Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 76, Issue -, Pages 224-232Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.03.037
Keywords
Wound healing; Electrospinning; PCL; Bioactive glass; Mineralization
Categories
Funding
- European program FEDER/COMPETE through project Matryoshkas [PTDC/CTM-BIO/1814/2012]
- European Union's Horizon research and innovation programme under the Marie Sktodowska-Curie [657264]
- Marie Curie Actions (MSCA) [657264] Funding Source: Marie Curie Actions (MSCA)
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This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(epsilon-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with Ag2O and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0.25%, 0.5% and 0.75 wt%). The composite membranes were characterized in terms of morphology, fiber diameter, weight loss, mineralization potential and mechanical performance. (C) 2017 Elsevier B.V. All rights reserved.
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