Review
Immunology
Jianwen Liu, Ling Zhang, Shuo Chen, Xin Lu, Shanshan Li
Summary: This report is a description of the clinical features and prognosis of pneumatosis cystoides intestinalis (PCI) in six adult patients with dermatomyositis (DM). Additionally, previous studies on this complication are reviewed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Gianluca Gazzaniga, Federica Villa, Federica Tosi, Elio Gregory Pizzutilo, Stefano Colla, Stefano D'Onghia, Giusy Di Sanza, Giulia Fornasier, Michele Gringeri, Maria Victoria Lucatelli, Giulia Mosini, Arianna Pani, Salvatore Siena, Francesco Scaglione, Andrea Sartore-Bianchi
Summary: This systematic review investigates the occurrence of pneumatosis intestinalis (PI) during oncological therapies, particularly in patients with respiratory system cancers and those treated with targeted therapies. PI mostly presents with mild to absent symptoms, but can lead to severe complications. Therefore, it is important to consider PI as a potential adverse event in oncological patients.
Review
Pharmacology & Pharmacy
Tingting Zhang, Mingnan Cao, Bin Zhao, Chen Pan, Li Lin, Chuanhao Tang, Zhigang Zhao, Jingli Duan, Li Wang, Jun Liang
Summary: A patient with lung squamous carcinoma developed pneumatosis intestinalis following methylprednisolone administration for immune-related adverse events. Literature review and FAERS database analysis identified additional cases of pneumatosis intestinalis. Steroids may be an etiologic factor, but immune checkpoint inhibitors-induced pneumatosis intestinalis should not be excluded.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Diogo Alpuim Costa, Pedro Modas Daniel, Joao Vieira Branco
Summary: Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by gas-filled cysts in the gastrointestinal tract wall, with varying degrees of severity and potential complications. Treatment options range from conservative approaches to surgery, with hyperbaric oxygen therapy (HBOT) showing promising results in selected cases. Further research is needed to fully understand the pathophysiology and optimal management strategies for PCI.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Lijun Shi, Juan Wang, Li Wei, Zhongrui Ma, Xaiohu Liu
Summary: This article reports a case of primary pancreatic lymphoma in a 48-year-old female patient who presented with lower back pain, jaundice, dark brown urine, nausea, and ascites. Radiological evaluation revealed a pancreatic head mass that was diagnosed as diffuse large B-cell lymphoma following biopsy. However, the patient developed complications after surgery and ultimately died due to multiple organ failure.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Khaled Ali, Mhd Baraa Habib, Ferial Alloush, Mohamed A. Yassin
Summary: This case report presents a rare case of severe upper gastrointestinal bleeding caused by gastric lymphoma. The patient was treated conservatively and underwent urgent radiotherapy, resulting in stable condition and a diagnosis of stage IV lymphoma.
Review
Oncology
Neerav Monga, Constantine Tam, Jamie Garside, Matthew S. Davids, Katherine Ward, Joan Quigley, Lori Parisi, Christoph Tapprich
Summary: Mantle cell lymphoma is a rare form of non-Hodgkin's lymphoma with a median overall survival of approximately 3-5 years. Studies have shown that treatment regimens and patient outcomes for MCL can vary based on age and suitability for stem cell transplantation. Despite a lack of directly comparable evidence on the efficacy and safety of MCL therapies, the need for newer treatments to improve patient outcomes is evident.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Medicine, General & Internal
Shi-Fu Hu, Han-Bo Liu, Yuan-Yuan Hao
Summary: The study reports a rare case of portal venous gas, pneumatosis intestinalis, and emphysematous cystitis coexistence in an 86-year-old female patient. Emergency surgery should be performed when CT shows signs of PVG with PI and EC along with clinical situation strongly suggestive of bowel ischemia. After surgery, the patient developed postoperative short bowel syndrome but had a good recovery with intravenous fluid infusion and enteral nutrition maintenance.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Gastroenterology & Hepatology
Liqing Yang, Xi Zhong, Hao Yang, Qin Wu, Yuping Gong, Bo Wang
Summary: This article reports a case of secondary Pneumatosis Cystoides Intestinalis (PCI) in a patient with hematological malignancies after chemotherapy. The diagnosis was made through CT and exploratory laparotomy. Additionally, the possibility of intra-abdominal pressure as a predictor for surgical intervention was proposed.
