Article
Chemistry, Multidisciplinary
Yiwen Chen, Thomas Szkopek, Marta Cerruti
Summary: By surface modification, temperature responsiveness can be introduced in colloidal systems of reduced graphene oxide (rGO), showing the concept of supramolecular temperature responsive assembly of nanomaterials (STRAN). This work demonstrates that non-responsive components can function cooperatively in supramolecules, whose interactions with solvents can be modulated by temperature changes, similar to macromolecular systems.
MATERIALS HORIZONS
(2023)
Article
Pharmacology & Pharmacy
Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: The study reports the generation of multi-component hydrogel beads incorporated with reduced graphene oxide, which are shown to be more effective in inhibiting the growth of MCF-7 cells. The drug release sustainability of the beads is affected by the pH of the release medium, increasing in neutral pH but decreasing in acidic environments.
Review
Chemistry, Multidisciplinary
Xiao Li, Minghao Li, Lisa Tang, Diwei Shi, Emily Lam, Jinhye Bae
Summary: This review explores the potential of stimuli-responsive hydrogels in mimicking the morphing behavior of living tissues or organisms, and discusses how functional additives can be combined with hydrogels to extend their functionalities. It also highlights the potential applications of stimuli-responsive composite hydrogels in various fields including soft robotics, information encryption/decryption, biomedical research, flexible electronics, and engineering living materials.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Polymer Science
Felipe Olate-Moya, Humberto Palza
Summary: The study developed an injectable poly(pseudorotaxane) (PPR) hydrogel containing graphene oxide for pH-responsive controlled release of doxorubicin hydrochloride (DOX). The gelation rates of the PEG/alpha-CD supramolecular structures were modulated depending on the reagent concentrations. Furthermore, disruption of ionic interactions between DOX and GO in the nanocomposite at pH = 5.5 resulted in a higher DOX release compared to physiological conditions.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Syed Farooq Adil, Mohammed Rafi Shaik, Fahd A. Nasr, Ali S. Alqahtani, Mohammad Z. Ahmed, Wajhul Qamar, Mufsir Kuniyil, Adibah Almutairi, Abdulrahman Alwarthan, Mohammed Rafiq H. Siddiqui, Mohammad Rafe Hatshan, Mujeeb Khan
Summary: The study revealed that functionalized graphene nanocomposites have enhanced anticancer properties against human breast cancer cells, demonstrating improved physical stability and dispersibility.
Article
Polymer Science
Muhammad Umar Aslam Khan, Zahida Yaqoob, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Sajjad Haider, Fauzi Mh Busra
Summary: Composite hydrogels of CS/PVA and GO/CS/PVA were successfully synthesized and analyzed using various techniques, showing good swelling and drug release properties. The study also revealed better antibacterial and cell viability behaviors of the composite materials, indicating their potential as biomaterials in biomedical applications.
Article
Chemistry, Multidisciplinary
Ahmed S. Doghish, Gharieb S. El-Sayyad, Al-Aliaa M. Sallam, Waleed F. Khalil, Waleed M. A. El Rouby
Summary: The synthesized GO-based nanocomposites showed significant anticancer activity, especially against the MCF-7 breast cancer cell line, with GO-EDTA exhibiting the strongest cytotoxic effect. Through various analytical techniques and cytotoxicity assays, the anticancer effects of the nanocomposites were confirmed.
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Mohammadjavad Ahmadi, Fatemeh Yazdian
Summary: Nanotechnology with drug carriers has achieved significant progress in cancer treatment by mitigating the adverse effects of traditional therapies such as curcumin. Targeting tumors without harming healthy cells can be achieved with the use of chitosan. Magnetic iron oxide provides a high specific area to enhance the ability of the nano-scale vehicle to load curcumin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
V. J. Sawant, B. Tawade, V. M. Desai, B. B. Dongare, S. Nipane
Summary: Graphene-tethered ZnO nanocomposites and oval-shaped 5-fluorouracil-loaded graphene-supported ZnO nanohybrids were successfully synthesized using a one pot wet chemical bottom up coprecipitation method. The presence of ZnO lattice with surface-tethered graphene sheets was confirmed, and the hexagonal ZnO core was maintained even after surface tailoring with graphene and drug loading. The nanocomposites exhibited higher anticancer activity on breast cancer cells than free drug, indicating their potential for pH-responsive drug delivery.
PROGRESS IN BIOMATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
M. Kurdtabar, S. Saif Heris, M. Dezfulian
Summary: Nanocomposite hydrogels are important biomaterials with unique characteristics, and can be used in drug delivery and tissue engineering applications. This study focused on the synthesis of graphene oxide and graphene oxide nanocomposite hydrogels. By adjusting reaction variables, the absorbency of the hydrogel was optimized. The structure and drug release behavior were analyzed using various techniques.
