Article
Polymer Science
Sofia Mares-Bou, Maria-Antonia Serrano, Jose Antonio Gomez-Tejedor
Summary: Electrospun membranes were developed for controlled drug release with different coating structures. The morphology of the fibers was analyzed and different release rates were obtained for the coated fibers, making them suitable for various applications.
Article
Biochemistry & Molecular Biology
Mohamed S. El-Okaily, Amira M. EL-Rafei, Mona Basha, Nour T. Abdel Ghani, Mayyada M. H. El-Sayed, Asim Bhaumik, Amany A. Mostafa
Summary: Nano-fiber composites consisting of a blend of polyvinyl alcohol (PVA) and chitosan (CS) with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning. The drug release efficiency of the developed nano-fiber composites with BG was enhanced and sustained, with the release pattern taking place through a two-stage intra-particle diffusion mechanism. The presence of BG in the nano-fibers significantly retarded the drug release profile compared to their BG-free counterparts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
E. Massarelli, D. Silva, A. F. R. Pimenta, A. Fernandes, J. L. G. Mata, H. Armes, M. Salema-Oom, B. Saramago, A. P. Serro
Summary: A new PVA/Ch based wound dressing was developed, which showed protection, hydration, and controlled release of antiseptics. The dressings exhibited antibacterial activity against S. aureus and S. epidermidis, with the ones loaded with PHMB showing better cytotoxicity and irritability properties. The application of this dressing in wound treatment in a dog led to faster recovery compared to conventional treatment, suggesting its potential as an alternative in wound care.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Seyedeh Zahra Hoseyni, Seid Mahdi Jafari, Hoda Shahiri Tabarestani, Mohammad Ghorbani, Elham Assadpour, Moslem Sabaghi
Summary: This study successfully encapsulated catechin in nanofibers from Azivash gum-polyvinyl alcohol using the electrospinning process. The increase in catechin concentration was found to affect encapsulation efficiency and loading capacity, while FTIR spectroscopy highlighted interactions between catechin and the polymer. The designed nanofibers showed potential for active packaging in improving oxidative stability of food and pharmaceutical products.
FOOD HYDROCOLLOIDS
(2021)
Article
Polymer Science
Isela Sandoval-Herrera, Jorge Romero-Garcia, Antonio Ledezma-Perez, Carmen Alvarado-Canche, Roman Torres-Lubian, Arxel De-Leon
Summary: This study synthesized poly(gamma-glutamic acid) (gamma-PGA) for wound dressing, using electrospun nanofibers of 10% polyvinyl alcohol (PVA) blended with 5% and 10% gamma-PGA with chlorogenic acid. The release kinetics showed that PVA with 5% gamma-PGA had a higher value and reached saturation first compared to other samples.
Article
Biochemistry & Molecular Biology
Fei Liu, Wenyu Li, Hongting Liu, Teng Yuan, Yu Yang, Wen Zhou, Yang Hu, Zhuohong Yang
Summary: The study introduces a 3D printed double-network hydrogel scaffold with improved mechanical properties and long-lasting antibacterial ability, allowing for adjustable drug release behavior for potential tissue regeneration applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Lele Chen, Zhao Liu, Jipeng Shi, Chengbo Wang, Ling Ding, Xu Ding, Guixiang Teng, Jianping Wu, Ji Zhang
Summary: In this study, environmentally friendly chitosan/polyvinyl alcohol nanofibrous mats were prepared using acetic acid, succinic acid, and citric acid as solvents. The effects of different organic acids on the properties of the nanofibres were systematically studied. The results showed that the nanofibrous mat prepared using citric acid exhibited higher water stability and optimal antibacterial activity and biocompatibility.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jorge Ivan Castro, Manuel N. Chaur, Carlos Humberto Valencia Llano, Mayra Eliana Valencia Zapata, Jose Herminsul Mina Hernandez, Carlos David Grande-Tovar
Summary: This study synthesized four different nanofibrous membranes of chitosan (CS)/(PVA)/oxidized carbon nano-onions (ox-CNO) using the electrospinning method and conducted subdermal implantations in Wistar rats. The results showed that the nanofibers were continuous, with narrow diameters, and the introduction of ox-CNO increased the crystallinity index, enhancing the material's performance, with good biocompatibility as evidenced by the subdermal implantations.
