Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Neurosciences
Mary E. Slingo
Summary: The unique property of the pulmonary circulation to constrict in response to hypoxia plays an important role in optimizing ventilation-perfusion matching. There is growing evidence linking the HIF pathway and pulmonary vascular tone in both acute and chronic settings. Research on the prolyl hydroxylase enzymes has also shed light on the importance of iron in hypoxic pulmonary vasoconstriction and pulmonary hypertension.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Pharmacology & Pharmacy
Isabel Blanco, Maribel Marquina, Olga Tura-Ceide, Elisabet Ferrer, Ana M. Ramirez, Manuel Lopez-Meseguer, Maria Callejo, Francisco Perez-Vizcaino, Victor Ivo Peinado, Joan Albert Barbera
Summary: This study aimed to explore the potential role of survivin in the pathogenesis of pulmonary arterial hypertension (PAH) and the effects of its inhibition. The results showed that survivin expression was increased in the pulmonary arteries and lung tissue of the PAH mouse model, along with upregulation of proliferation-related genes. Treatment with the survivin inhibitor YM155 effectively reduced PAH symptoms and downregulated the expression of survivin and proliferation-related genes. Similar findings were observed in lungs from patients with PAH. These findings suggest that survivin may play a role in the development of PAH and that inhibiting its activity could be a potential therapeutic approach.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jianying Deng
Summary: Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole, leading to right heart failure and death. Pulmonary vascular resistance plays an irreplaceable role in the pathophysiology, diagnosis, and treatment of pulmonary arterial hypertension.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Biophysics
Reinhard Puehringer, Hannes Gatterer, Martin Berger, Michael Said, Martin Faulhaber, Martin Burtscher
Summary: The study suggests that well-acclimatized mountain guides may have better preservation of VO(2)max at moderate altitude, especially for those with lower initial VO(2)max levels. Physiological responses, such as heart rate and blood lactate levels, remained stable or slightly decreased at submaximal exercise intensity in both groups at moderate altitude.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Kolja Becker, Anselm Uebing, Jan Hinnerk Hansen
Summary: The Fontan circulation is a palliative measure for patients with univentricular hearts, but its failure is relatively common. Pulmonary blood flow is determined by central venous pressure and pulmonary vascular resistance, highlighting the importance of a healthy lung with low PVR for compensation.
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Ning Huang, Tian-Tian Zhu, Ting Liu, Xiao-Yue Ge, Di Wang, Hong Liu, Guang-Xuan Zhu, Zheng Zhang, Chang-Ping Hu
Summary: Pulmonary vascular remodeling is the pathological basis of pulmonary hypertension, with Endothelial-to-mesenchymal transition playing a key role in its pathogenesis. Aspirin, through inhibiting the HIF-1 alpha/TGF-beta 1/Smads/Snail signaling pathway, shows promise in ameliorating PVR in hypoxia-induced PH, suggesting it as a potential therapeutic option for patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Letter
Respiratory System
Karen M. Olsson, Marius M. Hoeper, Christine Pausch, Ekkehard Gruenig, Doerte Huscher, David Pittrow, Stephan Rosenkranz, Henning Gall
Summary: Pulmonary vascular resistance is a stronger prognostic indicator than mean pulmonary arterial pressure in patients with pulmonary hypertension associated with interstitial lung disease.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ghaleb Khirfan, Manshi Li, Xiaofeng Wang, Raed A. Dweik, Gustavo A. Heresi, Adriano R. Tonelli
Summary: PVRI appears to have a stronger association than PVR with disease severity markers in PAH, but both PVR and PVRI were similarly associated with hospitalizations and survival in the overall cohort. In obese patients, PVRI was a risk factor for first PAH hospitalization, while neither PVR nor PVRI were risk factors for mortality.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Physiology
