Article
Medicine, Research & Experimental
Akanksha Behl, Parul Sarwalia, Sushil Kumar, Chittaranjan Behera, Mubashir Javed Mintoo, Tirtha Kumar Datta, Prem N. Gupta, Anil K. Chhillar
Summary: The synergistic potential of MUC1 inhibitors and Gemcitabine-loaded nanoparticles was discussed in this study, aiming to enhance the therapeutic efficacy. Gemcitabine and MUC1 inhibitors were loaded into polymeric nanoparticles using the double emulsion solvent evaporation method. The results showed that the twin-loaded nanoparticles exhibited better anticancer effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Ridan Lei, Meiling Zhou, Shusheng Zhang, Jinhua Luo, Can Qu, Yin Wang, Peiyu Guo, Ruixue Huang
Summary: This study investigates the prognostic value and molecular mechanisms of PRKCSH in lung cancer. It finds that higher PRKCSH expression is associated with poorer prognosis and increased infiltration of immune cells in lung cancer patients. PRKCSH deficiency promotes G2/M arrest in response to Nano-ZnO treatment by inducing STAT6 translocation and activating p53 expression. Targeting PRKCSH expression could be a potential therapeutic strategy for managing lung cancer by suppressing the activation of the STAT6/p53 pathway.
Article
Medicine, Research & Experimental
Marianna Abate, Angela Lombardi, Amalia Luce, Manuela Porru, Carlo Leonetti, Marco Bocchetti, Virginia Campani, Giuseppe De Rosa, Sossio Fabio Graziano, Valeria Nele, Francesco Cardile, Federica Zito Marino, Renato Franco, Andrea Ronchi, Marianna Scrima, Rossella Sperlongano, Roberto Alfano, Gabriella Misso, Evzen Amler, Michele Caraglia, Silvia Zappavigna
Summary: This study demonstrates that nanodiamonds can effectively deliver miRNA to inhibit tumor development and progression. The nanodiamonds have excellent biocompatibility, and the miR-34a conjugated with nanodiamonds can effectively inhibit cancer cell proliferation and migration. Furthermore, the miR-34a-conjugated nanodiamonds exhibit remarkable anti-tumor effects in mouse models.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Suzan Attia Mawed, Carlotta Marini, Mahmoud Alagawany, Mayada R. Farag, Rasha M. Reda, Mohamed T. El-Saadony, Walaa M. Elhady, Gian E. Magi, Alessandro Di Cerbo, Wafaa G. El-Nagar
Summary: This study elucidated the ultrastructure changes in the ovary in response to exposure to zinc oxide nanoparticles (ZnO-NPs) and explored the role of autophagy and apoptosis in the fertility of female zebrafish. The results showed that ZnO-NPs induced cytotoxicity, oxidative stress, and necroptosis, leading to a reduction in the fecundity of female zebrafish.
Article
Oncology
Hanan R. H. Mohamed, Maria M. H. Ibrahim, Ayman Diab
Summary: The study found that CaTiO3-NPs induced cytotoxicity, genomic instability, and apoptosis in human MCF-7 cells. These effects were time- and concentration-dependent.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Instruments & Instrumentation
Shloka Negi, Aiswarya Chaudhuri, Dulla Naveen Kumar, Deepa Dehari, Sanjay Singh, Ashish Kumar Agrawal
Summary: Autophagy is a catabolic process that responds to nutrient or metabolic emergencies. Nanoparticles can induce or block autophagy, playing a crucial role in cancer. Autophagy has paradoxical effects in cancer and its role varies at different stages of the disease.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Oncology
Azar Gharoonpour, Dorsa Simiyari, Ali Yousefzadeh, Fatemeh Badragheh, Marveh Rahmati
Summary: Autophagy is important in maintaining cellular function and has a dual role in tumor cells. The use of nanoparticles is a promising technique to modulate autophagy pathways in cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Applied
Yuanxiao Zhang, Yu Hai, Yuqing Miao, Xiao Qi, Weiming Xue, Yane Luo, Haiming Fan, Tianli Yue
Summary: The toxicity mechanism of superparamagnetic iron oxide nanoparticles (SPIONs) was investigated to reduce risks, with higher dosage and suitable sizes of SPIONs enhancing uptake into cells and leading to increased reactive oxygen species (ROS) formation. Smaller SPIONs tended to produce more ROS in mitochondria, damaging them, while larger SPIONs promoted ROS production in plasma to destroy cytomembrane. Different size SPIONs activated distinct cell death pathways, with ferroptosis playing a significant role in mitochondrial and cytomembrane damage. ROS levels correlated with gene expression, suggesting RNA-seq as a new method to assess oxidative stress and toxicity of nanomaterials.
