Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy

Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway

(2016) YUE GUAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nutraceuticals in Parkinson’s Disease

(2016) Liting Hang et al.   NEUROMOLECULAR MEDICINE

Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons

(2016) Bin Chen et al.   Biomed Research International

Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia

(2015) Alireza Sarkaki et al.   METABOLIC BRAIN DISEASE

Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

(2015) S. Schipper et al.   MOLECULAR NEUROBIOLOGY

Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice

(2014) Ran-ran Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

(2014) Emilio Russo et al.   BRAIN BEHAVIOR AND IMMUNITY

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-κB-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model

(2014) Emilio Russo et al.   NEUROLOGICAL SCIENCES

Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Chronic Metformin Treatment is Associated with Reduced Myocardial Infarct Size in Diabetic Patients with ST-segment Elevation Myocardial Infarction

(2013) Chris P. H. Lexis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling

(2012) Sheng-jun Wang et al.   BRAIN RESEARCH

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy

(2012) Emilio Russo et al.   NEUROPHARMACOLOGY

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fructose-1,6-diphosphate inhibits seizure acquisition in fast hippocampal kindling

(2010) Yao Ding et al.   NEUROSCIENCE LETTERS

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One