Article
Obstetrics & Gynecology
Jacqueline A. Bohn, Kimberley A. Bullard, Maria I. Rodriguez, Amanda M. Ecker
Summary: The study evaluated the cost effectiveness of various sequential medical and surgical therapy strategies for endometriosis-related dysmenorrhea. Results showed that all treatment strategies were cost effective compared to surgery alone, with strategy 2 being the most cost-effective. Delaying surgical management after trying more than three medications may decrease quality of life and increase costs.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Critical Care Medicine
Vincent Lau, Feng Xie, John Basmaji, Deborah J. Cook, Robert Fowler, Michel Kiflen, Emily Sirotich, Alla Iansavichene, Sean M. Bagshaw, M. Elizabeth Wilcox, Francois Lamontagne, Niall Ferguson, Bram Rochwerg
Summary: Cost utility analyses compare interventions' costs and health outcomes with quality-adjusted life years as a denominator, but non-standardized methods make comparisons difficult. Undertaking cost utility analyses in critical care presents challenges in measuring and reporting, potentially leading to differences that hinder comparisons.
CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Huai-liang Wu, Zi-yin Luo, Zong-lin He, Yue Gong, Miao Mo, Wai-kit Ming, Guang-yu Liu
Summary: This study aimed to estimate the costs and benefits of germline BRCA (gBRCA) testing and adjuvant olaparib therapy for patients with triple-negative breast cancer (TNBC) and hormone-receptor (HR)-positive and HER2-negative breast cancer (BC) in China and the United States of America (USA). The results showed that universal gBRCA testing for TNBC patients is cost-effective in both China and the USA. It is recommended to adopt this simplified criterion of gBRCA testing for breast cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
George Goshua, Cecelia Calhoun, Satoko Ito, Lyndon P. James, Andrea Luviano, Lakshmanan Krishnamurti, Ankur Pandya
Summary: Gene therapy is a potential cure for sickle cell disease. Conventional cost-effectiveness analysis and distributional cost-effectiveness analysis were used to compare the effects of gene therapy and standard care in patients with sickle cell disease.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Oncology
Preston J. Ngo, Sonya Cressman, Silvia Behar-Harpaz, Deme J. Karikios, Karen Canfell, Marianne F. Weber
Summary: Lung cancer screening with LDCT has been proven to lead to early diagnosis and reduced mortality, but investment decisions rely on cost-effectiveness analyses. This study reviewed 26 cost-effectiveness analyses conducted between 2005 and 2021 and found variations in the application of utility values. Recommendations include justifying the choice of baseline utilities, modeling the impact of false positive scans, and appropriately sourcing and calculating utilities for lung cancer diagnosis.
Review
Economics
Alison Scope, Arjun Bhadhuri, Becky Pennington
Summary: This systematic review examines the inclusion of family member health-related quality-adjusted life-years (QALYs) in cost-utility analyses (CUAs). The study finds that few economic evaluations have included family member QALYs and the methods for doing so are often inconsistent and data sources often limited. The estimation of family member QALYs in patient CUAs is frequently uncertain and substantial in magnitude. The findings highlight the need for greater consistency in methods for incorporating family member QALYs in patient CUAs.
Article
Medicine, General & Internal
Eirik Joakim Tranvag, Oystein Ariansen Haaland, Bjarne Robberstad, Ole Frithjof Norheim
Summary: This study presents and evaluates a systematic drug appraisal method that takes into account the severity of disease in cost-effectiveness analysis, forming the basis for price negotiations and coverage decisions.
Article
Gastroenterology & Hepatology
Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Masaki Kawamoto, Makoto Meguro, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Toru Kato, Toshio Ohyanagi, Thomas T. Hui, Toru Mizuguchi
Summary: This study summarizes the health utility scores and assessment tools for the normal population and chronic liver disease patients. The most popular questionnaire for health utility assessments is EQ-5D-5L, while HUI-Mark2/Mark3 scores indicate that hepatitis B patients have roughly 30% better health utility scores than hepatitis C patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Julia Simoes Correa Galendi, Vera Vennedey, Hannah Kentenich, Stephanie Stock, Dirk Mueller
Summary: The prevention of hereditary breast and ovarian cancer involves genetic counselling and highly preference-sensitive options like risk-reducing surgeries. Health economic models using heterogeneous data and assumptions on health preferences have shown varying utility values for cost-utility analyses. Impact of test results on utility values should be considered in future modeling studies, as women's health preferences may have changed due to improved oncologic care and genetic counselling.