Article
Biochemistry & Molecular Biology
Shuyi Chen, Yabiao Gao, Ping Zhu, Xue Wang, Linzi Zeng, Youping Jin, Xiuling Zhi, Huanjun Yang, Ping Zhou
Summary: In this study, it was found that anlotinib could inhibit breast cancer cell growth by inducing cell autophagy and promoting cell apoptosis. Furthermore, the Akt/GSK-3a pathway was inactivated by anlotinib treatment. These findings suggest that anlotinib may be an effective new drug for breast cancer treatment.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Medicine, General & Internal
Yu-Chih Hsu, Wen-Che Hsieh, Shu-Hsin Chen, Yi-Zhen Li, Mei-Yi Lin, Hui-Fen Liao, Shew-Meei Sheu
Summary: 180-GA can modulate autophagy and inhibit proliferation of luminal A subtype breast cancer cells through apoptosis promotion and JNK activation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Subashani Maniam, Sandra Maniam
Summary: Targeted chemotherapy has become the forefront of cancer treatment, offering more effective treatment with reduced side effects through selective and specific features; Research targeting the compensatory mechanisms in tumor cells is progressing in order to overcome drug resistance; Promising small molecules that target autophagy and apoptosis are being developed for the difficult-to-treat TNBC, showing potential in preclinical data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jieqing Li
Summary: This study aimed to confirm the possibility of using CHI combined with DOX to prevent chemotherapeutic BC resistance. The results showed that CHI could inhibit cell proliferation, tumor growth, and cell invasion in BC. It also promoted apoptosis and autophagy, and increased cell sensitivity to DOX, leading to decreased tumor growth.
Article
Oncology
Yichao Wang, Hongsheng Lu, Zhongrong Wang, Yueguo Li, Xiaoying Chen
Summary: This study successfully constructed a prognostic risk model for breast cancer and identified an autophagy-related prognostic gene, TP63. The study also demonstrated that TGF-beta 1 promotes autophagy and inhibits apoptosis in breast cancer cells by inhibiting the expression of TP63.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yongqi Zhen, Zhaoxin Yuan, Jiahui Zhang, Yao Chen, Yuning Fu, Yi Liu, Leilei Fu, Lan Zhang, Xian-Li Zhou
Summary: This study found that flubendazole could inhibit the proliferation and migration of breast cancer cells by impairing mitochondrial function. Moreover, excessive DRP1-mediated mitophagy plays a critical role in the anticancer effects of EVA1A.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Elham Kamal Kazemi, Fereydoon Abedi-Gaballu, Tala Farid Mohammad Hosseini, Ali Mohammadi, Behzad Mansoori, Gholamreza Dehghan, Behzad Baradaran, Nader Sheibani
Summary: Lipid-based nanoparticles are used as drug delivery carriers for anti-cancer therapies. By modifying the nanoparticles with specific ligands, they can be recognized by receptors on cancer cells and internalized, enhancing the uptake of desired drugs. The cellular uptake of these nanoparticles is influenced by their physical and chemical properties, as well as the internalization pathways utilized by cells.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pediatrics
Olachi J. Mezu-Ndubuisi, Yong-Seok Song, Erica Macke, Hailey Johnson, Ginika Nwaba, Akihiro Ikeda, Nader Sheibani
Summary: The study investigated the expression of Vegfa isoforms during oxygen-induced ischemic retinopathy (OIR), revealing that Vegfa(164a), Vegfa(164b), and Vegfr1 were overexpressed in OIR mice, leading to abnormal signaling and angiogenesis. Further research into the mechanisms of Vegf dysregulation may lead to novel therapies for ROP and other proliferative retinopathies.
PEDIATRIC RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Mina Hajizadeh, Zainab Moosavi-Movahedi, Nader Sheibani, Ali A. Moosavi-Movahedi
Summary: This review investigates the importance of suicide enzyme inhibition in drug design, treatment, and industrial applications. The development of biomimetic artificial enzymes to prevent inhibition and the classification of suicide enzyme inactivation classes based on target enzyme groups were highlighted as key points to address severe diseases.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Infectious Diseases
Ashutosh Arun, Kayla J. Rayford, Ayorinde Cooley, Tanu Rana, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria F. Lima, Nader Sheibani, Pius N. Nde
Summary: The protozoan parasite Trypanosoma cruzi uses the Wnt/beta-catenin and Hippo signaling pathways to infect host cells, with the protein TSP1 playing an important role. In the absence of TSP1, parasite infection leads to increased nuclear colocalization of beta-catenin/YAP, and inhibiting the beta-catenin pathway can significantly reduce parasite infectivity.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biology
Shoujian Wang, Ismail S. Zaitoun, Soesiawati R. Darjatmoko, Nader Sheibani, Christine M. Sorenson
Summary: Inflammation plays a crucial role in the pathogenesis of nAMD, and the expression of Bim is important for resolving inflammation.
