Article
Gastroenterology & Hepatology
Arvid Pourlotfi, Rebecka Ahl, Gabriel Sjolin, Maximilian Peter Forssten, Gary A. Bass, Yang Cao, Peter Matthiessen, Shahin Mohseni
Summary: The study found a strong correlation between regular statin therapy and reduced postoperative mortality following surgical resection for rectal cancer. Despite a higher rate of cardiovascular comorbidity, statin users demonstrated significantly higher survival rates after surgery. Further investigation is warranted to determine the causal relationship.
COLORECTAL DISEASE
(2021)
Review
Oncology
Matthew C. Bobel, Michael F. McGee
Summary: Preoperative radiotherapy has been shown to improve outcomes in rectal cancer patients, but the optimal interval between radiation and proctectomy is unknown. A review of contemporary literature suggests that an 8-12 week interval between radiation and surgery may improve tumor response rates and long-term oncologic outcomes. However, prolonged radiation-surgery intervals may impact later-term proctectomies and compromise perioperative and oncologic outcomes due to pelvic fibrosis.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lisanne Loogman, Lindsey C. F. de Nes, Thea C. Heil, Dieuwertje E. G. Kok, Renate M. Winkels, Ellen Kampman, Johannes H. W. de Wilt, Franzel J. B. van Duijnhoven
Summary: The study found that patients' preoperative lifestyle is associated with postoperative complications after colorectal cancer surgery, with smoking and physical activity being modifiable factors that influence postoperative complications.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Ali P. Mourad, Marie Shella De Robles, Soni Putnis, Robert D. R. Winn
Summary: This study analyzed the treatment patterns and long-term outcomes of patients over 80 years with rectal cancer in a health district in Australia. Results showed that patients over 80 were less likely to undergo surgery or receive adjuvant/neoadjuvant chemoradiotherapy, and had poorer cancer-specific survival, particularly after the first year of diagnosis.
Review
Medicine, General & Internal
Chengkui Liu, Xiaoqing Li, Qingfeng Wang
Summary: In this updated meta-analysis, both robotic and laparoscopic surgeries were found to have similar postoperative complications for the treatment of rectal cancer. No significant differences were observed between the two surgical approaches.
Article
Oncology
Giuseppe Minniti, Gaetano Lanzetta, Luca Capone, Martina Giraffa, Ivana Russo, Francesco Cicone, Alessandro Bozzao, Filippo Alongi, Luca Nicosia, Gioia Fineschi, Luca Marchetti, Tommaso Tufo, Federico Bianciardi, Vincenzo Esposito, PierCarlo Gentile, Sergio Paolini
Summary: The study evaluated the effects of postoperative stereotactic radiosurgery (SRS) with immunotherapy compared to SRS alone in patients with resected brain metastases (BM). The combination therapy showed a lower rate of leptomeningeal disease (LMD) and distant brain parenchymal failure (DBF), leading to reduced neurological death and prolonged survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Joshua Southern, Guadalupe Gonzalez, Pia Borgas, Liam Poynter, Ivan Laponogov, Yoyo Zhong, Reza Mirnezami, Dennis Veselkov, Michael Bronstein, Kirill Veselkov
Summary: This study utilizes machine learning to explore the space of bioactive molecules in food, identifying potential modulators that can improve radiotherapy outcomes. It provides phytochemically-enriched recipes that encapsulate the benefits of discovered radiotherapy modulators. Through genomic-driven network machine learning and domain knowledge, potential radioresponse modulators were identified.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Shaowen Lyu, Zheng Wu, Dehuan Xie, Zhiqing Long, Rui Zhong, Wang Lei, Wanqin Cheng, Jiang Hu, Xuekui Liu, Chuanmiao Xie, Yong Su
Summary: There is no international consensus on delineation of postoperative intensity-modulated radiotherapy (PO-IMRT) clinical target volumes (CTV) for major salivary gland carcinoma (SGC). This study reports on the feasibility of delineating CTVs based on distances between various reserved tissues and the primary tumor edge before surgery, showing improved overall survival and recurrence-free survival rates for patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
K. Carlwig, P. Fransson, M. Bengtsson, M. Gebre-Medhin, J. Sjovall, L. Greiff
Summary: This study compared complication rates in the mandibulotomy site between patients receiving preoperative radiotherapy and patients receiving postoperative radiotherapy for oral and oropharyngeal cancer. The findings suggest a significantly lower complication rate in patients receiving postoperative radiotherapy, indicating that postoperative radiotherapy may be preferred when planning combined treatment with radiotherapy and surgery involving mandibulotomy.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Surgery
Jan M. van Rees, Eva Visser, Jeroen L. A. van Vugt, Joost Rothbarth, Cornelis Verhoef, Victorien M. T. van Verschuer
Summary: The study found that high risk of malnutrition is a strong risk factor for major complications in patients with LARC or LRRC undergoing exenteration surgery. LRRC and lymphovascular invasion were identified as independent risk factors for impaired overall survival.
