Journal
MARINE DRUGS
Volume 15, Issue 2, Pages -Publisher
MDPI AG
DOI: 10.3390/md15020043
Keywords
Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling
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Funding
- Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]
- Natural Science Foundation of China [41606186, 41376160, 81673326]
- Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]
- Guangzhou Science and Technology Research Projects [201607010305]
- National Marine Public Welfare Research Project of China [201305017]
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Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 mu M. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 mu M, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
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