Article
Biochemistry & Molecular Biology
Lidia Lungu, Svetlana Blaja, Caleria Cucicova, Alexandru Ciocarlan, Alic Barba, Veaceslav Kulcitki, Sergiu Shova, Nicoleta Vornicu, Elisabeta-Irina Geana, Ionel I. Mangalagiu, Aculina Aricu
Summary: In this study, a feasible synthesis and in vitro antimicrobial activity evaluation of new homodrimane sesquiterpenoids with a benzimidazole unit were reported. Seven N-homodrimenoyl-2-amino-1,3-benzimidazoles and 2-homodrimenyl-1,3-benzimidazoles were successfully synthesized using homodrimane carboxylic acids, acyl chlorides, and intermediate monoamides. The synthesized compounds exhibited significant antifungal and antibacterial activities, with compounds 7 and 20 showing higher activities compared to the standards.
Article
Infectious Diseases
Victor Kartsev, Athina Geronikaki, Alexander Zubenko, Anthi Petrou, Marija Ivanov, Jasmina Glamoclija, Marina Sokovic, Lyudmila Divaeva, Anatolii Morkovnik, Alexander Klimenko
Summary: In this study, the design, synthesis, and antimicrobial activity of new heteroaryl (aryl) thiazole derivatives were reported. The compounds demonstrated moderate antibacterial activity and better antifungal activity. Compound 3 showed the highest activity among the tested compounds.
Article
Chemistry, Medicinal
Elvan Ustun, Neslihan Sahin, Ilknur Ozdemir, Selami Gunal, Nevin Gurbuez, Ismail Ozdemir, David Semeril
Summary: Two series of silver(I) nitrate complexes, bis(1-alkylbenzimidazole)silver(I) nitrate and bis(1-alkyl-5,6-dimethylbenzimidazole)silver(I) nitrate, were synthesized and characterized. These complexes showed moderate antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as good antifungal activity against Candida albicans and Candida glabrata. Molecular docking and reactivity descriptor calculations were also performed.
ARCHIV DER PHARMAZIE
(2023)
Review
Biochemistry & Molecular Biology
Thi Lan Anh Nguyen, Debanjana Bhattacharya
Summary: Quercetin, a plant flavonoid, has been extensively studied for its antimicrobial activity. It exhibits inhibitory effects on the growth of bacteria, fungi, and viruses through various mechanisms including cell membrane damage, inhibition of nucleic acids and protein synthesis, and reduction of virulence factors. Quercetin also shows potential against drug-resistant microorganisms. This review provides insights into its mechanism of action and potential clinical applications as an antimicrobial agent.
Review
Chemistry, Multidisciplinary
Johana Zuniga-Miranda, Julio Guerra, Alexander Mueller, Arianna Mayorga-Ramos, Saskya E. Carrera-Pacheco, Carlos Barba-Ostria, Jorge Heredia-Moya, Linda P. Guaman
Summary: The inappropriate use of antimicrobial agents has led to the rise of antimicrobial resistance, posing a global health threat. Nanotechnology provides a potential solution through the synthesis of nanoparticles with antimicrobial activity, such as iron oxide nanoparticles. This review highlights key findings in the green synthesis of iron oxide nanoparticles using bacteria, fungi, plants, and organic waste, discusses challenges encountered in green synthesis with diverse organisms and materials, and explores the applications of these nanoparticles as promising antibacterial, antifungal, antiparasitic, and antiviral agents.
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Gloria Maria Pontes-Quero, Susana Esteban-Rubio, Juan Perez Cano, Maria Rosa Aguilar, Blanca Vazquez-Lasa
Summary: Oregano essential oil has beneficial properties for biotechnological and biomedical applications, but its instability due to volatile nature and external factors can be addressed through micro- and nanoencapsulation. This encapsulation strategy enhances stability, bioactivity, and allows for controlled and targeted release of the oil.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Review
Infectious Diseases
Purnima Khatri, Asha Rani, Saif Hameed, Subhash Chandra, Chung-Ming Chang, Ramendra Pati Pandey
Summary: Antimicrobial resistance is a growing problem worldwide, and new antimicrobial agents are needed. Spices such as clove, ginger, coriander, garlic, and turmeric have the potential to combat resistant microbes. This study focuses on the bioactivity of active ingredients in naturally available spices and concludes that certain spices have good antimicrobial and antifungal properties, which can help control antimicrobial resistance and improve human health.
Article
Microbiology
Vanessa Duncan, Daniel Smith, Laura Simpson, Emma Lovie, Laura Katvars, Leon Berge, Jennifer Robertson, Shane Smith, Carol Munro, Derry Mercer, Deborah O'Neil
Summary: Fungi cause disease in nearly one billion individuals worldwide, and current antifungal agents face challenges such as emerging and drug-resistant fungi, toxicity, and drug-drug interactions. The development of NP339, a polyarginine peptide with potent antifungal activity against various pathogenic fungi, presents a promising solution to these challenges. NP339 targets fungal cell membranes specifically, demonstrating rapid fungicidal activity without inducing resistance, suggesting its potential as a differentiated antifungal candidate for serious fungal diseases.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Rewan Abdelaziz, Yasmine H. Tartor, Ahmed B. Barakat, Gamal EL-Didamony, Marwa M. Gado, Adina Berbecea, Habil Dr. Isidora Radulov
Summary: This study aimed to discover a broad-spectrum biomaterial for treating multidrug-resistant bacterial and fungal infections. Streptomyces species were isolated from soil samples, and the most active strains with antimicrobial activity were identified. The bioactive metabolites extracted from these strains showed significant inhibitory effects against MDR bacteria and fungi, and demonstrated therapeutic efficacy in mouse models.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Teresa Glomb, Piotr Swiatek
Summary: The development of new 1,3,4-oxadiazole derivatives as antimicrobial agents shows promising potential, with many new compounds displaying higher activity compared to known antibiotics and other antimicrobial agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Inorganic & Nuclear
Claudio Pettinari, Riccardo Pettinari, Corrado Di Nicola, Alessia Tombesi, Stefania Scuri, Fabio Marchetti
Summary: This article discusses the recent advances in antimicrobial MOFs, covering various aspects of their biomedical applications. It outlines the potential offered by MOFs and composite materials containing MOFs in the field of antimicrobial materials, along with describing the key parameters in the design and production of antimicrobial MOFs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Infectious Diseases
Ammar A. Al-Fadhli, MichaelD. Threadgill, Faez Mohammed, Paul Sibley, Wadie Al-Ariqi, Ifat Parveen
Summary: Macrolides produced by rare actinomycetes exhibit diverse biological activities, including antibacterial, antifungal, antimicrobial, antiprotozoal, and antimalarial properties. Several groups of macrolides, such as ammocidins, bafilomycins, and spinosyns, show a wide range of bioactivities. These compounds have the potential for future applications in medicine.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Materials Science, Ceramics
Afra M. Baghdadi, Amna A. Saddiq, Abdallah Aissa, Yousif Algamal, Nagy Mohamed Khalil
Summary: This study aimed to prepare Al2O3 nanoparticles from aluminum wastes and evaluate their antimicrobial activity. The nanomaterials were characterized using XRD, SEM, and EDAX techniques. The results showed that the prepared Al2O3 nanoparticles exhibited crystalline structure, and their size and growth were influenced by the calcination temperature. The EDX analysis revealed the presence of aluminum and oxygen in the material. The Al2O3 nanoparticles demonstrated antimicrobial activity, and the inhibitory effect increased with decreasing DMSO concentration.
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2022)