Article
Pharmacology & Pharmacy
Mahdieh Alimohammadi, Omid Fakhraei, Ali Moradi, Mona Kabiri, Ali Moradi, Mohammad Passandideh-Fard, Ali Tamayol, Mohammad Hosein Ebrahimzadeh, Seyed Ali Mousavi Shaegh
Summary: This research focuses on the development and characterization of electrospun composite nanofibrous membranes made of PCL and CS for sustained release of azithromycin. The study finds that the material composition and morphological features, such as fiber diameter, can be adjusted to tailor the release rate and amount of the drug.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alireza Rezaei, Elham Katoueizadeh, Seyed Mojtaba Zebarjad
Summary: In recent years, researchers have been interested in investigating the effect of nanoparticles with different morphologies in therapeutic applications. This study examines the effect of adding zinc oxide nanoparticles with a new morphology on the properties of PVA/CS nanofibers as a wound dressing. The results show that zinc oxide nanoparticles with pyramidal rod morphology increase the mechanical strength of the nanofibers, while star-like zinc oxide nanoparticles decrease the strength. Furthermore, incorporating zinc oxide nanoparticles enhances heat resistance, antibacterial activity, and wound healing. Therefore, PVA/CS nanofibers containing zinc oxide nanoparticles with pyramidal rod morphology have great potential in wound healing.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Rong Nie, Xu Hao, Guorong Liu, Zhao Wang, Zekang Zhu, Dongdong Yuan, Duoxia Xu
Summary: This study focused on the preparation and characterization of anti-microbial biodegradable films based on PVA-CS incorporated with Bifidocin A for active food packaging. The release kinetics of Bifidocin A were studied, showing faster release at higher temperature and concentration, with endothermic and spontaneous release according to thermodynamic parameters. The results indicated that the composite films had better mechanical properties and anti-microbial activity at 50% Bifidocin A content, but inclusion of glycerol was necessary to prevent structural impairment.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Chenwei Chen, Lin Zong, Jiaxi Wang, Jing Xie
Summary: The study focused on the impact of MFC content on the properties of ST/PVA films, showing that MFC enhanced the strength of the films and improved their crystallinity while reducing flexibility. The release of CIN from films was controlled by MFC, with potential for inhibiting the growth of putrefaction bacteria.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Xuemei Bai, Tingting Song, Jingmin Luan, Meijuan Chen, Jianxiang Yu, Huafeng Tian
Summary: The visible light catalytic antibacterial nanofiber membranes were developed as a new functional material to address bacterial infection and water pollution. Oxygenated graphite carbon nitride nanosheets (O-g-C3N4) with enhanced exfoliation and dispersion were synthesized and used to prepare the polyvinyl alcohol (PVA)/chitosan (CS)/O-g-C3N4 (PCO) composite nanofiber membranes with improved hydrophilicity. The PCO nanofiber membranes exhibited significantly higher antibacterial activity and have promising application prospects in biomedical-related fields.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Xiaohui Wei, Junjie Cai, Song Lin, Fan Li, Feng Tian
Summary: A facile methodology using glutaraldehyde as a cross-linking reagent was explored for in situ modification of PVA electrospun nanofibers doped with AgNPs. The different cross-linking degrees achieved through controlling glutaraldehyde amounts effectively controlled the release rates of Ag. Cross-linked PVA doped with AgNPs exhibited good antibacterial efficacy and low cytotoxicity against various cell lines.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Materials Science, Textiles
Stanley MacArthur Fergusson, Rajiv Padhye
TEXTILE RESEARCH JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Shayanti Mukherjee, Saeedeh Darzi, Anna Rosamilia, Vinod Kadam, Yen Truong, Jerome A. Werkmeister, Caroline E. Gargett
Article
Engineering, Chemical
Lihua Zhao, Chunrui Wu, Xiaolong Lu, Derrick Ng, Yen Bach Truong, Jianhua Zhang, Zongli Xie
JOURNAL OF MEMBRANE SCIENCE
(2020)
Review
Engineering, Biomedical
Ashley R. Murphy, Yen B. Truong, Carmel M. O'Brien, Veronica Glattauer
ACTA BIOMATERIALIA
(2020)
Article
Materials Science, Multidisciplinary
Sheeana Gangadoo, Aaron Elbourne, Alexander E. Medvedev, Daniel Cozzolino, Yen B. Truong, Russell J. Crawford, Peng-Yuan Wang, Vi Khanh Truong, James Chapman
Article
Materials Science, Multidisciplinary
Shadi Houshyar, G. Sathish Kumar, Rajiv Padhye, Robert A. Shanks, Amitava Bhattacharyya
Summary: Preparation and characterization of nanodiamond dispersed polyamide-based filament were studied, showing enhanced thermomechanical properties and superior tensile strength and toughness. The incorporation of nanodiamond also resulted in higher thermal stability, delaying thermal degradation, making this composite material suitable for high performance applications.
