiji Tamaoki, Reiko Okada, Akinori Ishihara, Nobuyoshi Shiojiri, Kazuki Mochizuki, Toshinao Goda, Kiyoshi Yamauchi
CELL AND BIOSCIENCE
(2016)
Article
Nutrition & Dietetics
Chie Taguchi, Yoshimi Kishimoto, Kazuo Kondo, Kazushige Tohyama, Toshinao Goda
EUROPEAN JOURNAL OF NUTRITION
(2018)
Article
Genetics & Heredity
Kimiko Yamakawa-Kobayashi, Sayaka Ishikawa, Nagi Miyake, Yuya Ohhara, Toshinao Goda
Summary: This study aimed to investigate the interactions between genetic variations of core circadian clock genes and lifestyle factors on metabolic parameters. The results showed associations between certain genotypes and lifestyle factors, indicating their importance in determining metabolic parameters.
LIFESTYLE GENOMICS
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
K. Endoh, K. Kuriki, T. Goda
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2015)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)