Article
Medicine, Research & Experimental
Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Hiroaki Wake, Wataru Ogawa, Yu Hirata, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki
Summary: This study reveals that the upregulation of KLF15 and IL-6, as well as the decrease in intracellular Ca2+ concentration, are involved in muscle atrophy induced by immobility. This finding has been validated in both mouse models and human samples.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo
Summary: The study revealed that tannic acid (TA) inhibits IL-1 beta-induced inflammation and matrix degradation in human OA chondrocytes by blocking IL-1 beta-IL-1R1 interaction. In addition, TA showed protective effects in a rat OA model by reducing pain, cartilage degradation, and IL-1 beta-mediated inflammation.
Article
Immunology
Hyun-ju Lee, Jin-Hee Park, Hyang-Sook Hoe
Summary: This study explores the effects of idebenone on neuroinflammatory responses, cognitive function, and underlying molecular mechanisms. The results suggest that idebenone can enhance neuroprotective NRF2 expression, reduce neuroinflammation, and improve learning and memory in mice. It also targets NLRP3 inflammasome activation and decreases gliosis and proinflammatory cytokine levels. In a mouse model of Alzheimer's disease, idebenone improves cognitive dysfunction and inhibits neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wen Chen, Xiang Ye, Qiong Tang, Ting Yu, Pengcheng Tu, Xiaodong Zheng
Summary: The study demonstrates that C3G can alleviate the toxic effects of PS exposure by improving mitochondrial function and regulating energy metabolism. C3G protects against the adverse effects of PS exposure on various organism models.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Biotechnology & Applied Microbiology
Juan Zhao, Xinrong He, Mei Zuo, Xinguo Li, Zhiming Sun
Summary: Anagliptin has a protective effect against cytokine-induced senescence in vascular smooth muscle cells, and this action may involve the expression of SIRT1.
Article
Critical Care Medicine
Dandan Yin, Dawei Lin, Yunbin Xie, Aihua Gong, Peng Jiang, Jin Wu
Summary: The study suggests that NRG-1beta can alleviate sepsis-induced skeletal muscle atrophy by inhibiting autophagy via the AKT/mTOR signaling pathway.
Article
Biotechnology & Applied Microbiology
Xin Huang, Changhong Chen, Yaofei Chen, Jun Xu, Lin Liu
Summary: This study found that Omentin-1 plays an important role in inhibiting inflammation-associated cellular aging in intervertebral disc degeneration, and may be a candidate for IVDD gene target therapy.
Article
Dermatology
Rintaro Shibuya, Yoshihiro Ishida, Sho Hanakawa, Tatsuki R. Kataoka, Yasuhide Takeuchi, Teruasa Murata, Arisa Akagi, Zachary Chow, Toshiaki Kogame, Satoshi Nakamizo, Saeko Nakajima, Gyohei Egawa, Takashi Nomura, Naotomo Kambe, Akihiko Kitoh, Kenji Kabashima
Summary: The CCL2-CCR2 signaling pathway plays a critical role in the development of SDS-induced cumulative irritant contact dermatitis (ICD). Treatment with SDS upregulates CCL2, and mice deficient in CCR2 show reduced neutrophil accumulation and alleviated ICD. Neutrophil depletion can alleviate SDS-induced ICD, and intradermal administration of IL-1 beta restores neutrophil accumulation and the development of ICD in CCR2-deficient mice.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mustafa Yalcinkaya, Panagiotis Fotakis, Wenli Liu, Kaori Endo-Umeda, Huijuan Dou, Sandra Abramowicz, Tong Xiao, Peter Libby, Nan Wang, Alan R. Tall, Marit Westerterp
Summary: This study reveals that IL-1β derived from macrophages promotes neutrophil extracellular trap formation in atherosclerotic plaques. This effect is achieved by increasing neutrophil accumulation in plaques and promoting neutrophil NLRP3 inflammasome activation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zoe Gonzalez-Carnicero, Raquel Hernanz, Marta Martinez-Casales, Maria Teresa Barrus, Angela Martin, Maria Jesus Alonso
Summary: Toll-like receptor 4 pathway is involved in the prooxidant and proinflammatory effects of Interleukin-1 beta. Furthermore, activation of nuclear factor-erythroid 2-related factor 2 prevents the deleterious effects of Interleukin-1 beta, likely by reducing Toll-like receptor 4-dependent pathway. Although further research is needed, the results are promising as they suggest that nuclear factor-erythroid 2-related factor 2 activators might protect against the oxidative stress and inflammation characteristic of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Neurosciences
Mami Yamada, Mitsuharu Okutsu
