Article
Polymer Science
Anna A. Dokuchaeva, Aleksandra B. Mochalova, Tatyana P. Timchenko, Kseniya S. Podolskaya, Oxana A. Pashkovskaya, Elena V. Karpova, Ilya A. Ivanov, Natalya A. Filatova, Irina Yu Zhuravleva
Summary: This study observed the hemodynamic and structural properties of electrospun, monolayered poly-epsilon-caprolactone (PCL) grafts in an in vivo experiment using a rat aorta replacement model. The results showed that PCL grafts maintained patency without stenosis or thrombosis throughout the follow-up period. The advantages of PCL scaffolds include excellent endothelialization and good surgical outcome, while the disadvantages include slow biodegradation, ineffective cellularization, and risks for mineralization and intimal hyperplasia.
Article
Pharmacology & Pharmacy
Yanping Zhang, Alice Le Friec, Menglin Chen
Summary: The study demonstrates the effectiveness of using anisotropic scaffolds along with electrical stimulation to promote elongation and maturation of muscle cells. The alignment and elongation of myotubes were significantly enhanced under electrical stimulation on the anisotropic scaffold, providing a promising platform for skeletal muscle tissue engineering.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Polymer Science
Guoxu Zhao, Hongwei Zhou, Guorui Jin, Birui Jin, Songmei Geng, Zhengtang Luo, Zigang Ge, Feng Xu
Summary: This review comprehensively discusses the importance of conductive biomaterials in tissue engineering and regenerative medicine applications, highlighting their role in regulating the biological functions of cells, tissues, and organs. Furthermore, it emphasizes the advanced electrical functionalities of conductive biomaterials in promoting the regeneration of excitable tissues.
PROGRESS IN POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Reza Karimi-Soflou, Iman Shabani, Akbar Karkhaneh
Summary: The design of antioxidant and electroconductive Alg-PPy/PLL hydrogels for treating neurodegenerative disorders is discussed. These hydrogels showed great potential for enhancing healing efficiencies due to their antioxidant effects and versatile features. The introduction of PPy enhanced the antioxidant activity of the hydrogels, while PLL provided excellent stem cell differentiation ability. Furthermore, the morphology, porosity, antioxidant activity, rheological behavior, and conductive characteristics of the hydrogels could be precisely adjusted by altering the amount of PPy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
David Sonnleitner, Natascha Schaefer, Annalena Wieland, Lena Fischer, Patrick Pasberg, Ingo Thievessen, Gregor Lang
Summary: This study presents a completely novel morphology of dumbbell-shaped PCL micro-particles, which combines structural features of fibers and spheres and has great potential in medical applications. The complex structures can be achieved by balancing parameters and spinning dope compositions, allowing for precise control over the aspect ratio of the particles and significantly enhanced cell adhesion.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Maryam Zarei, Abdolreza Samimi, Mohammad Khorram, Mahnaz M. Abdi, Seyyed Iman Golestaneh
Summary: The conductive electrospun nanofiber scaffold containing polypyrrole was fabricated to accelerate tissue healing, with polypyrrole dispersed perfectly in the fibers and enhancing their conductivity up to 164.274 x 10(-3) s/m. The nanofibers with 10% polypyrrole showed better cell adhesion, growth, and proliferation properties, making them suitable for various tissue applications and particularly appropriate for body parts with electrical signals such as cardiovascular, heart muscles, or nerves.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Filipe Miguel, Frederico Barbosa, Frederico Castelo Ferreira, Joao Carlos Silva
Summary: Articular cartilage is a crucial tissue for healthy joint motion, but its limited regenerative capacities and degeneration are major causes of disability worldwide. Tissue engineering, particularly with hydrogels, offers a promising approach to create cartilage substitutes. Hydrogels can be customized to match the properties of native cartilage and combined with conductive materials to simulate its electrochemical properties. This review highlights the common conductive materials combined with hydrogels, their applications, and the current research on electrically conductive hydrogels for cartilage tissue engineering, as well as the challenges and future perspectives in repairing articular cartilage.