Article
Medicine, General & Internal
Marika M. Cusick, Rebecca L. Tisdale, Glenn M. Chertow, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert
Summary: Adding SGLT2 inhibitors to CKD screening can be cost-effective, with a one-time screening at age 55 having an ICER of $86,300 per QALY gained, reducing the incidence of kidney failure. Screening every 10 years from age 35 to 75 costs less than $100,000 per QALY gained.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Hematology
Swetha Kambhampati, Monica Saumoy, Yecheskel Schneider, Steve Serrao, Pejman Solaimani, Lihua Elizabeth Budde, Matthew G. Mei, Leslie L. Popplewell, Tanya Siddiqi, Jasmine Zain, Stephen J. Forman, Larry W. Kwak, Steven T. Rosen, V. Alexey Danilov, Alex F. Herrera, Nikhil R. Thiruvengadam
Summary: The ZUMA-7 study demonstrated that second-line axicabtagene ciloleucel improved event-free survival in patients with relapsed/refractory DLBCL. However, its cost-effectiveness is highly dependent on long-term outcomes, and the routine use of this therapy will significantly increase healthcare expenditures.
Article
Oncology
Naomi R. M. Schwartz, Lynn M. Matrisian, Eva E. Shrader, Ziding Feng, Suresh Chari, Joshua A. Roth
Summary: This study evaluated the cost-effectiveness of CT screening for pancreatic cancer in patients with new-onset diabetes and found that risk-based screening in this population is likely to be cost-effective in the United States. However, a sufficient number of screen-detected pancreatic cancer cases need to be resectable to achieve lower cost per quality-adjusted life-year gained.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Neurosciences
Aung Zaw Zaw Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Elsdon Storey, Robyn L. Woods, Anne M. Murray, Suzanne G. Orchard, Raj C. Shah, Danijela Gasevic, Rosanne Freak-Poli, Joanne Ryan
Summary: In this study, higher Health-related quality of life (HRQoL), particularly the mental component scores (MCS), was associated with better cognition. Over time, higher MCS predicted a reduced risk of cognitive decline and dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Xiaoyan Liu, Huijun Zhou, Jie Wei, Minghui Li, Guofen Luo, Nasheen Naidoo, Guang Zhang, Ye Bi, Mengmeng Gao
Summary: This study examined the health utility and occupational diseases among university staff in China. The findings indicate that psychological conditions and musculoskeletal pain are major concerns. These results provide valuable information for cost-utility analysis and the implementation of cost-effective programs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Economics
Aurelie Meunier, Louise Longworth, Stacey Kowal, Sreeram Ramagopalan, James Love-Koh, Susan Grif Fin
Summary: Governments and health technology assessment agencies are increasingly focusing on health inequities and using cost-effectiveness analyses to inform funding decisions for new treatments. However, the implementation of distributional cost-effectiveness analysis (DCEA) faces challenges such as the lack of clearly defined equity concerns from decision makers and endorsed measures to define equity subgroups. This article highlights the data gaps and challenges in routinely conducting robust DCEA and suggests actions to overcome these hurdles.
Article
Public, Environmental & Occupational Health
Courtney L. Scherr, Sanjana Ramesh, Hannah Getachew-Smith, Kerstin Kalke, Kyra Ramsey, Baruch Fischhoff, Susan T. Vadaparampil
Summary: The study found that patients faced decision themes of managing ambiguity, medical risk management, and sharing results with others after receiving a variant of uncertain significance result. Factors such as genetic counselors' interpretations, psychosocial factors, and competing extrinsic demands influenced their decision-making.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Obstetrics & Gynecology
Marlyse F. Haward, John M. Lorenz, Annie Janvier, Baruch Fischhoff
Summary: This study explores the experiences of extremely preterm infant loss in the delivery room and the perspectives on antenatal consultation. The interactions between participants and healthcare providers strongly influence their experiences, well-being, and healing. Personalized information, individualized approaches, and emotional support are considered key elements to enhance antenatal consultation.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Health Care Sciences & Services
Emily Grayek, Yanran Yang, Baruch Fischhoff, Karen E. Schifferdecker, Steven Woloshin, Karla Kerlikowske, Diana L. Miglioretti, Anna N. A. Tosteson
Summary: This study evaluates the construct validity of a procedure for eliciting lay preferences among health care policy options. The procedure is illustrated with breast cancer screening and found to effectively measure public preferences, which are related to age and personal medical history. The study also reveals considerable heterogeneity in public preferences for health care screening options.
MEDICAL DECISION MAKING
(2022)
Article
Critical Care Medicine
Alexis Steinberg, Emily Grayek, Robert M. Arnold, Clifton Callaway, Baruch Fischhoff, Tamar Krishnamurti, Deepika Mohan, Douglas B. White, Jonathan Elmer
Summary: This study aims to explore how physicians formulate a neurological prognosis after cardiac arrest and compare the differences between experts and general providers. Through interviews with experts and general physicians, we found that their approach to prognostication is complex and influenced by many factors, including some rarely considered in current research. These findings can inform interventions designed to aid physicians in making more accurate prognostic predictions.