Martin Burtscher, Gines Viscor
Summary: The maximal rate of oxygen uptake (VO(2)max) decreases with increasing altitude, but mountaineers with a high sea level VO(2)max and proper acclimatization and ascent strategies can still climb high summits without supplemental oxygen, including Mount Everest.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rui Wang, Jinjin Pan, Jinzhen Han, Miaomiao Gong, Liang Liu, Yunlong Zhang, Ying Liu, Dingyou Wang, Qing Tang, Na Wu, Lin Wang, Jinsong Yan, Hua Li, Yuhui Yuan
Summary: This study demonstrates that melatonin can alleviate dasatinib-aggravated hypoxic pulmonary hypertension by inhibiting pulmonary vascular remodeling and protecting endothelial cells and inhibiting abnormal proliferation of smooth muscle cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Sport Sciences
Iker Garcia, Franchek Drobnic, Victoria Pons, Gines Viscor
Summary: This study evaluated changes in lung diffusing capacity in artistic swimmers during training, finding a significant increase after apnoeic swimming and a decrease after figures and choreography. Despite large inter-individual variability, there were no significant differences in lung diffusing capacity from pre- to post-training.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xin Li, Yi Zhang, Qin Luo, Qing Zhao, Qixian Zeng, Tao Yang, Qi Jin, Lu Yan, Anqi Duan, Jiaran Liu, Chenhong An, Xiuping Ma, Changming Xiong, Zhihui Zhao, Zhihong Liu
Summary: A baseline DLCO < 70% and Delta DLCO > 6% can independently predict unfavorable responses to BPA. Dynamic measurement of DLCO facilitates the identification of patients who might have unsatisfactory hemodynamic results after BPA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Respiratory System
Yingmeng Ni, Youchao Yu, Ranran Dai, Guochao Shi
Summary: DLCO % predicted is significantly lower in COPD patients with more severe airflow limitation, more symptoms, and higher exacerbation risk. It is also associated with exacerbation patients, non-survivors, emphysema dominant phenotype, and pulmonary hypertension in COPD patients. The current meta-analysis suggests that DLCO % predicted may be an important measurement for evaluating COPD patients in terms of severity, exacerbation risk, mortality, emphysema domination, and presence of pulmonary hypertension.
CHRONIC RESPIRATORY DISEASE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Federico Lombardi, Marco Vicenzi, Katerina Hnatkova, Georg Schmidt, Marek Malik
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Rheumatology
Alessandro Santaniello, Rosa Casella, Marco Vicenzi, Irene Rota, Gaia Montanelli, Maria De Santis, Chiara Bellocchi, Federico Lombardi, Lorenzo Beretta
Review
Hematology
Irene Motta, Marta Mancarella, Alessia Marcon, Marco Vicenzi, Maria Domenica Cappellini
EXPERT REVIEW OF HEMATOLOGY
(2020)
Article
Critical Care Medicine
Fabienne Durand, Anne-Fleur Gaston, Marco Vicenzi, Gael Deboeck, Enric Subirats, Vitalie Faoro
Article
Cardiac & Cardiovascular Systems
Gregorio Tersalvi, Marco Vicenzi, Katharina Kirsch, Hilka Gunold, Holger Thiele, Federico Lombardi, Norman Mangner, Marcus Sandri
JOURNAL OF CARDIOVASCULAR MEDICINE
(2020)
Letter
Respiratory System
Marco Vicenzi, Roberta Di Cosola, Massimiliano Ruscica, Angelo Ratti, Irene Rota, Federica Rota, Valentina Bollati, Stefano Aliberti, Francesco Blasi
EUROPEAN RESPIRATORY JOURNAL
(2020)
Letter
Medicine, General & Internal
Gregorio Paolo Milani, Emanuele Montomoli, Valentina Bollati, Benedetta Albetti, Claudio Bandi, Tommaso Bellini, Matteo Bonzini, Marco Buscaglia, Carlo Cantarella, Laura Cantone, Michele Carugno, Sergio Casartelli, Guido Cavaletti, Sarah D'Alessandro, Francesca De Chiara, Serena Delbue, Laura Dioni, Ivano Eberini, Chiara Favero, Luca Ferrari, Monica Ferraroni, Laura Galastri, Cristina Galli, Mirjam Hoxha, Simona Iodice, Carlo La Vecchia, Chiara Macchi, Ilaria Manini, Serena Marchi, Jacopo Mariani, Elena Pariani, Angela Cecilia Pesatori, Federica Rota, Massimiliano Ruscica, Tommaso Schioppo, Letizia Tarantini, Claudia Maria Trombetta, Maria Grazia Valsecchi, Marco Vicenzi, Giuliano Zanchetta
