Review
Infectious Diseases
Vasiliki Soulountsi, Theodoros Schizodimos, Serafeim Chrysovalantis Kotoulas
Summary: In recent decades, invasive candidiasis (IC) has become a significant cause of morbidity, mortality, and economic burden in the intensive care unit (ICU). The epidemiology of IC remains a difficult and unsolved puzzle for the literature. IC burden estimation is challenging due to various definitions and limitations in case-finding methodologies. Candidemia and intra-abdominal candidiasis (IAC) are the predominant types of IC in the ICU, with an increasing incidence of candidemia, particularly in elderly or immunosuppressed patients, and a shift towards non-albicans species worldwide.
Article
Immunology
Matteo Bassetti, Elie Azoulay, Bart-Jan Kullberg, Markus Ruhnke, Shmuel Shoham, Jose Vazquez, Daniele Roberto Giacobbe, Thierry Calandra
Summary: The EORTC/MSGERC recently revised the definitions of invasive fungal disease, focusing on cancer and transplant patients but not ICU patients. The challenges in diagnosing IFD in the ICU setting vary for different types of fungal infections.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Jiahui Zhang, Wei Cheng, Dongkai Li, Jianwei Chen, Guoyu Zhao, Hao Wang, Na Cui
Summary: A rapid invasive candidiasis (IC)-predictive risk score incorporating clinical risk factors and lymphocyte subtyping parameters was developed and validated in ICU patients. The scoring system demonstrated good discrimination and calibration for early IC diagnosis, outperforming the Candida score.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Liam Townsend, Ignacio Martin-Loeches
Summary: Invasive pulmonary aspergillosis is a serious disease with high mortality and morbidity among ICU patients. Diagnosis is challenging and requires integration of clinical, radiological, and microbiological features. Multidrug-resistant Aspergillosis is a growing concern, but there are new therapeutic options being developed.
Article
Infectious Diseases
Guojie Teng, Ning Wang, Xiuhong Nie, Lin Zhang, Hongjun Liu
Summary: This study identified risk factors for early-onset ventilator-associated pneumonia (EOVAP) among patients in the neurosurgery intensive care unit (NICU). Older age and therapeutic hypothermia were found to be independently associated with the risk of EOVAP in NICU patients.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Marcello Mariani, Alessandro Parodi, Diego Minghetti, Luca A. Ramenghi, Candida Palmero, Elisabetta Ugolotti, Chiara Medici, Carolina Saffioti, Elio Castagnola
Summary: This study retrospectively analyzed the etiology and antibiotic resistance profiles of bacteria in blood or cerebrospinal fluid cultures to evaluate the appropriateness of initial empirical therapy for neonatal sepsis. The results showed that early onset sepsis (EOS) was mainly caused by Gram-positive bacteria, while late onset sepsis (LOS) was predominantly due to Coagulase Negative Staphylococci (CoNS).
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Juan C. Lona-Reyes, Larissa M. Gomez-Ruiz, Araceli Cordero-Zamora, Sandra I. Cortes-Gonzalez, Moises Quiles-Corona, Rene O. Perez-Ramirez, Herlinda Pinto-Macedo
Summary: The study in a Neonatal Intensive Care Unit in Mexico found an incidence rate of 2.27 events/1000 live newborns for invasive Candida spp. infections. Factors such as mechanical ventilation, systemic antibiotics, and the use of central catheters and parenteral nutrition were associated with a higher risk of infection. However, prophylactic fluconazole was found to decrease the risk of infection.
ANALES DE PEDIATRIA
(2022)
Article
Geriatrics & Gerontology
Song- Lee, Younsuck Koh, Jin Won Huh, Sang-Bum Hong, Chae-Man Lim
Summary: This study found that 9.2% of elderly patients experienced ICU readmissions, which were associated with poor prognosis and higher mortality. Readmitted patients had longer ICU and in-hospital stays, as well as higher 28-day and in-hospital mortality rates compared to non-readmitted patients.
Article
Pediatrics
Flavia Indrio, Alessia Salatto, Orsola Amato, Fabio Bartoli, Letizia Capasso, Luigi Corvaglia, Gianfranco Maffei, Fabio Mosca, Massimo Pettoello Mantovani, Francesco Raimondi, Matteo Rinaldi, Paola Roggero, Arianna Aceti
Summary: The study found that implementing COVID-19-related NICU hygiene policies is likely to significantly reduce the incidence of late-onset sepsis in high-risk settings.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Nursing
Youn-Jung Son, Gi-Ock Kim, Yun Mi Lee, Minkyung Oh, JiYeon Choi
Summary: This study identified key risk factors associated with early and late ICU readmission, with early readmission being linked to ICU admission from the ward and mechanical ventilation support exceeding 14 days, and late readmission being associated with various factors such as specific procedures and duration of treatment. Preventing unplanned ICU readmission in high-risk patients requires further investigation into clinical judgment, team communication, and institutional support.
