Article
Gastroenterology & Hepatology
Shekhar Singh Jadaun, Rohit Mehtani, Ana Hasnain, Sushant Bhatia, Vikash Moond, Mukesh Kumar, Vikash Kuhad, Shweta Singh, Shaleen Agarwal, Subhash Gupta, Sanjiv Saigal
Summary: This retrospective study analyzed the outcomes of living donor liver transplant (LDLT) in primary sclerosing cholangitis (PSC) at a tertiary liver transplant center in north India. The study found that LDLT in PSC can achieve good long-term outcomes, but there is a risk of PSC recurrence in approximately one-fifth of patients.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Annarosa Floreani, Sara De Martin
Summary: PSC is a chronic cholestatic liver disease with no effective treatment currently available. There is controversy over the use of UDCA in PSC treatment. Novel pharmacological strategies targeting bile composition, immunomodulation, gut microbiome, and fibrosis are emerging, suggesting potential for personalized combination therapies for successful PSC treatment.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Gastroenterology & Hepatology
Tej I. Mehta, Simcha Weissman, Brian M. Fung, John Sotiriadis, Keith D. Lindor, James H. Tabibian
Summary: Despite significant variations in global incidence of PSC, characteristics such as male predilection, bimodal distribution in age of diagnosis, and high concurrence of PSC-IBD remain consistent. Further studies are needed to better understand the geoepidemiology of PSC.
LIVER INTERNATIONAL
(2021)
Article
Cell Biology
Nelli Sjoblom, Sonja Boyd, Hannu Kautiainen, Johanna Arola, Martti Farkkila
Summary: This study aimed to develop a histological classification system, the PSC histoscore, for PSC. The results showed that the PSC histoscore better correlated with clinical endpoints, and an elevated total PSC histoscore increased the risk for disease progression.
Article
Gastroenterology & Hepatology
Kim N. van Munster, Bregje Mol, Jorn C. Goet, Sanne N. van Munster, Rinse K. Weersma, Annemarie C. de Vries, Adriaan J. van der Meer, Akin Inderson, Joost P. Drenth, Karel J. van Erpecum, Kirsten Boonstra, Ulrich Beuers, Marcel G. W. Dijkgraaf, Cyriel Y. Ponsioen
Summary: This study aimed to assess the long-term burden of primary sclerosing cholangitis (PSC) in terms of survival, clinical course, quality adjusted life years (QALYs), medical consumption, and work productivity loss. The findings revealed substantial impact of PSC on patients' lives, with decreased life expectancy, impaired quality of life, increased medical costs, and work productivity loss.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jared Cooper, Ante Markovinovic, Stephanie Coward, Michelle Herauf, Abdel-Aziz Shaheen, Mark Swain, Remo Panaccione, Christopher Ma, Cathy Lu, Kerri Novak, Karen Kroeker, Siew C. Ng, Gilaad G. Kaplan
Summary: The incidence and prevalence rates of primary sclerosing cholangitis in the general population are low. Future research on the epidemiology of primary sclerosing cholangitis should focus on Asia, Africa, and Latin America to get a better understanding of its global prevalence and incidence.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Nora Cazzagon, Samantha Sarcognato, Annarosa Floreani, Giorgia Corra, Sara De Martin, Vincenza Guzzardo, Francesco Paolo Russo, Maria Guido
Summary: The study found that cellular senescence marker expression exists in cholangiocytes of PSC patients, which is related to the severity of the disease and patient outcomes. CS may serve as a new prognostic tool and potential therapeutic target in PSC.
