Hypopigmenting Effects of Brown Algae-Derived Phytochemicals: A Review on Molecular Mechanisms

Sargachromenol protects against vascular inflammation by preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation

(2017) Wi-Gyeong Gwon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes

(2017) Jae Chae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ethanolic extract of Sargassum serratifolium inhibits adipogenesis in 3T3-L1 preadipocytes by cell cycle arrest

(2017) Misung Kwon et al.   JOURNAL OF APPLIED PHYCOLOGY

Ethanolic extract from Sargassum serratifolium attenuates hyperpigmentation through CREB/ERK signaling pathways in α-MSH-stimulated B16F10 melanoma cells

(2017) Mohammed Shariful Azam et al.   JOURNAL OF APPLIED PHYCOLOGY

Antimelanogenic effects of luteolin 7-sulfate isolated fromPhyllospadix iwatensisMakino

(2016) J.Y. Kwak et al.   BRITISH JOURNAL OF DERMATOLOGY

Melanin pigmentation control by 1,3-thiazolidines: does NO scavenging play a critical role?

(2016) Alessandra Napolitano et al.   EXPERIMENTAL DERMATOLOGY

Anti-inflammatory action of the ethanolic extract from Sargassum serratifolium on lipopolysaccharide-stimulated mouse peritoneal macrophages and identification of active components

(2016) Eun-Ji Joung et al.   JOURNAL OF APPLIED PHYCOLOGY

Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen-activated Protein Kinase in B16F10 Cells

(2016) Joon-Seung Han et al.   JOURNAL OF FOOD SCIENCE

Anti-Inflammatory Effect of Ethanolic Extract ofSargassum serratifoliumin Lipopolysaccharide-Stimulated BV2 Microglial Cells

(2016) Sun-Ji Oh et al.   JOURNAL OF MEDICINAL FOOD

Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review

(2016) Kalu Kapuge Asanka Sanjeewa et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma

(2016) Feng Liu-Smith et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase

(2015) Hyo Jung Kim et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Inhibitory effect of ephedrannins A and B from roots of Ephedra sinica STAPF on melanogenesis

(2015) Ik-Soo Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide

(2015) Hyoeun Shin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Baicalin-induced Akt activation decreases melanogenesis through downregulation of microphthalmia-associated transcription factor and tyrosinase

(2015) Hyo-Soon Jeong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sargaquinoic acid attenuates inflammatory responses by regulating NF-κB and Nrf2 pathways in lipopolysaccharide-stimulated RAW 264.7 cells

(2015) Eun-Ji Joung et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation

(2015) Heun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sargaquinoic Acid Inhibits TNF-α-Induced NF-κB Signaling, Thereby Contributing to Decreased Monocyte Adhesion to Human Umbilical Vein Endothelial Cells (HUVECs)

(2015) Wi-Gyeong Gwon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway

(2015) Ping-Ya Zhu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model

(2015) Kil-Nam Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells

(2015) Yu Seok Song et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Hexane extract from Sargassum serratifolium inhibits the cell proliferation and metastatic ability of human glioblastoma U87MG cells

(2015) CHANG-WON KANG et al.   ONCOLOGY REPORTS

Effects of the melanogenic inhibitor, uracil, derived from Lactobacillus plantarum TWK10-fermented soy milk on anti-melanogenesis in B16F0 mouse melanoma cells

(2015) Chia-Jen Chang et al.   Journal of Functional Foods

Melanogenesis inhibitory effect of aerial part of Pueraria thunbergiana in vitro and in vivo

(2014) EunByeol Han et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation

(2014) Youngsic Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-inflammatory effects of sargachromenol-rich ethanolic extract of Myagropsis myagroides on lipopolysaccharide-stimulated BV-2 cells

(2014) Sunghee Kim et al.   BMC Complementary and Alternative Medicine

Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis

(2014) Mi-Soon Jang et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Inhibition of Melanogenesis by the Antidiabetic Metformin

(2014) Abdelali Lehraiki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells

(2014) Young-Jin Jun et al.   MOLECULES

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation

(2014) Jose C. García-Borrón et al.   Pigment Cell & Melanoma Research

ARP101 inhibits α-MSH-stimulated melanogenesis by regulation of autophagy in melanocytes

