Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jehan J. El-Jawhari, Yasser El-Sherbiny, Dennis McGonagle, Elena Jones
Summary: The pathogenesis of autoimmune rheumatological diseases such as RA and SLE is complex, involving various immune cell populations. MSCs may play a dual role in RA and SLE, having both pro-inflammatory effects and immunomodulatory potential. Although safety and proof of concept studies exist, robust phase 3 clinical trial data in therapy-resistant RA and SLE is still lacking.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuntian Zhang, Tzong-Yi Lee
Summary: This study used computational methods to analyze the immune repertoire of SLE and RA patients' peripheral blood and identified specific biomarkers for the diagnosis and treatment of these diseases. The study also investigated the alterations in immune cell subsets and cell-cell communication. The findings provide new insights into understanding SLE and RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren
Summary: This study compared the characteristics of the oral microbiome between patients with systemic lupus erythematosus (SLE) and healthy controls, and developed an SLE classifier based on the oral microbiota. The results showed that SLE patients had increased oral microbial diversity and a different microbial community compared to healthy controls. Specific microbial changes were identified and used to construct a classifier for diagnosing SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mansour Salesi, Milad Hayeri Dehabadi, Rasoul Salehi, Amirhossein Salehi, Bahram Pakzad
Summary: The methylation level of IFI44L promoter was found to be significantly lower in patients with SLE and RA compared to healthy controls, with no significant difference between the two disease groups. There was a negative correlation between IFI44L promoter methylation level and RA disease activity, but no significant association with clinical characteristics of SLE was observed.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Immunology
Carolina Hurtado, Liliana Yazmin Acevedo Saenz, Elsa Maria Vasquez Trespalacios, Rodrigo Urrego, Scott Jenks, Inaki Sanz, Gloria Vasquez
Article
Immunology
Dorottya Laczko, Michael J. Hogan, Sushila A. Toulmin, Philip Hicks, Katlyn Lederer, Brian T. Gaudette, Diana Castano, Fatima Amanat, Hiromi Muramatsu, Thomas H. Oguin, Amrita Ojha, Lizhou Zhang, Zekun Mu, Robert Parks, Tomaz B. Manzoni, Brianne Roper, Shirin Strohmeier, Istvan Tombacz, Leslee Arwood, Raffael Nachbagauer, Katalin Kariko, Jack Greenhouse, Laurent Pessaint, Maciel Porto, Tammy Putman-Taylor, Amanda Strasbaugh, Tracey-Ann Campbell, Paulo J. C. Lin, Ying K. Tam, Gregory D. Sempowski, Michael Farzan, Hyeryun Choe, Kevin O. Saunders, Barton F. Haynes, Hanne Andersen, Laurence C. Eisenlohr, Drew Weissman, Florian Krammer, Paul Bates, David Allman, Michela Locci, Norbert Pardi
Article
Immunology
H. Rincon-Arevalo, M. Rojas, A. Vanegas-Garcia, C. Munoz-Vahos, J. Orejuela-Erazo, G. Vasquez, D. Castano
Summary: Patients with seropositive RA exhibit an increased frequency of atypical B cell populations, decreased expression of CD22 in memory B cells, and increased frequency of CD86(+) B cells. They also show reduced interleukin-10 secretion, plasma cell differentiation, and IgM production compared to healthy donors.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Katlyn Lederer, Diana Castano, Daniela Gomez Atria, Thomas H. Oguin, Sidney Wang, Tomaz B. Manzoni, Hiromi Muramatsu, Michael J. Hogan, Fatima Amanat, Patrick Cherubin, Kendall A. Lundgreen, Ying K. Tam, Steven H. Y. Fan, Laurence C. Eisenlohr, Ivan Maillard, Drew Weissman, Paul Bates, Florian Krammer, Gregory D. Sempowski, Norbert Pardi, Michela Locci
Article
Immunology
Liseth Carmona-Perez, Mauricio Rojas, Carlos Munoz-Vahos, Adiana Vanegas-Garcia, Gloria Vasquez
Summary: In patients with active SLE, there is an increase in plasma MPs concentration that correlates positively with the SLEDAI score. CD14+ MPs are significantly more abundant in patients with SLE compared to healthy controls. SLE MPs have decreased levels of miR-146a, but increased levels of miR-126 in aSLE MPs, which correlates positively with the SLEDAI score.