Article
Biochemistry & Molecular Biology
Jingjing Tian, Thomas E. Paterson, Jingjia Zhang, Yingxing Li, Han Ouyang, Ilida Ortega Asencio, Paul V. Hatton, Yu Zhao, Zhou Li
Summary: The infection of implanted biomaterial scaffolds is a challenging issue, and traditional treatment methods are becoming less practical. In this study, a novel PCL scaffold functionalized with ZnO nanowires was developed and characterized. The results showed that the ZnO nanowires were successfully incorporated into the scaffold, and it exhibited excellent antibacterial properties and biocompatibility, making it a promising choice for implanted scaffolds in tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Abdel H. Mahmoud, Yuanyuan Han, Renan Dal-Fabbro, Arwa Daghrery, Jinping Xu, Darnell Kaigler, Sarit B. Bhaduri, Jos Malda, Marco C. Bottino
Summary: In this study, highly innovative nanoscale beta-tricalcium phosphate (β-TCP)-laden gelatin methacryloyl/polycaprolactone (GelMA/PCL-TCP) photocrosslinkable composite fibrous membranes were fabricated via electrospinning for guided bone regeneration (GBR). The composite microfibers showed a uniform porous network and successful integration of β-TCP particles. The GelMA/PCL-TCP membranes exhibited enhanced cell attachment, proliferation, mineralization, and osteogenic gene expression in alveolar bone-derived mesenchymal stem cells (aBMSCs) compared to pure PCL and GelMA/PCL. Furthermore, the GelMA/PCL-TCP membrane promoted robust bone regeneration in rat calvarial critical-size defects, demonstrating remarkable osteogenesis compared to PCL and GelMA/PCL groups. Overall, the electrospun GelMA/PCL-TCP composite showed great potential as a promising membrane for guided bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Marcus Himmler, Dirk W. Schubert, Thomas A. Fuchsluger
Summary: The study analyzed the light transmission through electrospun PCL scaffolds and its impact on the transparency of nanofibrous scaffolds. Results showed that scaffold thickness, fiber diameter, and surrounding medium play crucial roles in light transmission. Smaller fiber diameter and matching refractive indices help improve light transmission.
Review
Multidisciplinary Sciences
Louie Scott, Katrin Elidottir, Kamalan Jeevaratnam, Izabela Jurewicz, Rebecca Lewis
Summary: Electrical conductivity is important for cardiac tissue engineering and can mimic cardiac pacing. Carbon nanotubes are commonly used as conductive agents in biomaterials, and rodent-sourced cell types are commonly used for cardiomyocytes. The addition of electrical stimulation to in vitro culture has proven to be a powerful tool for creating optimal artificial cardiac tissue constructs.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Megane Beldjilali-Labro, Rachid Jellali, Alexander David Brown, Alejandro Garcia Garcia, Augustin Lerebours, Erwann Guenin, Fahmi Bedoui, Murielle Dufresne, Claire Stewart, Jean-Francois Grosset, Cecile Legallais
Summary: The goal of this study was to design and evaluate a multi-scale scaffold for promoting the differentiation of C2C12 skeletal myoblasts. The researchers found that the scaffold had tunable mechanical properties and improved the alignment and length of myotubes, leading to enhanced organization of reconstructed skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Fatemeh Asghari, Davood Rabiei Faradonbeh, Ziba Veisi Malekshahi, Houra Nekounam, Behnaz Ghaemi, Yaser Yousefpoor, Hossein Ghanbari, Reza Faridi-Majidi
Summary: In this study, a new hybrid nanofibrous scaffold composed of polycaprolactone/chitosan-polyethylene oxide (PCL/Cs-PEO) incorporated with Arnebia euchroma (A. euchroma) extract was synthesized by the two-nozzle electrospinning method. The scaffold showed improved and increased proliferation of skin cells in vitro, confirming its potential for skin tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Yubo Shi, Lei Wang, Liguo Sun, Zhennan Qiu, Xiaoli Qu, Jingyi Dang, Zhao Zhang, Jiankang He, Hongbin Fan
Summary: Melt electrospinning writing (MEW) is a promising 3D printing technology for scaffold fabrication. This study investigated the use of NaOH treatment to enhance the cytocompatibility and osteoinductive properties of polycaprolactone (PCL) scaffolds. The NaOH-treated PCL scaffold exhibited nanopits and nanogrooves on the surface, which increased surface roughness and wettability, leading to improved cell proliferation and adhesion. In vitro experiments demonstrated that the NaOH-treated surface could induce osteogenic differentiation of bone marrow mesenchymal stem cells via the integrin alpha 2/beta 1-PI3K-Akt signaling pathway. Animal studies showed that the NaOH-treated PCL scaffold promoted new bone formation. The study concluded that NaOH treatment is a simple and effective method to enhance the cellular affinity and osteoinductive property of MEW PCL scaffolds.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Polymer Science
Yan Chen, George Z. Tan, Yingge Zhou
Summary: This study utilized core-sheath electrospinning to fabricate nanoporous microtubes that mimic native capillaries, with high viscosity PCL/PEO ratio of 3:1 resulting in the largest microtube diameter and pore size. These microtubes demonstrate great potential in tissue vascularization for engineered scaffolds.