Article
Oncology
J. M. van Rees, S. Nordkamp, P. W. Harmsen, H. Rutten, J. W. A. Burger, C. Verhoef
Summary: This study aimed to investigate the impact of distant metastases on oncological outcomes in patients with locally recurrent rectal cancer (LRRC) undergoing curative treatment. The study found that LRRC patients with synchronous distant metastases undergoing curative surgery have relatively poor prognosis, but LRRC patients with a history of distant metastases diagnosed nearby the primary tumor have comparable oncological survival as LRRC patients without distant metastases.
Article
Oncology
Jose F. Carrillo, Jesus Manuel Flores, Gilberto Espinoza, Rafael Vazquez-Romo, Margarita C. Ramirez-Ortega, Liliana C. Carrillo, Beatriz Y. Cortes-Garcia, Francisco J. Ochoa-Carrillo, Luis F. Onate-Ocana
Summary: In patients with unresectable DTC, upfront EBRT followed by salvage surgery improves PFS and OS prognosis. High-risk histopathology and EBRT dose are independent factors affecting patient PFS and OS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Surgery
Armando G. Franchini Melani, Luis G. Capochin Romagnolo
Summary: Laparoscopic anterior resection (LAR) is now a common practice in specialized high-volume centers, showing comparable oncological outcomes to historical open surgery. Low anterior resection (LAR) for rectal cancer is a demanding procedure with high incidence of postoperative morbidities, including anastomotic leakage and site infections. Recognizing and addressing risk factors such as patient age, nutritional status, and surgeon experience are crucial in preventing postoperative complications.
Review
Oncology
Anna Slipsager, Sofie N. Henrichsen, Ursula G. Falkmer, Karen Dybkaer, Mattias Belting, Laurids O. Poulsen
Summary: This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of biomarkers were identified. Further research should focus on validating these genetic resistance markers.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Jared Millican, Mark Wong
Summary: Clinical guidelines recommend chemotherapy, radiotherapy and surgery for rectal cancer, but these treatments may be challenging for patients with prior prostate cancer. Few studies have examined treatment outcomes in this population. This retrospective study analyzed the treatment patterns and outcomes of rectal cancer patients with prior prostate cancer. It found that neoadjuvant chemotherapy was a well-tolerated option for stage III disease, while patients who did not receive neoadjuvant radiotherapy had acceptable outcomes but higher rates of loco-regional recurrence. These findings provide guidance for clinicians managing this challenging disease.
Review
Radiology, Nuclear Medicine & Medical Imaging
Nicolai Egholt Munk, Peter Bondeven, Bodil Ginnerup Pedersen
Summary: The combined use of MRI and endoscopy tends to improve the diagnostic performance for assessing complete tumor response after neoadjuvant chemoradiotherapy in rectal cancer. However, there is considerable heterogeneity between studies.
Article
Oncology
Mette Ebbesen, Karina Dalsgaard Sorensen, Bodil Ginnerup Pedersen, Svend Andersen
Summary: Recent developments in prostate cancer diagnostics require appropriate tools for ethical assessment. This includes identifying ethically important features and principles, and determining which ethical theory justifies these principles. The standard medical procedure for prostate cancer diagnostics in the Danish healthcare system is used as an example.
CANCER INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Susanne Haas, Anette Hojer Mikkelsen, Camilla Jensenius Skovhus Kronborg, Birthe T. Oggesen, Pia F. Moller, Janne Fassov, Nina Abild Frederiksen, Marianne Krogsgaard, Charlotte Graugaard-Jensen, Lise Venzel, Peter Christensen, Katrine Jossing Emmertsen
Summary: This study examines the extent of late treatment-related sequelae in colorectal cancer survivors and provides evidence-based management strategies, aiming to facilitate identification and treatment of these conditions. Results show common symptoms and provide recommendations and strategies for their management.
