Article
Materials Science, Multidisciplinary
Yu Zhuang, Anqi Liu, Shengjie Jiang, Usman Liaqat, Kaili Lin, Wenjun Sun, Changyong Yuan
Summary: This study investigated the osteogenic and angiogenic properties of four types of bioactive bioceramic with different strontium concentrations. The results showed that Sr-HA could enhance cell proliferation, osteogenic differentiation, and angiogenic gene expression through different signaling pathways. Additionally, the conditioned medium of cells also had a promoting effect on angiogenesis and osteogenesis. In vivo experiments demonstrated enhanced newly-formed vessels and new bone formation in Sr-HA scaffolds.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Fenbo Ma, Yuanjun Zhang, Liqiu Hu, Ying Peng, Yuqing Deng, Wenqi He, Yongmei Ge, Bin Tang
Summary: The study synthesized a novel polysaccharide-strontium complex LP-Sr, which promotes bone regeneration by enhancing osteogenesis and angiogenesis. Experimental results show that LP-Sr effectively increases cell proliferation and gene expression levels, while suppressing the expression of pro-inflammatory factor IL6.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Ceramics
Qing-qing Yi, Peng-chen Liang, Dong-yu Liang, Jun-feng Shi, Shuang Sha, Qing Chang
Summary: The study demonstrated that Sr coating on Mg-MAO has a hierarchical microstructure with a microporous structure evenly covered with nano-grains. Sr elements from the coating were released slowly and continuously. The Sr coating showed effective antibacterial properties, promoted cell adhesion, proliferation, ALP release, calcium nodule formation, and upregulated osteogenic gene expression. Additionally, the coating enhanced migration, tube formation, VEGF expression, and angiogenic gene upregulation in endothelial cells, as well as angiogenesis of CAM.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Ceramics
Zixin Zhou, Kexin Cai, Jiating Shen, Lei Cai, Binwei Dai, Zhen Wang, Pingping Ma, Jinsong Liu, Xinkun Shen
Summary: In this study, halloysite nanotubes (HNTs) were embedded on the surface of titanium via micro arc oxidation (MAO) treatment to enhance its early osseointegration. The results showed that the incorporation of HNTs into the MAO coating increased the surface wettability and negative charge. The HNT group exhibited no cytotoxicity and had the best performance for cell adhesion, migration, and tube formation, as well as osteogenic gene expression.
CERAMICS INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
Hao Liu, Ranli Gu, Wei Li, Lijun Zeng, Yuan Zhu, Boon Chin Heng, Yunsong Liu, Yongsheng Zhou
Summary: A cell-free scaffold engineering strategy that integrates strontium and highly bioactive serum exosomes has been developed for the treatment of large bone defects. The scaffold can maintain bone morphological characteristics and accelerate bone formation through controlled release of strontium, while the serum exosomes extracted from the fracture rabbit model promote osteogenesis and angiogenesis. The SrTi scaffold + BF EXO composite significantly accelerates bone repair in the radial critical bone defect of rabbits.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Dawei Cheng, Ruyuan Ding, Xin Jin, Yifan Lu, Weimin Bao, Yang Zhao, Shi Chen, Cailiang Shen, Qing Yang, Yuanyin Wang
Summary: Critical-size bone defects are a significant problem that cannot heal completely and autonomously. This study focuses on the use of nano-hydroxyapatite/chitosan composite microspheres to promote the regeneration of critical-size bone defects. The addition of stable strontium ions enhances osteogenesis and angiogenesis, resulting in improved bone regeneration. The in vitro and in vivo experiments demonstrate the potential of the composite microspheres as a promising approach for bone-defect regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Shi Cheng, Jin Ke, Mengyu Yao, Hongwei Shao, Jielong Zhou, Ming Wang, Xiongfa Ji, Guoqing Zhong, Feng Peng, Limin Ma, Yu Zhang
Summary: A 3D porous Ta scaffold with low elastic modulus was fabricated using selective laser melting (SLM), with Sr incorporated on the surface to improve osteointegration ability. The Sr-incorporated scaffolds exhibited stable Sr ion release and enhanced osteogenic and angiogenic behavior in vitro and in vivo, showing promising use in orthopedic implants.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yiding Shen, Kai Fang, Yun Xiang, Keyuan Xu, Liang Yu, Jiaquan Chen, Pingping Ma, Kaiyong Cai, Xinkun Shen, Jinsong Liu
