Article
Pharmacology & Pharmacy
Tong Zhao, Yuchen Zhu, Rui Zhao, Shiyi Xiong, Jing Sun, Juntao Zhang, Daidi Fan, Jianjun Deng, Haixia Yang
Summary: Nuciferine, an alkaloid found in Nelumbo nucifera Gaertn, has been shown to have various health benefits such as anti-obesity, lipid-lowering, and prevention of diabetes and cancer. It is closely related to inflammation and has intense anti-inflammatory effects in multiple models. This review summarizes the structure-activity relationships of dietary nuciferine, its biological activities and clinical applications in inflammation-related diseases, and the potential mechanisms involved. The findings contribute to a better understanding and utilization of nuciferine-containing plants in functional food and medicine.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Sabrin R. M. Ibrahim, Sana A. Fadil, Haifa A. Fadil, Rawan H. Hareeri, Sultan O. Alolayan, Hossam M. Abdallah, Gamal A. Mohamed
Summary: Marine environment serves as a vast reservoir of novel biometabolites beneficial for medical treatments and enhancing human health. Sponges, particularly Dactylospongia elegans, have been identified as potent producers of various classes of sesquiterpenes with diverse bioactivities such as antitumor, cytotoxic, antibacterial, and anti-inflammatory properties.
Review
Chemistry, Medicinal
Kong Zhang, Tianze Li, Xijie Shan, Rongfei Lu, Shaoyong Zhang, Hui Xu
Summary: Cholesterol and its derivatives have shown a wide range of biological activities, and structural modifications of cholesterol have been summarized from 2014 to 2020 in recent research. The bioactivities, mechanisms of action, and structure-activity relationships of cholesterol and related derivatives have also been discussed.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Van-Long Truong, Woo-Sik Jeong
Summary: Tea polyphenols act as direct antioxidants by scavenging reactive oxygen/nitrogen species, chelating transition metals, and inhibiting lipid, protein, and DNA oxidations. They also suppress pro-oxidant enzymes, induce endogenous antioxidants, and cooperate with vitamins. Furthermore, tea polyphenols regulate cellular signaling transduction pathways, significantly contributing to the prevention of chronic diseases and promotion of physiological functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Junjun Long, Wentao Ji, Doudou Zhang, Yifei Zhu, Yi Bi
Summary: Fusidic acid (FA), a natural compound isolated from fungi, exhibits various pharmacological activities such as antibacterial, antiviral, and anti-inflammatory effects. Research on its derivatives may provide valuable insights for drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Maan T. Khayat, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Summary: This article provides an overview of the naturally reported depsidones from 2018 to the end of 2022, including their structures, biosynthesis, sources, and bioactivities, as well as the reported structure-activity relationship and semisynthetic derivatives. A total of 172 metabolites with 87 references were reviewed. The findings demonstrate that these derivatives could be promising leads for therapeutic agents, but further in-vivo evaluation and mechanistic investigations are needed.
Review
Food Science & Technology
Xiaolong Ji, Jianhang Guo, Tengzheng Cao, Tingting Zhang, Yanqi Liu, Yizhe Yan
Summary: Diabetes mellitus is a common multifactorial disease that causes various complications, including chronic metabolism. Natural polysaccharides extracted from natural resources have the advantages of safety, accessibility, and anti-diabetic potential. This review summarizes recent research on natural polysaccharides with hypoglycemic activities, focusing on different pharmacological mechanisms in various cell and animal models. The relationship between structure and hypoglycemic effect is also discussed in detail, providing a comprehensive perspective for better understanding and developing natural polysaccharides against diabetes mellitus.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Chemistry, Medicinal
FuGui Zhou, Yiqing Zhou, ZhiYong Guo, XianJun Yu, Zhangshuang Deng
Summary: In this review, we summarized the literature on the biosynthesis, chemical synthesis, biological activities, and assumed work mechanisms of 10,11-dehydrocurvularin, highlighting its potential agricultural and pharmaceutical uses.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhiying Hou, Yang Lu, Bin Zhang, A. F. M. Motiur Rahman, Yufen Zhao, Ning Xi, Ning Wang, Jinhui Wang
Summary: Ruthenium (Ru)-based organometallic drugs have shown promise as chemotherapeutic and bioimaging agents, with fewer side effects and excellent optical properties. In this study, the relationship between the electronic structures of Ru(II) complexes and cytotoxicity was investigated by optimizing electron-withdrawing, electron-neutral, and electron-donating ligands. The results revealed that considering only the effect of electron-withdrawing or electron-donating properties on biological activities is not sufficient, and that complexes with electron-donating substituents exhibited unique luminescent emission phenomena when interacting with DNA. These findings provide valuable insights for the development of bifunctional chemotherapeutic agents with bioimaging abilities.
Review
Pharmacology & Pharmacy
Ting Liang, Xiangyang Sun, Wenhong Li, Guihua Hou, Feng Gao
Summary: Recent advances in research on 1,2,3-triazole-containing compounds with anti-lung cancer potential have been significant, with discussions on their structure-activity relationship and mechanisms of action to facilitate the rational development of novel anti-lung cancer candidates.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ye-Fan Wang, Xin-Yue Ren, Wen Zhang, Guo-Wu Rao
Summary: This review summarizes the clinical treatment, side effects, and potential therapeutic effects of sartans from 1995 to date. It also describes the synthesis, structural-activity relationship, and molecular docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimidazole derivatives, and other compounds. Novel Angiotensin Type 1 receptor antagonists with clear structure-activity relationship and abundant pharmacological effects are emerging for further research.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Gulab Said, Amjad Ali, Muhammad Umair, Farooq Ahmad, Salma Gul, Muhammad Ateeq
Summary: A series of 6 novel ester derivatives of natural product geodin 1 were semi-synthesized through one mild step reaction with high yield. These derivatives showed strong inhibitory activities against Staphylococcus aureus and potent antifungal activities against Candida albicans. Replacement of 4-OH group with benzoyl substituents enhanced the antibacterial and antifungal activities of geodin 1.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Senhua Chen, Runlin Cai, Zhaoming Liu, Hui Cui, Zhigang She
Summary: This review summarizes the discoveries of new metabolites isolated from mangrove-associated fungi over the past thirty years, focusing on the bioactivity and unique chemical diversity of these natural products.
NATURAL PRODUCT REPORTS
(2022)
Review
Microbiology
Ying Chen, Xiaoyan Pang, Yanchun He, Xiuping Lin, Xuefeng Zhou, Yonghong Liu, Bin Yang
Summary: Our study focused on the secondary metabolites of coral-associated fungi and resulted in a valuable and extensive chemical database. These compounds demonstrate strong biological activity and have potential as drug lead compounds. This review provides an overview of new compounds and bioactive compounds isolated from coral-associated fungi between 2010 and 2021. It covers 423 metabolites and emphasizes the diversity of their bioactivity and structure. Some of the compounds described in this review exhibit a wide range of bioactivities, including anticancer, antimicrobial, and antifouling activities. The aim of this review is to offer significant chemical and biological insights for future research on marine natural products and marine drug development.
Review
Pharmacology & Pharmacy
Denglang Zou, Qiqi Wang, Tao Chen, Duocheng Sang, Tingqin Yang, Yuhan Wang, Mengze Gao, Fangfang He, Yulin Li, Liangliang He, Duojie Longzhu
Summary: Bufadienolide, a key component of traditional Chinese medicine, shows excellent anti-inflammatory activity but has limitations due to severe side effects. Structural modifications through biotransformation can produce bufadienolide derivatives with minimal adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)