Article
Engineering, Biomedical
Xifeng Liu, Bipin Gaihre, Matthew N. George, A. Lee Miller, Haocheng Xu, Brian E. Waletzki, Lichun Lu
Summary: This study presents a new bioink made of OPF and gelatin for 3D bioprinting, showing excellent performance in terms of cell viability, spreading, and proliferation. The results indicate that OPF bioink holds great potential in future 3D bioprinting applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Mohamed Zoughaib, Kenana Dayob, Svetlana Avdokushina, Marat I. Kamalov, Diana V. Salakhieva, Irina N. Savina, Igor A. Lavrov, Timur I. Abdullin
Summary: Synthetic hydrogels, specifically oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels, have been developed as a potential biodegradable scaffold for spinal cord repair with improved control over properties. The combination of different components in the cryogels allows for optimization of cell-supporting characteristics. The results show that OPF-based cryogels can be a tunable synthetic scaffold for neural tissue repair with advantages over hydrogel counterparts.
Review
Polymer Science
Bipin Gaihre, Xifeng Liu, A. Lee Miller, Michael Yaszemski, Lichun Lu
Summary: Fumarate-based polymers like PCLF and OPF have gained significant interest in biomedical applications for their tunable mechanical properties and biodegradability. PCLF is used for scaffolds while OPF is mostly explored as a hydrogel system, showing important applications in nerve, cartilage, and bone tissue engineering as well as drug delivery. Innovations in synthesis methods and the development of nano- and micro-composites using these polymers are key areas of research in enhancing cartilage and bone tissue regeneration.
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Chemistry, Applied
Lisandro Ferrari, Fernando Tuler, Ezequiel Promancio, Leonardo Guse, Diego Garcia Touza, Carlos Casas, Raul A. Comelli
Summary: Glycerol, a co-product in the biodiesel process, can be used as a raw material in a biorefinery scheme. Studies have been conducted to selectively reduce and oxidize glycerol, as well as steam reform it, to produce valuable chemicals and energetic compounds. The integration of these processes into a biorefinery framework has been demonstrated. The conversion of glycerol to various compounds such as propylene glycol, ethylene glycol, hydrogen, dihydroxyacetone, lactic acid, syngas, carbon dioxide, and methane shows the potential of utilizing glycerol in expanding biorefinery schemes.
Article
Biophysics
Mariia Svyntkivska, Tomasz Makowski, Roza Pawlowska, Dorota Kregiel, Ele L. de Boer, Ewa Piorkowska
Summary: Novel PEF nonwovens were successfully produced by solution electrospinning and further modification, showing excellent performance. The hydrophilicity of the nonwovens was improved by sodium hydroxide treatment, and silver particles were deposited on the fiber surfaces through two-step modification with compounds and silver ions, exhibiting good antibacterial activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biochemistry & Molecular Biology
Shuaishuai Yuan, Xiuxia Sun, Yong Shen, Zhibo Li
Summary: This study developed a new bioactive wound dressing by incorporating PEG and ZnO nanoparticles into the P4HB matrix. In vitro and in vivo experiments demonstrated that the bioactive P4HB/PEG/ZnO dressings have synergistic hemostatic and antibacterial effects, making them potential candidates for clinical applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Renfei Cheng, Junchao Wang, Tao Hu, Yiming Zhao, Yan Liang, Xiaohui Wang, Yanchun Zhou
Summary: MXenes have promising applications due to their two-dimensional nature and adjustable functional groups. However, their fast degradation caused by dissolved oxygen and water molecules hinders their practical use. To address this issue, the researchers introduced glycerol as a protective agent for MXene suspension, achieving long-term storage.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
E. Suljovrujic, M. Krstic, Z. Rogic Miladinovic, S. Petrovic, A. Leskovac, G. Stamboliev
Summary: Hydrogels with OEG, OPG, and combined OEG/OPG pendant chains were synthesized and their properties were investigated. An optimized method for OPGMA synthesis was developed. PEG6MA, PPG5MA, and P(EG6/PG5)MA hydrogels were produced using gamma radiation-induced polymerization. The combination of OEG and OPG allowed easy tuning of the phase transition temperature, making it suitable for biomedical applications.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Irina M. Le-Deygen, Oxana E. Musatova, Victor N. Orlov, Nikolay S. Melik-Nubarov, Irina D. Grozdova
Summary: This study provides the first evidence of the interaction between PEG and HA in aqueous solutions. The binding of PEG to HA requires multiple free primary hydroxyls regularly distributed along the polysaccharide chain. Additionally, PEG-induced compaction of HA may be related to changes in plasma membrane properties and resealing of mechanical injuries.
Article
Biochemistry & Molecular Biology
Arn Mignon, Tom Gheysens, Sander Walraet, Pieter Tack, Petra Rigole, Tom Coenye, Laszlo Vincze, Sandra Van Vlierberghe, Peter Dubruel
Summary: Infections are still a major cause of morbidity in burn wounds. Complexing iodine in acrylate-endcapped urethane-based poly(ethylene glycol) (AUP) polymers with or without poly(vinyl pyrrolidone) (PVP) leads to antimicrobial wound dressings with superior swelling and mechanical strength than commercial wound dressings, holding potential for future application in treating infected wounds.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Applied
Natjaya Ekapakul, Tharit Lerdwiriyanupap, Theeranun Siritanon, Chantiga Choochottiros
Summary: The factors influencing the formation of DN hydrogel were studied using a water-based, environmentally friendly system. The hydrogel was prepared by crosslinking poly-saccharide-based polymer carboxymethyl chitosan (CMCS) and poly(ethylene glycol) via an ionic crosslinking reaction and a radical crosslinking reaction. The optimum hydrogel was obtained with 9.5%v/v of 1000PEGGMA, CMCS 5%w/v, and CaCl2 3%w/v.
CARBOHYDRATE POLYMERS
(2023)
Article
Spectroscopy
S. O. Liubimovskii, V. S. Novikov, L. Yu. Ustynyuk, P. V. Ivchenko, K. A. Prokhorov, V. V. Kuzmin, E. A. Sagitova, M. M. Godyaeva, S. V. Gudkov, M. E. Darvin, G. Yu. Nikolaeva
Summary: The Raman spectra of ethylene glycol (EG) and 1,3-propylene glycol (1,3-PG) aqueous solutions were measured and the diol content was found to have a weak influence on the spectra. The conformational compositions of both diols remain largely unchanged when dissolved in water. The intensity of the OH stretching band can be used to evaluate the chemical composition of the solutions, and the spectral region 2800-3800 cm(-1) is particularly useful for this purpose. DFT modeling confirms the prevalence of gauche-conformation of EG in water solutions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Visit Vao-soongnern
Summary: The structural and surface properties of PErP nanoparticles with different comonomer compositions were studied using Monte Carlo simulation. At higher ethylene fraction in PErP chains, the interior bulk densities of nanoparticles increased and the surfaces became sharper. Chain ends were preferentially segregated at the surface, while the comonomers in the middle position were homogeneously distributed inside the nanoparticles. Chain dimensions and shape changed mostly in the surface region and decreased significantly with higher ethylene fraction.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)