Article
Engineering, Biomedical
Wei Guo, Haichao Liu, Jiaxing Zhang, Jianzhong Zhang, Fei Wang, Peng Zhang, Yunbo Yang
Summary: This study developed a composite hydrogel that can increase the residence time of drugs in the bladder, improving the therapeutic effect. The hydrogel also showed good biocompatibility and antibacterial properties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biotechnology & Applied Microbiology
Jiangjiang Ru, Qian Zhang, Shaowei Zhu, Junrong Cai, Yunfan He, Feng Lu
Summary: The study found that HEP-ADGF-AAM, a surface-modified heparin-loaded acellular adipose matrix (AAM) containing adipose-derived growth factors (ADGFs), can promote wound healing. HEP-ADGF-AAM not only induced adipocyte regeneration but also enhanced fibroblast migration, promoted vessel formation, accelerated wound closure, and enhanced wound epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
D. Cai, S. Chen, B. Wu, J. Chen, D. Tao, Z. Li, Q. Dong, Y. Zou, Y. Chen, C. Bi, D. Zu, L. Lu, B. Fang
Summary: The study developed a dermal extracellular matrix hydrogel loaded with vancomycin as a novel approach for treating skin defects and controlling hemorrhage, showing rapid release of antimicrobial agents, promotion of wound healing, and effective antibacterial and hemostatic effects in in vivo experiments.
MATERIALS TODAY BIO
(2021)
Article
Biotechnology & Applied Microbiology
Shuwei Xiao, Pengchao Wang, Jian Zhao, Zhengyun Ling, Ziyan An, Zhouyang Fu, Weijun Fu, Jin Zhou, Xu Zhang
Summary: Bladder patches constructed with BAM and ASCs were incubated with omentum for bladder reconstruction, showing that the BAM-ASCs group could regenerate bladder wall structure better. ASCs could promote the regeneration of smooth muscle, neurons, and blood vessels, and restore physiological functions in the bladder.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fabio Camacho-Alonso, Nuria Garcia-Carrillo, Antonio Julian Buendia, Jose Antonio Navarro, David Penarrocha-Oltra, Miguel Penarrocha-Diago, Jose Lacal-Lujan
Summary: The study demonstrates that using porcine AUBM and neonatal myoblasts is an effective treatment for regenerating lingual musculature in hemiglossectomized rats, showing positive outcomes in terms of weight gain, tissue occupation, and antibody positivity.
Article
Biochemistry & Molecular Biology
Hyeon Jin Ju, Yun Bae Ji, Shina Kim, Hee-Woong Yun, Jae Ho Kim, Byoung Hyun Min, Moon Suk Kim
Summary: This study aims to develop an injectable hydrogel scaffold using a porcine cartilage-derived acellular matrix (CAM). The CAM is cross-linked with a biocompatible polyethylene glycol (PEG) cross-linker to replace glutaraldehyde (GA) cross-linker. The injectable Cx-CAM-PEG suspension shows controllable rheological properties and injectability. The in vivo formed Cx-CAM-PEG hydrogel scaffold exhibits host-cell infiltration and minimal inflammation, making it a potential candidate for (pre-)clinical scaffolds.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Tsong-Hann Yu, Tsu-Te Yeh, Chen-Ying Su, Ni-Yin Yu, I-Cheng Chen, Hsu-Wei Fang
Summary: This study prepared acellular cartilage matrix (ACM) powder through decellularization method and developed ACM hydrogels. The results showed that ACM hydrogels had good gel conditions, retained main components of cartilage, and exhibited good gelation and adhesive properties.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Alexey A. Ivanov, Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, Oleg O. Yanushevich
Summary: Cell-free therapy has rapidly developed in regenerative medicine over the past decade, aiming to control and enhance tissue repair processes by understanding molecular mechanisms and signaling pathways. The concept of endogenous regenerative medicine, involving the recruitment/homing of endogenous stem cells, has advantages in overcoming limitations and risks associated with cell therapy. Cell-free products such as decellularized extracellular matrix, growth factors, extracellular vesicles, and miRNAs show potential in endogenous bone and dental regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Massimo Garriboli, Koichi Deguchi, Giorgia Totonelli, Fanourios Georgiades, Luca Urbani, Marco Ghionzoli, Alan J. Burns, Neil J. Sebire, Mark Turmaine, Simon Eaton, Paolo De Coppi
Summary: A protocol for creating a natural-derived bladder extracellular matrix (BEM) was established for developing tissue-engineered bladder, and its structural and functional characteristics were investigated. The results showed that BEM retained structural characteristics, increased strength and stiffness, and had better compliance compared to native tissue, as well as angiogenic potential. These findings suggest the potential use of BEM for developing tissue-engineered bladder for patients requiring bladder augmentation.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Maobin Xie, Liming Lian, Xuan Mu, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Zhenrui Zhang, Arturo Lopez, Jennifer Manriquez, Xiao Kuang, Junqi Wu, Jugal Kishore Sahoo, Federico Zertuche Gonzalez, Gang Li, Guosheng Tang, Sushila Maharjan, Jie Guo, David L. Kaplan, Yu Shrike Zhang
