Article
Environmental Sciences
Genoa R. Warner, Diana C. Pacyga, Rita S. Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: The study revealed associations between phthalates and hot flashes in midlife women, suggesting a potential impact on hot flash risk. Factors such as menopause status, BMI, race/ethnicity, and depressive symptoms may influence these associations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Maelys Granal, Lydia Slimani, Nans Florens, Florence Sens, Caroline Pelletier, Romain Pszczolinski, Catherine Casiez, Emilie Kalbacher, Anne Jolivot, Laurence Dubourg, Sandrine Lemoine, Celine Pasian, Michel Ducher, Jean Pierre Fauvel
Summary: This study aimed to develop a reliable method to estimate dietary potassium intake in CKD patients in order to improve prevention of cardiovascular complications. A clinical tool was developed using 24-hour urinary potassium excretion as a surrogate of dietary potassium intake. The prediction tool showed an accuracy of 74% in classifying potassium diet.
Article
Obstetrics & Gynecology
Kerstin Rodstrom, Lilian Weman, Valter Sundh, Cecilia Bjorkelund
Summary: This study aimed to compare the prevalence of daily hot flashes in 50-year-old women over time. The results showed that the odds of reporting daily hot flashes were nearly two times higher in later-born women compared to earlier-born women. This difference persisted even after controlling for potential predictors.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Environmental Sciences
Ryan S. Babadi, Paige L. Williams, Zhong Li, Rebecca L. Smith, Rita S. Strakovsky, Russ Hauser, Jodi A. Flaws, Tamarra James-Todd
Summary: This study examines the associations between urinary phthalate metabolite concentrations and hot flash outcomes in midlife women. The results suggest that phthalate metabolites are associated with certain hot flash outcomes, indicating that midlife may be a sensitive period for higher phthalate metabolite concentrations and menopausal symptoms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Mabel Toribio, Evelynne S. Fulda, Sarah M. Chu, Zsofia D. Drobni, Magid Awadalla, Madeline Cetlin, Takara L. Stanley, Crystal M. North, Michael D. Nelson, Michael Jerosch-Herold, Lidia S. Szczepaniak, Tricia H. Burdo, Sara E. Looby, Tomas G. Neilan, Markella Zanni
Summary: Women with HIV transitioning through menopause have increased cardiovascular disease risk, with higher hot flash burden related to select CVD risk indices in this population.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Obstetrics & Gynecology
Sarah Witkowski, Rose Evard, Jacquelyn J. Rickson, Quinn White, Lynnette Leidy Sievert
Summary: This review summarizes the scientific evidence regarding the effect of physical activity and exercise on hot flashes (HFs) in menopausal women. The majority of randomized control trials suggest that aerobic and resistance exercise can decrease subjectively experienced HFs. Some studies also suggest that rhythmic exercise may be beneficial for reducing HF symptoms, but further research is needed.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Review
Obstetrics & Gynecology
Kentaro Miyazaki, Masayuki Kaneko, Mamoru Narukawa
Summary: This meta-analysis aimed to identify the factors associated with high placebo response in clinical studies for women with hot flashes. The study found that treatment period duration, number of treatment arms, and BMI were three individual factors associated with high placebo response.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Geosciences, Multidisciplinary
Yanan Zhu, Phillip Bitzer, Vladimir Rakov, Michael Stock, Jeff Lapierre, Elizabeth DiGangi, Ziqin Ding, Bruno Medina, Lawrence Carey, Timothy Lang
Summary: Previous studies have suggested that subsequent positive leaders in lightning flashes rarely follow pre-existing channels to ground. However, observations of +CG flashes in a supercell storm in Argentina show that this behavior may actually be common. The findings suggest a need to update the traditional explanation of the differences between positive and negative lightning.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Obstetrics & Gynecology
Zaher Merhi, Serin Seckin, Marco Mouanness
Summary: This case report presents a patient with very low ovarian reserve who inadvertently reported significant improvement in menopausal symptoms, including hot flashes, for 14 weeks following intra-ovarian PRP injection. The findings suggest that PRP may serve as a potential alternative therapy for hot flashes in women with contraindications for hormone replacement therapy.