Article
Biotechnology & Applied Microbiology
Sedigheh Abedanzadeh, Zainab Moosavi-Movahedi, Nader Sheibani, Ali A. Moosavi-Movahedi
Summary: This passage introduces nanozymes as alternatives to natural enzymes in industrial, medical, and biological fields, with a focus on designing enzyme models based on supramolecular scaffolds and the importance of supramolecular chemistry in understanding enzyme mechanisms.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Christine M. Sorenson, Mitra Farnoodian, Shoujian Wang, Yong-Seok Song, Soesiawati R. Darjatmoko, Arthur S. Polans, Nader Sheibani
Summary: This paper investigates the potential of using S1PR agonists to inhibit choroidal neovascularization. Through in vitro and in vivo experiments, it is confirmed that S1PR1 is the most abundantly expressed receptor in choroidal endothelial cells and S1PR agonists can significantly suppress choroidal neovascularization. These findings suggest a potential new application for S1PR agonists in the treatment of nAMD and other inflammation-related diseases.
Article
Biochemistry & Molecular Biology
Yong-Seok Song, Ismail S. Zaitoun, Shoujian Wang, Soesiawati R. Darjatmoko, Christine M. Sorenson, Nader Sheibani
Summary: CYP1B1 expression in the retina is crucial for maintaining cellular redox homeostasis. Its metabolism of 17β-estradiol affects iron metabolism and lipid peroxidation, leading to iron accumulation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yong-Seok Song, Nasim Jamali, Christine M. M. Sorenson, Nader Sheibani
Summary: The integrity of retinal endothelial cell (EC) is crucial for maintaining retinal blood barrier and proper vision. Vitamin D, mainly mediated through the vitamin D receptor (VDR), plays a protective role in EC function. However, little is known about the impact of vitamin D-VDR on retinal EC function and ocular angiogenesis and inflammation. In this study, using retinal EC from VDR-deficient mice, the authors found that VDR expression is essential for endothelial cell-cell and cell-matrix interactions, as well as proliferation, migration, and inflammatory response of retinal EC. Furthermore, VDR deficiency leads to down-regulation of endothelial nitric oxide synthetase, enhanced hepcidin expression, and increased intracellular iron levels, contributing to the altered angiogenic and inflammatory state of retinal EC.
Article
Environmental Sciences
Nesa Hamidian, Gholamreza Dehghan, Samaneh Rashtbari, Alireza Khataee, Mehdi Khoobi, Nader Sheibani
Summary: A magnetite/Gd3+/beta-cyclodextrin nanoplatform was prepared and used for the degradation of tetracycline. The nanoplatform showed higher peroxidase-mimic activity than natural enzymes. It was able to degrade tetracycline efficiently and could be reused.
Article
Endocrinology & Metabolism
Subramanian Dharmarajan, Casandra Carrillo, Zhonghua Qi, Jonathan M. Wilson, Anthony J. Baucum II, Christine M. Sorenson, Nader Sheibani, Teri L. Belecky-Adams
Summary: This study aimed to investigate the impact of chronic inflammation on the loss of pericytes in early diabetic retinopathy. The results showed that both type 1 and type 2 diabetes led to similar progression of retinal pericyte loss and gliosis. However, the expression of inflammatory factors differed between the two diabetes models, with peak expression occurring at different ages. Additionally, retinal vascular changes were more severe in the type 2 diabetes model. Chronic exposure of retinal pericytes to IFN gamma resulted in decreased PDGFR beta signaling and increased levels of active PKC delta and CC3, indicating increased pericyte apoptosis.
Article
Biochemistry & Molecular Biology
Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N'Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate
Summary: This study reveals the regulation of bone marrow cells by polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products through the aryl hydrocarbon receptor (AhR). The absence of Cyp1b1 and activation of AhR by PAH result in similar gene stimulations in these cells. Specific sources of Cyp1b1 are found to be linked to AhR and an OLFR network to modulate BM inflammation through diverse microbiome products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Ophthalmology
Yong-Seok Song, Ismail Zaitoun, Christine M. Sorenson, Nader Sheibani
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Collin Goebel, Ismail Zaitoun, Heather Potter, Nader Sheibani
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Mohamed Al-Sayed Al-Shabrawey, Amany M. Tawfik, Nader Sheibani, Mong Wang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
