Article
Chemistry, Multidisciplinary
Francesca Cestari, Francesca Agostinacchio, Anna Galotta, Giovanni Chemello, Antonella Motta, Vincenzo M. Sglavo
Summary: The study investigated the synthesis of bioactive calcium phosphates using different biogenic calcium carbonates and their effects on cell adhesion and proliferation. The phase composition and densification of the sintered materials were found to be influenced by the source of CaCO3 and sintering temperature. Preliminary in vitro tests showed good cell adhesion and proliferation, with variations observed among different materials.
Article
Chemistry, Applied
Katherine A. Pitrolino, Reda M. Felfel, Laura Macri Pellizzeri, Jane McLaren, Alexander A. Popov, Virginie Sottile, Colin A. Scotchford, Brigitte E. Scammell, George A. F. Roberts, David M. Grant
Summary: An innovative multi-layered chitosan scaffold was developed for repairing osteochondral defects, with a distinct gradient of pore size and the addition of nanohydroxyapatite for strength. The scaffold exhibited good mechanical performance under loading, supported attachment and proliferation of human mesenchymal stem cells, and facilitated osteogenic and chondrogenic differentiation in specific layers.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Ceramics
Wen-Fan Chen, Yu-Sheng Tseng, Yu-Man Chang, Ji Zhang, Yun-Han Su, Zhi-Hong Wen, Dorian Amir Henry Hanaor, Wen-Hsin Hsu, Cheng-Tang Pan
Summary: Mixed phase materials in the quasi-binary diopside - molybdite system were synthesized by a precipitation method, with the diopside content decreasing and molybdite content increasing result in lower hardness and bioactivity, while decreasing the capability to form HAp. The addition of molybdite lowered the ability of mixed phase CaMgSi2O6 - MoO3 bioceramics to form HAp.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Ceramics
Hamisah Ismail, Muhammad Naif Zakwan Zakri, Hasmaliza Mohamad
Summary: This study aimed to fabricate and characterise beta-wollastonite/cordierite scaffolds using the gel casting method, and investigated the effect of cordierite composition on the properties of the scaffolds. The results showed that the W3C7 scaffolds had the best composition for fabricating porous scaffolds.
CERAMICS INTERNATIONAL
(2022)
Article
Polymer Science
Lokesh Kumar, Dheeraj Ahuja
Summary: This article reports the development of bio nano composites as supportive structures for osteogenic cells in bone tissue engineering. The developed nano composites have open and interconnected pores, promoting cell growth and showing potential for rapid tissue regeneration.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
N. Valarmathi, K. Sasikumar, S. Sumathi, Ankita Das, Amit Kumar Jaiswal
Summary: Zinc substituted hydroxyapatite (Zn-HAP) with different weight ratios of polymer composite was synthesized and characterized. The increase in zinc content led to higher porosity and mechanical strength in the composite materials, while maintaining excellent biocompatibility and bioactivity.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Ceramics
Ammar Z. Alshemary, Rafaqat Hussain, Ali Deniz Dalgic, Zafer Evis
Summary: Hydroxyapatite (HA) particles with enhanced antibacterial properties can be prepared by integrating metal ions into the crystal structure of the nanoparticles. The HA particles containing cobalt and silicate ions exhibited reduced crystallite size, inhibited bacterial growth, and showed cytocompatibility, suggesting their potential applications in biomaterial-tissue engineering.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Hongyu Zhao, Hongyu Xing, Qingguo Lai, Tianxiang Song, Xiaopeng Tang, Kaiwen Zhu, Yanwei Deng, Yun Zhao, Weihua Liu, Runqi Xue
Summary: In this study, columnar beta-Si3N4 and La3+/Y3+ sintering aid were utilized to prepare beta-Si3N4/HA composite biomaterials, which showed excellent mechanical properties and promoted adhesion, proliferation, and osteogenic differentiation of osteoblast. The concentration range of La3+ from 4x10(-8) M to 6 x 10(-8)M was beneficial to cell proliferation and osteogenic differentiation.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Lu Wang, Jing Lian, Yijing Xia, Yanqin Guo, Changzhen Xu, Yufang Zhang, Jie Xu, Xinsong Zhang, Bing Li, Bin Zhao