Article
Biochemistry & Molecular Biology
Nehir Arik, Nesrin Horzum, Yen Bach Truong
Summary: The fabrication and properties of bio-based thermoplastic polyurethane fibrous scaffolds containing essential oils were reported. The results showed that the type and concentration of essential oils affected the electrospinnability, diameter, morphology, and wettability of the TPU fibers.
Article
Biochemistry & Molecular Biology
Cindy Bessey, Yuan Gao, Yen Bach Truong, Haylea Miller, Simon Neil Jarman, Oliver Berry
Summary: Passive collection is an emerging sampling method for environmental DNA (eDNA) in aquatic systems. This study compares the effectiveness of nine membrane materials for passively collecting fish eDNA and finds that most materials can collect comparable amounts of eDNA and species richness to that of conventional filtering within short periods of submersion. The collected eDNA particles show a diversity in size and structure. This passive approach is cost-effective, time-efficient, and suitable for biological surveys in remote areas or with limited equipment.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Chemistry, Analytical
Andrzej Krajewski, Shadi Houshyar, Lijing Wang, Rajiv Padhye
Summary: This work describes the design, manufacturing, and user interface of a thin-film gas transducer platform that can provide real-time detection of toxic vapor. The sensor can be integrated with unmanned aerial vehicles, combining high mobility with the ability to detect hazardous gases in real time, or used as a standalone system in industries dealing with harmful gaseous substances.
Review
Nanoscience & Nanotechnology
Yasamin Ziai, Seyed Shahrooz Zargarian, Chiara Rinoldi, Pawel Nakielski, Antonella Sola, Massimiliano Lanzi, Yen Bach Truong, Filippo Pierini
Summary: As scientists realized the potential of translating raw neurological signals into bioelectric information, massive growth has been witnessed in the field of brain-machine interfaces (BMI) for both experimental and clinical studies. The development of suitable materials to enable real-time recording and data digitalizing has three key requirements: biocompatibility, electrical conductivity, and mechanical properties similar to soft brain tissue. This review discusses the use of inorganic nanoparticles and intrinsically conducting polymers to enhance electrical conductivity, while soft materials like hydrogels offer reliable mechanical properties and a biocompatible substrate. Future goals include developing biohybrid conducting polymer-based interfaces loaded with cells for simultaneous stimulation and regeneration, as well as utilizing artificial intelligence and machine learning to design advanced materials for multi-modal BMIs.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Piumie Rajapaksha, Rebecca Orrell-Trigg, Yen B. Truong, Daniel Cozzolino, Vi Khanh Truong, James Chapman
Summary: Textile dyes and pharmaceutical discharges have serious impacts on the environment and human health. In this study, graphene oxide and two composite materials were prepared to test their adsorption capacities for textile dyes and antibiotics. The results showed that graphene oxide had a high adsorption capacity for dye removal, while the composite materials were effective in removing antibiotics. The adsorption processes of all materials followed chemical adsorption models, and thermodynamic analysis confirmed their spontaneity.
ENVIRONMENTAL SCIENCE-ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Maryanne E. Spiers, David J. Nielsen, Karl D. Pavey, Yen B. Truong, Gregory C. Rutledge, Peter Kingshott, Daniel S. Eldridge
Summary: A novel dissolution method for preparing high-concentration, high-molecular-weight doped polyaniline solutions was reported, which were processed into nanofibers for colorimetric gas sensing. Substrates generated from electrospinning of PANi-CSA demonstrated linear response to ammonia exposure at different levels of humidity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Ryan Go, Shadi Houshyar, Kate Fox, Yen Bach Truong
Article
Nanoscience & Nanotechnology
Piumie Rajapaksha, Samuel Cheeseman, Stuart Hombsch, Billy James Murdoch, Sheeana Gangadoo, Ewan W. Blanch, Yen Truong, Daniel Cozzolino, Chris F. McConville, Russell J. Crawford, Vi Khanh Truong, Aaron Elbourne, James Chapman
ACS APPLIED BIO MATERIALS
(2019)
Article
Engineering, Electrical & Electronic
Abu Shaid, Lijing Wang, Rajiv Padhye, Martin Gregory
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