Summary: The study demonstrates that doxorubicin triggers severe muscle atrophy through oxidative stress and decreased expression of the antioxidant enzyme EcSOD. However, supplementation with EcSOD recombinant protein can inhibit oxidative stress and muscle atrophy. Transient treatment with interleukin-1 beta (IL-1 beta) can increase EcSOD expression and attenuate doxorubicin-induced muscle atrophy.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Food Science & Technology
Hong Ju Kim, Hyun Chul Koh
Summary: This study investigated the role of chaperone-mediated autophagy (CMA) and macro-autophagy in diquat (DQ)-induced alpha-synucleinopathy, finding a cooperative relationship between the two in clearing pathological alpha-synuclein. Modulation of autophagy may be a potential treatment strategy for pesticide-induced neurodegenerative disorders by preventing alpha-synucleinopathy and cytotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Physiology
Siyu Chen, Lei Zhou, Jingquan Sun, Yaqian Qu, Min Chen
Summary: The study shows that lactate promotes intramuscular triglyceride accumulation by inhibiting lipolysis, which is regulated by the cAMP-PKA pathway. Lactate also increases mitochondrial content in skeletal muscle, but the specific mechanism is still unclear. Other metabolism-related mechanisms may play a prominent role in lactate-induced mitochondria content increase.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Maria Faas, Natacha Ipseiz, Jochen Ackermann, Stephan Culemann, Anika Grueneboom, Fenja Schroeder, Tobias Rothe, Carina Scholtysek, Martin Eberhardt, Martin Boettcher, Philipp Kirchner, Cornelia Stoll, Arif Ekici, Maximilian Fuchs, Meik Kunz, Benno Weigmann, Stefan Wirtz, Roland Lang, Joerg Hofmann, Julio Vera, David Voehringer, Alessandro Michelucci, Dimitrios Mougiakakos, Stefan Uderhardt, Georg Schett, Gerhard Kroenke
Summary: Uncoupling protein-2 and the transcription factor GATA3 were found to regulate the differentiation of AAMs in response to IL-33, leading to their polarization. IL-33 induced metabolic rewiring in macrophages, which subsequently triggered GATA3-mediated AAM polarization.
Article
Cell Biology
Christian W. Keller, Monika B. Kotur, Sarah Mundt, Nikolaos Dokalis, Laure-Anne Ligeon, Ajay M. Shah, Marco Prinz, Burkhard Becher, Christian Muenz, Jan D. Lueneman
Summary: This study reveals that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 in conventional dendritic cells (cDCs) regulates MOG antigen processing through LC3-associated phagocytosis (LAP), enabling encephalitogenic T helper cells to initiate and sustain autoimmune neuroinflammation. Genetic ablation of Cybb in cDCs restrains T-H cell recruitment into the CNS and ameliorates clinical disease development upon the adoptive transfer of MOG-specific CD4(+) T cells.
Article
Cell Biology
Keertana Srimat Kandadai, Monika B. Kotur, Nikolaos Dokalis, Irmgard Amrein, Christian W. Keller, Christian Muenz, David Wolfer, Marco Prinz, Jan D. Luenemann
Summary: The study shows that the loss of ATG5 in adult microglia does not affect CNS tissue integrity, microglial cell survival, immune activation, learning task performance, or the development of experimental autoimmune encephalomyelitis. This suggests that ATG5 expression in microglia is not essential for maintaining CNS homeostasis or for the development of autoimmune neuroinflammation.
Article
Clinical Neurology
Christian W. Keller, Johanna Oechtering, Heinz Wiendl, Ludwig Kappos, Jens Kuhle, Jan D. Luenemann
Summary: The study showed that activation profiles of complement pathways in early relapse-onset MS patients were not correlated with disease activity, suggesting that complement activation products are not suitable biomarkers for assessing disease activity in early MS.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Virology
Christian Munz
Summary: The oncogenes encoded by EBV and KSHV manipulate cellular processes like autophagy, proliferation, and apoptosis to ensure their efficient persistence and dissemination in hosts without causing pathologies in most carriers. These mechanisms allow the viruses to strike a balance between infectivity and host immune response, preventing clearance and minimizing symptoms.
Review
Oncology
Yun Deng, Christian Muenz
Summary: Epstein-Barr virus (EBV) infects over 95% of the adult human population, usually controlled by immune responses. Genetic variations affect cytotoxic lymphocytes' role in immune control against EBV. Humanized mice models offer insights into molecular mechanisms during EBV infection and potential vaccine development.