JOURNAL OF NURSING SCHOLARSHIP
(2021)
Article
Pediatrics
Mariana M. Lanata, Alejandro Diaz, Shaina M. Hecht, Aspasia Katragkou, Nathaniel Gallup, Don A. Buckingham, Jessica L. Tansmore, Cheryl Sargel, Joshua R. Watson, Todd Karsies
Summary: The study aimed to reduce unnecessary vancomycin use for CAIs in PICU by developing empirical vancomycin indications based on MRSA risk factors. Through education, posting of indications, and revising the antibiotic order set, the empirical vancomycin use decreased significantly without any negative impact on patients' outcomes or balancing measures. Retrospective validation of the recommendations with local data proved to be crucial in gaining buy-in from PICU clinicians.
Article
Clinical Neurology
Sophia Wang, Anthony J. Perkins, Rosalyn Chi, Brandon A. Yates, Sikandar H. Khan, Sujuan Gao, Malaz Boustani, Babar A. Khan
Summary: A secondary data analysis of ICU patients revealed that stroke and depression were identified as risk factors for post-ICU dementia, highlighting the need for interventions targeting these factors to reduce dementia incidence.
ALZHEIMERS & DEMENTIA
(2023)
Article
Critical Care Medicine
Sonia O. Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J. Brett, Silvia Calvino-Gunther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy Francois, Patrick M. Honore, Radmilo Jankovic, Ashish K. Khanna, Mireia Llaurado-Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn Blot
Summary: A study of 13,254 adults in 1117 ICUs across 90 countries found a high prevalence of pressure injuries, with 59.2% being ICU-acquired. Risk factors for ICU-acquired pressure injuries included age, sex, weight, comorbidities, and organ support. Increasing severity of pressure injuries was associated with higher mortality rates, highlighting the importance of prevention and proper care in ICU settings.
INTENSIVE CARE MEDICINE
(2021)
Article
Pediatrics
Elizabeth Heiny, Sarah Wolf, Margaux Collins, Polly Durant Kellner, Roberta Pineda
Summary: The study investigated the relationship between infant medical and sociodemographic factors and enrolment in early therapy services following NICU discharge. Results showed that 82% of families enrolled in early therapy services, with factors such as public insurance, maternal psychiatric diagnosis, and having other children at home influencing the decision to enrol. 18% of families declined therapy services despite reduced barriers to access, indicating a need for targeted interventions to increase enrolment rates among this population.
Article
Critical Care Medicine
Fei Peng, Chenglong Liang, Wei Chang, Qin Sun, Jianfeng Xie, Haibo Qiu, Yi Yang
Summary: Elevated plasma HGF levels in sepsis patients are associated with poor prognosis and correlated with established markers of endothelial cell injury, indicating their potential as an efficient indicator for outcome prediction in septic patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Engineering, Biomedical
Chenglong Li, Haixiu Xie, Jun Li, Bingyu Qin, Junyu Lu, Jinsong Zhang, Liwen Lv, Binfei Li, Chengbin Zhou, Yongjie Yin, Haibo Qiu, Yimin Li, Xiaojun Liu, Xiaotong Hou
Summary: Dynamic or hybrid ECMO configurations are used for patients with changing clinical conditions. VV patients who converted to other configurations had higher in-hospital mortality. Careful selection of initial configuration is important for patient outcomes.
