Article
Engineering, Biomedical
Gyeong Min Lee, Se-jeong Kim, Eun Mi Kim, Eunhyung Kim, Sangmin Lee, Eunjin Lee, Hee Ho Park, Heungsoo Shin
Summary: A composite hydrogel incorporating epigallocatechin-gallate (EGCG)-coated nanofiber particles (EF) was developed. Compared to traditional GelMA hydrogel, this composite hydrogel showed significant improvements in cell viability, intracellular oxidative stress, and cell spreading and migration ability.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Dax Calder, Ali Fathi, Farshad Oveissi, Simin Maleknia, Terence Abrams, Yiwei Wang, Joanneke Maitz, Kevin Hung-Yueh Tsai, Peter Maitz, Wojtek Chrzanowski, Ivan Canoy, Vivek Ashoka Menon, Kenneth Lee, Benjamin J. Ahern, Natasha E. Lean, Dina M. Silva, Paul M. Young, Daniela Traini, Hui Xin Ong, Rasoul Seyed Mahmoud, Hossein Montazerian, Ali Khademhosseini, Fariba Dehghani
Summary: The engineered injectable hydrogel supports the body's healing capability by providing a temporary matrix for cell growth and vascularization. This synthetic biomaterial shows great therapeutic potential in clinical applications and addresses current challenges faced by injectable systems.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Polymer Science
Cecilie Hoeeg, Alireza Dolatshahi-Pirouz, Bjarke Follin
Summary: Cell therapy has the potential to regenerate cardiac tissue and treat various cardiac diseases. Injectable hydrogels have been investigated for their potential to improve cell graft retention and enhance the effects of cardiac cell therapy.
Article
Biochemistry & Molecular Biology
Purabi Sarkar, Christy Lite, Praveen Kumar, Mukesh Pasupuleti, N. T. Saraswathi, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Aziz Arshad, Jesu Arockiaraj
Summary: The study identified the antioxidant role of sulfite reductase derived from Arthrospira platensis through the short peptide TL15, which showed strong antioxidant activity without toxicity in human leukocytes. In zebrafish larvae, TL15 peptide reduced H2O2-induced ROS levels and enhanced antioxidant enzyme activity. Overall, TL15 acts as a potential antioxidant with dose-specific properties, making it promising for biopharmaceutical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Lei Lei, Rui Cong, Yifei Ni, Xin Cui, Xulei Wang, Hongmei Ren, Zun Wang, Mengyuan Liu, Jiasheng Tu, Lei Jiang
Summary: This study reports a dual-functional injectable hydrogel for treating osteoarthritis, which can scavenge reactive oxygen species (ROS) to inhibit inflammation and provide lubrication to reduce joint wear and tear. The hydrogel possesses a unique structure that allows it to be injected, self-heal, and provide lubrication, offering a new approach for osteoarthritis treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Wenjing Zhang, Lingting Zeng, Huan Yu, Ziheng He, Cuishan Huang, Cairong Li, Yangyi Nie, Long Li, Feifei Zhou, Ben Liu, Yuantao Zhang, Zhenyu Yao, Wei Zhang, Ling Qin, Di Chen, Qianjun He, Yuxiao Lai
Summary: This study developed an injectable calcium boride nanosheets (CBN) loaded hydrogel platform (CBN@GelDA hydrogel) as a high-payload and sustainable hydrogen (H2) precursor for osteoarthritis (OA) treatment. The CBN@GelDA hydrogel maintained constant physiological pH conditions, released more H2 than CBN alone, and lasted for more than one week. The hydrogel had ROS scavenging ability, reduced inflammatory cytokine expression, stimulated M2 macrophages, and decreased chondrocyte apoptosis, effectively alleviating the progression of OA.
