Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Revathi Shanmugasundaram, Keila Acevedo, Mohamad Mortada, Gabriel Akerele, Todd J. Applegate, Michael H. Kogut, Ramesh K. Selvaraj
Summary: The study suggests that Salmonella infection induces an increase in CD4(+)CD25(+) T regulatory cells and enhances IL-10 mRNA transcription, allowing the pathogen to evade host immune responses in chickens.
Article
Immunology
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko
Summary: This study found that isolating Tregs using a CD4(+)CD25(+)CD226(-) strategy leads to a population with increased purity, lineage stability, and suppressive capabilities, which may be beneficial for the treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priska Jost, Franziska Klein, Benjamin Brand, Vanessa Wahl, Amanda Wyatt, Daniela Yildiz, Ulrich Boehm, Barbara A. A. Niemeyer, Martin Vaeth, Dalia Alansary
Summary: Mitochondria play a crucial role in modulating T cell function through their control of energy production and Ca2+ homeostasis. The mitochondrial Ca2+ uniporter (MCU) regulates Ca2+ signals and affects T cell activation. However, the specific effects of MCU on regulatory CD4 T cells (Treg) and their suppressive potential are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Felipe Valenca-Pereira, Qian Fang, Isabelle J. Marie, Emily L. Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David E. Levy, Mercedes Rincon
Summary: IL-6 enhances the mechanics of CD4 T cells, increasing their motility and mitochondrial Ca2+, ultimately improving their competitive fitness. This noncanonical pathway could lead to alternative therapeutic strategies for inflammatory diseases where IL-6 plays a pathogenic role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Article
Immunology
Ying Pan, Huiping Wang, Furun An, Fan Wu, Qianshan Tao, Yingwei Li, Yanjie Ruan, Zhimin Zhai
Summary: This study found that higher levels of circulating Tregs, especially one week after CD19 CAR-T cell infusion, served as a poor predictor for CD19 CAR-T therapy in R/R B-ALL patients, indicating a significant association with treatment efficacy and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaelle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann, Sophie Brouard
Summary: In this study, single cell transcriptomics were used to characterize in vitro induced GZMB+ regulatory B cells (Bregs), showing differential gene expression involved in proliferation, apoptosis, metabolism, and antigen presentation. Compared to total B cells, Bregs exhibited strong inhibition of T cell genes associated with proliferation, activation, inflammation, and apoptosis. Lymphotoxin alpha (LTA) was identified as a new and potent Breg ligand implicated in Breg suppressive properties.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Prashant S. Giri, Ankit H. Bharti, Jyoti Kode, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: This study suggests that Harmine and Kaempferol treated Tregs may control the proliferation and production of CD8+ and CD4(+) T-cells in GV patients, leading to melanocytes' survival and proliferation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Prashant S. Giri, Ankit H. Bharti, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: NFATs and FOXP3 are associated with impaired regulatory T-cells (Tregs) in generalized vitiligo (GV). This study investigated the calcium mediated NFATc1 signaling pathway and its effect on Treg suppressive capacity in GV. The results showed altered calcium homeostasis in GV Tregs, leading to decreased calcineurin and NFATc1 activity. Elevated GSK-3 beta activity and DYRK1A transcripts were also involved in reduced NFATc1 activity in GV Tregs. Calcium treatment enhanced Treg-mediated suppression and increased Tregs associated cytokines, suggesting the potential of calcium-NFATc1 signaling pathway as a therapeutic target for improving Treg function in GV.
Article
Biochemistry & Molecular Biology
Mohammad Fayyad-Kazan, Redouane Rouas, Makram Merimi, Mehdi Najar, Bassam Badran, Philippe Lewalle, Hussein Fayyad-Kazan
Summary: CD4(+)CD25(+) FOXP3(+) regulatory T cells are important in suppressing immune reactions, but difficult to distinguish from conventional CD4(+) T cells. This study identifies differentially transcribed genes between Tregs and conventional T cells using qRT-PCR and bioinformatics analysis, providing new molecular targets for understanding Tregs' function and isolation.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2023)
Article
Pharmacology & Pharmacy
Huiling Chen, Lufeng Hu, Huaizhong Li, Guangliang Hong, Tao Zhang, Jianshe Ma, Zhongqiu Lu
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2017)
Article
Immunology
Wei Chen, Jie Lian, Jing-jing Ye, Qing-fei Mo, Jie Qin, Guang-liang Hong, Long-wang Chen, Shao-ce Zhi, Guang-ju Zhao, Zhong-qiu Lu
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Guangju Zhao, Kaiqiang Cao, Changqin Xu, Aifang Sun, Wang Lu, Yi Zheng, Haixiao Li, Guangliang Hong, Bing Wu, Qiaomeng Qiu, Zhongqiu Lu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2017)
Review
Biochemistry & Molecular Biology
Chao Ren, Ya-lin Tong, Jun-cong Li, Zhong-qiu Lu, Yong-ming Yao
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2017)
Article
Multidisciplinary Sciences
Yadong Wang, Yao Chen, Lu Mao, Guangju Zhao, Guangliang Hong, Mengfang Li, Bin Wu, Xiaorong Chen, Meng Tan, Na Wang, Zhongqiu Lu
Article
Cell Biology
Zhi-qiang Hu, Yong-ming Yao, Wei Chen, Jia-lan Bian, Lin-jun Zhao, Long-wang Chen, Guang-liang Hong, Zhong-qiu Lu, Guang-ju Zhao
Article
Immunology
Longwang Chen, Yang Lu, Linjun Zhao, Lili Hu, Qiaomeng Qiu, Zhuoling Zhang, Mengfang Li, Guangliang Hong, Bing Wu, Guangju Zhao, Zhongqiu Lu
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Chang Xu, Dan-Wei Jiang, Wei-Yong Qiu, Yan-Xue Zhou, Long-Wang Chen, Guang-Liang Hong, Guang-Ju Zhao, Zhong-Qiu Lu
Summary: Among critically ill patients, a J-shaped relationship was observed between median PaO2 and hospital mortality. Patients with PaO2 values in the range of 80-100 mmHg and 120-140 mmHg had higher mortality rates, as did those with PaO2 levels <80 mmHg and >= 140 mmHg. Patients spending more time within the 100-120 mmHg range tended to have lower mortality rates.
Article
Chemistry, Medicinal
Shanshan Dai, Bozhi Ye, Longwang Chen, Guangliang Hong, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that emodin has a protective effect on septic myocardial injury by alleviating the inflammatory response and cardiomyocyte pyroptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Immunology
Yang Lu, Xinyong Liu, Suxian Lin, Ping Chen, Longwang Chen, Guangju Zhao
Summary: Stanniocalcin-1 (STC-1) has anti-inflammatory, anti-oxidative stress, and anti-apoptosis properties, and it alleviates rheumatoid arthritis (RA) by inhibiting Th17 cell differentiation through regulating STAT3 phosphorylation.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zhongwang Li, Baoli Cheng, Kai Zhang, Guohao Xie, Yan Wang, Jinchao Hou, Lihua Chu, Jialian Zhao, Zhijun Xu, Zhongqiu Lu, Huaqin Sun, Jian Zhang, Zhiyi Wang, Haiya Wu, Xiangming Fang
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)
Article
Pharmacology & Pharmacy
Bin Zhou, Haiying Li, Chongyun Xing, Haige Ye, Jianhua Feng, Jianbo Wu, Zhongqiu Lu, Jing Fang, Shenmeng Gao
BIOCHEMICAL PHARMACOLOGY
(2017)
