Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 27, Issue 2, Pages 470-475Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-017-2073-9
Keywords
Heracleum dissectum; Ethnic herb; New compounds; Adipogenesis; Antidiabetes
Categories
Funding
- Natural Science Foundation of Shaanxi province [2015JM8413]
- Natural Science Foundation of China [81673564]
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Heracleum dissectum Ledeb. is an ethnic herb used by Oroqen people in Northeast China. The roots of this plant are usually used for treatment of several diseases. However, chemical constituents and pharmacological study were rarely reported. In this present study, phytochemical investigation of H. dissectum methanolic extract (HdME) led to the isolation of a new benzofuran derivative glycoside, 6-methoxycarbonylethyl-benzofuran-5-O-beta-d-xylopyranosyl (1 -> 2)-beta-d-glucopyranoside (1) and a new coumarin glycoside, 6aEuro(3)-beta-d-glucopyranosyl-apterin (2). Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. Adipogenesis accumulating activity was assayed in 3T3-L1 cells. Compound 2 could potently accelerate the accumulation of triglycerides (TG) in 3T3-L1 adipocytes in which TG concentrations were 15.6 +/- 2.3, 26.8 +/- 1.8, and 35.6 +/- 2.6% higher than those of the control group at the concentration of 3, 10, and 30 mu M, respectively. In contrast, compound 1 exhibited comparatively weak activity on TG accumulation in adipocytes. This result denoted that the new compound 2 might possess antidiabetic activity in vivo.
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