Article
Gastroenterology & Hepatology
Michael Praktiknjo, Taotao Zhou, Maximiliane Krusken, Torid Jacob, Alois M. Sprinkart, Sebastian Nowak, Markus Kimmann, Leona Dold, Johannes Chang, Christian Jansen, Christian P. Strassburg, Julian Luetkens, Tobias J. Weismuller
Summary: This study found that intramuscular fat fraction (IMFF) is associated with transplant-free survival in patients with primary sclerosing cholangitis (PSC). IMFF may serve as an indicator for identifying patients in urgent need of liver transplantation.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Surgery
Wisam Sbeit, Tawfik Khoury, Eran Goldin, Mahmud Mahamid
Summary: The study found that fully-covered metal stent (FCMS) was a safe and effective treatment option for patients with Primary Sclerosing Cholangitis (PSC) related refractory Dominant Strictures (DS).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Jessica T. Hochberg, Aalam Sohal, Priya Handa, Bryan D. Maliken, Take-Kyun Kim, Kai Wang, Eric Gochanour, Yu Li, J. Bart Rose, James E. Nelson, Keith D. Lindor, Nicholas F. LaRusso, Kris V. Kowdley
Summary: This study investigated the changes in serum miRNA and cytokine profiles in patients with PSC treated with high-dose ursodeoxycholic acid (hd-UDCA) or placebo. The results showed significant alterations in serum miRNA profiles after hd-UDCA treatment, suggesting a potential link to liver toxicity.
Article
Medicine, Research & Experimental
Shouyan Wu, Yuhan Cao, Henglei Lu, Xinming Qi, Jianhua Sun, Yang Ye, Likun Gong
Summary: This study identified the upregulation of chemokines and fibrosis in PSC patients and the significant ductular reaction and PBG proliferation in the chronic PSC model. In vitro experiments showed that MCP-1 secreted by cholangiocytes in PBG niche recruited macrophages and promoted inflammation and fibrosis. Further research revealed that POU6F1 could activate MCP-1 transcription, and 18 beta-Glycyrrhetinic acid (GA) reduced macrophages and fibrosis, benefiting acute and chronic PSC models. These findings provide potential targets and a theoretical basis for the clinical treatment of PSC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Florian Fronhoffs, Leona Dold, Marijo Parcina, Arne Schneidewind, Maria Willis, Thomas F. E. Barth, Tobias J. Weismueller, Taotao Zhou, Philipp Lutz, Julian A. Luetkens, Peter Gerlach, Steffen Manekeller, Joerg C. Kalff, Tim O. Vilz, Christian P. Strassburg, Glen Kristiansen
Summary: Primary sclerosing cholangitis is a significant cause of liver transplantation. Hepatic alveolar echinococcosis, caused by Echinococcus multilocularis, can be detected by ultrasound or CT scan of the liver showing characteristic calcified conglomerates. Symptoms of alveolar echinococcosis occur after a long period of infection, accompanied by cholestasis or cholangitis. This report presents a case of presumed autoimmune hepatitis and primary sclerosing cholangitis in a patient, and post-transplantation diagnosis revealed alveolar echinococcosis in the explanted liver.
Article
Medicine, General & Internal
Mindy C. Ward, Blake Studer, Ian Nora, Nathan Seepaulsing, Charles Loewe
Summary: Crohn's disease is a type of inflammatory bowel disease that commonly presents with symptoms like abdominal pain, diarrhea, and weight loss. Diagnosis typically involves imaging studies and biopsies. Treatment may include steroid therapy, but complications need to be monitored closely during the course of treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Mark R. Deneau, Cara Mack, Emily R. Perito, Amanda Ricciuto, Pamela L. Valentino, Mansi Amin, Achiya Z. Amir, Madeleine Aumar, Marcus Auth, Annemarie Broderick, Matthew DiGuglielmo, Laura G. Draijer, Eleonora Druve Tavares Fagundes, Wael El-Matary, Federica Ferrari, Katryn N. Furuya, Nitika Gupta, Jessica T. Hochberg, Matjaz Homan, Simon Horslen, Raffaele Iorio, M. Kyle Jensen, Maureen M. Jonas, Binita M. Kamath, Nanda Kerkar, Kyung Mo Kim, Kaija-Leena Kolho, Bart G. P. Koot, Trevor J. Laborda, Christine K. Lee, Kathleen M. Loomes, Mercedes Martinez, Alexander Miethke, Tamir Miloh, Douglas Mogul, Saeed Mohammad, Parvathi Mohan, Stacy Moroz, Nadia Ovchinsky, Sirish Palle, Alexandra Papadopoulou, Girish Rao, Alexandre Rodrigues Ferreira, Pushpa Sathya, Kathleen B. Schwarz, Uzma Shah, Eyal Shteyer, Ruchi Singh, Vratislav Smolka, Nisreen Soufi, Atsushi Tanaka, Raghu Varier, Bernadette Vitola, Marek Woynarowski, Melissa Zerofsky, Andreanne Zizzo, Stephen L. Guthery
Summary: The study developed a prognostic tool, the SCOPE index, for pediatric PSC that can predict disease progression and complications risk effectively, showing a strong correlation with the extent of liver fibrosis in patients.
