Journal
MARINE DRUGS
Volume 15, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/md15050128
Keywords
marine-derived fungus; Thielavia sp.; antifouling; Balanus (=Amphibalanus) amphitrite; thielavins
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Funding
- China Ocean Mineral Resources Research and Development Association [DY135]
- Youth Innovation Promotion Association CAS [QC2015388]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB06010204]
- Hainan Special Project for Ocean Exploration [XH201410]
- Natural Science Foundation of Hainan Province [414186]
- Institute of Deep-Sea Science and Engineering [SIDSSE-QN-201303]
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Eleven new depsides-thielavins W-Z (1-4) and thielavins Z(1)-Z(7) (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 +/- 0.59 to 69.19 +/- 9.51 mu M, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
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