Letter
Clinical Neurology
Christian W. Keller, Joseph A. Lopez, Eva-Maria Wendel, Sudarshini Ramanathan, Catharina C. Gross, Luisa Klotz, Markus Reindl, Russell C. Dale, Heinz Wiendl, Kevin Rostasy, Fabienne Brilot, Jan D. Lunemann
ANNALS OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Christian Muenz
Summary: The Epstein Barr virus can be controlled by the immune system in most carriers, but deficiencies in certain molecular pathways can lead to EBV-associated pathologies. Co-stimulatory and co-inhibitory molecules play a crucial role in EBV-specific immune control.
Review
Clinical Neurology
Rachel Zeng, Stefanie Glaubitz, Jens Schmidt
Summary: Inflammatory myopathies, or myositis, are rare diseases characterized by progressive muscle weakness, with each subtype having different autoantibody profiles, histological findings, and extramuscular manifestations. New molecular pathways for targeted therapy have been discovered due to a better understanding of the muscle inflammation's pathogenesis in myositis. Current therapies aim at different components of the immune response, and therapeutical antibodies have shown promising results in clinical trials.
Letter
Clinical Neurology
Omar Chuquisana, Christine Strippel, Anna M. Troscher, Tobias Baumgartner, Attila Racz, Christian W. Keller, Christian E. Elger, Nico Melzer, Stjepana Kovac, Heinz Wiendl, Jan Bauer, Jan D. Lunemann
ACTA NEUROPATHOLOGICA
(2022)
Article
Clinical Neurology
Christian W. Keller, Omar Chuquisana, Judith Derdelinckx, Catharina C. Gross, Klaus Berger, James Robinson, Falk Nimmerjahn, Heinz Wiendl, Nick Willcox, Jan D. Luenemann
Summary: This study found that FcγRIIB expression levels are significantly reduced in B lineage cells derived from early-onset MG patients, and genetic variants associated with impaired FcγRIIB expression are not common in MG, suggesting that post-transcriptional dysregulation plays an important role in the disease.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
D. Lemmer, J. Schmidt, K. Kummer, B. Lemmer, A. Wrede, C. Seitz, P. Balcarek, K. Schwarze, G. A. Mueller, D. Patschan, S. Patschan
Summary: This study aimed to compare parameters of early endothelial progenitor cell (eEPC) integrity in patients with dermatomyositis (DM), necrotizing myopathy (NM), and non-myopathic controls. The findings showed a loss of intramuscular microvessels and endothelial activation in DM patients. Vascular regeneration was impaired in both DM and NM. These findings suggest the role of inflammation-associated vascular damage in the pathogenesis of DM.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cell Biology
Fabienne Laederach, Christian Muenz
Summary: Strong epidemiologic evidence supports the association between Epstein-Barr virus (EBV) infection and altered immune control to the development of multiple sclerosis (MS). The mechanisms linking the two remain largely unknown. Two main possibilities for this association are discussed. Immune responses induced during a symptomatic primary EBV infection might be amplified over time, leading to central nervous system inflammation and demyelination. Alternatively, genetic predisposition and environmental factors may result in insufficient immune control of EBV-infected B cells, leading to autoimmune T cell stimulation or CNS inflammation. Understanding EBV's contribution to MS could potentially open new treatment possibilities for this autoimmune disease.
Article
Clinical Neurology
Frauke Stascheit, Omar Chuquisana, Christian W. Keller, Philip Alexander Ambrose, Sarah Hoffmann, Catharina C. Gross, Sophie Lehnerer, Heinz Wiendl, Nick Willcox, Andreas Meisel, Jan D. Luenemann
Summary: In patients with AChR-Ab(+) MG, there is significantly increased activation of the complement system, which remains present even under standard immunosuppressive therapies but is not evident in patients with MuSK-Abs or seronegative MG. Further exploration of complement inhibition proximal to C5 cleavage is suggested for potential therapeutic benefits in AChR-Ab(+) MG.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Christian W. Keller, Iannis E. Adamopoulos, Jan D. Luenemann
Summary: Autophagy plays important roles in response to energy deprivation, organelle turnover and proteostasis. It has been increasingly linked to various aspects of immunity, including host defence against pathogens and antigen presentation. Deregulated autophagy pathways can contribute to autoimmune responses.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
M. Weiss, M. T. Holzer, F. Muehlensiepen, Y. Ignatyev, C. Fiehn, J. Bauhammer, J. Schmidt, S. Schlueter, A. Dihkan, D. Scheibner, U. Schneider, L. Valor-Mendez, G. Corte, L. Gupta, H. Chinoy, I. Lundberg, L. Cavagna, J. H. W. Distler, G. Schett, J. Knitza
Summary: This study investigated the symptoms, diagnostic delay, medical care, health status, working status, disease knowledge, and willingness to participate in research of ASSD patients by conducting an international web-based survey. The results highlight the significance of internet-based research in gaining insights and understanding rare diseases among patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
