Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement

(2017) Michael R. Weigand et al.   JOURNAL OF BACTERIOLOGY

Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells

(2017) Elise S. Hovingh et al.   PLoS One

Biofilm forming potential and antimicrobial susceptibility of newly emerged Western AustralianBordetella pertussisclinical isolates

(2016) Dorji Dorji et al.   BIOFOULING

Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species

(2016) Bodo Linz et al.   BMC GENOMICS

Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood

(2016) Tara Bancroft et al.   CELLULAR IMMUNOLOGY

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development

(2016) Nicholas H. Carbonetti et al.   Clinical and Vaccine Immunology

Epidemiology of pertussis in Denmark, 1995 to 2013

(2016) Tine Dalby et al.   Eurosurveillance

Surveillance of pertussis: methods and implementation

(2016) Nicole Guiso et al.   Expert Review of Anti-Infective Therapy

Genomic dissection of Australian Bordetella pertussis isolates from the 2008–2012 epidemic

(2016) Azadeh Safarchi et al.   JOURNAL OF INFECTION

Immunogenicity and protective efficacy of recombinant iron superoxide dismutase protein fromBordetella pertussisin mice models

(2016) Çiğdem Yılmaz et al.   MICROBIOLOGY AND IMMUNOLOGY

Bordetellaadenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formationin vitro

(2016) Casandra Hoffman et al.   MOLECULAR MICROBIOLOGY

Pertussis Vaccine Effectiveness in the Setting of Pertactin-Deficient Pertussis

(2016) L. Breakwell et al.   PEDIATRICS

Differential regulation of type III secretion and virulence genes inBordetella pertussisandBordetella bronchisepticaby a secreted anti-σ factor

(2016) Umesh Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study

(2016) Azadeh Safarchi et al.   VACCINE

The multifaceted RisA regulon of Bordetella pertussis

(2016) Loïc Coutte et al.   Scientific Reports

The potential of adjuvants to improve immune responses against TdaP vaccines: A preclinical evaluation of MF59 and monophosphoryl lipid A

(2015) Valentina Agnolon et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation inBordetella bronchiseptica

(2015) Dustin J. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity

(2015) René H. M. Raeven et al.   JOURNAL OF PROTEOME RESEARCH

Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model

(2015) Azadeh Safarchi et al.   VACCINE

Cooperative Roles for Fimbria and Filamentous Hemagglutinin in Bordetella Adherence and Immune Modulation

(2015) Erich V. Scheller et al.   mBio

Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells

(2015) César Martín et al.   Scientific Reports

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States

(2015) Manoj Gambhir et al.   PLoS Computational Biology

Bordetella pertussis Isolates from Argentinean Whooping Cough Patients Display Enhanced Biofilm Formation Capacity Compared to Tohama I Reference Strain

(2015) Laura Arnal et al.   Frontiers in Microbiology

Bordetella pertussis,B. parapertussis, vaccines and cycles of whooping cough

(2015) Valérie Bouchez et al.   Pathogens and Disease

Bordetellabiofilms: a lifestyle leading to persistent infections

(2015) Natalia Cattelan et al.   Pathogens and Disease

Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure.

(2015) Nicholas H. Carbonetti   Pathogens and Disease

Highly differentiated human airway epithelial cells: a model to study host cell–parasite interactions in pertussis

(2015) Claudia Guevara et al.   Infectious Diseases

Bordetella pertussis FbpA Binds Both Unchelated Iron and Iron Siderophore Complexes

(2014) Sambuddha Banerjee et al.   BIOCHEMISTRY

Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage

(2014) S. W. Martin et al.   CLINICAL INFECTIOUS DISEASES

Type III secretion system

(2014) Andrea Puhar et al.   CURRENT BIOLOGY

Investigations into the emergence of pertactin-deficient Bordetella pertussis isolates in six European countries, 1996 to 2012

(2014) A Zeddeman et al.   Eurosurveillance

OtherBordetellas, lessons for and from pertussis vaccines

(2014) Nicole Guiso et al.   Expert Review of Vaccines

Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

(2014) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

Acellular pertussis vaccine effectiveness for children during the 2009–2010 pertussis epidemic in Queensland

(2014) Sarah L Sheridan et al.   MEDICAL JOURNAL OF AUSTRALIA

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine

(2014) A Dunne et al.   Mucosal Immunology

Correction: Differentially Expressed Genes in Bordetella pertussis Strains Belonging to a Lineage Which Recently Spread Globally

(2014) Daan de Gouw et al.   PLoS One

A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

(2014) Rigmor Thorstensson et al.   PLoS One

Proteomics-Identified Bvg-Activated Autotransporters Protect against Bordetella pertussis in a Mouse Model

