Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 76, Issue -, Pages 944-950Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.03.131
Keywords
Cetuximab; Silica nanoparticles; Doxorubicin; Liver cancer
Categories
Funding
- Chinese National Natural Science Foundation [81473131]
- Science & Technology Planning Project of Guangdong Province [2016A020217012]
- Science & Technology Planning Project of Guangzhou [2016201604030039]
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In the present study, we successfully developed a preferable doxorubicin (Dox) loaded drug delivery system based on Cetuximab and silica nanoparticles (Cet-SLN/Dox). By employing the tumor homing property of Cetuximab and the drug-loading capability of silica nanoparticles, the prepared Cet-SLN/Dox was able to load Dox to achieve the co-delivery of two drugs (Cetuximab and Dox). In vitro analysis revealed that Cet-SLN/Dox was nano-sized particles with decent drug loading capabilities and smart drug release profile. Further studies demonstrated that Cet-SLN/Dox was superior in tumor-homing and anti-cancer efficiency than Cetuximab free SLN/Dox and free Dox, possibly due to EGFR mediated endocytosis and the combined anti-cancer effects of Cetuximab and Dox within Cet-SLN/Dox. (C) 2017 Published by Elsevier B.V.
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