Article
Medicine, General & Internal
Steven Woloshin, Barry Dewitt, Tamar Krishnamurti, Baruch Fischhoff
Summary: This study aimed to evaluate how users of at-home COVID-19 self-test kits interpret and act on results, and found that users relying on authorized instructions may not appropriately follow quarantine recommendations. Redesigned instructions based on decision science principles may improve compliance.
JAMA INTERNAL MEDICINE
(2022)
Article
Environmental Studies
Caitlin Drummond Otten, Baruch Fischhoff
Summary: The study found that research funded by NSF generally satisfied both NSF's and Smith's criteria, with explicit references to societal impacts slightly improving ratings. However, noting NSF support specifically did not improve ratings.
SCIENCE AND PUBLIC POLICY
(2022)
Article
Medicine, Research & Experimental
Emily N. Grayek, Baruch Fischhoff, Alexander L. Davis, Tamar Krishnamurti
Summary: This study proposes a method to evaluate the cost-effectiveness of adherence monitoring methods in clinical trials. The results show that the most cost-effective method depends on trial participant adherence and drug forgiveness. The study also estimates the effects of evaluable patient analysis.
Article
Behavioral Sciences
Ryan Kenny, Baruch Fischhoff, Alex Davis, Kathleen M. Carley, Casey Canfield
Summary: The study found that individuals have limited ability to detect social bots, with lower sensitivity to mistaking bots for humans. Participants with more social media experience, stronger bias, and less analytical reasoning ability performed worse in detecting bots.
Article
Geosciences, Multidisciplinary
Dana Rose Garfin, E. Alison Holman, Baruch Fischhoff, Gabrielle Wong-Parodi, Roxane Cohen Silver
Summary: This study examined media exposure, psychological fear and worry, risk perceptions, and health protective behaviors during the 2014 Ebola virus outbreak. Findings showed that more hours and more graphic media exposure were associated with higher levels of fear and worry, as well as higher perceived risk. Higher risk perceptions and fear and worry were linked to more health protective behaviors. The amount and content of media exposure had indirect effects on behaviors performed and intentions.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Public, Environmental & Occupational Health
Victor L. Rodriguez, Baruch Fischhoff, Alexander L. Davis
Summary: The movie industry developed guidelines for returning to operation after the COVID-19 pandemic and used heatmaps to communicate the risks to workers. The study found that these heatmaps effectively conveyed complex risk information to lay audiences, but faced challenges when applied to complex settings.
Article
Psychology, Applied
Caitlin Drummond Otten, Baruch Fischhoff
Summary: Scientific reasoning ability can help individuals use scientific evidence in making judgments and decisions. This study found that individuals with greater scientific reasoning ability are better calibrated with respect to their ability. Additionally, scientific reasoning ability is associated with success in avoiding negative decision outcomes and holding beliefs consistent with the scientific consensus.
JOURNAL OF BEHAVIORAL DECISION MAKING
(2023)
Article
Obstetrics & Gynecology
Marlyse F. F. Haward, John M. M. Lorenz, Annie Janvier, Baruch Fischhoff
Summary: This study aims to analyze and compare perspectives on antenatal consultation and decision-making from participants with different levels of prematurity experience and clinician experts. Open-ended interviews were conducted and mixed methods analysis was used. The results showed that non-clinician participants had different views on the amount and content of desired information, decision-making strategies, and who should direct consultations, parents or clinicians.
JOURNAL OF PERINATOLOGY
(2023)
Article
Medicine, Research & Experimental
Deepika Mohan, Jonathan Elmer, Robert M. Arnold, Raquel M. Forsythe, Baruch Fischhoff, Kimberly Rak, Jacqueline L. Barnes, Douglas B. White
Summary: This study plans to conduct a pilot parallel randomized trial to test a novel deliberate practice intervention in reducing physician diagnostic errors in trauma triage. The intervention involves using a customized serious video game as the training task and providing coaching sessions with content experts. The results of the trial will inform the decision to proceed with a future effectiveness-implementation trial and deepen the understanding of using deliberate practice to modify physicians' diagnostic skills.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Biochemistry & Molecular Biology
Steven Woloshin, Yanran Yang, Baruch Fischhoff
Summary: Well-designed visual displays have the power to effectively convey health messages to non-experts, while poorly designed ones can confuse and alienate recipients. This Perspective proposes a structured framework for effective visual communication of health information, using case examples and practical evaluation methods. The framework is grounded in research and experience in health risk communication, visualization, and decision science.
Article
Economics
Hanzelle Kleeman, Baruch Fischhoff, Daniel Erian Armanios
Summary: Researchers modified a behavior change model to understand decision-making of low-income residents regarding energy efficiency programs, and developed a more informative communication framework. Testing the framework by redesigning web pages, the study found that the change improved low-income respondents' assessment, increased their intentions to apply for and complete the program. These findings have practical implications for organizations and policymakers aiming to increase participation in energy efficiency programs.