(2014) Daan de Gouw et al.   PLoS One

c-di-GMP Enhances Protective Innate Immunity in a Murine Model of Pertussis

(2014) Shokrollah Elahi et al.   PLoS One

B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial

(2014) Maja Jahnmatz et al.   VACCINE

The vaccine potential of Bordetella pertussis biofilm-derived membrane proteins

(2014) Daan de Gouw et al.   Emerging Microbes & Infections

Comparison of lipopolysaccharide structures of Bordetella pertussis clinical isolates from pre- and post-vaccine era

(2013) Sami AlBitar-Nehme et al.   CARBOHYDRATE RESEARCH

Pertussis immunisation and control in England and Wales, 1957 to 2012: a historical review

(2013) G Amirthalingam et al.   Eurosurveillance

Quantification of the Adenylate Cyclase Toxin of Bordetella pertussisIn Vitroand during Respiratory Infection

(2013) Joshua C. Eby et al.   INFECTION AND IMMUNITY

The Bordetella pertussis Type III Secretion System Tip Complex Protein Bsp22 Is Not a Protective Antigen and Fails To Elicit Serum Antibody Responses during Infection of Humans and Mice

(2013) Rodrigo Villarino Romero et al.   INFECTION AND IMMUNITY

Genetic analysis of Bordetella pertussis in Ontario, Canada reveals one predominant clone

(2013) Michelle Shuel et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Waning Immunity to Pertussis Following 5 Doses of DTaP

(2013) S. Y. Tartof et al.   PEDIATRICS

Genome-Wide Gene Expression Analysis of Bordetella pertussis Isolates Associated with a Resurgence in Pertussis: Elucidation of Factors Involved in the Increased Fitness of Epidemic Strains

(2013) Audrey J. King et al.   PLoS One

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

(2013) J. M. Warfel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bordetella pertussis iron regulated proteins as potential vaccine components

(2013) Jimena Alvarez Hayes et al.   VACCINE

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

DTaP-IPV-Hep B-Hib Vaccine (Hexaxim®)

(2013) Paul L. McCormack   PEDIATRIC DRUGS

Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

(2013) Pádraig J. Ross et al.   PLoS Pathogens

Appearance of Bordetella pertussis Strains Not Expressing the Vaccine Antigen Pertactin in Finland

(2012) Alex-Mikael Barkoff et al.   Clinical and Vaccine Immunology

Resurgence of pertussis calls for re-evaluation of pertussis animal models

(2012) Arno AJ van der Ark et al.   Expert Review of Vaccines

Construction and Preliminary Immunobiological Characterization of a Novel, Non-Reverting, Intranasal Live Attenuated Whooping Cough Vaccine Candidate

(2012) R. Cornford-Nairns   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA

(2012) K. B. Decker et al.   MICROBIOLOGY-SGM

Prevalence and Genetic Characterization of Pertactin-Deficient Bordetella pertussis in Japan

(2012) Nao Otsuka et al.   PLoS One

The Type III Secreted Protein BspR Regulates the Virulence Genes in Bordetella bronchiseptica

(2012) Jun Kurushima et al.   PLoS One

Small Mutations in Bordetella pertussis Are Associated with Selective Sweeps

(2012) Marjolein van Gent et al.   PLoS One

Transcriptome Profiling Reveals Stage-Specific Production and Requirement of Flagella during Biofilm Development in Bordetella bronchiseptica

(2012) Tracy L. Nicholson et al.   PLoS One

Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores

(2012) Radovan Fiser et al.   PLoS Pathogens

Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the β-domain pore

(2011) Yujia Zhai et al.   BIOCHEMICAL JOURNAL

Antibodies Recognizing Protective Pertussis Toxin Epitopes Are Preferentially Elicited by Natural Infection versus Acellular Immunization

(2011) Jamie N. Sutherland et al.   Clinical and Vaccine Immunology

The reemergence of pertussis and infant deaths: is it time to immunize pregnant women?

(2011) Beth A Halperin et al.   Future Microbiology

BpsR Modulates Bordetella Biofilm Formation by Negatively Regulating the Expression of the Bps Polysaccharide

(2011) M. S. Conover et al.   JOURNAL OF BACTERIOLOGY

Attenuated Bordetella pertussis Vaccine Candidate BPZE1 Promotes Human Dendritic Cell CCL21-Induced Migration and Drives a Th1/Th17 Response

(2011) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

BapC autotransporter protein is a virulence determinant of Bordetella pertussis

(2011) Mojtaba Noofeli et al.   MICROBIAL PATHOGENESIS

Differential Expression of Type III Effector BteA Protein Due to IS481 Insertion in Bordetella pertussis