BMC GASTROENTEROLOGY
(2022)
Review
Oncology
Xiaoju Li, Fanlin Zhou, Shijie Li, Yangyang Wang, Jianing Fan, Xiao Liang, Yan Peng, Yudi Jin, Weiyang Jiang, Fang Liu, Yixing Zhou, Shuke Liu, Tao Wang, Yi Peng, Jianbo Xiong, Jia Liu, Jing Zhang, Changqing He, Hui Zhang, Yu Li
Summary: This study analyzed the prevalence and clinicopathological features of mantle cell lymphoma (MCL) with Epstein-Barr virus (EBV) infection in the largest series so far. The incidence of MCL with EBV infection was found to be low and most infected cells were background cells rather than tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Erika Yuki Yvamoto, Spencer Cheng, Guilherme Henrique Peixoto de Oliveira, Joao Guilherme Ribeiro Jordao Sasso, Mateus Bond Boghossian, Mauricio Kazuyoshi Minata, Igor Braga Ribeiro, Eduardo Guimaraes Hourneaux de Moura
Summary: Pneumatosis cystoid intestinalis (PCI) is a rare condition characterized by abnormal accumulation of gas within the submucosa, subserosa, or both layers of the intestine. It is classified into primary and secondary forms and can be associated with various underlying etiologies. Colonoscopy, surgery, and radiological findings are commonly used for diagnosis, but colorectal endoscopic ultrasound (EUS) can provide a reliable and non-radiation option. However, more studies are needed to define the best approach for PCI diagnosis due to its rarity.
Article
Surgery
Kadie Clancy, Esmaeel Reza Dadashzadeh, Robert Handzel, Caroline Rieser, J. B. Moses, Lauren Rosenblum, Shandong Wu
Summary: The study indicates that a combination of radiographic and clinical features can effectively identify pathologic pneumatosis intestinalis and assist in selecting patients for surgery. This tool may improve the surgical decision-making process for patients with pneumatosis intestinalis.
Review
Rheumatology
Melis Dilbil, Funda Erbasan, Bengisu Aslan, Tahir Saygin Ogut, Mine Nokay, Veli Yazisiz, Mustafa Ender Terzioglu
Summary: This article presents a rare case of a polymyositis patient who experienced pneumomediastinum, pneumatosis intestinalis, and pneumoperitoneum simultaneously. The complications were detected during immunosuppressive treatment but resolved spontaneously without intervention. The article also reviews similar cases reported in literature.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Health Care Sciences & Services
Fu-Chou Lee, Junn-Liang Chang, Hung-Ming Chen, Wan-Chen Tsai, Po-Jen Hsiao
Summary: This case report describes a 60-year-old male patient who initially presented with symptoms of acute appendicitis, but was later diagnosed with mantle cell lymphoma. Following combination chemotherapy treatment, the patient remained stable during a one-year follow-up period. Positive immunochemical staining of cyclin D1 and SOX-11 can help differentiate mantle cell lymphoma from other appendiceal lymphomas and guide appropriate treatment.
Review
Biochemistry & Molecular Biology
Qichao Ge, Yang Liu, Fan Yang, Guangwei Sun, Jintao Guo, Siyu Sun
Summary: This study reported a case of familial GISTs with a novel germline mutation within exon 18 of KIT. Whole-exome sequencing and Sanger sequencing identified a primary driver mutation that could lead to cell proliferation and imatinib resistance. Cell models were established to explore potential mechanisms and ripretinib was identified as an applicable targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)