Review
Rheumatology
Camila Andrea Guerrero-Bermudez, Andres Felipe Cardona-Cardona, Edwin Jesus Ariza-Parra, Juan Ignacio Arostegui, Anna Mensa-Vilaro, Jordi Yague, Gloria Vasquez, Carlos Horacio Munoz-Vahos
Summary: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome (VEXAS syndrome) is a recently described genetic disorder characterized by autoinflammatory symptoms and myeloid dysplasia. This paper reports the first case of VEXAS syndrome in Colombia and South America, presenting with supraglottic larynx involvement and costochondritis. The unique features and poor response to treatment can aid in the diagnosis of VEXAS syndrome, which can be confused with other diseases such as relapsing polychondritis and polyarteritis nodosa.
CLINICAL RHEUMATOLOGY
(2022)
Article
Immunology
Manuel G. Feria, Cecilia Chang, Eduardo Ticona, Anissa Moussa, Bin Zhang, Isabel Ballena, Ruben Azanero, Cesar Ticona, Carlo N. De Cecco, Carl J. Fichtenbaum, Robert E. O'Donnell, Alberto La Rosa, Jorge Sanchez, Sandra Andorf, Laura Atehortua, Jonathan D. Katz, Claire A. Chougnet, George S. Jr Jr Deepe, Moises A. Huaman
Summary: This study investigated the activation and pro-inflammatory profile of monocytes in individuals with latent tuberculosis infection (LTBI) and their association with coronary artery disease (CAD). The results showed distinct monocyte alterations in individuals with LTBI, suggesting an exacerbated inflammatory response and tissue migration. These alterations may contribute to the pathogenesis of cardiovascular disease.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Laura Atehortua, Mirza Baig, Jamie Morris, Sarah Trentman, W. Sean Davidson, Carl J. Fichtenbaum, Claire A. Chougnet
Summary: Memory regulatory T cells in HIV patients have lower numbers and reduced responsiveness to high density lipoproteins, which may contribute to increased risk of cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Dario Gonzalez, Mauricio Rojas, Benjamin Rojano, Giovanni Restrepo
Summary: This study evaluated the effects of LDL, Q and R on the quality of boar semen during cooling. Results showed that LDL improved sperm motility and modulated mitochondrial activity, while Q may negatively impact sperm motility.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Microbiology
Carolina Zapata-Zapata, Mauricio Rojas-Lopez, Liliana T. Garcia, Wendy Quintero, Maria C. Terron, Daniel Luque, Ana C. Mesa-Arango
Summary: Combined use of Lippia origanoides essential oil or thymol with fluconazole showed synergistic effects against azole-resistant Candida tropicalis, reversing the drug-resistant phenotype.
Review
Multidisciplinary Sciences
Karen Alvarez, Mauricio Rojas
Summary: Autoimmune diseases are challenging to diagnose and treat. Nanoparticles offer promising strategies for targeting monocyte populations and delivering drugs for the diagnosis and treatment of autoimmune diseases. This field of research is of great importance.
Article
Rheumatology
Hector Rincon-Arevalo, Catalina Burbano, Laura Atehortua, Mauricio Rojas, Adriana Vanegas-Garcia, Gloria Vasquez, Diana Castano
Summary: The study found that m/lEVs have a certain regulatory effect on the activation and response of B cells, especially affecting the expression of CD69(+) and CD86(+) B cells. Similar responses were observed in patients with rheumatoid arthritis. However, despite the direct inhibitory effect of m/lEVs on early B cell responses, an increased frequency of CD69(+) B cells from patients with RA was observed when B cells were co-cultured with autologous monocyte-derived macrophages exposed to m/lEVs or m/lEV-ICs, but not with cells from healthy donors.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Karen Alvarez, Juan Villar-Vesga, Blanca Ortiz-Reyes, Adriana Vanegas-Garcia, Diana Castano, Mauricio Rojas, Gloria Vasquez
Article
Geriatrics & Gerontology
Juan Villar-Vesga, Julian Henao-Restrepo, Danielle C. Voshart, David Aguillon, Andres Villegas, Diana Castano, Julian D. Arias-Londono, Inge S. Zuhorn, Lais Ribovski, Lara Barazzuol, Gloria P. Cardona-Gomez, Rafael Posada-Duque
FRONTIERS IN AGING NEUROSCIENCE
(2020)