CHINESE JOURNAL OF POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Manxiu Huai, Mingliang Pei, Jiaxing Pan, Yun Zhu, Yingwen Chen, Peng Du, Yanming Duan, Huixiong Xu, Wensong Ge
Summary: A colon microenvironment-responsive hydrogel (AL/HA hydrogel) was developed and used to package IFX, creating a facile oral antibody delivery system for IBD treatment. The AL/HA hydrogel showed significant therapeutic effect on IBD and helped alleviate the drawbacks of IFX.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Farya Shabir, Asif Mahmood, Nadiah Zafar, Muhammad Zaman, Rai Muhammad Sarfraz, Hira Ijaz
Summary: In this study, a novel pH-responsive hydrogel nanocomposite was developed for safe oral delivery of insulin. The Ins-Mmt-BA6 hydrogel NC showed the best formulation, with 96.17% maximum insulin released in 24 h. In vivo studies demonstrated a significant decrease in blood glucose levels and relative bioavailability for the Ins-Mmt-BA hydrogel NC compared to other formulations and subcutaneous administration.
Article
Chemistry, Physical
Baojin Ma, Yuta Nishina, Alberto Bianco
Summary: The study designed a multifunctional nanoplatform using reduced graphene oxide and manganese dioxide nanoparticles for efficient photothermal and chemodynamic combined therapies in cancer treatment. The nanoplatform enhanced cancer therapy efficiency by depleting GSH and generating ROS.
Article
Engineering, Multidisciplinary
Renhua Xiao, Guangying Zhou, Yuming Wen, Junhu Ye, Xiaoyun Li, Xiaoying Wang
Summary: Drug delivery is crucial in medical therapy, and stimuli-responsive nanocarriers have shown high efficacy in delivery by changing their properties in response to in vivo or external stimuli. Biopolymer-based nanocomposites have attracted attention as drug carriers due to their biocompatibility, biodegradability, easy modification, and low immunogenicity. This review summarizes the strategies and recent progress of stimuli-responsive nanocomposites based on polysaccharides and proteins, and details their fabrication and application in drug delivery.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Ceramics
Qing Lin, Xiaojuan Zhang, Wei Wang, Shuiping Li, Junlin Li, Lingyun Hao
Summary: Bioglass implanted in femoral defects bonds directly with new mineralized bone tissue. The rapid releases of Na and Ca ions lead to the transformation of Bioglass to the Si-rich layer, causing a density loss of over 21% after 6 weeks of implantation. Further releases of Ca and Na ions contribute to the disproportionation reaction in the Si-rich layer, resulting in degradation of Bioglass and a more polymerized silica network.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Engineering, Biomedical
Qing Lin, Xiaojuan Zhang, Dong Liang, Junlin Li, Wei Wang, Zhao Wang, Ching-Ping Wong
Summary: The study investigated the in vivo dissolution of tricalcium silicate bone cement and found that the dissolution model was a mass loss rather than a volume decrease. The initial dissolution was attributed to the release of Ca(OH)2, while the later dissolution was due to the decalcification of C-S-H gel. Despite a decrease in mass after 6 weeks, the pores created were not large enough for bone tissue migration into the cement.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Electrical & Electronic
Yuan Zhao, Mengqi Zhang, Wei Wang, Wenli Song, Kanrui Jiang, Xiaojuan Zhang
Summary: Ti3+/N-co-doped TiO2 was successfully synthesized by one-step hydrothermal method, with nitrogen effectively doped into TiO2 lattice to reduce band gap and enhance charge separation efficiency. The photocatalytic performance increased first and then decreased with the increase of hydrazine hydrate, reaching optimal performance at a hydrazine hydrate/TBOT volume ratio of 1:5.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Zhao Wang, Xinhua Li, Xiaojuan Zhang, Ruilong Sheng, Qing Lin, Wenli Song, Lingyun Hao
Summary: Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability were successfully developed using drug-loaded nanogels. These contact lenses can sustainably deliver drugs and exhibit good biocompatibility compared to traditional eye drops or ointment formulations, making them a promising alternative for long-term oculopathy treatment.
Article
Nanoscience & Nanotechnology
Wenke Xiao, Xiaojuan Zhang, Lingyun Hao, Yuan Zhao, Qing Lin, Zhao Wang, Wenli Song, Dong Liang
Summary: It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). In this study, modified silicone hydrogel (MSL) contact lenses were synthesized with good porous structure and mechanical properties. Molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were successfully prepared with high adsorption capacity for OFL. The MIP/OFL-MSL contact lenses also exhibited good antibacterial properties.
JOURNAL OF NANOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Pengfei Wei, Dong Liang, Chunxiu Hu, Xiaojuan Zhang, Yuanfeng Ye, Xu Peng, Jiayan Ji, Yirong Xiu, Weixia Gao
Summary: WO3:Eu3+ nanoparticles with different pH values were prepared by citric acid method, and the luminescence properties of the nanoparticles were found to vary depending on the pH conditions.
