Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 80, Issue -, Pages 460-467Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.06.018
Keywords
Hydrogel; Gelatin; Cellulose; Interpenetrating polymer network (IPN); Wound dressing
Categories
Funding
- National Natural Science Foundation of China [21407125]
- Six Top Talents Program of Jiangsu Province [2015-XCL-034]
- Science and Technology Project from Ministry of Housing and Urban-Rural Development of the People's Republic of China [2014-K7-007]
Ask authors/readers for more resources
Interpenetrating polymer network (IPN) hydrogels composed of gelatin and hydroxypropyl cellulose (HPC) were prepared by successive enzymatic and chemical crosslinlcing approaches. The hydrogels displayed porous structure and the pore size decreased with the increase of HPC content. Due to the entanglement and interpenetrating between the two crosslinked networks, the IPN hydrogels exhibited excellent mechanical strength and light transmittance. The maximum tensile and tear strengths of the IPN hydrogels reached 3.1 and 5.2 MPa, respectively. The water vapor permeability of the IPN hydrogels was within the acceptable range to maintain appropriate moisture for wound healing. The cytotoxicity evaluation indicated that the IPN hydrogels exhibited no toxicity to fibroblast cells. In addition, the hydrogels were loaded with chloramphenicol by pre-soaking in drug solutions to evaluate drug-loading capacity and in vitro release behavior. It was found that the drug loaded hydrogels could act as drug delivery devices to create microbe free microenvironment, which was advantageous for wound healing. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available