REPRODUCTIVE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ayaka Matsuoka, Toru Miike, Hirotaka Yamazaki, Masahiro Higuchi, Moe Komaki, Kota Shinada, Kento Nakayama, Ryota Sakurai, Miho Asahi, Kunimasa Yoshitake, Shogo Narumi, Mayuko Koba, Takashi Sugioka, Yuichiro Sakamoto
Summary: Education and clinical experience are necessary for conducting appropriate medical interviews. The use of a medical interview support application has been found to improve the quality of interviews conducted by residents. The application not only increases the rate of appropriate medical interviews, but also enhances the number of questions asked and the duration of the interviews.
Article
Medicine, General & Internal
Shudan Yu, Xin He, Hangyu Shi, Yu Chen, Zhishun Liu
Summary: This study aims to evaluate the effectiveness and safety of electro-press needles (EPN) treatment in relieving hot flash symptoms in perimenopausal and postmenopausal women. The study design includes a 2-arm randomized waitlist controlled trial with follow-up at 6 weeks and 24 weeks. The primary outcome is the percentage of participants with a 50% reduction in 24-hour mean hot flashes at Week 6.
Article
Oncology
Jun He, Domingo G. Perez, Jennifer L. Le-Rademacher, Andrew Dodge, Paul Enck, Charles L. Loprinzi, David Zahrieh
Summary: In multi-dose hot flash clinical trials, placebo dose levels do not appear to have a significant impact on hot flash scores and related distress.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Clinical Neurology
Helena Hachul, Laura Siqueira Castro, Andreia Gomes Bezerra, Gabriel Natan Pires, Dalva Poyares, Monica Levy Andersen, Lia Rita Bittencourt, Sergio Tufik
Summary: The study showed a higher frequency of hot flashes among women in postmenopause and similar characteristics of insomnia between menopausal and premenopausal women, with menopausal women being more prone to isolated insomnia symptoms and sleep graph changes. The prevalence of hot flashes was especially high among women with insomnia disorder.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Su-Ji Choi, Dong-Il Kim, Sang Ho Yoon, Chang -Min Choi, Jeong-Eun Yoo
Summary: This study found that pharmacopuncture with PLC did not significantly differ from normal saline in reducing hot flash scores for perimenopausal and postmenopausal women. While the therapy appeared safe, further research is needed to assess the long-term effects of PLC extract in a large randomized controlled trial.
INTEGRATIVE MEDICINE RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Hana Kahleova, Danielle N. Holtz, Noah Strom, Alex La Reau, Sinjana Kolipaka, Natalie Schmidt, Ellen Hata, Tatiana Znayenko-Miller, Richard Holubkov, Neal D. Barnard
Summary: This study investigated the role of gut microbiome changes in mediating the effects of a dietary intervention on postmenopausal vasomotor symptoms. The results showed that changes in the gut microbiome were associated with a significant reduction in both frequency and severity of hot flashes. However, further clinical trials are needed to validate these findings.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Article
Geriatrics & Gerontology
Catheryne Chiang, Lisa Gallicchio, Howard Zacur, Sue Miller, Jodi A. Flaws, Rebecca L. Smith
Article
Reproductive Biology
Chan Jin Park, Radwa Barakat, Alexander Ulanov, Zhong Li, Po-Ching Lin, Karen Chiu, Sherry Zhou, Pablo Perez, Jungyeon Lee, Jodi Flaws, ChemYong Jay Ko
REPRODUCTIVE TOXICOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Andressa Gonsioroski, Vasiliki E. Mourikes, Jodi A. Flaws
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Karen Chiu, Shah Tauseef Bashir, Liying Gao, Jessica Gutierrez, Maria R. C. de Godoy, Jenny Drnevich, Christopher J. Fields, Isaac Cann, Jodi A. Flaws, Romana A. Nowak
Summary: Subacute exposure to DEHP during pregnancy significantly affected the cecal microbiome in pregnant mice, increasing alpha diversity and altering beta diversity. DEHP exposure led to an increase in the relative abundance of Bacteroidetes and a decrease in the relative abundance of Firmicutes and Deferribacteres. In addition, DEHP exposure significantly altered 14 functional pathways, but did not have a significant impact on fertility and birth outcomes.
