Journal
MARINE DRUGS
Volume 15, Issue 12, Pages -Publisher
MDPI AG
DOI: 10.3390/md15120367
Keywords
marine cyanobacteria; malyngamides; glucose uptake; AMPK
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21710237]
- University of the Ryukyus Strategic Research Grant
- Grants-in-Aid for Scientific Research [21710237] Funding Source: KAKEN
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Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).
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