Summary: This study demonstrates the rapid volumetric printing of unmodified silk sericin and silk fibroin inks, which exhibit shape-memory and tuneable mechanical properties. The inks are cytocompatible, providing expanded bioink libraries for volumetric additive manufacturing and offering potential for diverse biomedical applications.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Jules D. Allbritton-King, Megan Kimicata, John P. Fisher
Summary: The study investigates a graded-concentration hydrogel composed of porcine urinary bladder matrix (UBM) for potential chronic wound treatment, showing stability, cellular activity, and resistance to fibroblast-mediated contraction. The gradient hydrogel maintained cross-sectional area during degradation and supported high surface cell viability, leveraging the unique advantages of high and low-concentration ECM hydrogels.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Marta Pokrywczynska, Arkadiusz Jundzill, Jakub Tworkiewicz, Monika Buhl, Daria Balcerczyk, Jan Adamowicz, Tomasz Kloskowski, Marta Rasmus, Kaja Mecinska-Jundzill, Damian Kasinski, Malgorzata Frontczak-Baniewicz, Marcin Holysz, Joanna Skopinska-Wisniewska, Magdalena Bodnar, Andrzej Marszalek, Paulina Antosik, Dariusz Grzanka, Tomasz Drewa
Summary: The study evaluated the utility of bladder acellular matrix (BAM) for reconstructing large urinary bladder wall defects in a long-term porcine model. Six out of ten animals survived the 6-month follow-up, with four dying due to scaffold failure or other complications. Reconstructed bladders showed normal function with lower expression of urothelial, smooth muscle, blood vessel, and nerve markers compared to the native bladder.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Polymer Science
Huynh-Quang-Dieu Nguyen, Chen-Yu Kao, Chien-Ping Chiang, Yu-Han Hung, Chun-Min Lo
Summary: This study investigates the immunomodulatory properties of extracellular matrix (ECM) and mesenchymal stem cells (MSCs). The results show that degradation products from porcine bladder ECM can reduce inflammation and increase the production of anti-inflammatory cytokines from macrophages. MSCs cultured on the ECM hydrogel demonstrate immunomodulatory properties at both gene and protein levels. The findings provide a basis for further research on immunomodulation therapy.
Review
Biochemistry & Molecular Biology
Marcin Gierek, Wojciech Labus, Diana Kitala, Andrzej Lorek, Gabriela Ochala-Gierek, Karolina Mikus Zagorska, Dariusz Waniczek, Karol Szyluk, Pawel Niemiec
Summary: Reconstructive surgery often deals with large tissue defects and requires materials that are both immunogenic but offer tissue filling. ADM, an acellular dermal matrix, is a commonly used biological collagen matrix without immunogenicity. This literature review examines the use of human ADM in reconstructive surgery across different fields, emphasizing the need for further research in this area.
Article
Materials Science, Biomaterials
Suna Fan, Kai Chen, Wei Yuan, Dongliang Zhang, Siqing Yang, Ping Lan, Lujie Song, Huili Shao, Yaopeng Zhang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Lihong Geng, Yuhua Cai, Li Lu, Yaopeng Zhang, Yanxiang Li, Binyi Chen, Xiang-Fang Peng
Summary: Composite filaments of lignin and cellulose nanofibers were fabricated using microfluidic spinning technique, resulting in bio-based carbon fibers with high tensile strength and electrical conductivity after stabilization and carbonization. The hierarchical assembly and in situ interfacial complexation played a key role in achieving the superior mechanical and electrical performance of the fibers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Ao Zhuang, Qichao Pan, Ying Qian, Suna Fan, Xiang Yao, Lujie Song, Bo Zhu, Yaopeng Zhang
Summary: A transparent conductive RSF/PEDOT-OH film was successfully developed in this study, overcoming the trade-off between transparency and the electroconductive property with a composite oxidant recipe and electrostatic interaction of oppositely charged doping ions. The film exhibited good conductivity, transparency, strong adhesion to RSF, and favorable electrochemical stability, allowing real-time observation of live cells and improved adhesion and differentiation of PC12 cells compared to RSF surface alone.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Materials Science, Composites
Menglu Zhao, Yanan Geng, Suna Fan, Xiang Yao, Meifang Zhu, Yaopeng Zhang
Summary: In this study, a strong customized dental crown was successfully prepared using high-viscosity hybrid paste and direct ink writing 3D printing technology, demonstrating low shrinkage ratio and superior mechanical properties. The printed samples showed higher flexural strength and compressive strength compared to traditional molding counterparts.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Yi Zhang, Fang Han, Suna Fan, Yaopeng Zhang
Summary: A silk fibroin-based memristor with low power and low operating current has been developed through doping with Ag and ethanol-based post-treatment, enhancing stability and transport performance. The space-charge-limited conduction mechanism is observed in SF-based memristors with different Ag contents, showing potential applications in bioelectronics.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Chun-Fei Hu, Zhi-Gang Qian, Qingfa Peng, Yaopeng Zhang, Xiao-Xia Xia
