Article
Surgery
Chikashi Shibata, Toru Nakano, Akihiro Yasumoto, Atsushi Mitamura, Kentaro Sawada, Hitoshi Ogawa, Tomoya Miura, Ichiro Ise, Kazuhiro Takami, Kuniharu Yamamoto, Yu Katayose
Summary: The study suggests that CA19-9 may be more useful than CEA in predicting recurrence after curative gastrectomy for gastric cancer.
Article
Surgery
Sang Hun Park, Jun Ho Shin, Kyung Uk Jung, Sung Ryol Lee
Summary: This study assessed the role of preoperative serum CA 19-9 and CEA concentrations in the survival prognosis of patients with periampullary carcinoma and found that CA 19-9 may be a useful marker in predicting prognosis at the time of diagnosis.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Hua-qiang Zhu, Dong-ye Wang, Lin-shen Xu, Jian-le Chen, Er-wei Chu, Cai-jin Zhou
Summary: This study aimed to investigate the diagnostic value of enhanced magnetic resonance imaging (MRI) combined with carcinoembryonic antigen (CEA) and carbohydrate antigen in detecting liver metastasis of colorectal cancer. The results showed that the combination of MRI and CEA had high specificity and positive predictive value, while the combination of MRI and parallel CEA had high sensitivity and negative predictive value. These combinations can exclude non-metastatic patients and identify colorectal cancer patients with liver metastasis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiao-Dong Zhu, Li-Xiang Zhang, Pan-Quan Luo, Hai Zhu, Zhi-Jian Wei, A-Man Xu
Summary: This study found that the elevation of tumor markers CEA and CA19-9 before and after gastric cancer surgery is associated with poor prognosis, and this increment has a greater impact on prognosis than preoperative CEA/CA19-9 levels. A new prognostic model was established and shown to have reliable accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zuowei Wu, Pengcheng Zhao, Zihe Wang, Xing Huang, Chao Wu, Mao Li, Li Wang, Bole Tian
Summary: This study adjusted CA19-9 values based on clinical stage and bilirubin levels to better predict the overall survival of patients who underwent radical pancreatic cancer surgery. The results showed that CA19-9>219.4 predicted poor survival in individuals in clinical stage 1, while CA19-9/TB>18.8 predicted poor survival for individuals in stages 2 and 3.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ivan David Lozada-Martinez, Maria Paz Bolano-Romero, Lina Lambis-Anaya, Yamil Liscano, Amileth Suarez-Causado
Summary: This study identified CEA as a potential clinical biomarker for determining undifferentiated tumor phenotype, advanced clinical stage, and poor therapeutic response in rectal cancer with positive expression of cancer stem cells (CSCs).
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jingjing Shan, Benxing Gu, Liming Shi, Xuanxuan Wang, Wenyuan Ye, Weiwen Zhou, Xiaonan Sun
Summary: The study demonstrates a correlation between high levels of CEA and CA19-9 with poor prognosis in LARC patients undergoing neo-CRT, surgery, and adjuvant chemotherapy. Elevated levels of CEA and/or CA19-9 are associated with worse outcomes, indicating a need for more intensive or additional treatment strategies for this subset of patients.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Huiping Wang, Weibiao Jin, Chuanqi Wan, Chen Zhu
Summary: The combined use of serum tumor markers CEA, CA19-9, and CA72-4 has higher sensitivity and specificity in the diagnosis of gastric cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Yubin Ma, Junpeng Lin, Jianxian Lin, Junfang Hou, Qin Xiao, Fang Yu, Zhijun Ma, Ping Li, Ruhong Tu, Jianwei Xie, Chaohui Zheng, Su Yan, Changming Huang
Summary: The study established a CNLR prognostic scoring system by combining CEA and NLR, finding that CNLR is an independent prognostic factor for GC patients and can improve the accuracy of predicting long-term survival outcomes.
Article
Oncology
Hailun Xie, Lishuang Wei, Mingxiang Liu, Yanren Liang, Qiwen Wang, Shuangyi Tang, Jialiang Gan
Summary: This study aimed to evaluate the clinical value of incorporating carcinoembryonic antigen (CEA) levels into the TNM staging system. The results showed that combining CEA status with TNM staging can provide a more accurate prognosis assessment for colorectal cancer (CRC) patients, with CEA positivity being strongly associated with worse prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhendan Yao, Hong Yang, Ming Cui, Jiadi Xing, Chenghai Zhang, Nan Zhang, Lei Chen, Fei Tan, Kai Xu, Maoxing Liu, Xiangqian Su
Summary: Resectable gastric cancer patients with small para-aortic lymph node (sPAN) were rarely reported, and existing guidelines did not provide definite treatment recommendations for them. The presence of sPAN was an independent risk factor for poor prognosis. Standard lymphadenectomy can be effective for patients with sPAN and normal preoperative CEA and CA19-9 levels. Patients with elevated CEA or CA19-9 levels may benefit from a multimodal approach.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Jin Moriyama, Yoko Oshima, Tatsuki Nanami, Takashi Suzuki, Satoshi Yajima, Fumiaki Shiratori, Kimihiko Funahashi, Hideaki Shimada
Summary: This study evaluated the clinical impact of CEA and CA19-9 values at the time of recurrence in gastric cancer patients. The results suggest that CA19-9 positive status at recurrence may have a negative prognostic impact, particularly in patients with lymph node recurrence.
Article
Gastroenterology & Hepatology
Jia-Ming Liu, Yan-Yan Wang, Wei Liu, Da Xu, Kun Wang, Bao-Cai Xing
Summary: Preoperative CA19-9 is a promising predictor of recurrence for CRLM patients undergoing hepatectomy, especially for those with low-level CEA. Patients with high-level CA19-9 have significantly worse 5-year recurrence-free survival and overall survival.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Pratham Batra, Arun H. Narasannaiah, Venkatesh Reddy, Vignesh Subramaniyan, K. Manjunath, R. Yeshwanth, Ravi Arjunan, Syed Althaf, Srinivas Chunduri, Ali Z. Anwar
Summary: This study aimed to investigate the prognostic significance of preoperative carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 in resectable gastric cancer. The results showed that CEA levels can predict prognosis and are associated with the grade of adenocarcinoma of the stomach and occult intra-abdominal metastasis in gastric cancer. CA 19-9 levels were not significantly associated with the grade of adenocarcinoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Wei Cai, Yongjian Zhu, Ze Teng, Dengfeng Li, Qinfu Feng, Zhichao Jiang, Rong Cong, Zhaowei Chen, Siyun Liu, Xinming Zhao, Xiaohong Ma
Summary: This study aimed to evaluate the significance of baseline computed tomography (CT) imaging features and carbohydrate antigen 19-9 (CA19-9) in predicting the prognosis of locally advanced pancreatic cancer (LAPC) receiving intraoperative radiotherapy (IORT). The study found that CT imaging features such as relative enhanced value in portal-venous phase (REV-PVP), peripancreatic fat infiltration, necrosis, and CA19-9 were significantly associated with progression-free survival (PFS). A nomogram was established based on these variables and showed good performance in predicting the risk of progression.
FRONTIERS IN ONCOLOGY
(2023)