Article
Rheumatology
Edward Chia-Cheng Lai, Ya-Chun Huang, Tzu-Chi Liao, Meng-Yu Weng
Summary: This study found that primary Sjogren's syndrome, SLE, SSc, and SV are associated with an increased risk of premature coronary artery disease.
Review
Biochemistry & Molecular Biology
Lluis Rusinol, Luis Puig
Summary: The Jak/STAT pathways play a crucial role in cytokine signaling and have become a focus of research for immune-mediated inflammatory diseases. Dysfunction of Tyk2, a member of the Jak family, has been linked to protection from psoriasis and prevention of IMID without increasing the risk of serious infections. Deucravacitinib, an allosteric inhibitor that binds to the regulatory domain of Tyk2, has shown greater selectivity and a reduced risk of adverse events. In September 2022, deucravacitinib became the first Tyk2 inhibitor approved for the treatment of moderate-to-severe psoriasis. Tyk2 inhibitors hold promise for the future with the development of newer drugs and broader indications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Article
Medicine, General & Internal
Rabia Khan, M. Ellen Kuenzig, Furong Tang, James H. B. Im, Jessica Widdifield, Jeffrey D. Mccurdy, Gilaad G. Kaplan, Eric I. Benchimol
Summary: This study investigated the risk of venous thromboembolisms (VTEs) in individuals with Immune-mediated inflammatory diseases (IMIDs) following COVID-19 infection. The study found that individuals with IMIDs did not have a higher risk of VTE compared to those without IMIDs.
Article
Immunology
Mohamed Attauabi, Jakob Benedict Seidelin, Oluf Krautwald Felding, Mads Damsgaard Wewer, Laura Kirstine Vinther Arp, Melek Zahra Sarikaya, Alexander Egeberg, Nora Vladimirova, Flemming Bendtsen, Johan Burisch
Summary: The study found a lower occurrence but a more severe disease course of COVID-19 among patients with IMIDs, associated with the use of systemic steroids and suspension of other immunosuppressants. Therefore, it emphasizes the importance of weighing risks before suspending immunosuppressants during COVID-19.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Immunology
Anne-Charlotte Heba, Simon Toupance, Djesia Arnone, Laurent Peyrin-Biroulet, Anthanase Benetos, Ndeye Coumba Ndiaye
Summary: Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that play a crucial role in maintaining the integrity and stability of the genome. Research has shown a close connection between telomere length dynamics and immune-mediated inflammatory diseases, although the causality between these diseases and telomere attrition remains controversial.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Gastroenterology & Hepatology
Shintaro Akiyama, Soma Fukuda, Joshua M. Steinberg, Hideo Suzuki, Kiichiro Tsuchiya
Summary: This review discusses the pathogenesis, disease phenotypes, and clinical outcomes in IBD patients with concurrent IMIDs. It suggests that having multiple IMIDs can exacerbate the severity of IBD and increase the risk of requiring biologics and related surgeries.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Xiaoshuo Lv, Xixi Gao, Jingwen Liu, Yisen Deng, Qiangqiang Nie, Xueqiang Fan, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: This study using Mendelian randomization (MR) analysis revealed a causal relationship between immune-mediated inflammatory diseases (IMIDs) and the risk of venous thromboembolism (VTE), particularly in patients with inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Beatriz Garcillan, Miguel Salavert, Jose R. Regueiro, Sabela Diaz-Castroverde
Summary: Patients with immune-mediated inflammatory diseases (IMIDs) receiving biologic therapies may experience attenuated vaccine responses. Certain therapies impair the immunogenicity and antibody responses to vaccines, while others do not affect immune responses. SARS-CoV-2 vaccination appears to be safe and well tolerated in IMID patients, but the efficacy may be reduced compared to healthy individuals.
Article
Rheumatology
Yuetian Yu, Ying Sun, Yuying Wang, Yuefeng Yu, Bin Wang, Chi Chen, Xiao Tan, Yingli Lu, Ningjian Wang
Summary: There is an association between immune-mediated diseases and cardiovascular disease. This study analyzes the risk of developing cardiovascular disease in people with 20 different immune-mediated diseases. The results show a significant increase in the risk of cardiovascular disease in individuals with immune-mediated diseases.