Article
Medicine, General & Internal
Haythem Yacoub, Sarra Ben Azouz, Hajer Hassine, Habiba Debbabi, Dhouha Cherif, Feriel Ghayeb, Seif Boukriba, Hela Kchir, Nadia Maamouri
Summary: This article reports two rare cases of overlap syndrome between primary biliary cholangitis and primary sclerosing cholangitis. The importance of recognizing and treating this condition is highlighted.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Dermatology
Yael A. A. Leshem, Philip B. B. Sugerman, Clara Weil, Gabriel Chodick, Huifang Liang, Hongwei Wang, Brian Calimlim, Ana Dorfman, Varda Shalev, Dan Ben Amitai
Summary: This study found that patients with atopic dermatitis often have various infectious and inflammatory cutaneous comorbidities, and these comorbidities are closely associated with disease severity.
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Medicine, Research & Experimental
Clara Weil, Philip B. Sugerman, Gabriel Chodick, Huifang Liang, Hongwei Wang, Brian M. Calimlim, Ana Dorfman, Varda Shalev, Dan Ben Amitai, Yael A. Leshem
Summary: This study describes the prevalence and economic burden of atopic dermatitis in Israel using data from a healthcare provider. The incidence of atopic dermatitis was 7.0 per 1000 person-years, and the overall prevalence was 4.4%, with 42.3% suggestive of moderate to severe disease. Patients with atopic dermatitis had higher healthcare service utilization and costs compared to those without the condition.
ADVANCES IN THERAPY
(2022)
Article
Gastroenterology & Hepatology
Ailsa Hart, Geert D'Haens, Mareike Bereswill, Tricia Finney-Hayward, Jasmina Kalabic, Gweneth Levy, Huifang Liang, Cynthia H. Seow, Edward V. Loftus, Remo Panaccione, Walter Reinisch, Jack Satsangi
Summary: This study presents post hoc analyses of observational data from pregnant patients with CD who were receiving adalimumab treatment in the PYRAMID registry. The results showed that adalimumab treatment did not have additional adverse effects on the course of pregnancy or pregnancy outcomes.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Correction
Medicine, Research & Experimental
Clara Weil, Philip B. Sugerman, Gabriel Chodick, Huifang Liang, Hongwei Wang, Brian M. Calimlim, Ana Dorfman, Varda Shalev, Dan Ben Amitai, Yael A. Leshem
ADVANCES IN THERAPY
(2022)
Meeting Abstract
Dermatology
Joseph F. Merola, Raghava Danwada, Brennan Ertmer, Huifang Liang, Sarah Ofori, Whitney Krueger
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongwei Zhang, Zhibin Liao, Weijian Wang, Yachong Liu, He Zhu, Huifang Liang, Bixiang Zhang, Xiaoping Chen
Summary: The TGF-beta signaling pathway plays crucial roles in hepatocellular carcinoma (HCC) progression, and long intergenic non-protein coding RNAs (lincRNAs) are important components of this pathway. This study identified LINC02551 as a TGF-beta transcriptionally activated lincRNA that encodes a peptide called Jun binding micropeptide (JunBP). The functional study revealed that JunBP promotes HCC metastasis by binding to c-Jun and enhancing its phosphorylated activation. The study also discovered a positive feedback mechanism involving the interaction between c-Jun and SMAD3, leading to increased recruitment of SMAD3 to the promoter region of LINC02551. This mechanism provides a potential prognostic biomarker and therapeutic target for HCC.
