Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

(2017) Thu Lan Nguyen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates

(2017) David Newman et al.   Marine Drugs

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

(2016) Peng Wu et al.   DRUG DISCOVERY TODAY

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play”

(2016) David Newman et al.   PLANTA MEDICA

Marine natural products as inhibitors of cystathionine beta-synthase activity

(2015) Megan K. Thorson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25–35 peptide administration in mice

(2015) Gaëlle Naert et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Sponge grade body fossil with cellular resolution dating 60 Myr before the Cambrian

(2015) Zongjun Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

(2015) Sònia Najas et al.   EBioMedicine

Long-range crystalline order in spicules from the calcareous sponge Paraleucilla magna (Porifera, Calcarea)

(2014) Andre L. Rossi et al.   Acta Biomaterialia

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells

(2014) Nan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

(2013) Najma Rachidi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzylidene 2-Aminoimidazolones Derivatives: Synthesis and in Vitro Evaluation of Anti-tumor Carcinoma Activity

(2013) Yong Ling et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold

(2013) Paul S. Baron et al.   MAGNETIC RESONANCE IN CHEMISTRY

2-Aminoimidazoles in Medicinal Chemistry

(2013) AleŠ Žula et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products

(2012) Mélanie Roué et al.   NATURAL PRODUCT REPORTS

Antioxidant benzylidene 2-aminoimidazolones from the Mediterranean sponge Phorbas topsenti

(2012) Tien Dat Nguyen et al.   TETRAHEDRON

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

(2011) Mansour Debdab et al.   JOURNAL OF MEDICINAL CHEMISTRY

An efficient approach to dispacamide A and its derivatives

(2011) Solène Guihéneuf et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cellular Localization of Clathridimine, an Antimicrobial 2-Aminoimidazole Alkaloid Produced by the Mediterranean Calcareous SpongeClathrina clathrus

(2010) Mélanie Roué et al.   JOURNAL OF NATURAL PRODUCTS

Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

(2010) Panduka B. Koswatta et al.   NATURAL PRODUCT REPORTS

Preparation of Hymenialdisine, Analogues and Their Evaluation as Kinase Inhibitors

(2009) T. Nguyen et al.   CURRENT MEDICINAL CHEMISTRY

An Efficient Method for the Preparation of New Analogs of Leucettamine B under Solvent-Free Microwave Irradiation

(2009) François Carreaux et al.   HETEROCYCLES

Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance

(2009) Dobroslawa Bialonska et al.   Marine Drugs

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

A microwave-assisted stereoselective synthesis of polyandrocarpamines A and B

(2008) Rohan A. Davis et al.   TETRAHEDRON LETTERS