ACTA BIOMATERIALIA
(2023)
Review
Nanoscience & Nanotechnology
Ye Eun Kim, Jaeyun Kim
Summary: Regulating the amount of reactive oxygen species (ROS) and utilizing ROS-scavenging hydrogels can effectively treat various inflammatory diseases, showing effects such as promoting wound healing, accelerating regeneration, and demonstrating synergy with other therapeutic molecules.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Xiaomin Su, Boshu Ouyang, Yao Liu, Yang Wang, Ruizhe Xu, Lili Niu, NanNan Li, Ce Xu, Zanya Sun, Huishu Guo, Zhiqing Pang, Xiangrong Yu
Summary: In this study, a new tumor starvation strategy was developed by closing the valve of glucose transporter protein 1 (GLUT1) and reducing glucose uptake and ATP levels through radical enhancement.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aimon Saleem, Roeya Rehman, Sania Hussain, Mohamed A. Salem, Faisal Ali, Sayyed Asim Ali Shah, Umer Younas, Salah M. El-Bahy, Zeinhom M. El-Bahy, Munawar Iqbal
Summary: In this study, hydrogel films were fabricated using the cross-linking property of two biopolymers, sodium alginate (SAlg) and okra gel (OkG). The films showed porosity, amorphousness, and agglomerated morphology through SEM analysis. TGA and DSC analyses revealed the degradation temperature and stability of the films, and in-vitro degradation tests showed the influence of okra gel. The films also exhibited non-toxicity and suitable characteristics for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Giuseppina Biscari, Giovanna Pitarresi, Calogero Fiorica, Domenico Schillaci, Valentina Catania, Fabio Salvatore Palumbo, Gaetano Giammona
Summary: This study successfully developed an injectable hydrogel with antioxidant, antibacterial, and tissue adhesion functions by synthesizing dopamine and PEG functionalized Gellan Gum. The hydrogel showed radical scavenging activity, specific and non-specific antibiotic/antimicrobial properties, as well as photothermal transformation for on-demand antibiotic release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Gorka Calvo-Martin, Daniel Plano, Ignacio Encio, Carmen Sanmartin
Summary: A series of 30 novel N,N-disubstituted selenoureas were synthesized and tested for their antioxidant and cytotoxic activities. Some compounds showed potential anti-cancer properties, with selenourea 6c demonstrating promising anticancer activity in the NCI60 cell line panel.
Article
Food Science & Technology
Juan David Figueroa, Noreima Barroso-Torres, Marcela Morales, Barbara Herrera, Mario Aranda, Eva Dorta, Camilo Lopez-Alarcon
Summary: The ORAC assay does not differentiate between peptides based on their chemical structures and the contribution of oxidation products. Peptides showed similar ORAC values, but the bond dissociation energy (BDE) varied.
Article
Polymer Science
Yikun Ren, Dan Zhang, Yuanmeng He, Rong Chang, Shen Guo, Shanshan Ma, Minghao Yao, Fangxia Guan
Summary: Hydrogels with injectable and antioxidant properties, such as the HT/QGA hydrogel prepared in this study, show promising qualities for wound healing. The hydrogel exhibited excellent injectability, favorable antioxidant activity, and good biocompatibility, and showed potential application in wound healing in a full-thickness skin injury model.
Review
Biochemistry & Molecular Biology
Wenzhen Du, Qida Zong, Ranran Guo, Guixia Ling, Peng Zhang
Summary: Hydrogel is a 3D polymer network with strong swelling ability and potentially important applications in biomaterials, soft machines, and artificial tissues. Nanoparticles can enhance the properties of traditional hydrogels for better performance and potential in various fields.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biophysics
Vineeth M. Vijayan, Remya Komeri, Sunita P. Victor, Jayabalan Muthu
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Biotechnology & Applied Microbiology
Sunita P. Victor, V. M. Vineeth, Remya Komeri, Shivaram Selvam, Jayabalan Muthu
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2015)
Article
Chemistry, Multidisciplinary
Remya Komeri, Finosh Gnanaprakasam Thankam, Jayabalan Muthu
Article
Biophysics
Sunita Prem Victor, Willi Paul, V. M. Vineeth, Remya Komeri, Muthu Jayabalan, Chandra P. Sharma
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Engineering, Biomedical
Remya Komeri, Jayabalan Muthu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Materials Science, Biomaterials
Sunita PremVictor, Jibin Kunnumpurathu, M. G. Gayathri Devi, K. Remya, Vineeth M. Vijayan, Jayabalan Muthu
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Biochemistry & Molecular Biology
P. L. Reshma, B. S. Unnikrishnan, G. U. Preethi, H. P. Syama, M. G. Archana, K. Remya, R. Shiji, J. Sreekutty, T. T. Sreelekha
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Engineering, Biomedical
Anne Behre, Joshua W. Tashman, Caner Dikyol, Daniel J. Shiwarski, Raphael J. Crum, Scott A. Johnson, Remya Kommeri, George S. Hussey, Stephen F. Badylak, Adam W. Feinberg
Summary: This study develops a process using 3D bioprinting and computed tomography imaging to fabricate large volume, patient-specific dECM patches for soft tissue wounds. The analysis shows that these patches are dimensionally accurate and adapt well to complex wound surfaces. Additionally, the study demonstrates the ability to create clinically relevant dECM scaffolds with precise control over fiber alignment and micro-architecture.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Remya Komeri, S. Maya, B. S. Unnikrishnan, J. Sreekutty, G. U. Preethi, Kaustabh Kumar Maiti, Therakathinal T. Sreelekha
ACS APPLIED NANO MATERIALS
(2019)
Article
Biophysics
Remya Komeri, Jayabalan Muthu
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)