Summary: In this study, silk fibroin/nano-hydroxyapatite/graphene oxide composite scaffolds with directional channels were prepared and systematically studied. The directed channel scaffolds showed better connectivity, porosity, degradation rate for osteogenesis, and ability to induce bone-like apatite. They were also more beneficial to the adhesion and proliferation of bone marrow mesenchymal stem cells, and exhibited stronger biological activity and osseointegration ability. Therefore, this material has great potential in repairing bone tissue defects.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biochemistry & Molecular Biology
Pardis Keikhosravani, Hossein Maleki-Ghaleh, Amir Kahaie Khosrowshahi, Mahdi Bodaghi, Ziba Dargahi, Majid Kavanlouei, Pooriya Khademi-Azandehi, Ali Fallah, Younes Beygi-Khosrowshahi, M. Hossein Siadati
Summary: The study biofunctionalized hydroxyapatite (HA) properties by doping it with lithium (Li) to enhance its bioactivity, and concluded that 1.0 wt.% Li doping was optimal for maximizing the bioactivity of HA. Furthermore, the experiment demonstrated that HA doped with Li exhibited enhanced antibacterial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zong-Ju Chen, Hui-Hong Shi, Liang Zheng, Hua Zhang, Yu-Ying Cha, Hui-Xian Ruan, Yi Zhang, Xiu-Cheng Zhang
Summary: The composite aerogel with a dual network structure composed of sheet-like silk fibroin and reticular cellulose wrapping nano-hydroxyapatite on the surface showed high mechanical strength and toughness. In vitro cell culture demonstrated that HEK-293T cells had a high ability of adhesion, proliferation and differentiation on the composite aerogels, indicating potential application in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Hayriye Ertek Emre, Sennur Arslan
Summary: The study found that increasing the laser welding speed and reducing the heat input positively affected the bioactivity and biocorrosion features of Ti6Al4V laser welded joints, exhibiting better biocorrosion behavior with higher welding speeds and lower heat inputs.
METALS AND MATERIALS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Chander Prakash, Gurmider Singh, Sunpreet Singh, W. L. Linda, H. Y. Zheng, Seeram Ramakrishna, Roger Narayan
Summary: The study focused on investigating the mechanical reliability and in vitro bioactivity of 3D printed PLA/HA porous scaffolds. Various factors such as HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus were studied to analyze their effect on mechanical properties. The results showed a strong influence of processing parameters on mechanical properties and excellent growth of osteoplastic cells in vitro, along with the mechanical reliability of the printed porous scaffolds demonstrated by Weibull distribution.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2021)
Article
Materials Science, Multidisciplinary
Hamid Ait Said, Hassan Noukrati, Hicham Ben Youcef, Ismail Mahdi, Hassane Oudadesse, Allal Barroug
Summary: Hydroxyapatite-chitosan composites loaded with ciprofloxacin antibiotic were successfully formulated and showed enhanced compressive strength and sustained release of ciprofloxacin. The composites also exhibited good antibacterial effects against Staphylococcus aureus and Escherichia coli bacteria.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Francesco De Angelis, Mirco Vadini, Matteo Buonvivere, Antonio Valerio, Michele Di Cosola, Adriano Piattelli, Virginia Biferi, Camillo D'Arcangelo
Summary: Recent studies show that graphene incorporation in dental materials improves their mechanical properties but may not be superior to traditional materials in terms of hardness and mechanical response to compressive stress. In this study, the flexural strength, compressive strength, and hardness of a graphene-reinforced resin, a conventional resin, and a bis-acryl composite resin were compared. Flexural strength did not differ significantly among the materials. However, the conventional resin had a higher flexural modulus and stiffness compared to the graphene-reinforced resin. The hardness of the conventional resin was significantly higher than that of the graphene-reinforced resin and the traditional resin.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