Article
Materials Science, Multidisciplinary
Bolun Sun, Xiang Li, Rui Zhao, He Ji, Ju Qiu, Nan Zhang, Dayong He, Ce Wang
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Chemistry, Physical
Nan Zhang, Rui Zhao, Dayong He, Yuying Ma, Ju Qiu, Changxian Jin, Ce Wang
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Engineering, Environmental
Rui Zhao, Tingting Ma, Shuai Zhao, Huazhen Rong, Yuyang Tian, Guangshan Zhu
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Nanoscience & Nanotechnology
Tingting Ma, Rui Zhao, Zhangnan Li, Xiaofei Jing, Muhammad Faheem, Jian Song, Yuyang Tian, Xijuan Lv, Qinghai Shu, Guangshan Zhu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Rui Zhao, Tingting Ma, Fengchao Cui, Yuyang Tian, Guangshan Zhu
Article
Nanoscience & Nanotechnology
Rui Zhao, Xiaoyuan Shi, Tingting Ma, Huazhen Rong, Ziyang Wang, Fengchao Cui, Guangshan Zhu, Ce Wang
Summary: Researchers constructed interconnected mesopores in electrospun zeolitic imidazolate framework-8 (ZIF-8)/polyacrylonitrile (PAN) fibers with the assistance of poly(vinylpyrrolidone) to expose more adsorption sites and improve stability. The obtained fibers showed faster adsorption kinetics and larger adsorption capacity for antibiotic tetracycline removal compared to other strategies, demonstrating great potential for antibiotic drug removal.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Dingyang Chen, Qing Bai, Tingting Ma, Xiaofei Jing, Yuyang Tian, Rui Zhao, Guangshan Zhu
Summary: In this study, zeolite bead-supported ZIF-67 composites were prepared and utilized for the activation of PMS to remove tetracycline from water. The obtained composites exhibited high catalytic activity, recycling stability, and effective removal of tetracycline in a continuous flow process.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Tingting Ma, Rui Zhao, Jian Song, Xiaofei Jing, Yuyang Tian, Guangshan Zhu
Summary: Extraction of gold from e-waste is a promising method for environmental remediation, but cost-ineffective for normal usages. Direct conversion of gold from e-waste to higher value materials is advantageous. In this study, a porous aromatic framework (PAF) called iPAF-7 was synthesized and demonstrated rapid extraction of gold from e-waste. An aerogel monolith incorporating iPAF-7 was also successfully fabricated, showing potential for continuous-flow catalysis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Rui Zhao, Dingyang Chen, Nvwa Gao, Liyong Yuan, Wei Hu, Fengchao Cui, Yuyang Tian, Weiqun Shi, Shengqian Ma, Guangshan Zhu
Summary: A fibrous adsorbent, called porous cationic electrospun fibers (PCE fibers), was successfully prepared and exhibited excellent performance in removing radioactive technetium-99. It showed fast adsorption kinetics, high adsorption capacity, and good selectivity for the target pollutant.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Dingyang Chen, Tingting Ma, Xinyue Zhao, Xiaofei Jing, Rui Zhao, Guangshan Zhu
Summary: This study presents a novel electrospun fiber adsorbents with high efficiency for capturing iodine species. The adsorbents can effectively remove iodine from both saturated iodine solution and iodide solution. The high iodine uptake capacity is attributed to the multiple active sites on the adsorbents, which exhibit high binding affinity towards iodine species through physical and chemical adsorption. Additionally, the adsorbents can be used as an adsorption column for dynamic iodine capture due to their macroscopic architecture.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Tingting Ma, Zhangnan Li, Rui Zhao, Jian Song, Yuyang Tian, Shuang Ding, Guangshan Zhu
Summary: The study demonstrated effective extraction and sustainable utilization of palladium by modifying a cyclic molecule on a nanoporous aromatic framework, showing good adsorption capacity and catalytic activity.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Environmental
Dingyang Chen, Zhaoli Liu, Shuying Li, Xiaofei Jing, Yuyang Tian, Wei Hu, Fengchao Cui, Rui Zhao, Guangshan Zhu
Summary: Developing efficient cationic adsorbents for the removal of radioactive pertechnetate (99TcO4-) from water is highly significant in the fields of nuclear fuel management and nuclear-related environmental treatment. In this study, novel cationic electrospun nanofibers were synthesized, which exhibited satisfying adsorption performance for nonradioactive perrhenate (ReO4-) ions. The adsorbents showed high adsorption capacity, fast kinetics, good removal depth, large dynamic column adsorption volume, and excellent capture from solution with high ionic strength or acidity/alkalinity, surpassing existing adsorbents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Dingyang Chen, Xinyue Zhao, Xiaofei Jing, Rui Zhao, Guangshan Zhu, Ce Wang
Summary: The development of efficient adsorbents with anti-biofouling properties for uranium extraction from seawater is highly attractive. Inspired by the structures of phospholipid, the bio-inspired zwitterionic phosphate groups were created onto the electrospun nanofibers to manipulate the affinity with uranium and the anti-biofouling property. The constructed hyperbranched zwitterionic phosphate groups functionalized nanofiber adsorbents (ZP-PAN fibers) exhibited high distribution coefficient k(d) (7.38 x 10(6) mL/g) and large adsorption capacity (1294.0 mg g(-1)) in the uranium-spiked seawater, surpassing most of reported polymeric adsorbents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Rui Zhao, Yuyang Tian, Shuying Li, Tingting Ma, Hengtao Lei, Guangshan Zhu
JOURNAL OF MATERIALS CHEMISTRY A
(2019)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)