Article
Microbiology
Run Dong, Li Jiang, Ting Yang, Changsong Wang, Yi Zhang, Xu Chen, Jianfeng Xie, Yuanbin Guo, Li Weng, Yan Kang, Kaijiang Yu, Haibo Qiu, Bin Du
Summary: Recombinant human SARS-CoV-2 monoclonal antibody JS016, which has shown neutralizing and therapeutic effects in preclinical studies, did not demonstrate clinical efficacy among hospitalized Chinese patients with moderate to severe COVID-19 disease.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Changde Wu, Xiwen Zhang, Jianfeng Xie, Qing Li, Jie He, Linlin Hu, Haofei Wang, Airan Liu, Jingyuan Xu, Congshan Yang, Yi Yang, Haibo Qiu, Yingzi Huang
Summary: Linezolid demonstrates higher concentration in the ELF compared to plasma in pneumonia-induced sepsis patients, with even higher levels observed in those with septic shock. The probability of target attainment in the ELF is higher than in plasma, especially in patients with septic shock, suggesting that linezolid may be more effective in targeting the lungs of septic patients.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Correction
Cell & Tissue Engineering
Feng Liu, Jianfeng Xie, Xiwen Zhang, Zongsheng Wu, Shi Zhang, Ming Xue, Jianxiao Chen, Yi Yang, Haibo Qiu
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Chun Pan, Hui Chen, Jianfeng Xie, Yingzi Huang, Yi Yang, Bin Du, Haibo Qiu
Summary: Convalescent plasma therapy can improve the negative conversion rate of SARS-CoV-2 but does not improve the 60-day mortality in patients with severe and life-threatening COVID-19 infection.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Le Zhang, Yuxing Wang, Chang Cao, Yike Zhu, Wei Huang, Yi Yang, Haibo Qiu, Songqiao Liu, Dayong Wang
Summary: In this study, the potential of Xuebijing treatment against bacterial infection and the underlying mechanisms were investigated using Caenorhabditis elegans as an animal model. The results showed that Xuebijing could inhibit the reduction of lifespan caused by Pseudomonas aeruginosa infection by inhibiting colonization of the bacteria in the intestinal lumen. Xuebijing treatment also suppressed the increase in antimicrobial gene expression induced by Pseudomonas infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Linhui Hu, Haibo Qiu, Ling Liu, Claude Guerin, Chunbo Chen
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Zhichang Wang, Feiping Xia, Huishui Dai, Hui Chen, Jianfeng Xie, Haibo Qiu, Yi Yang, Fengmei Guo
Summary: In non-COVID ARDS patients, prone positioning leads to a more significant decrease in VR among responders, who have higher successful weaning rates at day 28. The change in VR is independently associated with liberation from mechanical ventilation at day 28.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Songqiao Liu, Chen Yao, Jianfeng Xie, Hong Liu, Hongliang Wang, Zhaofen Lin, Bingyu Qin, Difen Wang, Weihua Lu, Xiaochun Ma, Yan Liu, Ling Liu, Chi Zhang, Lei Xu, Ruiqiang Zheng, Feihu Zhou, Zhongmin Liu, Guoqiang Zhang, Lixin Zhou, Jian Liu, Aihua Fei, Guoxiu Zhang, Yimin Zhu, Kejian Qian, Ruilan Wang, Yafeng Liang, Meili Duan, Dawei Wu, Rongqing Sun, Ying Wang, Xijing Zhang, Quan Cao, Mingshi Yang, Minggen Jin, Yan Song, Ling Huang, Fachun Zhou, Dechang Chen, Qun Liang, Chuanyun Qian, Zhongzhi Tang, Zhong Zhang, Qiming Feng, Zhiyong Peng, Renhua Sun, Zhenju Song, Yunbo Sun, Yanfen Chai, Lihua Zhou, Chen Cheng, Li Li, Xiaoyan Yan, Junhua Zhang, Yingzi Huang, Fengmei Guo, Chuan Li, Yi Yang, Hongcai Shang, Haibo Qiu, EXIT-SEP Investigators
Summary: In this multicenter, randomized double-blind, placebo-controlled trial, the administration of XBJ was found to reduce 28-day mortality among patients with sepsis.
JAMA INTERNAL MEDICINE
(2023)
Article
Critical Care Medicine
Hui Chen, Qin Sun, Yali Chao, Yue Liu, Qian Yu, Jianfeng Xie, Chun Pan, Ling Liu, Yi Yang, Haibo Qiu
Summary: The association between ventilator variables and mortality varies among ARDS patients with different lung morphology. A novel ventilator variable (4xDP + RR) is found to have significant impact on mortality in ARDS patients, but further validation is needed.
Article
Critical Care Medicine
Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu, Yi Yang
Summary: This study successfully identified three novel longitudinal phenotypes for ARDS patients using 24-hourly data from the first four days of invasive ventilation. These phenotypes were validated in four clinical trials, and simple classifier models were constructed for accurate identification.
Letter
Critical Care Medicine
Ling Liu, Jianfeng Xie, Changsong Wang, Zhanqi Zhao, Yang Chong, Xueyan Yuan, Haibo Qiu, Mingyan Zhao, Yi Yang, Arthur S. Slutsky
Article
Medicine, General & Internal
Shanshan Meng, Feiping Xia, Jingyuan Xu, Xiwen Zhang, Ming Xue, Mingyuan Gu, Fengmei Guo, Yingzi Huang, Haibo Qiu, Yi Yang
Summary: Pulmonary microvascular endothelial cells play a crucial role in the pathogenesis of acute lung injury. This study demonstrated that hepatocyte growth factor (HGF) protects the endothelium by suppressing oxidative stress and mitochondria-dependent apoptosis, thereby maintaining the integrity of the endothelial barrier. The mTOR/STAT3 signaling pathway was found to be involved in these protective effects.
CHINESE MEDICAL JOURNAL
(2022)