Summary: Titanium (Ti) implants are commonly used for tooth loss treatment due to their excellent biocompatibility and mechanical properties. However, improving the biological properties of Ti implants to enhance osteointegration remains a challenge. Micro-arc oxidation (MAO) has been proposed as a surface modification technique to improve the comprehensive properties of Ti by forming a protective oxide layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Xuanzhe Liu, Yi Sun, Junjie Shen, Hong Sung Min, Jia Xu, Yimin Chai
Summary: Distraction osteogenesis (DO) is a powerful method for reconstructing bone defects in extremities, but it has a lengthy consolidation period. This study investigates the use of strontium-doped mesoporous silica nanoparticles as a dual-ion releasing drug delivery system to accelerate mineralization during DO. The system promotes osteogenesis and angiogenesis, while inhibiting bone resorption.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Materials Science, Ceramics
Tingting Wu, Teliang Lu, Haishan Shi, Jinchao Wang, Jiandong Ye
Summary: Introducing silicon (Si) and strontium (Sr) ions into calcium phosphate cement (CPC) using strontium doped calcium silicate (Sr-CS) can enhance osteogenesis and angiogenesis while suppressing osteoclastogenesis, making it a promising strategy for osteoporotic bone repair. In this study, the 20Sr-CS/CPC extract showed increased proliferation, ALP activity, osteogenesis-related gene and protein expression, as well as enhanced angiogenesis and suppressed osteoclastogenesis. It has great potential for stimulating osteoporotic bone regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Jing Guo, Xuedong Shu, Huan Deng, Junwei Zhang, Yao Wang, Guolong Meng, Jing He, Fang Wu
Summary: This study integrates double network cross-linking with enzymatic mineralization to synthesize stiff and tough hydrogels. The synergistic effect of ionic cross-linking and enzymatic mineralization enhances the compressive and tensile stiffness of the hydrogels, as well as the toughness, swelling stability, and cellular response. The mineralized hydrogel cross-linked with Sr2+ shows the highest compressive Young's modulus and exhibits improved cell proliferation, adhesion, and osteogenic differentiation. This research provides an effective approach for preparing hydrogels with osteogenesis and demonstrates their potential in bone tissue engineering applications.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Xinkun Shen, Kai Fang, Kendrick Hii Ru Yie, Zixin Zhou, Yiding Shen, Shuyi Wu, Yue Zhu, Zhennan Deng, Pingping Ma, Jianfeng Ma, Jinsong Liu
Summary: This study investigates the osteoinduction capabilities of a series of strontium-doped titanium implants under normal and osteoporotic conditions. The results indicate that high proportion strontium-doped coatings are more favorable for implant restorations in osteoporosis patients.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Haishan Shi, Xiaoling Ye, Jing Zhang, Tingting Wu, Tao Yu, Changren Zhou, Jiandong Ye
Summary: Investigation of thermostability in ion-doped octacalcium phosphate revealed that Fe-OCP and Sr-OCP exhibited different properties and ion release at various temperatures, with adjusted thermostability enhancing protein adsorption and cellular behavior. This work lays the foundation for developing bioactive materials for tissue repair utilizing ion doping strategy.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Jianwen Hou, Zhaozhao Ding, Xin Zheng, Yixin Shen, Qiang Lu, David L. Kaplan
Summary: Tough porous cryogels with angiogenesis and osteogenesis features remain a design challenge. In this study, deferoxamine (DFO) is loaded in silk nanofiber-derived cryogels to introduce angiogenic capacity. The concentration of silk nanofibers in the system is tuned to control the mechanical cues and the sustained release of DFO, resulting in faster regeneration of vascularized bone tissue.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Yen-Hong Lin, Alvin Kai-Xing Lee, Chia-Che Ho, Min-Jie Fang, Ting-You Kuo, Ming-You Shie
Summary: Numerous studies have shown that calcium silicate can be doped with trace metal elements like strontium or magnesium to enhance bone regeneration. With the development of 3D printing, it is now possible to fabricate bone grafts with precise structural designs. This study used multi-ceramics and trace metal elements to create a hybrid scaffold that can better promote bone regeneration.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Zehui Peng, Ziqiang Cheng, Shanwu Ke, Yongyue Xiao, Zhaoer Ye, Zikun Wang, Tongyu Shi, Cong Ye, Xin Wen, Paul K. Chu, Xue-Feng Yu, Jiahong Wang
