Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 79, Issue -, Pages 499-506Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.05.083
Keywords
Silver nanoparticles; Silica; Lipoic acid, antioxidant activity; Antimicrobial activity; Cytotoxicity
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Funding
- Romanian National Authority for Scientific Research (CNCS-UEFISCDI) [PN-II-RU-PD-2012-3-0090]
- EU (ERDF) [INFRANANOCHEM19 / 01.03.2009]
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A novel nanocomposite was obtained through the covalent immobilization of lipoic acid on the surface of silver nanoparticles-decorated silica nanoparticles (SiO2@Ag). The hybrid organic inorganic material obtained was characterized by Fourier transform infrared spectroscopy, thermal analysis, scanning and transmision electron microscopy, X-ray photoelectron spectroscopy and UV-Visible spectroscopy. Its antioxidant, cytotoxic, antimicrobial activity and influence on mammalian cells cycle were evaluated. The results of this study have shown that the functionalization of SiO2@Ag with lipoic acid resulted in a composite with increased specificity of interaction with different mammalian cell lines and antioxidant activity, but with decreased cytotoxicity and antimicrobial properties. Therefore, the SiO2@Ag functionalized with lipoic acid could be successfully used in certain concentrations to modulate the cell cycle, in order to obtain the desired anti-proliferative or stimulatory therapeutic effect. (C) 2017 Elsevier B.V. All rights reserved.
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