Review
Rheumatology
Shirish Dubey, Nilay Joshi, Olivia Stevenson, Caroline Gordon, John A. Reynolds
Summary: This review focuses on chilblains secondary to immune-mediated inflammatory disorders, primarily discussing the epidemiology, pathogenesis, and treatment of CHLE.
Article
Immunology
Jie Feng, Yanqing Wu
Summary: The immune response plays a crucial role in the initiation and progression of cardiovascular diseases. IL-35, a novel anti-inflammatory and immunosuppressive cytokine, has been found to have a significant impact on the regulation of inflammation and immune homeostasis. It is closely associated with cardiovascular diseases, particularly in protecting against atherosclerosis and myocarditis. Although the specific molecular mechanisms of IL-35's protective effects are still unclear, targeted therapies with IL-35 have the potential to provide a promising and effective solution for preventing and treating cardiovascular diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Rebecca J. Song, Vanessa Xanthakis, Alexa Beiser, Charles DeCarli, Gary F. Mitchell, Sudha Seshadri
Summary: This study examined the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in a community-based study. The findings showed that the prevalence of HMOD varied across different blood pressure guidelines and that the presence of HMOD increased the risk of cardiovascular disease.
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Atsushi Sakuraba, Alexander Luna, Dejan Micic
Summary: The meta-analysis showed that patients with immune-mediated inflammatory diseases have a reduced response to mRNA COVID-19 vaccines, especially those receiving anti-CD20 and anti-tumor necrosis factor therapy. These patients are less likely to achieve a serologic response even after completing the full vaccine series.
Article
Gastroenterology & Hepatology
Javier P. Gisbert, Maria Chaparro
Summary: Publication is vital for the dissemination of scientific knowledge. Scientific journals play a key role in publishing original and high-quality articles. Peer review, considered the gold standard, ensures the quality of scientific publication. This manuscript explores the peer review process, its importance, guidelines for conducting effective reviews, report format, ethical considerations, common errors, limitations, and suggestions for improvement, with the aim of encouraging researchers and authors to become peer reviewers of scientific manuscripts.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Review
Rheumatology
Lihi Eder, Ashish J. Mathew, Philippe Carron, Heidi Bertheussen, Juan D. Canete, May Azem, Andrea Delle Sedie, Carlo Salvarani, Roberto Ranza, Ashley Elliott, Anthony Turkiewicz, Ricardo Acayaba de Toledo, Hulya Bukulmez, Maria S. Stoenoiu, Arthur M. Mandelin II, Michaela Koehm, Chris A. Lindsay, Evan Siegel, Philip J. Mease
Summary: This article summarizes existing evidence regarding pharmaceutical and nonpharmaceutical interventions for enthesitis in patients with psoriatic arthritis (PsA) to facilitate an evidence-based update of the Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for PsA. The article found several classes of systemic conventional and advanced therapies and local measures were recommended for active enthesitis in patients with PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Raimon Sanmarti, Beatriz Frade-Sosa, Rosa Morla, Juan D. Canete