COLORECTAL DISEASE
(2023)
Article
Oncology
Marianne Krogsgaard, Helle O. Kristensen, Edgar J. B. Furnee, Sanne J. Verkuijl, Nuno Jose Rama, Hugo Domingos, Joao Maciel, Alejandro Solis-Pena, Eloy Espin-Basany, Marta Hidalgo-Pujol, Sebastiano Biondo, Annika Sjovall, Katrine J. Emmertsen, Anne Thyo, Peter Christensen
Summary: This study investigates the impact of stoma-related problems on the daily life of rectal cancer survivors with long-term stomas. The study finds that stoma-related problems, such as leakage, odour, skin problems, and frequent appliance changes, are highly prevalent and significantly affect daily activities. Supportive care strategies should focus on reaching out to patients with long-term stomas.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Gastroenterology & Hepatology
Reem A. Alharbi, Hossam Elfeki, Katrine J. Emmertsen, Alexander R. Mortensen, Asbjorn M. Drewes, Peter Christensen, Soren Laurberg, Therese Juul
Summary: The chronic pain score (CP score) has been translated and validated in a cohort of colon cancer patients. The score demonstrated good convergent and discriminative validity, and was able to differentiate between different genders and age groups. It also showed the ability to identify patients with a major impact on quality of life.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Helene Mathilde Larsen, Klaus Krogh, Mette Borre, Tine Gregersen, Mette Mejlby Hansen, Anne K. Arveschoug, Peter Christensen, Asbjorn Mohr Drewes, Katrine Jossing Emmertsen, Soren Laurberg, Janne Ladefoged Fassov
Summary: A case-control study found that patients with right-sided hemicolectomy for colon cancer may experience long-term bowel dysfunction, with chronic loose stools associated with bile acid malabsorption but not with small intestinal bacterial overgrowth.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Helene R. Dalby, Anders Dige, Bodil G. Pedersen, Klaus Krogh, Jorgen Agnholt, Helene T. Hougaard, Lilli Lundby
Summary: This study aimed to investigate the efficacy of injection with freshly collected autologous adipose tissue into complex cryptoglandular anal fistulas. The results showed that 51% of patients achieved fistula healing 6 months after their final treatment. This treatment is safe and low-cost, serving as an alternative to cultured autologous and allogenic adipose tissue-derived mesenchymal stem cells.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Annette Boesen Braeuner, Nicolas Avellaneda, Peter Christensen, Asbjorn Mohr Drewes, Katrine Jossing Emmertsen, Klaus Krogh, Soren Laurberg, Michael Bodker Lauritzen, Uffe Schou Love, Ole Thorlacius-Ussing, Therese Juul
Summary: This study examined changes in bowel function and quality of life after colon cancer surgery and found that some symptoms worsened in the right-sided colon resection group while improving in the left-sided colon resection group. At 12 months, both groups still experienced bowel dysfunction and impaired quality of life, highlighting the need for systematic screening and early treatment of symptoms.
Article
Oncology
Jacob Fredsoe, Mads Sandahl, Peter Vedsted, Jorgen Bjerggaard Jensen, Benedicte Parm Ulhoi, Michael Borre, Karina Dalsgaard Sorensen, Bodil Ginnerup Pedersen
Summary: This study compared the effectiveness of the STHLM3 and PSA tests as entry tests for PC diagnosis. The results showed that the STHLM3(11) test improved sensitivity for detecting GG≥2 PC but did not improve specificity. Further research is needed to validate the potential benefits of using a higher cutoff for STHLM3 positivity as an entry test for MRI.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jacob Fredsoe, Eske Glud, Lars Boesen, Vibeke Logager, Mads Hvid Poulsen, Bodil Ginnerup Pedersen, Michael Borre, Karina Dalsgaard Sorensen
Summary: The Danish Prostate Cancer Consortium Study 1 aims to validate a novel urine-based microRNA biomarker called uCaP for prostate cancer diagnosis. This study will measure the levels of three microRNAs in urine samples to assess if uCaP can improve specificity and sensitivity for prostate cancer and reduce unnecessary scans and biopsies.
Article
Surgery
Tinne Laurberg, Sara Frandsen, Helene M. Larsen, Louise L. Lehrskov, Susanne B. Graversen, Asbjorn M. Drewes, Katrine J. Emmertsen, Klaus Krogh
Summary: Colorectal cancer survivors with type 2 diabetes may have a higher risk of long-term gastrointestinal sequelae, particularly following rectal resection. The study also found that type 2 diabetes is associated with increased risk of severe pain and impaired quality of life among colorectal cancer survivors.
Article
Health Care Sciences & Services
Sidse Bregendahl, Peter Bondeven, Therese Koops Gronborg, Gina Brown, Soren Laurberg, Bodil Ginnerup Pedersen
Summary: Intensive training improves radiologists' interpretive performance in rectal cancer MRI staging, especially among specialists with lower performance at baseline. Individual feedback has a significant impact on improved interpretive performance.
Article
Urology & Nephrology
Mads Sandahl, Kristian Juul Sandahl, Edvard Marinovskij, Tomas Frahm Nielsen, Karina Dalsgaard Sorensen, Michael Borre, Benedicte Parm Ulhoi, Bodil Ginnerup Pedersen
Summary: This study compared the detection rates (DRs) of prostate cancer (PC) between manually operated in-bore magnetic resonance imaging (MRI) targeted prostate biopsy (MO-MRGB) and robot-assisted in-bore MRI targeted prostate biopsy (RA-MRGB). The results showed no significant difference in PC detection ability between the two systems.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Jacob Damgaard Eriksen, Katrine Jossing Emmertsen, Anders Husted Madsen, Rune Erichsen, Troels Norgaard Bachmann, Lene Hjerrild Iversen
Summary: This study evaluated the occurrence and predictors of anastomotic leakage (AL) in rectal cancer patients undergoing minimally invasive restorative rectal resection (RRR). The study found that AL is still a challenge, especially in men, and cautioned against using multiple firings when transecting the rectum. The impact of AL on long-term survival was not statistically significant.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Jacob Damgaard Eriksen, Katrine Jossing Emmertsen, Anders Husted Madsen, Lene Hjerrild Iversen
Summary: Anastomotic leakage after restorative rectal resection is a significant predictor for the presence of a stoma 1 year postoperatively. Patients treated with endo-SPONGE for AL may have worse outcomes compared to other anastomosis preserving treatment options, affecting the likelihood of receiving adjuvant chemotherapy and stoma presence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.