Article
Environmental Sciences
Karen K. Chiu, Shah Tauseef Bashir, Ahmed M. Abdel-Hamid, Lindsay V. Clark, Mary J. Laws, Isaac Cann, Romana A. Nowak, Jodi A. Flaws
Summary: This study examines the impact of DiNP exposure on the gut microbiota and immune-related factors, revealing that DiNP exposure can alter the composition of the gut microbiota and that the gut contains microbes capable of degrading DiNP.
Article
Environmental Sciences
Diana C. Pacyga, Brad A. Ryva, Romana A. Nowak, Serdar E. Bulun, Ping Yin, Zhong Li, Jodi A. Flaws, Rita S. Strakovsky
Summary: This study investigated the association between phthalates and fibroids and found that each two-fold increase in sigma DEHP or sigma AA was associated with a 13% and 16% greater risk of prior fibroid diagnosis in women. These associations were strongest in women who were overweight/obese and in those diagnosed with fibroids within 5 years before phthalate assessment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Endia J. Fletcher, Ramses Santacruz-Marquez, Vasiliki E. Mourikes, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: This review discusses the effects of phthalate mixtures on the female reproductive system. Phthalates have been found to target the ovaries, disrupting normal reproductive function and potentially affecting folliculogenesis and steroidogenesis. Additionally, phthalates can cross the placental barrier and impact fetal development. However, the specific effects of phthalate mixtures on the ovary and female reproduction are still not well understood.
Review
Biochemistry & Molecular Biology
Nitya Shree, Zehuan Ding, Jodi Flaws, Mahua Choudhury
Summary: The prevalence of poor metabolic health is increasing exponentially worldwide, with exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs), gaining attention as a contributing factor. Recent reports suggest that non-coding RNAs, specifically microRNAs (miRs), may play a vital role in this phenomenon.
Review
Environmental Sciences
Xing Zhang, Jodi A. Flaws, Michael J. Spinella, Joseph Irudayaraj
Summary: Endocrine disrupting chemicals (EDCs) are exogenous substances that can alter the endocrine function of an organism, leading to adverse effects on growth, development, metabolism, and reproductive function. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in both animals and humans. This review discusses the renal accumulation of specific EDCs, such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and explores how exposure to these EDCs can result in renal lesions and diseases, including cancer. The regulation of target genes and activation of related pathways by typical EDCs are also summarized.
Article
Environmental Sciences
Vasiliki E. Mourikes, Ramses Santacruz Marquez, Ashley Deviney, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: Imidacloprid is a neonicotinoid pesticide used in agriculture, gardening, and veterinary medicine. It has the potential to accumulate in the environment and harm non-targeted species. Imidacloprid and its metabolite desnitro-imidacloprid have different effects on follicle growth and steroidogenesis. These compounds also alter the expression of genes related to hormone regulation and apoptosis.
Article
Genetics & Heredity
Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschenes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Cote, Ayelet Ziv-Gal, Jodi A. Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L. Bailey
Summary: The study found that paternal exposure to POPs pollutants can impact the development and pregnancy outcomes of offspring, with this effect potentially explained by sperm DNA methylation. Experimental results suggest that the paternal methylome is sensitive to the environment, with some perturbations persisting for at least two subsequent generations.
Article
Endocrinology & Metabolism
Quanxi Li, Catherine R. Lawrence, Romana A. Nowak, Jodi A. Flaws, Milan K. Bagchi, Indrani C. Bagchi
Article
Endocrinology & Metabolism
Emily Brehm, Saniya Rattan, Liying Gao, Jodi A. Flaws
Article
Reproductive Biology
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A. Flaws
BIOLOGY OF REPRODUCTION
(2018)
Article
Endocrinology & Metabolism
Zuzana Drobna, Anne D. Henriksen, Jennifer T. Wolstenholme, Catalina Montiel, Philip S. Lambeth, Stephen Shang, Erin P. Harris, Changqing Zhou, Jodi A. Flaws, Mazhar Adli, Emilie F. Rissman