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Manuel Barreiro-de Acosta, Agnes Fernandez-Clotet, Francisco Mesonero, Francisco Javier Garcia-Alonso, Maria Jose Casanova, Margarita Fernandez-de la Varga, Fiorella Canete, Luisa de Castro, Ana Gutierrez, Beatriz Sicilia, Victoria Cano, Olga Merino, Ruth de Francisco, Irene Gonzalez-Partida, Gerard Suris, Leyanira Torrealba, Rocio Ferreiro-Iglesias, Beatriz Castro, Lucia Marquez, Ana Sobrino, Ainara Elorza, Xavier Calvet, Pilar Varela, Raquel Vicente, Luis Bujanda, Laura Lario, Noemi Mancenido, Mariana F. Garcia-Sepulcre, Eva Iglesias, Cristina Rodriguez, Marta Piqueras, Juan Angel Ferrer Rosique, Alfredo J. Lucendo, Olga Benitez, Melody Garcia, David Olivares, Carlos Gonzalez-Munoza, Beatriz Lopez-Cauce, Victor Jair Morales Alvarado, Katerina Spicakova, Alicia Brotons, Fernando Bermejo, Pedro Almela, Nahia Ispizua, Pau Gilabert, Carlos Tardillo, Fernando Munoz, Pablo Navarro, Rosa Eva Madrigal Dominguez, Pau Sendra, Esther Hinojosa, Empar Sainz, Maria Dolores Martin-Arranz, Daniel Carpio, Elena Ricart, Berta Caballol, Laura Nunez, Jesus Barrio, Javier P. Gisbert, Marisa Iborra, Margalida Calafat, Vicent Hernandez, Roser Munoz Perez, Jose Luis Cabriada, Eugeni Domenech, Iago Rodriguez-Lago
Summary: This study evaluated the effectiveness of biologic agents in Crohn's disease complicated with internal fistulizing disease. It found that biologic therapy is beneficial for approximately three-quarters of patients, achieving a fistula closure rate of 24%, but around one-third of patients still require surgery. Patient- and lesion-related factors can identify patients who will obtain more benefit from these drugs.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Olga P. Nyssen, Javier P. Gisbert
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Ivan Guerra, Luis Bujanda, Miriam Manosa, Isabel Perez-Martinez, Maria Jose Casanova, Luisa de la Pena, Marina de Benito, Montserrat Rivero, Pilar Varela, Lorena Bernal, Ana Carolina Franco, Yolanda Ber, Marta Piqueras, Carlos Tardillo, Angel Ponferrada, Sonsoles Olivares, Alfredo J. J. Lucendo, Pau Gilabert, Monica Sierra Ausin, Maria Bellart, Amaia Herrarte, Margalida Calafat, Ruth de Francisco, Javier P. Gisbert, Jordi Guardiola, Eugeni Domenech, Fernando Bermejo
Summary: An increased risk of lymphoma has been found in patients with inflammatory bowel disease (IBD). This study aimed to analyze the management and evolution of lymphomas in IBD patients. The majority of IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these treatments did not impact the relapse and mortality of lymphoma.
Review
Biochemistry & Molecular Biology
Ana Belen Azuaga, Julio Ramirez, Juan D. D. Canete
Summary: Psoriatic arthritis is a chronic inflammatory disease associated with psoriasis and other comorbidities. Its complex pathogenesis involves genetic predisposition, environmental factors, and immune system activation. Research has identified therapeutic targets based on immune-inflammatory pathways, but heterogeneous responses remain a challenge. Translational research and integration of omics technologies are needed to improve outcomes and identify new targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Javier P. Gisbert, Maria Chaparro
Summary: The de-escalation of biologic therapy in inflammatory bowel disease (IBD) carries risks and uncertainties and should be tailored to individual patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Laura Cano-Garcia, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Carmen Dominguez-Quesada, Juan Crisostomo Vacas, Pedro Armenteros-Ortiz, Desiree Ruiz-Vilchez, Jose Maria Martin-Martin, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Natalia Mena-Vazquez, Antonio Fernandez-Nebro
Summary: This study aims to investigate the frequency and risk factors of malnutrition in older patients with rheumatoid arthritis (RA). The findings show that approximately one-third of older RA patients have impaired nutritional status, which is associated with factors such as age, inflammatory disease activity, and quality of life. The MNA and GNRI are valuable tools for assessing the nutritional status of patients with RA.
