Review
Oncology
Ruimin Hu, Yan Zhang, Siying Liu, Pamela Lee, Chaohong Liu, Aiguo Liu
Summary: This meta-analysis aimed to evaluate the predictive values of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for progression-free survival (PFS), event-free survival (EFS), and overall survival (OS) in neuroblastoma patients. The results showed that higher SUVmax was associated with shorter OS, while no significant associations were found between SUVmax and PFS or EFS. MTV and TLG were not associated with OS and PFS. These findings suggest that high SUVmax may serve as an indicator of poor prognosis in neuroblastoma patients, and further validation is needed for MTV and TLG as potential prognostic predictors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ozlem Okumus, Khaled Mardanzai, Till Plones, Dirk Theegarten, Kaid Darwiche, Martin Schuler, Felix Nensa, Hubertus Hautzel, Ken Hermann, Martin Stuschke, Balazs Hegedus, Clemens Aigner
Summary: This study aimed to assess the association of preoperative PET parameters with nodal upstaging in lung adenocarcinoma and squamous cell carcinoma. The results showed that high preoperative PET-SUVmax values were associated with squamous cell carcinoma and larger tumors. However, SUVmax and metabolic PET parameters MTV and TLG were not significant predictors of nodal upstaging, except for tumor size and number of removed lymph nodes.
Review
Oncology
Weibo Wen, Dongyuan Xu, Yongnan Piao, Xiangdan Li
Summary: The present study conducted a systematic review and meta-analysis on the prognostic value of SUVmax, TLG, and MTV in MPM cases, finding an association between increased SUVmax and TLG values with an increased risk of mortality. However, there was no significant relationship between increased MTV and overall survival. The study suggests that PET/CT can significantly impact the prognosis prediction in MPM cases.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Ferdinando Corica, Maria Silvia De Feo, Maria Lina Stazza, Maria Rondini, Andrea Marongiu, Viviana Frantellizzi, Susanna Nuvoli, Alessio Farcomeni, Giuseppe De Vincentis, Angela Spanu
Summary: This study evaluates the reliability of qualitative and semiquantitative parameters of F-18-FDG PET-CT in predicting the risk of malignancy in patients with solitary pulmonary nodules (SPNs) before the diagnosis of lung cancer. The results show that these parameters are reliable tools, with good sensitivity and specificity, in predicting malignancy.
Article
Oncology
Omar Freihat, Zoltan Toth, Tamas Pinter, Andras Kedves, David Sipos, Zsolt Cselik, Norbert Lippai, Imre Repa, Arpad Kovacs
Summary: The study found that pre-treatment ADC values of the primary tumor can predict HPV status and treatment response, while metabolic PET parameters TLG and MTV can predict the primary tumor's response to therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Yanarates, E. Budak, A. Budak, A. Hamdi Inan, A. Goksel Kanmaz, A. Oral, B. Yazici
Summary: The study aimed to establish the prognostic value of metabolic parameters of the primary tumor in patients diagnosed with vulvar squamous cell carcinoma (VSCC) who underwent a pretreatment F-18 FDG PET/CT scan. Results showed that PET parameters were significantly associated with overall survival and progression-free survival, indicating their potential as prognostic factors for VSCC.
REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR
(2021)
Article
Oncology
Ronit Gill, Roxolyana Abdah-Bortnyak, Amnon Amit, Uval Bar-Peled, Zohar Keidar
Summary: This study evaluated the relationship between quantitative metabolic and volumetric parameters extracted from FDG PET/CT imaging data and the response rate to definitive chemoradiation therapy in locally advanced cervical cancer patients. The study found that these quantitative parameters are higher in patients who will not respond to the treatment.
Review
Medicine, General & Internal
Aihua Jin, Xing Lin, Xuezhe Yin, Yinfeng Cui, Liguang Ma
Summary: This study investigated the predictive value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in the prognosis of head and neck squamous cell carcinoma (HNSCC) using 18 F-FDG PET parameters. The findings suggest that elevated MTV and TLG are associated with decreased overall survival (OS) and disease-free survival (DFS) in HNSCC cases. PET/CT was found to be a predictive tool in HNSCC cases.