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2020)
Letter
Cardiac & Cardiovascular Systems
Jorge Sanz-Sanchez, Dimitrios A. Vrachatis, Bernhard Reimers, Spyridon G. Deftereos, Marinos Kallikourdis, Marco Vicenzi, George Giannopoulos, Sotiria G. Giotaki, Dimitrios Tousoulis, Giuseppe Ferrante, Gianluigi Condorelli, Giulio G. Stefanini
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alberto Palazzuoli, Massimo Mancone, Gaetano M. De Ferrari, Giovanni Forleo, Gioel G. Secco, Gaetano M. Ruocco, Fabrizio D'Ascenzo, Silvia Monticone, Anita Paggi, Marco Vicenzi, Anna G. Palazzo, Maurizio Landolina, Erika Taravelli, Guido Tavazzi, Francesco Blasi, Fabio Infusino, Francesco Fedele, Francesco G. De Rosa, Michael Emmett, Jeffrey M. Schussler, Kristen M. Tecson, Peter A. McCullough
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Medicine, General & Internal
Marco Vicenzi, Massimiliano Ruscica, Simona Iodice, Irene Rota, Angelo Ratti, Roberta Di Cosola, Alberto Corsini, Valentina Bollati, Stefano Aliberti, Francesco Blasi
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Alberto Palazzuoli, Kristen M. Tecson, Marco Vicenzi, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari, Silvia Monticone, Gioel G. Secco, Guido Tavazzi, Giovanni Forleo, Paolo Severino, Francesco Fedele, Francesco De Rosa, Peter A. McCullough
Summary: Continuing the use of renin-angiotensin system inhibitors (RASi) in hospitalized COVID-19 patients can reduce in-hospital mortality in patients treated with diuretics, but does not alter the risk in patients treated with RASi alone.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Marco Vicenzi, Sergio Caravita, Irene Rota, Rosa Casella, Gael Deboeck, Lorenzo Beretta, Andrea Lombi, Jean-Luc Vachiery
Summary: Our study aimed to investigate the relationship between surrogate echocardiographic markers and risk stratification in patients with PAH. We found that TAPSE/TRV and TAPSE/sPAP were the most powerful markers of prognosis. When added to the COMPERA strategy, TAPSE/TRV or TAPSE/sPAP significantly stratified the intermediate-risk group into intermediate-to-low-risk or intermediate-to-high-risk subgroups. Similarly, TAPSE/TRV or TAPSE/sPAP was able to select patients at lower risk among those with low-risk criteria in both invasive and non-invasive FPHN registries.
Article
Medicine, General & Internal
Gabriele Tumminello, Lucia Barbieri, Carlo Avallone, Nello Bellissimo, Luca Mircoli, Federico Colombo, Marco Vicenzi, Massimiliano Ruscica, Stefano Carugo
Summary: The Woggle technique is a simple, effective, and safe approach for the management of large bore venous in percutaneous structural heart interventions, achieving rapid post-procedural hemostasis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Giuseppe Locatelli, Luca Donisi, Luca Mircoli, Federico Colombo, Lucia Barbieri, Gabriele Tumminello, Stefano Carugo, Massimiliano Ruscica, Marco Vicenzi
Summary: Antecubital access for right heart catheterization (RHC) has advantages over proximal vein access, including shorter fluoroscopy time, reduced radiation dose, and fewer guidewires used. A retrospective study of patients who underwent RHC showed that antecubital access resulted in lower fluoroscopy time (6 vs. 3 min) and radiation exposure (61 vs. 30 cGy/m(2)). The number of patients requiring guidewires was also lower in the antecubital access group (55% vs. 43%).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Federico B. M. Blasi, Irene Rota, Giovanna Graziadei, Marco Vicenzi
Summary: This article discusses vascular issues in thalassemic patients, emphasizing the importance of correct diagnosis and treatment of PH, and highlights chronic thromboembolic PH as a treatable cause of PH in patients with thalassemia.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2021)