(2013) Eun Sung Kim et al.   FEBS LETTERS

Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells

(2013) Kil-Nam Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-diabetic and hypolipidemic effects of Sargassum yezoense in db/db mice

(2012) Su-Nam Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dioxinodehydroeckol inhibits melanin synthesis through PI3K/Akt signalling pathway in α-melanocyte-stimulating hormone-treated B16F10 cells

(2012) Min-Sup Lee et al.   EXPERIMENTAL DERMATOLOGY

Protective effect of chromene isolated from Sargassum horneri against UV-A-induced damage in skin dermal fibroblasts

(2012) Jung-Ae Kim et al.   EXPERIMENTAL DERMATOLOGY

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH2-Terminal Kinases, and Akt in Microglial Cells

(2012) A-Reum Kim et al.   INFLAMMATION

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro

(2012) Jo-Anne de la Mare et al.   INVESTIGATIONAL NEW DRUGS

Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tacrine-Treated HepG2 Cells

(2012) Min-Sup Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The effect of fucoidan on tyrosinase: computational molecular dynamics integrating inhibition kinetics

(2012) Zhi-Jiang Wang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

(2012) Lei Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

cAMP-Binding Site of PKA as a Molecular Target of Bisabolangelone against Melanocyte-Specific Hyperpigmented Disorder

(2012) Eunmiri Roh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals

(2012) Talita Pizza Anunciato et al.   Journal of Cosmetic Dermatology

5,7-Dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP-dependent signalling

(2011) Young-Gyu Kang et al.   EXPERIMENTAL DERMATOLOGY

Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells

(2011) Y.Y. Chan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy

(2011) Jasper G. van den Boorn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Therapies from Fucoidan; Multifunctional Marine Polymers

(2011) Janet Helen Fitton   Marine Drugs

Nitric oxide enhances melanogenesis of alpaca skin melanocytes in vitro by activating the MITF phosphorylation

(2011) Yanjun Dong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin Inhibits Melanogenesis in Human Melanocytes

(2011) Cai-Xia Tu et al.   PHYTOTHERAPY RESEARCH

The pleiotropic roles of autophagy regulators in melanogenesis

(2011) Hsiang Ho et al.   Pigment Cell & Melanoma Research

Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to α-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor

(2010) Yanjun Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae

(2010) Isuru Wijesekara et al.   CARBOHYDRATE POLYMERS

Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage

(2010) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

Screening of marine algae for potential tyrosinase inhibitor: Those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish

(2010) Seon-Heui CHA et al.   JOURNAL OF DERMATOLOGY

CREB: a multifaceted regulator of neuronal plasticity and protection

(2010) Kensuke Sakamoto et al.   JOURNAL OF NEUROCHEMISTRY

Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation

(2010) Dong-Seok Kim et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules

(2010) Hiroshi Shimoda et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation

(2010) Barbara Bellei et al.   Pigment Cell & Melanoma Research

Cardamonin suppresses melanogenesis by inhibition of Wnt/β-catenin signaling

(2009) Munju Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FcεRI expression

(2009) Sun-Yup Shim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

(2009) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibitory Effect of Phlorotannins Isolated from Ecklonia cava on Mushroom Tyrosinase Activity and Melanin Formation in Mouse B16F10 Melanoma Cells

(2009) Na Young Yoon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation

(2009) Soo-Jin Heo et al.   TOXICOLOGY IN VITRO

Inhibition of MITF and Tyrosinase by Paeonol-Stimulated JNK/SAPK to Reduction of Phosphorylated CREB

(2008) Jin Bu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Prospective of the cosmeceuticals derived from marine organisms

(2008) Se-Kwon Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Efficacy and safety of innovative cosmeceuticals

(2008) Xing-Hua Gao et al.   CLINICS IN DERMATOLOGY

Sargaquinoic acid and sargahydroquinoic acid fromSargassum yezoensestimulate adipocyte differentiation through PPARα/γ activation in 3T3-L1 cells

(2008) Su-Nam Kim et al.   FEBS LETTERS