Article
Oncology
Luca Urso, Laura Evangelista, Pierpaolo Alongi, Natale Quartuccio, Corrado Cittanti, Ilaria Rambaldi, Naima Ortolan, Francesca Borgia, Alberto Nieri, Licia Uccelli, Alessio Schirone, Stefano Panareo, Gaspare Arnone, Mirco Bartolomei
Summary: This study aimed to investigate whether semiquantitative parameters derived from baseline [F-18]Fluorodeoxyglucose ([F-18]FDG) positron emission computed tomography/computed tomography (PET/CT) could predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) and survival outcomes in breast cancer patients of different molecular subtypes. The results showed that these parameters could be used as predictors of treatment response and prognosis in certain subtypes.
Article
Otorhinolaryngology
Jefferson Rijo-Cedeno, Jorge Mucientes, Sara Seijas Marcos, Jesus Romero, Ana Royuela, Sandra Carbonell, Raquel Benlloch, Jose Ramon Garcia-Berrocal
Summary: This study showed that high values of MTV and TLG can be considered independent prognostic factors for disease-free survival (DFS) and overall survival (OS) in patients with head and neck squamous cell carcinoma (HNSCC). These easily obtainable factors may be useful for predicting clinical outcomes in these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Jefferson Rijo-Cedeno, Jorge Mucientes, Ithzel Maria Villarreal, Ana Royuela, Patricia Garcia Vicente, Jose Ramon Garcia-Berrocal
Summary: This study aimed to compare the discrimination ability of two relevant segmentation methods in head and neck cancer (HNC) and evaluate the potential benefit of adding lymph nodes' metabolism (LNM) to the measurements. The results showed that the use of background-level threshold (BLT) achieved better discrimination ability, and the addition of LNM improved the discrimination ability in prognostic models. Despite its limitations, this study proposed a practical approach to using these parameters in standard clinical practice.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Yongjiang Li, Wenbiao Zhang, Hu Zhang, Junfeng Hu, Chao Zhou, Xu Zhang, Wei Fan
Summary: This study demonstrated that MTV and TLG have independent prognostic significance for pulmonary LELC, supporting their use in predicting PFS and OS. MTV and TLG showed higher predictive value for prognosis compared to SUVmax, and non-colinearity was detected between metabolic burdens of different regional lesions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wenbin Yan, Chunhua Sun, Xiaomin Ou, Chaosu Hu
Summary: This study investigated the prognostic role of FDG PET/CT maximal standard uptake values of metastatic lesions (SUVmax-M) in de novo metastatic nasopharyngeal carcinoma (mNPC) patients receiving palliative chemotherapy and locoregional radiotherapy (LRRT). The results showed that high SUVmax-M (>=10), liver involvement, and elevated serum LDH (>=229) were independently associated with poor survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Song Sun, Zhi-Wen Xiao, Sai-Lan Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study developed and validated a nomogram model to predict the overall survival of patients with nasopharyngeal carcinoma without distant metastasis. The model incorporates clinical characteristics, serum biomarkers, and the presence of nasopharyngeal necrosis.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Zizheng Xiao, Yiwen Mo, Wen Long, Ruping Li, Xinling Li, Yuan Wei, Wei Fan, Xu Zhang
Summary: The baseline metabolic parameters of F-18-FDG PET/CT can predict treatment response and prognosis in pediatric patients with Burkitt lymphoma (BL), with tMTV and TLG significantly connected with treatment response and prognosis.