Summary: A flexible memristor using 2D cadmium phosphorus trichalcogenide nanosheets as the functional layer was fabricated and showed excellent resistive switching performance under different radius and over 10(3) bending times. The device mechanism was systematically investigated, and synaptic plasticity including paired-pulse facilitation and spiking timing-dependent plasticity were observed. Additionally, the linear conductance modulation capacity of the flexible memristor was utilized for decimal operation, achieving successful addition, subtraction, multiplication, and division of decimal calculation. These results demonstrate the potential of metal phosphorus trichalcogenide in novel flexible neuromorphic devices, which accelerate the application process of neuromorphic computing.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Guomin Wang, Kaiwei Tang, Wenjuan Jiang, Qing Liao, Yong Li, Pei Liu, Yuzheng Wu, Mengting Liu, Huaiyu Wang, Bin Li, Jianzhong Du, Paul K. Chu
Summary: Adjustable electro-mechanical forces can effectively kill bacteria and adding electrical charges can enhance the antibacterial efficacy.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
De Gao, Shuzhen Deng, Xiaogang Li, Yingxi Zhang, Tuan Lv, Yang He, Weijian Mao, Hui Yang, Jingwei Zhang, Paul K. Chu, Kaifu Huo
Summary: We report a dendrite-free Li composite anode with minimum volume change, which is composed of 3D interpenetrating Li and lithiophilic MoN nanosheets. The conductive 2D MoN nanosheets induce planar Li plating and suppress dendrite growth. The MoN nanosheets interwoven framework provides abundant Li accommodation sites, while Li3N generated in situ enhances the ionic conductivity and interface stability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Biomedical
Dorsa Dehghan-Baniani, Babak Mehrjou, Paul K. Chu, Wayne Yuk Wai Lee, Hongkai Wu
Summary: Articular cartilage (AC) has limited healing capacity due to its avascular and acellular nature. Cartilage tissue engineering faces challenges in remodeling the complex cartilage composition and architecture. Understanding intrinsic AC properties and cell response to stimuli is crucial for producing functional cartilaginous constructs. Biopolymers have shown promise in creating polymeric scaffolds that mimic zonal AC layers using physical, mechanical, and biological/chemical signals. This review discusses the properties, challenges, and potential ways to overcome them.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Gongbin Tang, Fenghua Su, Xiaochu Liu, Zhongwei Liang, Tao Zou, Paul K. Chu
Summary: In this study, the dots of gold nanoparticles on black phosphorus have been shown to enhance superlubricity at the Si3N4/MoN interface in PAO6 oil. It is found that the strong hydrogen bonding between oil molecules and the nano-Au, as well as the incommensurate interlayer stacking of BP facilitated by nano-Au, contribute to the superlubricity. This study provides fundamental knowledge about nanoscale frictional behavior and superlubricity mechanisms, and offers a novel concept for designing nanoadditives with superlubricity.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Xingwang Yan, Xiaolin Zhang, Bin Wang, Ziran Chen, Junze Zhao, Gaopeng Liu, Dan Li, Qingdong Ruan, Liangliang Liu, Yue Xu, Mengxia Ji, Paul K. Chu, Huaming Li, Jiexiang Xia
Summary: Efficient heterojunction photocatalysts with spatial separation of photogenerated carriers are crucial to photo-catalysis. The unique carbonized polymer dots/ZnIn2S4 (CPDs/ZIS) Z-scheme heterojunction is designed to realize efficient spatial directional separation of photogenerated carriers and deliver enhanced photocatalytic performance in pollutant degradation. The CPDs generate more superoxide radicals to facilitate mineralization of organic pollutants and retain more holes for oxidation, while the Z-scheme migration mechanism of photogenerated carriers in the CPDs/ZIS composite preserves the original valence band potential of ZIS.
APPLIED SURFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Yuanhong Gao, Shuai Sun, Dan Qiu, Yu-Ming Wei, Mengpei Zhang, Jin Liu, Paul K. Chu, Wen-Long You, Jia Li
Summary: A novel device architecture composed of a PQD/organic semiconductor (OSC) heterojunction and a polar polymer capping layer was utilized to overcome the limitations of inefficient charge transport/extraction and high trap state density in PQD films. This resulted in highly sensitive photodetection with promising potential for high-performance photodetectors.