(2011) Hyun-Ja Han et al.   PLoS One

Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

(2011) Nikolaus Rieber et al.   PLoS One

Extracellular DNA Is Essential for Maintaining Bordetella Biofilm Integrity on Abiotic Surfaces and in the Upper Respiratory Tract of Mice

(2011) Matt S. Conover et al.   PLoS One

Bordetella pertussis Autotransporter Vag8 Binds Human C1 Esterase Inhibitor and Confers Serum Resistance

(2011) Nico Marr et al.   PLoS One

FHA-Mediated Cell-Substrate and Cell-Cell Adhesions Are Critical for Bordetella pertussis Biofilm Formation on Abiotic Surfaces and in the Mouse Nose and the Trachea

(2011) Diego O. Serra et al.   PLoS One

Identification of a new protective antigen of Bordetella pertussis

(2011) Jimena Alvarez Hayes et al.   VACCINE

The role of bacterial biofilm in persistent infections and control strategies

(2011) Li Chen et al.   International Journal of Oral Science

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

(2011) Supachoke Mangmool et al.   Toxins

Antibody Response Patterns to Bordetella pertussis Antigens in Vaccinated (Primed) and Unvaccinated (Unprimed) Young Children with Pertussis

(2010) J. D. Cherry et al.   Clinical and Vaccine Immunology

Synergic Effect of Genotype Changes in Pertussis Toxin and Pertactin on Adaptation to an Acellular Pertussis Vaccine in the Murine Intranasal Challenge Model

(2010) E. Komatsu et al.   Clinical and Vaccine Immunology

Pertussis toxin and adenylate cyclase toxin: key virulence factors ofBordetella pertussisand cell biology tools

(2010) Nicholas H Carbonetti   Future Microbiology

Development of improved vaccines against whooping cough: Current status

(2010) Ibrahim Marzouqi et al.   Human vaccines & immunotherapeutics

Pertactin Is Required for Bordetella Species To Resist Neutrophil-Mediated Clearance

(2010) C. S. Inatsuka et al.   INFECTION AND IMMUNITY

Resemblance and divergence: the “new” members of the genus Bordetella

(2010) Roy Gross et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin

(2010) Matt S. Conover et al.   MOLECULAR MICROBIOLOGY

Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA

(2010) Qing Chen et al.   MOLECULAR MICROBIOLOGY

Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1

(2010) Pascal Feunou Feunou et al.   VACCINE

Bordetella Adenylate Cyclase Toxin Mobilizes Its β2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

(2010) Ladislav Bumba et al.   PLoS Pathogens

Should fimbriae be included in pertussis vaccines? Studies on ELISA IgG anti-Fim2/3 antibodies after vaccination and infection

(2009) HANS O. HALLANDER et al.   APMIS

Efficacy and effectiveness of acellular pertussis vaccines: a 20-year Swedish experience

(2009) Hans O Hallander et al.   Expert Review of Vaccines

Changes in Genetic Diversity of the Bordetella pertussis Population in the United Kingdom between 1920 and 2006 Reflect Vaccination Coverage and Emergence of a Single Dominant Clonal Type

(2009) D. J. Litt et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Pertussis Vaccine

(2009) John B. Robbins et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content

(2009) Lotte H. Hendrikx et al.   VACCINE

First report and detailed characterization of B. pertussis isolates not expressing pertussis toxin or pertactin

(2009) V. Bouchez et al.   VACCINE

Bordetella pertussis vaccine strains and circulating isolates in Serbia

(2009) Gordana Dakic et al.   VACCINE

Bordetella pertussis Isolates in Finland: Serotype and Fimbrial Expression

(2008) Eriikka Heikkinen et al.   BMC MICROBIOLOGY

Bordetella pertussis Expresses a Functional Type III Secretion System That Subverts Protective Innate and Adaptive Immune Responses

(2008) N. K. Fennelly et al.   INFECTION AND IMMUNITY

Differential expression of Bordetella pertussis iron transport system genes during infection

(2008) Timothy J. Brickman et al.   MOLECULAR MICROBIOLOGY

BordetellaBsp22 forms a filamentous type III secretion system tip complex and is immunoprotectivein vitroandin vivo

(2008) Bob Medhekar et al.   MOLECULAR MICROBIOLOGY

Proteome approaches combined with Fourier transform infrared spectroscopy revealed a distinctive biofilm physiology in Bordetella pertussis

(2008) Diego Omar Serra et al.   PROTEOMICS

Antibody responses to defined regions of theBordetella pertussisvirulence factor pertactin

(2008) Marcel Hijnen et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model

(2008) Nico Marr et al.   VACCINE

Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection

(2007) S. R. Fry et al.   JOURNAL OF MEDICAL MICROBIOLOGY