Article
Biochemistry & Molecular Biology
Chen Jin, Dong Han-hua, Liu Qiu-meng, Ning Deng, Du Peng-Chen, Mo Jie, Xu Lei, Zhang Xue-Wu, Liang Hui-fang, Chen Yan, Chen Xiao-ping, Zhang Bi-xiang
Summary: This study identifies DDX17 as a novel binding partner of MTDH and reveals its role in promoting tumor initiation and progression in Hepatocellular Carcinoma. DDX17 acts as a transcriptional regulator that interacts with Y-box binding protein 1 (YB1), leading to increased transcription of the epidermal growth factor receptor (EGFR) gene and activation of the downstream MEK/pERK signaling pathway. These findings suggest that the DDX17/YB1/EGFR axis contributes to tumorigenesis and metastasis of Hepatocellular Carcinoma.
Article
Biochemistry & Molecular Biology
Yi-xiao Xiong, Xiao-chao Zhang, Jing-han Zhu, Yu-xin Zhang, Yong-long Pan, Yu Wu, Jian-ping Zhao, Jun-jie Liu, Yuan-xiang Lu, Hui-fang Liang, Zhan-guo Zhang, Wan-guang Zhang
Summary: Cancer stem cells (CSCs) are a minority population of cancer cells with stemness and multiple differentiation potentials, leading to cancer progression and therapeutic resistance. However, the concrete mechanism of CSCs in hepatocellular carcinoma (HCC) remains obscure. We found that in advanced HCC tissues, collagen I was upregulated, which is consistent with the expression of its receptor DDR1. Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo. The combined inhibition of DDR1 and YAP synergistically abrogated HCC cell stemness in vitro and tumorigenesis in vivo. A radiomic model based on T2 weighted images can noninvasively predict collagen I expression. These findings reveal the molecular basis of collagen I-DDR1 signaling inhibiting Hippo signaling and highlight the role of CD44/DDR1/YAP axis in promoting cancer cell stemness, suggesting that DDR1 and YAP may serve as novel prognostic biomarkers and therapeutic targets in HCC.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Immunology
Huifang Liang, Junqin Li, Kaiming Zhang
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes and infiltration of immune cells. S100 proteins, including S100A2, -A7, -A8/A9, -A12, -A15, are upregulated in psoriatic skin and play various roles in intracellular Ca2+ sensing, Ca2+ signaling transduction, response to extracellular stimuli, energy metabolism, and regulation of cell proliferation and apoptosis. Evidence suggests the important role of S100 proteins in the pathogenesis of psoriasis, making them potential therapeutic targets and diagnostic biomarkers. This review focuses on the pathogenic role of S100 proteins in psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin Chen, Deng Ning, Pengcheng Du, Qiumeng Liu, Jie Mo, Huifang Liang, Wanguang Zhang, Mingzhi Zhang, Li Jiang, Bixiang Zhang, Xiaoping Chen
Summary: USP11 is significantly upregulated in hepatocellular carcinoma (HCC) and is closely associated with tumor number, vascular invasion, and poor prognosis. USP11 promotes HCC metastasis and epithelial-mesenchymal transition (EMT) by inducing the transcription factor Snail. Mechanistically, USP11 interacts with and deubiquitinates eEF1A1, leading to increased expression of HGF and activation of the PI3K/AKT signaling pathway through the eEF1A1/SP1/HGF axis. Thus, USP11 could be a potential therapeutic target for the treatment of HCC.
Meeting Abstract
Public, Environmental & Occupational Health
Huifang Liang, Brenna Kirk, Dionna Attinson, Dongmu Zhang, Jianzhong Liu, Ryan Kilpatrick
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)