Summary: Spider dragline silk is a remarkable fiber made by spiders from an aqueous solution of spidroins, and the synergizing role of terminal domains in the storage and processing of recombinant analogues into tough synthetic fibers has been highlighted in this study.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Li Lu, Suna Fan, Lihong Geng, Jinyou Lin, Xiang Yao, Yaopeng Zhang
Summary: The study investigates the orientation and alignment of fibers spun through a bioinspired microfluidic chip, revealing higher orientation and alignment of composite suspensions in the chip. This confinement is attributed to the decrease in extrusion pressure of silk proteins and shear and elongation forces from the anisotropic microchannel.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Nanoscience & Nanotechnology
Ao Zhuang, Xiangyu Huang, Suna Fan, Xiang Yao, Bo Zhu, Yaopeng Zhang
Summary: By developing a one-step facile PEDOT:PSS modification approach based on a suitable post-treatment process of RSF films, PEDOT:PSS was successfully embedded and fixed into the shallow surface of an RSF film, forming a tightly conjunct conductive layer with excellent stability under a cell culture environment. The robust RSF/PEDOT:PSS film achieved in the post-treatment formula with 70% ethanol proportion possessed best comprehensive properties, including a sheet resistance of 3.833 x 10(3) Omega/square, a conductivity of 1.003 S/cm, and transmittance over 80% at maximum in the visible range.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Menglu Zhao, Danlei Yang, Suna Fan, Xiang Yao, Jiexin Wang, Meifang Zhu, Yaopeng Zhang
Summary: This study successfully achieved high-precision dental crown printing using a bottom-up step-by-step strategy with extrusion-based 3D printing technology, incorporating supergravity + HAp nanorods. By arranging the HAp nanorods in an ordered manner, a complex crown structure with excellent mechanical performance was achieved in the printed samples.
Review
Engineering, Biomedical
Shengzhi Zou, Xiang Yao, Huili Shao, Rui L. Reis, Subhas C. Kundu, Yaopeng Zhang
Summary: Silk fibroin is a promising biomaterial due to its good biocompatibility, availability, and mechanical properties. Nonmulberry silk fibroin, extracted from nonmulberry silkworm silk, has unique arginine-glycine-aspartic acid sequences that enhance cell adhesion. This makes it more suitable for cell culture and tissue regeneration applications.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Multidisciplinary
Zhanao Hu, Qianqian Niu, Benjamin S. S. Hsiao, Xiang Yao, Yaopeng Zhang
Summary: Neural interface is a powerful tool to control brain activities, and recent bioelectronic innovation has led to the development of flexible electrodes with low inflammation compared to rigid inorganic electrodes. This review focuses on the use of bioactive polymers such as silk fibroin and cellulose, as well as synthetic polymers, for constructing flexible electrode substrates for a conformal neural interface. The review covers the development of neural interfaces, biocompatibility and flexibility of implanted electrodes, material selection, structure design, and integration of neural interfaces.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Yi Zhang, Suna Fan, Yaopeng Zhang
Summary: Bio-memristors based on silk fibroin exhibit excellent performance and potential, playing important roles in non-volatile storage and bionic synapse fields. They provide new avenues for the design and application of high-performance bio-integrated systems.
MATERIALS HORIZONS
(2021)
Article
Materials Science, Biomaterials
Shengzhi Zou, Xinru Wang, Suna Fan, Xiang Yao, Yaopeng Zhang, Huili Shao
Summary: By using conductive metal meshes as collectors to prepare modified regenerated Antheraea pernyi silk fibroin (RASF) scaffolds, significant improvements can be made in pore size, porosity, and mechanical properties. The new scaffold (RASF-7mmG) exhibits higher cell viability, deeper cell permeation, and faster cell migration compared to traditional intact plate-collected scaffolds.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Paper & Wood
Li Huang, Wei Yuan, Yue Hong, Suna Fan, Xiang Yao, Tao Ren, Lujie Song, Gesheng Yang, Yaopeng Zhang
Summary: A novel biomaterial ink composed of regenerated silk fibroin and TEMPO-oxidized bacterial cellulose nanofibrils has been developed for 3D printing lung tissue scaffolds. The addition of OBC nanofibrils increased ink viscosity and improved scaffold shape fidelity, with optimal printing parameters identified as 0.3 bar printing pressure, 45 mm/s printing speed, and 410 μm nozzle diameter. OBC nanofibrils were aligned along print lines, guiding the orientation of lung epithelial stem cells and maintaining their proliferation ability and epithelial phenotype after 7 days of culture.
Article
Neurosciences
Fang Han, Zhijie Wang, Hong Fan, Yaopeng Zhang
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