Article
Nanoscience & Nanotechnology
Xiaojuan Zhang, Pengfei Wei, Zhao Wang, Yuan Zhao, Wenke Xiao, Yong Bian, Dong Liang, Qing Lin, Wenli Song, Wei Jiang, Huan Wang
Summary: This study presents a synthesis of a diagnosis and therapy integration nanocarrier for magnetic resonance imaging-guided breast cancer-targeted chemotherapy. The nanocarrier, Fe3O4/P(NIPAM-AA-MAPEG) nanogels (MNLs), was prepared using in situ loading of doxorubicin (DOX) by miniemulsion polymerization. The MNLs showed excellent stability in a physiological environment and could be disrupted in an acidic environment to release the loaded drug. The dual-targeted pH-responsive nanogels demonstrated enhanced therapeutic effects and potential advantages in magnetic resonance imaging (MRI) for breast cancer diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Zhao Wang, Wenli Song, Ruilong Sheng, Xinyu Guo, Lingyun Hao, Xiaojuan Zhang
Summary: A new series of cholesterol-bearing poly(methacrylate)s with pendant cationic (l-)-lysine (Chol-PHML) were synthesized. These polymeric vectors efficiently bound/load pDNA and formed nanoparticles. The gene transfection efficiency and cytotoxicity depended on the molecular weight of the polymer.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Engineering, Chemical
Huan Xi, Xiaojuan Zhang, Ai Hua Zhang, Feng Guo, Yan Yang, Zhiyong Lu, Guobing Ying, Jianfeng Zhang
Summary: This study reports the excellent concurrent removal ability of a new adsorbent, SA-Mg@BC/BT, for phosphate and ammonium. The adsorbent has a high specific surface area and abundant functional groups, and its maximum adsorption capacities for phosphate and ammonium surpass those of other relevant adsorbents. The removal ability for phosphate remained stable in the presence of monovalent anions, while the adsorption capacity for ammonium was enhanced by divalent salts. The adsorption capacity in actual wastewater was almost the same as that in simulated wastewater, demonstrating the potential of SA-Mg@BC/BT for nutrient recovery.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Physical
Zhao Wang, Xinyu Guo, Lingyun Hao, Xiaojuan Zhang, Qing Lin, Ruilong Sheng
Summary: A biocompatible drug delivery system with long circulation times, high cellular endocytosis efficiency, and targeted drug release was designed and synthesized. The system showed smart surface charge conversion and accelerated drug release under the tumor microenvironment, leading to enhanced cellular uptake and inhibition of tumor cell proliferation. This system has the potential to serve as a multifunctional nanoplatform for effective oncology treatment.
Article
Nanoscience & Nanotechnology
Yijie Zhao, Xuan Hu, Rongrong Hu, Xingjian Wang, Zhangyu Gu, Xiaojuan Zhang, Yuan Zhao
Summary: The study successfully synthesized fluorinated-defective titanium dioxide catalyst with high photocatalytic activity and stability for dye degradation. The addition of hydrofluoric acid had an impact on the catalytic performance, with the best performance achieved at 0.3 mL.
JOURNAL OF NANOMATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Qing Lin, Xiaobei Guo, Hailuo Fu, Yuan Zhao, Dong Liang, Zhao Wang, Xiaojuan Zhang
Summary: This work demonstrates a significant improvement in visible photocatalytic activity by fabricating a 0D/3D composite photocatalyst of AuPt@g-C3N4 foam. The bimetallic alloy nanoparticles of Au and Pt with a mole ratio of 1:1 are uniformly dispersed on the surface of g-C3N4 foam. The AuPt@g-C3N4 foam with an average nanoparticle size of 21 nm exhibits the highest photocatalytic activity, which is about 1 times higher than that of bare g-C3N4 foam. The enhanced photocatalytic activity of AuPt@g-C3N4 foam is mainly attributed to the increase in visible-light absorption and the acceleration of charge separation.
Article
Materials Science, Ceramics
Dong Liang, Sang Xiong, Xiaojuan Zhang, Qing Lin
Summary: Tungsten trioxide nanoparticles doped with Eu3+ were prepared using hydrothermal method with sodium tungstate and ammonium paratungstate as the tungsten sources. The morphology, structure, and optical performance of the nanoparticles were investigated. The results showed that the samples prepared with sodium tungstate had a rod-like structure and monoclinic crystal system, while the samples prepared with ammonium paratungstate had a spherical structure and triclinic crystal system. The sample prepared with ammonium paratungstate at a reaction temperature of 160 degrees C had the smallest grain average size and the highest luminous intensity.
POWDER METALLURGY AND METAL CERAMICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Lin Qing, Liu Miao-Miao, Wu Xi-Hang, Li Shui-Ping, Wang Yuan-Yuan, Hu Xue-Min, Wang Wei, Zhang Xiao-Juan
Summary: In this study, Au@g-C3N4 structure with a high specific surface area, excellent UV-Vis absorption performance, and stable photocatalytic degradation effect was successfully prepared.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Junlin Li, Xiangfei Li, Dong Liang, Xiaojuan Zhang, Qing Lin, Lingyun Hao
Summary: This study synthesized zinc oxide nanoparticles with different morphologies and explored their potential as catalysts and antibacterial agents. Flower-shaped ZnO-NPs showed the highest antibacterial activity among the samples due to their largest surface area, promising effective bactericidal mechanisms.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