Review
Chemistry, Multidisciplinary
Yuzheng Wu, Pei Liu, Babak Mehrjou, Paul K. Chu
Summary: The discovery of antibiotics has saved many lives, but antibiotic-resistant bacteria have become a problem in modern medicine. To address this issue, researchers are developing smart antibacterial materials to improve sterilization and reduce the risk of drug resistance. Interdisciplinary collaboration is crucial for the research and development of these materials.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Shuai Feng, Donglian Li, Hao Dong, Song Xie, Yaping Miao, Xuming Zhang, Biao Gao, Paul K. Chu, Xiang Peng
Summary: In this study, MoO2/Mo2N heterostructures were prepared by regulating the coordination of Mo atoms. The electrocatalyst exhibits high current density and excellent stability for hydrogen evolution reaction.
APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY
(2024)
Article
Engineering, Biomedical
Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang, Linyuan Han, Zhihai Huang, Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu
Summary: In this study, a self-healing polymeric coating was constructed on a magnesium alloy for orthopedic implants. The coating incorporated a stimuli-responsive drug delivery nanoparticle platform and showed fast and stable water-enabled self-healing capacity. It also exhibited good antibacterial properties and promoted cell compatibility, osteogenesis, and angiogenesis.
Article
Chemistry, Physical
Shuyu Fan, Yinong Chen, Shu Xiao, Kejun Shi, Xinyu Meng, Songsheng Lin, Fenghua Su, Yifan Su, Paul K. Chu
Summary: Graphene coatings are promising solid lubrication materials due to their mechanical properties. This study presents a new method for in situ deposition of high-quality graphene coatings on hard substrates using NiCo solid solution and competitive reaction strategies. The graphene coating deposited on substrates with deep NiCo solid solution demonstrates superior low-friction and durability.
Article
Optics
Guangrong Sun, Qiang Liu, Haiwei Mu, Yudan Sun, Shimiao Wang, Mingzhu Han, Jianxin Wang, Jingwei Lv, Paul K. Chu, Chao Liu
Summary: A novel terahertz anti-resonant fiber is designed with high-resistivity silicon in the fiber and nested double-layer U-shape tubes, which effectively reduce the transmission loss. The fiber's confinement loss and effective material loss are analyzed and optimized using the finite element method. The optimized fiber demonstrates a low total loss of 3.1 x 10-3 dB/m at 1 THz and a low-loss transmission bandwidth of 0.44 THz in the range of 0.5-1.5 THz. Bending analysis shows that the bending loss is less than 2.1 x 10-2 dB/m at 1 THz for bending radii bigger than 60 cm. This anti-resonant fiber exhibits excellent performance and holds high commercial potential in terahertz waveguides.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Applied
Zanling Huang, Shuqi Zhu, Yuan Duan, Chaoran Pi, Xuming Zhang, Abebe Reda Woldu, Jing-Xin Jian, Paul K. Chu, Qing-Xiao Tong, Liangsheng Hu, Xiangdong Yao
Summary: In this study, it was found that Ni sites act as a host to attract Fe(III) to form Fe(Ni)(III) binary centers, which promote the oxygen evolution reaction (OER) activity and stability by cyclical formation of intermediates. Additionally, other ions can also catalyze the OER process on different electrodes.
JOURNAL OF ENERGY CHEMISTRY
(2024)
Article
Chemistry, Physical
Hanxue Zhao, Kaishuai Yang, Kailan Zhu, Mai Li, Wendong Xu, Waqar ul Hasan, Jiale Wang, Qinglin Deng, Jun Yu, Zhongyi Sun, Paul K. Chu
Summary: In this study, the surface activity of the electrode is enhanced by combining gold particles and MOF-derived CPCN with α-MnO2. The Au-MnO2/CPCN@CC electrode exhibits higher specific capacity and better cycling stability in 1 M Na2SO4. The use of Au nanoparticles and CPCN improves the surface electron transport of MnO2, resulting in superior performance.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Review
Chemistry, Multidisciplinary
Yunlei Zhou, Liting Yin, Shuangfei Xiang, Sheng Yu, Hannah M. Johnson, Shaolei Wang, Junyi Yin, Jie Zhao, Yang Luo, Paul K. Chu
Summary: This review provides a comprehensive overview of the synthesis and fabrication strategies employed in the development of MXene-based flexible materials for energy storage applications. The paper analyzes the current state of the field and explores the challenges and research opportunities in this dynamic area.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