Meeting Abstract
Gastroenterology & Hepatology
M. Chaparro, D. Acosta, C. Rodriguez, F. Mesonero, M. Vicuna, M. Barreiro-de Acosta, A. Fernandez-Clotet, A. Hernandez Martinez, M. Arroyo, I. Vera, A. Ruiz-Cerulla, B. Sicilia, M. J. Cabello Tapia, C. Munoz Villafranca, J. Castro-Poceiro, J. Martinez Cadilla, M. Sierra-Ausin, M. Vazquez Moron, E. Montil Miguel, F. Bermejo, V. Royo, M. Calafat, C. Gonzalez-Munoza, E. Leo Carnerero, N. Mancenido Marcos, L. Torrealba, H. Alonso-Galan, M. Benitez, Y. Ber Nieto, M. T. Diz-Lois Palomares, M. J. Garcia, J. F. Munoz, E. M. Armesto Gonzalez, X. Calvet, A. Hernandez-Camba, R. E. Madrigal Dominguez, L. Menchen, J. L. Perez Calle, M. Piqueras, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Chaparro, M. Garcia Donday, S. Rubio, C. Calvino Suarez, A. Nunez Ortiz, M. Figueira, S. Marin Pedrosa, M. Rivero, A. Fernandez-Clotet, L. Madero, M. T. Diz-Lois Palomares, I. Perez-Martinez, A. Ruiz-Cerulla, M. Arroyo, M. Piqueras, C. Suarez Ferrer, M. Aguas, M. Calvo Moya, I. Guerra, P. Lopez Serrano, J. M. Vazquez Moron, L. Arias Garcia, M. J. Casanova, J. M. Huguet, G. Valldosera Gomis, B. Zuniga de Mora-Figueroa, R. Armesto, P. Martinez Montiel, I. Rodriguez-Lago, P. Sendra Rumbeu, R. Camargo Camero, D. Hervias Cruz, G. Molina Arriero, M. Barreiro-de Acosta, D. Acosta, Y. Brenes, S. Hermida, P. Parra, A. Garre, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Chaparro, M. Garcia Donday, S. Riestra, A. J. Lucendo, J. M. Benitez, M. Navarro-Llavat, J. Barrio, V. J. Morales-Alvarado, M. Rivero, D. Busquets, E. Leo Carnerero, O. Merino Ochoa, O. Nantes Castillejo, P. Navarro, M. Van Domselaar, A. Gutierrez Casbas, I. Alonso-Abreu, R. Mejuto, L. Fernandez Salazar, M. Iborra, M. D. Martin-Arranz, R. Pineda, M. J. Sampedro, K. Serra Nilsson, A. Bouhmidi Assakali, L. Batista, C. Munoz Villafranca, I. Rodriguez-Lago, D. S. Ceballos Santos, I. Guerra, M. Manosa, I. Marin Jimenez, I. Vera Mendoza, M. Barreiro-De Acosta, E. Domenech, M. Esteve, V. Garcia-Sanchez, P. Nos, J. Panes, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
I. Soleto, M. Baldan, C. Ramirez, M. Orejudo, S. Garcia, J. Mercado, M. Azkargorta, I. Lloro, L. Ortega Moreno, L. Aldars Garcia, S. Riestra, M. Rivero, A. Gutierrez, I. Rodriguez-Lago, L. Fernandez, D. Ceballos, J. M. Benitez, M. Aguas, I. Baston Rey, F. Bermejo, M. J. Casanova, R. Lorente, Y. Ber, D. Ginard, M. Esteve, F. Elortza, J. P. Gisbert, N. Martin-Cofreces, M. Chaparro
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
I. Soleto, C. Ramirez, C. Gomez, B. Montse, S. Garcia, M. Orejudo, J. Mecado, M. Chaparro, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Cell & Tissue Engineering
M. Pineiro-Ramil, C. Sanjurjo-Rodriguez, S. Rodriguez-Fernandez, T. Hermida-Gomez, F. J. Blanco-Garcia, I. Fuentes-Boquete, C. Vaamonde-Garcia, S. Diaz-Prado
Summary: The aim of this study was to develop immortalized chondrocyte cell lines from articular cartilage of patients with and without osteoarthritis (OA). By transducing primary articular chondrocytes with telomerase reverse transcriptase (hTERT) and SV40 large T antigen (SV40LT), the researchers successfully immortalized the chondrocytes. Although these cell lines were unable to synthesize cartilage-like tissue under the experimental conditions, they retained the ability to respond to IL-113 cytokine, making them advantageous for OA investigation.
BONE & JOINT RESEARCH
(2023)