LEUKEMIA & LYMPHOMA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuelei Ma, Wenwu Ling, Fan Xia, Yifan Zhang, Chenjing Zhu, Jialing He
CONTRAST MEDIA & MOLECULAR IMAGING
(2019)
Article
Oncology
Yang Zhang, Lan Shang, Chaoyue Chen, Xuelei Ma, Xuejin Ou, Jian Wang, Fan Xia, Jianguo Xu
FRONTIERS IN ONCOLOGY
(2020)
Article
Clinical Neurology
Fan Xia, Xuexin Yu, Yunke Li, Yuqi Chen, Wei Zhang, Chao You, Xin Hu
Review
Clinical Neurology
Yuqi Chen, Fan Xia, Chengzhi Cai, Hao Li, Lu Ma, Xin Hu, Chao You
Summary: The study found that compared with short-term use, long-term prophylactic use of antiepileptic drugs (AEDs) in SAH patients has a similar effect in preventing in-hospital seizures but is associated with poor clinical outcomes. However, these findings are based on a small number of studies with obvious heterogeneity in study design. Further well-designed studies are needed to clarify these questions.
NEUROSURGICAL REVIEW
(2021)
Letter
Clinical Neurology
Fan Xia, Yuqi Chen, Xin Hu
Article
Medicine, General & Internal
Yunmei Luo, Fan Xia, Xuexin Yu, Peiyi Li, Wenzhi Huang, Wei Zhang
Summary: The study found an increasing trend in hypertension incidence in China from 1991 to 2015, with individuals in eastern, central and northeastern China being more likely to develop hypertension compared to those in western China. The results indicate the need for more focus on hypertension prevention and health education for high-risk individuals.
Article
Neurosciences
Yuqi Chen, Fan Xia, Yunke Li, Hao Li, Lu Ma, Xin Hu, Chao You
Summary: This study compared the clinical characteristics and treatment outcomes of hemorrhagic stroke patients during the COVID-19 period with those before the pandemic. It found that patients during the COVID-19 period had milder stroke severity, longer door-to-department time, higher rate of pneumonia complications, and lower percentage of good outcomes in patients with moderate hemorrhagic stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-ming Li, Jia-yu Tsauo, Kai-yu Jia, Yan-biao Liao, Fan Xia, Zheng-gang Zhao, Mao Chen, Yong Peng
Summary: In patients with prior cardiac surgery and aortic stenosis, endovascular TAVR treatment showed similar outcomes to SAVR and was superior to transapical TAVR treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ting Chen, Xiaoxiao Tan, Fan Xia, Ya Hua, Richard F. Keep, Guohua Xi
Summary: The study found that macrophages in the choroid plexus play a key role in the pathogenesis of hydrocephalus. Injection of Prx2 into the choroid plexus can alter the number, location, and immunophenotype of macrophages, while co-injection of clodronate liposomes can reduce the number of macrophages and attenuate Prx2-induced hydrocephalus and ventricular wall damage.
Review
Neurosciences
Katherine Holste, Fan Xia, Hugh J. L. Garton, Shu Wan, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) leads to activation of the complement cascade, resulting in brain edema/injury, but inhibition of specific components of the complement cascade can reduce edema and improve functional outcomes. Additionally, complement plays a significant role in neurologic recovery after ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Ming Wang, Fan Xia, Shu Wan, Ya Hua, Richard F. Keep, Guohua Xi
Summary: This study demonstrated that C3-deficient mice had less severe erythrolysis and brain injury following ICH compared with C3-sufficient mice. The release of Prx2 after erythrolysis was found to cause brain damage and neuroinflammation in mice.
Review
Cell Biology
Furong Qin, Fan Xia, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen, Min Luo
Summary: Nucleic acid vaccines show promising prospects in clinical applications due to their high efficiency and low cost compared to traditional vaccines, but their development is hindered by low immunogenicity and instability. Research efforts are focused on enhancing their immunogenicity and stability to support further progress in clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xuexin Yu, Fan Xia, Wei Zhang
Summary: The study found that the incidence of self-reported diabetes in China approximately doubled during the study period, with a steeper increase among men than among women. Geographic variations in diabetes incidence across regions can mostly be explained by differences in BMI and waist circumference.
Letter
Clinical Neurology
Fan Xia, Yuqi Chen, Xin Hu
Review
Cell & Tissue Engineering
Manni Wang, Fan Xia, Yuquan Wei, Xiawei Wei
